>Tge x-------------------------xxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- -------------------------------------------------- -------xG------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------x-- -------------------------------------------------- -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR TRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTLEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHRTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE EHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tbi xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------G------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------E-- -------------------------------------------------- -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR TRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTLEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHRTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE EHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tte xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------G------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------x-- -------------------------------------------------- -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR TRPQSLQADQGTTLTMSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTLEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHRTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE EHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxx- -------------------------------------------------- ------xxG------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------x-- -------------------------------------------------- -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLNNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR MRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tms -------------------------------------------------- --------xxxRLRALLLLALLVTRVSAGEQRFAMEPQDQTAIVGxxxxx xCRVINKTGVLQWTKDDFGLGTHRNLSGFDRYSxxxSDEE---------- -------------------------AIHGxxxNxxxxxxxxxxxxxVLAI MSxxxxxxVVFxxxxxxxxxxxxxxxxxxxxxxxxxxxTYWYGAYDGLxx xxGGGSPRAVHKQFVRRSKSRPNHENLQFANGSVRRYGxxxFxYILLTPS TFIxxxSLLEATTTYLDPxxxxxxxxxxxxAxxxxADxVSRVxxxxRxxx -------------------------------------------------- -------------------------------------------------- -------PFKTNxxxxxxxxSLVRGAxxxKSxxxxxxxxxxxxMxxxxx- -------------------------------------------------- ------xxG------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------xxx xxDHVATGxxNTxEVxDxxVSNNDLSDSDGLTALLGHARMCDVSPRLIRV MC------------------------TRRHIRAKTYIKSTSNxxxNxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLNNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR MRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tps xV------------------------TARSPWMSISFTLPPSSSPPLTPL NSMDRSRGxxxRLRALLLLALLVTRVSAGEQRFAMEPQDQTAIVGxxxxx xCRVINKTGVLQWTKDDFGLGTHRNLSGFDRYSxxxSDEEGRRTTLxLPE IREQKETNELHTMPSQCELRTPLRSS------------------------ ------------------------------------------------xx xxGGGSPRAVHKQFVRRSKPRPNHENLQLANGSAR--------------- -------------------------------------------------R IxYYxxxKTEAARSASPGSKxxxxxxPPTxxxxxxxxxxxxxxxRxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAxxx xxDDxxxPIRTNxxxxxxxxSLVRGAxxxKSxxxxxxxxxxxxM------ -------------------------------------------------- -------xxxxxxxxxxxTxxxxxxxxxxxxxxxxxxxxDYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAAx-------------------xxxxVLGSLVYSESS ALDHAATGxxSMxx------------------------------------ -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR MRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxx-----------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAAx-------------------xxxxVLGSLVYSESS ALDHAATGxxSMxx------------------------------------ -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDIS----YGPRFR MRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tsi xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------PIRTNxxxxxxxxxxxRGAxxxKSxxxxxxxxxxxxxxxxxEA RVNIVFLxxxxxxxxxxx-------------------------------- ---xxxxxG------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAA--------------------------------E-- -------------------------------------------------- -------------------------------------------------- --------------------------------ITWIDGLGTVLTDGIEYI KEFLPDGRRITAKSILKLTPKKEHHNTTFTCQAQNTADRTYRSAKLRLQV KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDISxIGQNGPRFR TRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQK------------------NFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPPxNFNHVFIEFPFLFKAANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tcm xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------PIRTNxxxxxxxxSLVRGAxxxKSxxxMxxxxxxxxxxxxxxx xVNIVxxAxxxxxxxxxxExPPPVHTTEIRTSISPSSAVGLNTTSALAxx xxxx----G------------------------------DYSLDIYPVML DDDARFQCQVGPGLLGEPGIRSKFATLTILVPPEPPRIIQGDFLVTTEDR EIELECVSLAGKPAAxxxxxxxxxxxxxYTLLRLxTSxxVLGSLVYSESS ALDHAATGxxSM-------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxx-------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------V KYAPKVTLSVVGAHNGRLLEGQEVRLACQADANPLDLTYRWYINDKPVPG DYTTELLLSNISRKFHDAIVKCEVHNPVGKSEESETLDISxIGQNGPRFR TRPQSLQADQGTTLTLSCDVDGNPPPDIVWIHDSTGKVVGTSVNLTVEVD PDTAGRYYCKASVMGFPEIGAEATIYLKGPPTIISHHTQFGIQGDNVRLE CVAFSIPRPDHVMWTYKGNEVNSKDKDYTILEDRLPEGIKSTLVIRESQE GHFGSYNCSVINPYGSDVVEIILKPQKMRAVELFGTKGISVRITxNFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPPxNFNHVFIEFPFLFKAANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxNFPLL MILVGVIGGVVVIIAIAMVVILCQRREKKPP---------------SANC QDAEKQCKESDRSSNISDLKLELRTGSSVSNVHCELEYGPGDSETGSESV VTRVGVPLAGPVSMPVNGGEHLYPRYSAEFTDPTFPPKDGQNNNGYVPYV DYSRDYNPPPPIESSRESLSTVTAIDPRYSAVYGNPYLRNSNTSLPAPHT VGTPAPPPYSAATRNGAVPQVARLPNSPTSQYIVPNSQPPTMKRGTLATH V