>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------x------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPTPVK--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAVEELTHGQ MLQAQLCGYSDDGVPVVYLYSIQGTQ------------------------ -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxNRLx-------------------- -------------- >Tms MTxxxLAxEPAALTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVQWY TQAGLSQDSGxHYGVSExxxxGQEMxxxxxxxxxxxxxxxx--------- --------------------xxxxPARHxSPGRFYWxVGRGEDFTRTHP- ---------------------CTLYRHVRWVWQCGAWxxxxxxxVHLGFS EH------------------------------------------------ --------VRLHQWFSFFVHDTTGVxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------SQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSP-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVVIPRSDNSQTIGTPEERIEPVKSNQVTA IAPKTSLVENKSKV-DVVDTLTLSDQPDELHRFDSIDLLGESKITSLDTT ASQKNILYCDLESPGDKINQLGLATQEIEDTNLSTLDLSSSSSHSDVSVR DLVSGGEEELVSVEGHSELLSLERSFVFSPALVDLVTESDSSPEVKERTV SSLAVCSSGKVTP-------VCSAPSSPGAGSDVLESSDRRGTVTGAVPV EEDED-SASSADSCSEATVMARKSSVDLAMERKTPDGAAALEHKLSALQL SGDD--GGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPIPSVYEFVLPQFLVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTKFKICAVEGLQMDIEGAL------- ------EMIRQKFPLKKYPNITLEQVCFMPTGPIIPILPEFxx------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNGLNACMNICYSEPTVPPLPSPVN--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAMEELTHGQ MLQAQLCGYSDDGVPVVYLYSIQGTQ---------------------VVF VNYELVNRGLAQWVEAGVET------------------------------ -------------------------------------------------- -------------------------------------------------- --------EVPAEA >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSQ-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVAVPRSGNSQTTGTPEERIEPVKSSEVTA IAPKTSLVENKSKVxDVVDTLTLSDRPDELHRVDSADLLGELKITSLDTT ASQKNILRCDLENPGDKVNQLGSTTREIEDTNLSTLDLSSSSSRSDVSVI DLVSGGEEDLVNVEGHSQVLSLERSFAFSPPLVDLVTESDSSPEVKERTV SPLAVCSSGKVTL-------VCSAPSSPGAGSDVLESGDRRGTVSGAVPA EEDED-SASSADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDDxxGGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPVPSVYEFVLPQILVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTDLKICAVEGMQMDIEGAL------- ------EMIRQKFPIKRYPDITLEQVCFMPTGPIIPILPEF--------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPSPVN--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEESDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAMEELTQGQ MLQAQLCGYSDDGVPVVYLYSIQGTQ---------------------VVF VNYELVNRGLAQWVEAGVET------------------------------ -------------------------------------------------- -------------------------------------------------- --------EVPAEA >Tdi Mx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx -----------xxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxSQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSQ-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVAIPRSGNSQTTGTPEERIEPVKSSEVTA IAPKTSLVENKSKV-DIVDTLILSDQPDELHRVDSTDLLGESKITSLDTT ASQKNILRCDLENPADKVNQLGSASREIEDTNLSTLDLSSSSSRSDVSVI DLVSGGEEDLVNVEGHSQVLSLERSFAFSPPLVDLVTESDSSPEVKERTV SPLAVCSSGKVTP-------VCSAPSSPGAGSDVLESGDRRGTVSGAVPA EEDED-SASSADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDD--GVEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPVPSVYEFVLPQILVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTDLKICAVEGMQMDIEGAL------- ------EMIRQKFPIKRYPDITLEQVCFMPTGPIIPILPEFxx------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPSPVNxxxxxxxxxxxLTDSSQLTSx xxHxxxYSCPVASxVLTxxxxxxSHSQH---------------------- ------LVSVICVAPTMGGWYRAMVVSVDEESDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAMEELTQGQ MLQAQLCGYSDDGVPVVYLYSIQGTQ---------------------VVF VNYELVNRGLAQWVEAGVET------------------------------ -------------------------------------------------- -------------------------------------------------- --------EVPAEA >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------SQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSQ-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVAIPRSDNSQTIGTPEERIEPVKSSEVTA IAPKTSLVENKSKV-YVVDTFTLSDQPDELHRVDSTDLLGESKITSLDTT SSQNNILCCDLESPGDKVNQLGSATREIEDTNLSTLDLSSSSSRSDVSVI DLVSGGEEDLVSIEGHSQVLSSERSFAFSPTLVDLVTESDSSPEVKQRTV SPLAVCSSGKVTP-------VCWAPSSPGAGSDVLESGGGRGTVSGAVPA EEDEDxSASSADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDD-xGGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPVPSVYEFVLPQILVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTDLKICAVEGMQMDIEGAL------- ------EMIRQKFPIKRYPDITLEQVCFMPTGPIIPILPEFxx------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPSPVN--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAMEELTHGQ ILQAQLCGYSDDGVPVVYLYSIQGTQ---------------------VVF VNYELVNRGLAQWVEAGVET------------------------------ -------------------------------------------------- -------------------------------------------------- --------EVPAEA >Tsi ME------------------------------------------------ ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxLHPLH----------------------------- --------------------------HVRWVWQCRAWxxxxxxxVHLGFS EHxxxxxxLGKTSLSTPDRDSNLGHHVIGRIVYGESSALDHAATEAGxxx PALLSxxCF----------HDTTGVSAKRMRR------------------ ----------------xxxNHSCGEGEGKTVEDYHPHCTRPGLDPDLPVF RSLVQHDGSVLDRAVTECSQNxxxxxxxxxxxxxxxx------------x xxxxxxxxxxxxxxxxSPAQGYNNRKNHPQFTLPxxxxxxxxxxxVExxx xxxxxxxxxxxxxxGGSIxMCPHLSWxxPMLWATMRQPPxSPVSMLGVRA xxxGRxxxxxxxGxxxx------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx-------SQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSQ-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVAIPRSDNSQTIGTPEERIEPVKSSEVTA IAPKTSLVENKSKV-YVVDTFTLSDQPDELHRVDSTDLLGESKITSLDTT SSQNNILCCDLESPGDKVNQLGSATREIEDTNLSTLDLSSSSSRSDVSVI DLVSGGEEDLVSIEGHSQVLSSERSFAFSPTLVDLVTESDSSPEVKQRTV SPLAVCSSGKVTPxxxxxxxx----------------------------- ---------SADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDD-xGGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPVPSVYEFVLPQILVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTDLKICAVEGMQMDIEGAL------- ------EMIRQKFPIKRYPDITLEQVCFMPTGPIIPILPEF--------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPSPVN--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGGVEAEWSKESLIAMEELTHGQ ILQAQLCGYSDDGVPVVYLYSIQGTQ---------------------VVF VNYELVNRGLAQWVEAGVET------------------------------ -------------------------------------------------- -------------------------------------------------- --------EVPAEA >Tbi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------SQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSRASLxxSRPxEEESDP SKEAELITVDxAQIKKSLHNGAVTPSSDNSQIVGTLEERIELVKSSKVTA IAPKTSLVENKSKV-DVVDALKLSDQPDELHRVDSADSLGESKITSLDTT ASQKNILCCDLENPGDKANQLGSSTQEIEDTNSSTLDLSSSSSHSDVSVI DLVSGGEEDLVSVEGYTEVLSLAHSFNFSPELVDLVTESDSSPEVKERTV SPLAVCSSVNVTP-------VCSAPSSSSVGSDVLESSDRKGAVSGAVPV EEDED-SASSADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDD--GGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPIPSVYEFVLPQLLVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTKLKICAVEGMQMDIEGAL------- ------EMIRQKFPIKKYPNITLEQVCFMPTGPVMPILPEF--------- --------------------LQLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPTPVK--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMLLPFQATECYLANVSPVGGVEAEWSKESLIAVEELTHGQ MLQAQLCGYSDDGVPVVYLYSIQGTQxxxxxxxxxxxxxxxxxxRQxxxx xxxxxxxxGxxxxxxxxVETxxxxxxxx---------------------- -------------------------------------------------- ---------------------------------------LxSIIWxxxxx xKKNxxxx------ >Tte xx------------------------------------------------ -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------KLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNSLNACMNICYSEPTAPPLPTPVK--------------------- -------------------------------------------------- -------VSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMLLPFQATECYLANVSPVGGVEAEWSKESLIAVEELTHGQ MLQAQLCGYSDDGVPVVYLYSIQGTQxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------KG SSDSGKGCSDVATPPSRTPASGSSVAGDLPIPSVYEFVLPQLLVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTKLKICAVEGMQMDIEGALEMIRxxx xxxxxxEMIRQKFPIKKYPNITLEQVCFMPTGPVMPILPEFxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------- >Tce TG------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------PLLATASQTVSPRGx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxx-------------------- -------------x-------SQLVQRSLPRWRESMAPQSSRQLLVWSVP TLAFLLSLLWYRRKKNSLRSDPGGTVSVASNISSP-----SRP-EEESDL SKEAELIAFD-AQINKSLHNGVVIPRSDNSQTIGTPEERIEPVKSNQVTA IAPKTSLVENKSKV-DVVDTLTLSDQPDELHRFDSIDLLGESKITSLDTT ASQKNILYCDLESPGDKINQLGLATQEIEDTNLSTLDLSSSSSHSDVSVI DLVSGGEEELVSVEGHSELLSLERSFVFSPALVDLVTESDSSPEVKERTV SSLAVGSSGKVTP-------VCSAPSSPGAGSDVLESSDRRGTVSGAVPV EEDED-SASSADSCSEATVMARKSSVDLAMERKTPDEAAALEHKLSALQL SGDD--GGEQQASSSAEQARGERDSANHSPADVMLGSPAISNFSDVHSEG SSDSGKGCSDVATPPSRTPASGSSVAGDLPIPSVYEFVLPQFLVGRLIGR HGTFVHQIKEKTNASILIKRHPDTTKFKICAVEGLQMDIEGAL------- ------EMIRQKFPLKKYPNITLEQVCFMPTGPIIPILPEFxxxSQQVNQ HALLAPMTRSIPHGxxxxxxRKLLEGVSNDVYLSSLVSTTHFFLQQPLHP TFPALNGLNACMNICYSEPTVPPLPSPVN--------------------- ---------------------------xxxxxxxxxxxGWYRAMVVSVDE EXLFLCLVSVICVAPTMGGWYRAMVVSVDEENDTCDVKFVDYGGYQTVEN SALRQIRSDFMMLPFQATECYLANVSPVGG-------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -----------------------------xxxxxxxxxxx---------- --------------