>Tms M------------------------xxxxxxxxxxxxxxxVRVRxIPxxG xxNTPxxAxFxxQxExxxxxxxxxxxxxxxxxxxxxxxxxxxxQxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- ---------------------------------VFVRELISNASDALEKL RHMTLTGENLEEGTSSRPLEIHIATDKQxxxxxxxxHLxxxxxxxGTSGT GYSRYRYIWHRILTIQVHLARDTHDTGTSSTGYSQYRYIWHWILTIQVHL ALDTHDTGTSSTGYSRYQDTGVGMTKEELVDNLGTIARSGSKAFLEQLKG QSGSSEASSIIGQFGVGFYSSFMVADRVEVFTKSSSPGAL---------- -----------GYKWTSDGTGSYEIQEAEGVSPGTKIVLHLKPESREFSD EDTI---------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------R----- -------------------------------------------------- -GVIKKYSNFVGCPIFLNGQRANVI---------QVRLxxxxxVRGTGKL RQIATLTGFNNITSTSLALVAAWFKALFESRSGSTEGGFPxxxxALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKPVV SNINxxxxxxxxxxxxxxxxxxGxDNSKxESEGKRIxEGKxxxxxxxG-- --------------------------------------LFEMNRESDAGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQTVLTNRLLRFLHDKSTKEQEQFDLFYKDYSPFLKEGIVMSQEQL EKNFPCPLNLCEKQYKKCRGEGRYKxxxxxxxxxxxxx------------ -------------------------------------------------- --------------TNGTSARTRSxSxxxxxxxEEIAKLLRFESSRCSPG EKVSLPQYIGRLAEGQKDVFYLAAPS------------------------ -------------------------------------------------- --------------RALAEASPYYExLxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxKxxxxxxx---------x------------- ------xxHNVTSxxxEMRQDKEKDDLTTLGKFRPLxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- ----------------xxxxxxxxxxQDKEKDDLTTLGGESLLRPEVENL LPWLKKCLGGKVHAVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQEVALL------ -------------VSHSLLMSSDRMKPRSWDWALLANAMVSAGLVEDPRT LVTSLNELLSMALEAH >Tce xx-------xxxxxRxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxIWHRxxxxxxxxxxDTHDTGTSSTGYSRYxxxQHRILTI---- -----------------QDTGVGMTKEELVDNLGTIARSGSKAFLEQLKG QSGSSEASSIIGQFGVGFYSSFMVADRVEVFTKSSSPGAL---------- -----------GYKWTSDGTGSYEIQEAEGVSPGTKIVLHLKPESREFSD EDTI---------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------R----- -------------------------------------------------- -GVIKKYSNFVGCPIFLNGQRANVI---------QVRLxxxxxVRGTGKL RQIATLTGFNNITSTSLALVAAWFKALFGSRSGSTEGGFPxxxxALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------G-- --------------------------------------LFEMNRESDAGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQTVLTNRLLRFLHDKSTKEQEQFDLFYKDYSPFLKEGIVMSQEQL EK------------------------------------------------ -------------------------------------------------- ---------------------------------EEIAKLLRFESSRCSPG EKVSLPQYIGRLAEGQKDVFYLAAPS------------------------ -------------------------------------------------- --------------RALAEASPYYExxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx---------xxxRKTTSQLxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- ------------------xxxxxxxxQDKEKDDLTTLGGESLLRPEVENL LPWLKKCLGGKVHAVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----------- ---------------------------------LLANAMVSAGLVEDPRT LVTSLNELLSMALEAH >Tcm -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxRAVDQKIF Lxxxxxx------------xxRxxxxRxMxxxxxxxxxxxxxxxxxxxxx xxxxxxxSDxxxFQAETxxxxxxxxxxxxxxxxVFVRELISNASDALEKL RHMTLTGENLEEGTSSRPLEIHIATDKQ---------------------- ----------------------------------------HRILTI---- -----------------QDTGVGMTKEELVDNLGTIARSGSKAFLEQLKG QSGSSEASSIIGQFGVGFYSSFMVADRVEVFTKSSSPGAL---------- -----------GYKWTSDGTGSYEIQEAEGVSPGTKIVLHLKPESREFSD EDTI---------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------R----- -------------------------------------------------- -GVIKKYSNFVGCPIFLNGQRANVI---------Q--------------- --------------------------------------------ALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------G-- --------------------------------------LFEMNRESDVGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQTVLTNRLLRFLHDKSTKEPEQFDLFYKDYSPFLKEGIVMSQQQL EK------------------------------------------------ -------------------------------------------------- ---------------------------------EEIAKLLRFESSRCSPG ERVSLPQYIGRLAEGQKDVFYLAAPS------------------------ -------------------------------------------------- --------------RALAEASPYYExLxxxxxxxxxxxxxxxxxxxxxLR xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxLGGESLLRPEVENL LPWLKKCLGGKVHAVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----------- ---------------------------------LLANAMVSAGLVEDPRT LVTSLNELLSMALEAH >Tte xxxxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- ---------------------------------VFVRELISNASDALEKL RHMTLTGENLEEGTSSRPLEIHIATDKQ---------------------- ----------------------------------------HRILTI---- -----------------QDTGVGMTKEELVDNLGTIARSGSKAFLEQLKG QPGSSEASSIIGQFGVGFYSSFMVADRVEVFTKSSFPGAL---------- -----------GYKWTSDGTGSYEIQEAEGVFPGTKIVLHLKPESREFSD EDTI---------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------RxVVSQ TQTGDVLRGTPGVVSQTQHLxxxxxPHALNVSxxxxxxxxxxGxxxxxSE