>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGVGCVKYLRWTKVKPNTESQSEELKRVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKQVLL AEFPKAYQRVLNKPWDIVDYGVCEMEDLLLELPENSVVVSQQEYHVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVKxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------ >Tte M------------------------------------------------- -------------------------------------------------- ----------------------------------------LxxSNIVLTL SPPxxTLPPTxTHVAGTSFCSTKTNVxxxLVSEHNVAVVMTSTSxPQSCT RKLRHNSRSDDENVLSQSPxxxxxxMSGxxxLxSIPTPNVxxxxxxxxxx xxAxxxxxxxxxNxxxxxxxxxxIEAAVKGWENGTxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxHGGLQSSRHGNTNQELNS AGAMPIPSCHLVNGTNPSILKRCRTSSPTADLHQIQTPAVFGFPFPLKRR SPSPYTVLEAETDVLGENSQ-----------------------HFFHPIA PSKTELLTASVNSSIQLIVTNLDQTIEPKEMKRVLLALFREHVMVIHISV FTQTDGNVAAHVKVPSLQDAQYAISRLHRRKVGFKRMLIAYAHGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLTSISVSDMYKMKDVCIIR EDPSGRMVSLNPDHRNTPSPSFGVGTQDGQLDLPYCTLHPQRPGAGKGWA EQDLEALPNFRIGLNILAERIHTLLHSHNGSLPLP--------------- ------------------S------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGVGCVKYLRWTKVKPNTESQSEELKCVSPPLA TQLALFSRELVDLLKTSPHCLLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHHMQVRRFCSDLLRVLKSQATKHVLL AEFPKAYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVFQQENDVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVKxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------ >Tcm x------------------------------------------------- ------------------------------------------------xV VCxPYVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxR-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------LQNSRHGNTNQELNS AGAMPLSSCHLVNGTNPSILKRCRTSSPTADLQQIQTPAVFGLPFPLKRR TPSPYTLLEAETDVLGENSKLVNALVVLSCSTAEDGEIEVRIxHFFHPIT PSNTELLTASVNSSIQLVVTNLDQTIEPKEMKRVLLALFREHVMVIHISV FTQTDGNVAAHVKVPSLQDAQYAISQLHRRKIGFKRMLIAYANGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLSSISVSDMYKMKDVCIIK EDPSGRMVSLNPDHRNTPSPSFGVGTQDGQLDLPYCTLHPQRLGAGKGWA EQDLEALPNFRIGLNILAERIHTLLHSHNGSLPLP--------------- ------------------SLxxxxxxxGLTLCCxxTNPxxxxxxxxxxxx xxxRFxxxxxxxxxxxxxxxxxxxFITSANIxxxxxxxxxxxxxxxxxxx SASNFACEALANALVVLSSTAEDGKIEVRISVGLPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGASCVKYLRWTKVKPNTESQSEELKCVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKNVLL TEFPKVYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQESDVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVK-------------IEDASEGERKVSLTLK ESLKVLSEQMVALLRFCSNSSLLLSAVPAEYLQLYGHALRPQMYERASLE ELMDCIKHVVExxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx------------xxx---------xxx-- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx--- -----------xxxxxxxxxxxxxxxxxxxxxx----------------x xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x----------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ >Tsi MATTLWHMQSSGELxxxxxxxHANIEVWESHSKxxLxxxxxGSGAPMxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLQSSRHGNTNQELNS AGAMPLSSCHLVNGTNPSILKRCRTSSPTADLQQIQTPAVFGFPFPLKRR TPSPYTLLEAETDVLGENSQ-----------------------HFFHPIT PSNTELLTASVNSSIQLVVTNLDQTIEPKEMKRVLLALFREHVMVIHISV FTQTDGNVAAHVKVPSLQDAQYAISQLHRRKIGFKRMLIAYANGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLSSISVSDMYKMKDVCIIK EDPSGRMVSLNPDHRNTPSPSFGVGTQDGQLDLPYCTLHPQRPGAGKGWA EQDLEALPNFRIGLNILAERIHTLLHSHNGSLPLPxFTDFRSRSPGFDPQ CFQFCLRGSEFEMEPKSTS------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGASCVKYLRWTKVKPNTESQSEEPKCVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKNVLL TEFPKVYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQESDVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVK-------------IEDASEGERKVSLTLK ESLKVLSEQMVALLRFCSNSSLLLSAVPAEYLQLYGHALRPQMYERASLE ELMDCIKHVVExxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx------------xxx---------xxx-- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------- >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------MLIAYAHGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLSSISVSDMYKMKDVCIIK EDSSGRMVSLNPDHRNTPSPSFGVGTQDGQLDLPYCTLHPQRPGADKGWA