>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------AAIQKLRDIKPARLYEGGQNNQIK KAAVLVPLCIVNGEVSLLYTVRSPDLKRNSGQVSFPGGLMDKTDKDLQET ALRETFEELGIQKSSVQIWGHG---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVxxxxxxxxxxx xxxxxx-------xxxxxxxVSWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGVSNDNLLLTGGFTLALSGFVVLFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEDILPVWHGWLLISIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------IK KAAVLVPLCIVNGEVSLLYTVRSPDLKRNSGQVSFPGGLMDKTDKDLQET ALRETFEELGIQKSSVQIWGHGNLFGTHTKDMVVLPVIGYLGxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxYTQFRGHYVLPx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx-------xxxxxxxxxxxxxxxxxxxxCDDPVxxxxxxxxxxx xxxxxxxxxxxxx---------WVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGVSNDNLLLTGGFTLALSGFVVLFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEDILPVWHGWLLISIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE--------------------YYILLLLYNQNPRLSEIKKL QVHDPNCRTRYSDHILCPQSSRPSLGWFQYFTNSYWYDWKTYFKHRVFMA SVGLALLYMTVLG------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx x-----------------------------------x >Tms M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxQALTAAHHLIKTxxTASVxSSKVRENSLLPS---------- -------------------------------------------------- ----------------VMRRSISLLVCFTLVLVTWA-------------- -------------------------------------------------- -------ERSPKRRHACICPRIYWPVCGTDGRSYSNECMLRCASSKGETR Sxxxxxxx---------------------------------xx------- ------------------R------LRCITKLRNIKPAQLYEGGQNNQIK KAAVLVPLCIVNGELSLLYTVRSPDLKRNSGQVSFPGGIMDKTDKDLQET ALRETFEELGIQKSNVQIWGHGNLYGTHTKDMVVLPVIGYLGxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxYTQFRGHYVLPxxxxxxxxxxxxxII THFxxxxxxxxxxxx----------------------------------- --xxx--------------xxxxxxx------------------------ -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------xVSWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMSHDNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEGILPVWHGWLLVSIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE--------------------YYILLLLYNQNPRLSEIKKH QVHDPNCRTRYSDHILCPQSSRPSLGWFQYFTNSYWYDWKTYLKHRVFMA SIGLALLYMTVLGFDAITTAFVSMQISSTLAGVSQGLAAIFGIIGSVSFP FLRQRIGLKLVGMVGLGSEIAAILACIISIWLPGSLFMAVAIDPTWKPNV ENGTNNSDDSLEEKASVMALLGGIVVSRFGLWLADITITQIMQEEIEENK RGVLNGVQDSLNMGMDMLKSILVMVYPYPAQFGYCIILSFVSICTGGKPN TANQEQ---------KNETEAENSHVTKVHIAQPLQDA------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------S >Tps xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------VHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMSHNNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTMVGLTFYFWDDILPVWHGWLLISIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE--------------------YYILLLLYNQNPRLSEIKKH QVHDPNCRTRYSDHMLCPQSSRPSLGWFQYFTNSYWYDWKTYLKHRVFMA SIGLAMLYMTVLGFDAITTAFVSMQISSTLAGVSQGLAAIFGIIGSVSFP FLRQRIGLKLVGMVGLGSEIAAILACIVSIWLPGSLFMAVAIDPTWKPNV ENGTNKSDDSLEEKASVMALLGGIVVSRFGLWLADITITQIMQEEIEENK RGVLNGVQDSLNMGMDMLKSILVMVYPYPAQFGYCIILSFVSICTGGKPN IANQEQKNEDGKVSTKNETEAENSHVTKVHIAQPLQDA------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------S >Tcm M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------SVGVSELREGAGGCx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxNSCQGGxxxxxDPxxxxxx xxxVxxxERSPKRRHACICPRIYWPVCGTDGRSYSNECMMRCASSKGETR S------------------------------------------------- -------------------------------------AQLYEGGQNNQIK KAAVLVPLCIVNGELSLLYTVRSPDLKRNSGQVSFPGGIMDKTDKDLQET ALRETFEELGIQKSNVQIWGHGNLYGTHTKDMVVLPVIGYLGxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxYTQFRGHYVLxxxxxxxxxxxxxxII THFxxxxxxxxxxxx----------------------------------- --xxx--------------xxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------ITWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMPHNNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEGILPVWHGWLLVSIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMMAE--------------------YYILLLLYNQNPRLSEIKKH QVHDPNCRTRYSDHMLCPQSSRPSLGWFQYFTNSYWYDWKTYLKHRVFMA