>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------GRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHTHGGPQSFP PRIPEGPNGPHHG----------SNGPYQGPNGPHEGPNGPRGPHGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTGVMNGSRFNSTPNHDLERMDMKTDGSKTNQD SNKDKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRHATINKLQP RLVRNDADKNKRPEVMERSVPKVWSW------------------------ -------------------------------------------------- -------------------------------------------------- - >Tpa x---xxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPPYIPPVNTDRV PPPRPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDTFLFYCSAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQENHWMFAWNSLDPRCDPHDNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHTHGGPQSFP PRIPEGPNGPHHG----------SNGPYQGPNGPHEGPNGPRGPHGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTGVMNGSRFNSTPNHDLERMDMKTDGSKTNQD SNKDKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRHATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREVxxx-------x------------------------------- -------------------------------------------------- - >Tte -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------CFLRSRTGFRFARAIAKVSLTVPSLHECE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVHGPHPPSET---------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNTDRV PPPRPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDTFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQENHWMFAWNSLDPRCDPHDNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHTHGGPQSFP PRIPEGPNGPHHG----------SNGPYQGPNGPHEGLNGPRGPHGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTGVMNGSRFNSTPNHDLVRMDMKTDGSKTNQD SNKDKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRHATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREVxxx-------x------------------------------- -------------------------------------------------- - >Tbi M---VEVL------------------------------------------ GEALAxx--------------EAMNTGTIIGQVEALEGPMGEGMVLEEAG GQATKGGA-------RVKGQGGGAILDLHGIQVGRNGTPTDPGAGVQSLQ SMEDIYRALLGTRTWASLDSLDHHWGPQKV-------------------- ---------------------------RTPYLQNHIKVIVSEGESKGHIP SNNVFNQNTxxIK--------CFLRSRTGFRFARAIAKVSLTVPSLHECE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVHGPHPPSET---------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNTDRV PPPRPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDTFLFYCTAISFRxDVFGEGVHPDQKGGGKVQNYIEQQLSFVDGAKNK EKQLCHFIKVGPASEQLGHFPEVWAFPGNMNSPxDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQENHWMFAWNSLDPRCDPHDNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHTHGGPQSFP PRIPEGPNGPHHG----------SNGPYQGPNGPHEGLNGPRDPHGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTGVMNGSRFNSTPNHDLVRMDMKIDGSKTNQD SNKDKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRHATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREVQSP-------xxxxxxxAGSDKCVGSNRGESKGVGTLSPDDV VSGVRIGVGMDLETSIxVWRVIQSxxxxxxxHMLVYFTDPLHTRYTPGST x >Tms xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------ECFLRVRSGQRLDQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV --xxPPQGPNKPTDELCYVGYGGPARLLPSSIRSSMRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEDHWMFAWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHPHGGPQSFP PRIPEGPNGPHHGxxxxYQGHNHPNGPYQGPNGPHEGPNGPQGPHGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTDIMNGSRFNSTQTHDLVRMDMKTGGSKTNQD SNKDKVLFEIVDEKDDLSSSEIINGGGDESVDLSLKASDNRRATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREV--PMSITKVNK------------------------------- -------------------------------------------------- - >Tcm M---VEVL------------------------------------------ GEVLAxxxxxxxAMGQV----EAMNTGTIIGQGEALEGPMGEGMVLEEVG GQTTKGGARGTKGGxRVKGQDGGAILDLHGIQVGRNGTPTDPGAGGQSLP SMEDIFRALLGTRTWASLDSLDPHWGPQKVxxxxxxxxxDLFLAACHITC LGYPHIYNxxxxxxxxLEExxPHVxxxT---------------------- ------------K--------CFLRSRTGFRFARAIAKASLTVPSLHGCE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVQGPHPPSET---------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV PPPPPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEDHWMFAWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDRYFPYRGHPHGGPQSFP