>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxVxxxxxxxxxxxxx xxxxxxxxxxxxxRDAVQDCDYxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxILTSxxxKAxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxEKxxxxxxxxxDYEEDEEAFQFPEVV--------- ------PYPNVYDYxxxxxxxxxFYIGNMLSEMDKDSDFEITY-----LR xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- --x----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWENND PPEAEKQYYQHVHKTLRVLLQVVPM----------SRELLLQSIVNRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRDMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWGGMKSTYSL MLHTFEHVVLPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEK------------------------------ ---------SGKDISPLYREYEQTDMDDDHLEAEERQPQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tpa xxxxxxxxxxxxxxxxxxxxxxMx-------------------------- -----------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxRDAVQDCDYxxx------------------------- --xxxxxxxxxxxxILTSxxxKAxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxEKxxxxxxxxxDYEEDEEAFQFPEVL--------- ------PYPNVYDYxxxxxxxxxFYIGNMLSEMDKDSDFEINY-----LR xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWENND PPEAEKQYYQHVHKTLRVLLQVVPM----------SRELLLQSIVNRFPY LKVDLHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRDMFDIEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWGGMKSTYSL MLHTFEHVVLPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEK------------------------------ ---------SGKDISPLYREYEQTDMDDDHLEAEERQPQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tte -----------------------x-------------------------- -----------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxGxxxxxxxxxxxVxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- --xxxxxxxxxxxxILTSxxxKAxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxEKxxxxxxxxxDYEEDEEAFQFPEVV--------- ------PYxNVYDYxxxxxxxxVFYIGNMLSEMDKDSDFEITY-----LR xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTNDQSELRSGKAKSRKWNLHGPQRNRYRVNRDEPFGDKEWENNN PPEAEKQYYQHVHKTLRVLLQVVPM----------SRELLLQSIVNRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRDMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWGGMKSTYSL MLHTFEHVVLPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------xxxxxxxEMxxxxxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEK------------------------------ ---------SGKDISPLYREYEQTDMDDDHLEAEERQPQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------RVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWENNN PPEAEKQYYQHVHKTLRVLLQVVPIVLTAIIHCSRSRELLLQSIVNRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRDMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWGGMKSTYSL MLHTFEHVVLPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAASxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tms -----------------------x-------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxRxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEHSSKS ELxxxIGFVTFYAKFISNxxxxxxxxxxLxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxLSxxxxxxxxxxxxxxxVxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------EEIEMVLDYSSYYEEYEEVFWFPQVVxxxxxxxxx xxxxxxx---------------VFYIDFFLSEMDKDSDFEVTYxx----- -------------------------------------------------- -------------------------------------------------- ----------------xTKKATSSSILKSPGILRRxxxxxxxxxxxFHLP TQLESIFNNFINRSDTKPYEELICALKDSEVH------------------ -----------------------------------DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALRVLLQVVPM----------SRELLLQSIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRGMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWDGMKSTYSL MLHTFEHVILPTYATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPH-- --------------------------FTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI TRSxxxxxTFFPFDPYLLEKQ-------------xxxxxxxxxxxxExxx xxxxxxxx-SGKDISPLYREYEQTDMDDDHVEAEERRPQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxKAKKATSSSILKSPGVLRRxxxxxxxxxxxFHLP TQLESIFNNFISRSDTKPYEELICALKDSEVH------------------ -----------------------------------DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALCVLLQVVPM----------SRELLLQSIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQERDMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWDGIKSTYIL MLHTFEHVILPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEKQxxxISxAKLTSx----------------- ---------SSKDISPFYREYEQTDMDADHVEAEERQHQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxKAKKATSSSILKSPGVLRRxxxxxxxxxxxFHLP TQLESIFNNFISRSDTKPYEELICALKDSEVHELQExxxxxxxxxxxxED xxxxxxxxxxxxxxxxxxxExxxxxxxxxxx----DDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALCVLLQVVPM----------SRELLLQSIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQERDMFDMEDVLSERSLAHTLDTLLAMMFRYLRSQCLDWDGIKSTYIL MLHTFEHVILPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEKQVDMISFAKLTSx----------------- ---------SSKDISPFYREYEQTDMDDDHVEVEERQHQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tps -----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxx- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxKAKKATSSSILKSPGVLRRxxxxxxxxxxxFHLP TQLESIFNNFINRSDTKPYEELICALKDSEVHELQExxxxxxxxxxxxED KPSRTFTTKSMATAFHRIQ-GLQMLADEDPxxxCxDDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALCVLLQVVPM----------SRELLLQSIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNAPRSVLE LSQDRDMFDMEDVLAERSLAHTLDTLLAMMFRYLRSQCLDWDGIKSTYIL MLHTFEHVILPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxx--------------------------------------------- ---------SGKDISPLYREYEQTDMDDDHVEAEERQHQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tdi -----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxKAKKATSSSILKSPGVLRRxxxxxxxxxxxFHLP TQLESIFNNFINRSDTKPYEELICALKDSEVHELQExxxxxxxxxxxxED KPSRTFTTKSMATAFHRIQ-GLQMLADEDPxxxxxDDDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALCVLLQVVPM----------SRELLLQSIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNAPRSVLE LSQDRDMFDMEDVLAERSLAHTLDTLLAMMFRYLRSQCLDWDGIKSTYIL MLHTFEHVILPTHATCHVQFLMFYLCSFKPVLGEAFLNALWRKVTSPHVP PVIRQAAAS--------------VLxFTLAEMxxWIxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKGVAI ARSxxxxxTFFPFDPYLLEKQ----------xxxx--------------- -------xxSGKDISPLYREYEQTDMDDDHVEAEERQHQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH >Tce -----------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- --------------xxTxxxxKAxxxxxxxxxxxxxxxxxNKFSKNLxxx xxxxxxxxxxxxxxxxxxxxxxxxxxYYEEDEEVFWFxQVVxxxxxxxxx xxxxxxx---------------xFYIAFFLSEMDKDSDFEVTYxxxx--- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxSILKSPGxxxxxxxxxxxxxxxxxxx xxxxSIFNNFxxxxxxxxYEELIxxxxxxxVH------------------ -----------------------------------DNDLQPLLQEARKCI SLVDESLHHFVRALLRVPWVKRSPKLVELYQGLLVDLVSAHNYYTVGVLD SLVLQFTN-------------------------------AFGDKEWEDND PPEAEKQYYQHVHKALRVLLQVVPM----------SRELLLQTIVSRFPY LKVDSHIQECFLYNLFQIIDYEPALSQDLYTLIINRLVALDVNTPRSVLE LSQDRGMFDMEDVLSERSLALTLDTLLAMMFRYLRSQCLDWDGMKSTYSL MLHTFEHVILPTYATCHVQFLMFYLCSFKPVLGEAFLNALWR-------- -------------------------xFTLAEMxxxxxxxxxxQDSLECAN SDIRVHTVFYSVCQALFYVVAFRHGDLVQSKKDLTFMQSLNMAQIVTCRL NPLRVCLPVVVRNFAAVTRTYQLAYCYTIIEHNSRNSMPIIHTDDKxxxx xxxxxxxxT----------------------------------------- ---------SGKDISPLYREYEQTDMDDDHVEAEERRPQGKNQDEEDDDF LCETTGGSESSQNMFTYSISPGFKSRH