SIGLALLYMTVLGFDAITTAFVSMQISSTLAGVSQGLAAIFGIIGSVSFP FLRQRIGLKLVGMVGLGSEIAAILACIISIWLPGSLFMAVAIDPTWKPNV ENGTNNSDDSLEEKASVMALLGGIVVSRFGLWLADITITQIMQEEIEENK RGVLNGVQDSLNMGMDMLKSILVMVYPYPAQFGYCIILSFVSICTGGKPN TANQEQKNEDGKVSTKNETEAENSHVT----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Tce x---------------xxxxLQxxxxxSLPRVLSPYGQCHEYESKEKLRL KGFSYSCATTASFMTRKALSSAILGQLSPKMTRxxKSQKPLSGKTSSEGT DECSHKGEQLxxxxxxxxxYFKPVPVVTRPLVFSCQVxxxxxxQGKSRVC SEREQTSExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxNTCQ GGxxxxxxxxxxxxxxxxVSTLGARDTNLCSCSGSTSAQPVLGTLSPHQV LGRDPVYTPGTKDPVYTPGTRDPVSTPGTRDPVYTPGxxxxVSIPGTRDP VSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPG TRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPV STPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGTRDPVSTPGx xxxxxxxxxxxxxxxxxxxxxxxxxxxLPSRDLDNLKKKVDSPxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKIRENSLLPS---------- -------------------------------------------------- ----------------VMRRSISLLVCFTLVLVTWx-------------- -------------------------------------------------- -------ERSPKRRHACICPRIYWPVCGTDGRSYSNECMLRCASSKGETR S-----------------------------------------DVKVAREG LCEEKIPQIKDNVVVNNPK------LKCITKLRNIKPAQLYEGGQNNQIK KAAVLVPLCIVNGELSLLYTVRSPDLKRNSGQVSFPGGIMDKTDKDLQET ALRETFEELGIQKSNVQIWGHG---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ---------------------SWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMSHDNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEGILPVWHGWLLVSIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLAK---------------------- -------------VNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAExxxxxxxxxxxxxKYCSSCxYYILLLLYNQNPRLSEIKKH QVHDPNCRTRYSDHILCPQSSRPSLGWFxYFTNSYWYDWKTYLKHRVFMA SIGLALLYMTVLGFDAITTAFVSMQISSTLAGVSQGLAAIFGIIGSVSFP FLRQRIGLKLVGMVGLGSEIAAILACIISIWLPGSLFMAVAIDPTWKPNV ENGTNNSDDSLEEKASVMALLGGIVVSRFGLWLADITITQIMQEEIEENK RGVLNGVQDSLNMGMDMLKSILVMVYPYPAQFGYCIILSFVSICTG---- -------------------------------------Axxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxVLWVATHGSLLGSISVPxxPK RLxxxxxxxxxGPDDLSRVPLLLWTTLTLPAQQSESQMxxxxxx------ --LVGLGPEQSPVSSAPDLVSAGNxxxxHLVTQIPGFCGCDTIFVIYRKG KTQFVKLYEQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxSSLLPTEGSAKYHSFRAYLQVQQWPGxxx xxxIWRWRNSGLPLLAASRSIMRPGVHTITSAPRFSSAICSEMPVxxxTH TARRFxxxxxxxxSLPICMQSSLSC------------------------- LRPPPRTPSAxxxxxxxxxxAAYLLDKEGDRENKERx >Tsi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xERVIVDTTEQ SISHSRLRDASTFCVRHGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxVMRRSISLLVCFTLVLVTWA-------------- -------------------------------------------------- -------ERSPKRRHACICPRIYWPVCGTDGRSYSNECMMRCASSKGETR S-----------------------------------------DVKVAREG LCEEKIPRIKDNVVVNNP------------KLKNIKPAQLYEGGQNNQIK KAAVLVPLCIVNGELSLLYTVRSPDLKRNSGQVSFPGGIMDKTDKDLQET ALRETFEELGIQKSNVQIWGH----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VSWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMPHNNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEGILPVWHGWLLVSIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLARQERGPTDNWTPCKRNLPKATCW LSADLVEMMVITxVNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE--------------------YYILLLLYNQNPRLSEIKKH QVHDPNCRTRYSDHMLCPQSSRPSLGWFQYFTNSYWYDWKTYLKHRVFMA SIGLALLYMTVLGFDAITT------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDVKVAREG LCEEKIPQIKDNIVVNNPKLNKENxLRCITKLRNIKPAQLYEEGQNNQIK KAAVLVPLCIVNGELSLLYTVRSPDLKRNSGQVSFPGGIMDKTDKDLQET ALRETFEELGIQKSNVQIWGHGNLYGTHTKDMVVLPVIGYLGxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxYTQFRGHYxxxxxxxxxxxxxxxxII THFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VSWVHGFTFKIYCCSIFSSWGDRMWWFAGG IFMKDLSGMSHNNLLLTGGFTLALSGFVVVFGSHVGRWVDKSPRLKAAGT ALVTQNLLLVICVTLVGLTFYFWEGILPVWHGWLLVSIQTAIVLTAAFSQ VASVALQIILQKDWIIILCGGDLNKLARQERGPTYNWTPCKRNFPKATCW LSADLVEMM-ITxVNSMLRTINLGTQVLAPIFVGVVQDQVSKLACVITIG VWNVISMVAE---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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