SGVIKKYSNFVGCPIFLNGQRANVIxxxWxxxxxQ--------------- --------------------------------------------ALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------G-- --------------------------------------LFEMNRESDAGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQRVLTNRLLRFLHDKSTKEQEQFDLFYKDYSPFLKEGIVMSQEQV EK------------------------------------------------ -------------------------------------------------- ---------------------------------EEIAKLLRFESSRCSPG ERVSLPQYISRLAEGQKDVFYLAAPS------------------------ -------------------------------------------------- --------------RALAEASPYYExLxxxxxxxxxxxxxxxxxxxxxLR xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxLGGESLLRPEVENL LPWLKKCLGGKVHTVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----------- ---------------------------------LLANAMVSAGLVEDPRT LVISLNELLSLALEAH >Tbi xxxxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------xxx------------------------ ------xxxxxxxxxxxxxxxR---------------------------- ---------------------------------VFVRELISNASDALEKL RHMTLTGENLEEGTSSRPLEIHIATDKQ---------------------- ----------------------------------------HRILTI---- -----------------QDTGVGMTKEELVDNLGTIARSGSKAFLEQLKG QPGSSEASSIIGQFGVGFYSSFMVADRVEVFTKSSFPGAL---------- -----------GYKWTSDGTGSYEIQEAEGVSPGTKIVLHLKPESREFSD EDTIRxxxxxxVRYTRRSVPDTNWEHVRYTRRxxxxxxxxxxxxxxxxxx xxxxWGHHVRYTxRSVPDTNxxxxxxxTRCSVPxxxxGHHVRYTRHSVPD TNWGRLVRYTRRSVPDTNWGRxxxxxKxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx-------------------xxxxxxxxxx----- -------------------------------------------------- -SVIKKYSNFVGCPIFLNGQRANVIQALWLVxxxQ--------------- --------------------------------------------ALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------G-- --------------------------------------LFEMNRESDTGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQRVLTNRLLRFLHDKSTKEQEQFDLFYKDYSPFLKEGIVMSQEQV EK------------------------------------------------ -------------------------------------------------- ---------------------------------EEIAKLLRFESSRCSPG ERVSLPQYISRLAEGQKDVFYLAAP------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxx--------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxRIxxxxxxxxxxxR---------------------GESLLRPEVENL LPWLKKCLGGKVHTVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----------- ---------------------------------LLANAMVSAGLVEDPRT LVISLNELLSLALEAH >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------MD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------G-- --------------------------------------LFEMNRESDVGV ALYSRKVLIKSKTDNILPKWLRFVKGESQDTSPPNKVRVQSGLLRLTRCL FPFLPGVVDSEDIPLNLSRELLQNSALIR--------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- ------SRALTGFSTNGTPARTRSxxxxxxxxxEEIAKLLRFESSRCSPG ERVSLPQYIGRLAEGQKDVFYLAAPS------------------------ -------------------------------------------------- --------------RALAEASPYFExLxxxxxxxxxxxxxxxxxxxMQLR xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------GESLLRPEVENL LPWLKKCLGGKVHAVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----------- ---------------------------------LLANAMVSAGLVEDPRT LVTSLNELLSMALEAH >Tsi xxxx---------------------------------------------- ------------------------------------xx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------G-- --------------------------------------LFEMNRESDVGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIR--------------------- ---KLQTVLTNRLLRFLHDKSTKEPEQFDLFYKDYSPFLKEGIVMSQQQL EK------------------------------------------------ -----------------ALKWPLSRNNEGFExxxxxxPPLVSxxxxxxNP AxxxxxSHALMGSSTNGTSARTRPxSxxxxxxxEEIAKLLRFESSRCSPG ERVSLPQYIGRLAEGQKDVFYLAAPSNLTRQLECQQCTAQYVGLATETLR KRRNEHRHDTRIKNPEKPVSAHASARNLNFEDCHTVK------------- -------------VRALAEASPYYExLxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxKxxxxxxxxxxxxxxxxx------------- ------xxxxx--------------------------------------- -------------------------------------------------- ------------------xxxxxxxxQDKEKDDLTTLGGESLLRPEVENL LPWLKKCLGGKVHAVKVTRRLDSHPCVITVEDMGAARHFLRMQSHQLTEE NRYALLQPQLEINPSHPIIKKLSKLVTSNPRLAELVSQQ----LANAPVV LSSTPEDGEIEVRVS------------------LLANAMVSAGLVEDPRT LVTSLNELLSMALEAH >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxx----- -------------------------------------------------- -GVIKKYSNFVGCPIFLNGQRANVI---------Q--------------- --------------------------------------------ALWLMD PKEVTPQMHDEFYRFVGNTFDKPRFTLHYRTDAPLTLRALLYFPEGKP-- -----------------------------------------------GKW IKESKxxxxxxxxxRMxxGVTIAxDxAVEDExIRVxxxLFEMNRESDVGV ALYSRKVLIKSKTDNILPKWLRFVK------------------------- -----GVVDSEDIPLNLSRELLQNSALIRxxxxTERVEASARCVPQTARS CFSKLQTVLTNRLLRFLHDKSTKEQEQFDLFYKDYSPFLKEGIVMSQEQF EKNFGLPK---------------------------------------VQS NEVLxxxxxxCFTxxxxx-------------------------------- ------SHVLMGSSTNGT-------SxxxxxxxEEIAKLLRFESSRCSPG ERVSLPQYIGRLAEGQKDVFYLAAP------------------------- --xNGHRHDTKIKNPEKTVSAHASARNLNFEDCYAVKVLKSFHKTQCNMS QLRRWELAQQWITNRALAEASPYYExxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------