PRIPEGPNGPHHGxxxxYQGHNHPNGPYQGPNGPHEGPNGPHGPNGDPYG PPRYWPVAYLHAEGPPNSTVISPGDKQPALLLTKYDSQEGFDNYIDMNRY NYGKKMILFSPSKKxNNNTDIMNGSRFNSTPTHDLVRMDMKTGGSKTNQD SNKDTVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRRATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREV--PMSITKVNKS------------------------------ -------------------------------------------------- - >Tsi xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPFVVDCELECLx------------YGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV PPPPPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEDHWMFAWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCS------------------ -------------------------------------------------- --------------PPNSTVISPGDKQPALLLTKYDSQEGFDNYIDMNRY NYGKKMILFSPSKKxNNNTDIMNGSRFNSTPTHDLVRMDMKTGGSKTNQD SNKDTVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRRATINKLQP RLVRNDVDKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATRDV--PMPVTKVNKS------------------------------ -------------------------------------------------- - >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxCFLRSRTGFRFARAIAKVSLTVPSLHGCE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVQGPHPPSET---------------------- -----------------------------------ECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV -xxPPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEEHWMFAWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDR---------------- -------------------------------------------------- --------------PPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK-xNNTDIMNGSRFNSTPTHDLVRMDMKTGGSKTNQD SNNEKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRRATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREV--PMSITKVNKS------------------------------ -------------------------------------------------- - >Tdi M---VEVL------------------------------------------ GEALAxxxxxxxAMGQVxVPGEAMNTGTIIGQGEVPEGPMGEGMVLEEVG GQTTKGGARGTKVGxRVKGQDGGALLDLHGIQVGRNGTPTDPGAGGQSLP SMEDIFRALLGTRTWASLDSSDPHWGPQ---------------------- -------------------------------------------------- ------------K--------CFLRSRTGFRFARAIAKVSLTVPSLHGCE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVQGPHPPSETGTGRLCCIASLHLIKTKEGTEL KVVERSWNERAAKVTKHLLLFLTDHVVSKKxxxxxECFLRVRSGQRLNQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV -xxPPPQGPNKPTDELCYVGYGGPARLLPSSIRSSLRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEEHWMFAWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCS------------------ -------------------------------------------------- --------------PPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK-xNNTDIMNGSRFNSTPTHDLVRMDMKTGGSKTNQD SNNEKVLFEIVDEKDDLSSSEINNGGGDESVDLSLKASDNRRATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREV--PMSITKVNKS------------------------------ -------------------------------------------------- - >Tce M---VEVL------------------------------------------ GEALAxxxxxxxxxxQV----EAMNTGTIIGQEEAPEGPMGEGMVLEEVG GQTTKSGARGTKGxxRVKGQDGEAILDLHGIQVGRNGTPTDPGAGGQSLP LMEDIFRALLGTRTWASLDSLDPHWGPQKV-------------------- ---------------------------STPYLQNHxKVIVSxxx------ ------------K--------CFLRSRTGFRFARAIAKVSLTVPSLHGCE AECANEKHFVCNTFSFRYSLEPAFPQDNCLLGEVVYRELDPYNDLIPDRD YDIYTRNEFARTCQPPFPVQGPHPPSET---------------------- -----------------------------------ECFLRVRSGQRLDQA VVKDSLNVPSVVDCELECLRSRFFTCRIFSYRYGPAVIGGPLDNCQLSDW PFVELDSRRDLVEDVGYELYERGSYGHGCEVDRRPPRPPSYIPPVNNDRV -xxPPLQGPNKPTDELCYVGYGGPARLLPSSIRSSMRVPTEQDCKTECSR ARDKFLFYCTAISFR----------------------------------- ---------------------------------SDSVRHHDGGPNCLLSD IDQRDLRPGLDYVHQEDHWMFVWNSLDPRCDPHSNPQTIGHYQDHFQDHL IPGPGGPEVWQRFTVSGRPCRYGTFCAENREAGFWSCELEGGDAGSFDYC CRPGHQCGYSEGFNYPWCYVGSAARDQWRPCSDR---------------- -------------------------------------------------- --------------PPNSTVISPGDKQPALLLTKYDSQEGFDNYIDVNRY NYGKKMILFSPSKK--NNTDIMNGSRFNSTQTHDLVRMDMKTGGSKTNQD SNKDKVLFEIVDEKDDLSSSEIINGGGDESVDLSLKASDNRRATINKLQP RLVRNDADKNKRPEVMERSVPKVWSWRDNDSDDQLPGPVEFRRKTIPRMA FVTATREV--PMSITKVNK------------------------------- -------------------------------------------------- -