EQDLEALPNFRIGLNILAERIHSLLHSHNGSLPLP--------------- ------------------S------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGAGCVKYLRWTKVKPNTESQSEELKCVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKHVLL TEFPKVYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQENDVAISI PKREQTLEEIEKTKQFSGE------------------------------- ----------------------------------IEDASEGERKVSLTVK ESLKVLSEQMVALLRFSSNSSLLLSAVPAEYLQLYGHALRPQMYERASLE ELMDCIKHVVE--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VVPTQSGLMITLVNQSQDHQLGLQTRRILMGRPDFKMAAPDFLQAFWRLY KKAFDLRKAEDELADIIKVDNSGLVMTFELKPLQKFACNVYRLLYECKGT IPLVSFDFMYLRLFAVPCQPALLGYPSLEALLRAIPETVLLRGGIRDQRM LVLNKDLA----------------------------------------xx xxxxxxxxxxxAKALRCDSDAPLNQFKLWSPPSFSYYNQACMPPQVNLPP CPPAPPLSYTADLLSPEKTLLSAHTLPHVVPPHPSELPLPELPSKKSCNS MDSSFGSNEPGSPSQMRR---------------xxxxxx----------- -------------------------------------------x >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------MLIAYAHGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLSSISVSDMYKMKDVCIIK EDSSGRMVSLNPDHRNTPSPSFGVGTQDDQLDLPYCTLHPQRPGADKGWA EQDLEALPNFRIGLNILAERIHSLLHSHNGSLPLP--------------- ------------------S------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGAGCVKYLRWTKVKPNTESQSEELKCVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKHVLL AEFPKVYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQENDVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVK-------------IEDASEGERKVSLTVK ESLKVLSEQMVALLRFSSNSSLLLSAVPAEYLQLYGHALRPQMYERASLE ELMDCIKHVVE--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VVPTQSGLMITLVNQSQDHQLGLQTRRILMGRPDFKMAAPDFLQAFWRLY KKAFDLRKAEDELADIIKVDNSGLVMTFELKPLQKFACNVYRLLYECKGT IPLVSFDFMYLRLFAVPCQPALLGYPTLEALLRAIPETVLLRGGIRDQRM LVLNKDLAxxxxDSNRQTHKNSAELLIRNLANGSSHFQTIGEPELDTP-- -----------AKALRCDSDAPLNQFKLWSPPSFSYYNQACMPPQVNLPP CPPAPPLSYTADLLSPEKTLLSAHTLPHVVPPHPSELPLPELPSKKSCNS MDSSFGSNEPGSPSQMRR---------------xxxxxxxxxxxxxxxxx YTTTM--------------------------------IVSSxDH >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----PLPSCHLVNGTNPSILKRCRTSSPTADLQQIQTPAVFGFPFPLKRR SPSPYTVLEAETDVLGENSQ-----------------------HFFHPIA PSKTELLTASVNSSIQLIVTNLDQTIEPKEMKRVLLALFREHVMVIHISV FTQTDGNVAAHVKVPSLQDAQYAISQLHRRKVGFKRMLIAYAHGGGPSPQ LIRSQIVSLLLEVPGHSLPLFKFRELFESRYLSSISVSDMYKMKDVCIIR EDPSGRMVSLNPDHRNTPSPSFGVGTQDGQMDLPYCTLHPQRPGAGKGWA EQDLEALPNFRIGLNILAERIHTLLHSHNGSLPLP--------------- ------------------S------------------------------- -------------------------------------------------- ---------------------------------LPNCYQVQFNKLEEDKD GVPLEHLVSCLPGIEIYQGVGCVKYLRWTKVKPNTESQSEELKRVSPPLA TQLALFSRELVDLLKTSPHCQLLFNRFIPAYHHHFGRQCRVADYGFTKLI ELMEALPNIVQVMGEGNKRVVTLSHRMQVRRFCSDLLRVLKSQATKQVLL AEFPKAYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQENHVAISI PKREQTLEEIEKTKQFSGE------------------------------- ----------------------------------IEDASEGERKVSLTVK ESLKVLSDQMVALLRFSSNSSLLLSAVPAEYLQLYGHALRPQMYERASLE ELMACIKHVVE--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VVPTQSGLMITLVNQSQAHQLGLQTRRILMGRPDFKMAAPDFLQAFWRLY KKAFDLRKAEDELADIIKVDNSGLVMTFELKPLQQFACNVYRLLYECKGS IPLVSFDFMYLRLFATPCQPALLGYPTLEALLRAIPETVLLRGGIRDQRM LVLNKDLAxxxxDSNRPTYKNSAELLIRNLANGSSHFQTVGELELDTP-- -----------AKALRRDSDAPLNQFKLWSPPSFSYNDQACMPPQVNLPP CPPAPPLSSTADLLSPEKNLLSAHTLPYVVPPHPSELPLPELPSKKSCNS MDSSLGSNESGSPSQMRRxxxxxxxFHTPIQLP----------------- -------------------------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MEALPNIVQVMGEGNKRVVTLSHHMQVRRFCSDLLRVLKSQATKHVLL AEFPKAYQRVLNKPWDIVDYGVCEMEDLLSELPENSVVVSQQENDVAISI PKREQTLEEIEKTKQFSGEVVELMRHAPQCSMLFSKFIPAYHHHFGHQCR VSDFGFTKLIELFEAIPEVVKxRKMYNILSLA--IEDASEGERKVSLTVK ESLKVLSDQMVALLRFSSNSSLLLSAVPEEYLQLYGHALRPQMYERASLE ELMDCIKHVVExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxLSTAVSxWLGGxxxSVLDIAVSWWV GSWNSxxLDTVAENGAFGDEEDNSxVxxx------xxx------------ ----------------------------xxVAEAxxxxxxxxxxxxxxxx xxxxQSxxxxxxxxxxxAxxxxxxxxxxxxxxPDFKMxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxFACNVYRLLYECKGS IPLVSFDFMYLRLFAIPCQPALLGYPTLEALLRAIPETVLLRGGIRDQRM LVLxxxxxxxxxxxxxxxxxxxAELxIRNLANGSSHFQTVGELELDTP-- -----------AKALRRDSDAPLNQFKLWSPPSFSYNNQACMPPQVNxxx xxxxxxxxxxxxLLSPEKNLLSAHTLPYxxPPHPSELPLPELPSKKSCNS MDSSLGSNESGSPTQMxxxxxxxxxFHTPIQLP----------------- --------------------------------------------