>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxTALNYRSDPS VCDWLHSAHLGTILVQQAQRVCTDMxxxYAKDILKCCLEKxxxGELVISS ETLRTIMAELYKALDTPWTTDTHKSCAALVAELVLMLYHGDLTLSPWLRC NPPAEGLVLLLFQGSCLHNGVYAEKRTDITHAWQAAVVALARTHGPLGEP FLELLGRFSSVLAGELLG-------------------------------- -------------------------SVAWRVGGVSTCLGSQVGSGGxxAx xxxxxxxxxxxxxxRxxxxxxxIVSFYGNSYTxLDVAGVDHIAKMTASLL RVGATDSMGATDTTTLARIYDVVMSNVFQSVPSWTHITDLCLYADNLRGH HYITQTYARRAMENKSVTSATSNPV------D--------SLYKYYTVAL FSITVLMELCHENLDNSADDDESETDDEITEDCNHLVSSQSWPLLQSHLL NIHYANVIAHTFTAHFKS-------------------------------- -----------------TLHYSSLSHKFELLNLRFCSFQEKSGFERDQLI IATQEK------------------------------------AKQEGDLW VKAALSLTDANFTWLSVEVGETENSINTSSLHADQVCKTNEGMSDTDPEL PTLTSEGLAVVNNCQCRAGAKEESLIINQLDNVGEAGSIVRVK------- -------------------RCCMCMIKANRTNLLFESPISKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAGP LSLPLVTPTMNTRFGPNKVCNDVTNKYELNQLNAEYNGPLLTKLPCGRPV QSVIMLAYTHKNISTPSEGGPADFTSPTIEAPPTTKKKSSNLTQPxxGAS IENSVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEE- -----VYKSLLSIFIYVADHCDIQQLTCHDLLLLEPLCKAVSLMNPEYFL VHSKQGHERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLHLWMLNGALELTQGFVDTLYSDQRLGDCCTVQPHTDAYTF TLAYLLLWDIVLDMCGWAGAQLRYHYAAGLSNKGLMQTLLQTVFCLMPEE ILRLLDVKGSKISEVLMSGLNLKYGVSSRSETLQDLACWMYFCSLRRLPA MVRQWWSGEEPRVASLVEKVTTRYMSPLLCSLEMQSVQKENTRTGNMAMS EPSEEDSREAKTGEYSREAKTGEYSREAKNGEYSREDKTGEYSREAKTGE YSREAKTGEYSREAKTGEYSREAKTGI----------------------- ----FKVKVHPTAREVVAVYHVDEVSLELSIQLPLNHPLGPVIVESSKQM VDTSQWRNWLMQLNVFLTYQNGSLWDGLALWKSNLDKRFEGIEECYICFS VIHGSNFQIPKLCCSTCKKKFHSPC------------------------- ----------------------x--------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxx >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xVLSYLVVPFCxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------ELVISS ETLRTIMAELYKALDTPWTTDTHKSCAALVAELVLMLYHGDLMLSPWLRC NPPAEGLVLLLFQGSCLHNGVYAEMRTDITHAWQAAVVALARTHGPLGEP FLELLGRFSSVLAGELLG-------------------------------- -------------------------S------------------------ ---------------------------------LDVAGVDHIAKMTASLL RVGATDSMGATDTTTLARIYDVVMSNVFQSVPSWTHITDLCLYADNLRGH HYITQTFARRAMENKSVTSATSNPV------D--------SLYKYYTVAL FSITVLMELCHEKLDNSADDDESETDDEITEDCNHLVSSQSWPLLQSHLL NIHYANVIAHTFTAHFKS-------------------------------- -----------------TLYYSSLSxKxxLLxLRFCLFQExxxxxxxxxx IATQEK------------------------------------AKQEGDLW VKAALSLTDANFTWLSVEVGEIDDSNNTSSPHADQVCKTDEGMSDTDPEL PTLTSKGLAVINNCRCQAGAKEESLIVNQLDNVGEAGSIVRVK------- -------------------RCCMCMIKANRTNLLFESHISKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAGP LSLPLVTPTMNIR------------------------------------- -----------------------------------------------GAS IENLVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEE- -----VYKSLLSIFIYVADHCDIQQLTCHDLLLLEPLCEAVSLMNPEYFL VHSKQGHERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLNLWMLNGALELTQGFVDTLYSDQRLGDCCTVQPHTDAYTF TLAYLLLWDIVLDMCGWAGAQLRYHYAAGLSNKGLMQTLLQTVFCLMPEE ILRLLDVKGSKISEVLMSGLNLKYGVSSRSETLQDLACWMYFCSLRRLPA MVRQWWSGEEPRVASLVEKVTTRYMSPLLCSLEMQSVQKENTRTGNMA-- -------------------------------------------------- -------------------------------------------------- ------VKVHPTAREVVAVYHVDEVSLELSIQLPLNHPLGPVVVESSKQM VDTSQWRNWLMQLNVFLTYQNGSLWDGLALWKSNLDKRFEGIEECYICFS VIHGSNFQIPKLCCSTCKKKFHSPC------------------------- ----------------------L--------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxx >Tte xxxxxxxRMLPEVVLDGGHLQFPVQIHTVNISGGVYNDPQPSSSGRSAQL LGNAAPTFVGFSAAKDGGFVPVLPGFTLTNFDDLDPNINPNFQMVLKKMN KKDSTTKLKVLMSASVNMEPRMSEAQIVALQEFAELIRNSEQEAVKAVLP FWPRLYCHLVVDVEHRVRESAHQAHRAVVLRAKRNIAPYLRQLAGPWFTS QYDTYPPAASAATQAFQDAFPPNKLIEAIVFCQEEIINYIHDNLIVQTAQ TLSNPKTATEDEMEAKYQRVLVSSLQGYSLYLAKLPQDQLKMVYDINKKL VSSKKFWKYSKHTIPMVRNAWFSTLIALCQKAPELLADETAHVCVSVFNN LDEADPTVLPTVWDAALHVLTTVQDCWSHVSAEKLVLPKLWNILRQGGQG NAATIFPNLMPLLSKIPVPVRGDTASFYTKFFSNMRQGLSQKCVYQSHSE SNAAAKCYMECLRYIISGHQEDDKLCRELLNHELMPCLELVLQESKYTIL SVALFHHTSLLVQAWSHGQGNSALLELFWDSIMNLNKQLLLSYSGEQESL EHR------------PLPPHWLLDRQVSLCLSLRNPKLGRKRENLRVKFN SPDEEEHISESTSTDSSAECNQETAAALQCFVHTISESYLCETRRCHSSH FLGHLSKLVKNFASKELFEHLAICDGSSTLEGFFEITLLSWLKEEETCTQ DVMELSFILLQYLNPKNKGHILDALCEVSSPNPALLWCMxxxLNYRSDPS VCDWLHSAHLGTILLQQAQRVCTDVxxxYPKDILKCCLEKxxxGELVISS ETLRTIMAELYKALDTPWTTDTHKSCAALVAELVLMLYHGDLTLSPWLRC NPPAEGLVLLLFQGSCLHNGVYAEMRTDITHAWQAAVVALARTHGPLGEP FLELLGRFSSVLAGELLGxGNSRALASGHKLVVEVTVRExxQxxxxxxxx xxxxxxxLxxxxxxxSHLKHIARLRR------------------------ ---------------------------------LDVAGVDHIAKMTASLL RVGATDSMGATDTTTLARIYDVVMSNVFQSVPSWTHITDLCLYADNLRGH HYITQTYARRAMENKSVTSATSNPV------D--------SLYKYYTVAL FSITVLMELCHEKLDNSADDDESETDDEITEDCNHLVSSQSWPLLQSHLL NIHYANVIAHTFTAHFKS-------------------------------- -----------------TLYYSSLSHKFELLNLRFCLFQEKSGFERDQLI IATQEK------------------------------------AKQEGELW VKAALSLTDANFTWLSVEVGEIDDSNNTSSPHADQVCKTDEGMSDTDPEL PTLTSKGLAVINNCRCQAGAKEESLIVNQLDNVGEAGSIVRVK------- -------------------RCCMCMIKANRTNLLFESHISKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAGP LSLPLVTPTMNTR------------------------------------- -----------------------------------------------GAS IENSVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEEx xxxxx-----------VSDHCDIQQLTCHDLLLLEPLCEAVSLMNPEYFL VHSKQGHERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLNLWMLNGALELTQGFVDTLYSDQRLGDCCTVQPHTDAYTF TLAYLLLWDIVLDMCGWAGAQLRYHYAAGLSNKGLMQTLLQTVFCLMPEE ILRLLDVKGSKISEVLMSGLNLKYGVSSRSETLQDLACWMYFCSLRRLPA MVRQWWSGEEPRVASLVEKVTTRYMSPLLCSLEMQSVQKENTRTGNMA-- -------------------------------------------------- -------------------------------------------------- ------VKVHPTAREVVAVYHVDEVSLELSIQLPLNHPLGPVVVESSKQM VDTSQWRNWLMQLNVFLTYQNGSLWDGLALWKSNLDKRFEGIEECYICFS VIHGSNFQIPKLCCSTCKKKFHSPC------------------------- ----------------------Lxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxLxxxxxxxxxxPxxxAGTxxxxxxxxxxFPALVSELDExxSVQDSVH H------------------- >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxD--------SLYKYYTVAL FSITVLMELCHENLDNSAD------DDEIKEDCNHLVSSQSWPLLQSHLL NILYANVIAHTFTEHFKS-------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAKQEGDLW VKAALSLTDANFTWLSVEVGETDDSNNTSSPHADQLCKTNEVMSDTDPEL PTLTLERLAVINNCQCQAGAKEESLIVNQLDNVGEAGSVVRVK------- -------------------RCCMCMIKANRTNLLFESHIGKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAAP FSLPLVTSTMNNR------------------------------------- -----------------------------------------------GAS VENLVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEE- -----VYKSLLSIFIYVADHCDIQQLTCHDLLLLEPLCEAVSLMNPEYFL VHNNQAQERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLHLWMLNGALELTQGFVDTLYSDQRLGDCCTVQPHTDAYTF TLAYL--------------------------NKGLMQTLLQTVFCLMPEE ILRLLDVKVSKISEVLMSGLNLKYGVSSRSETLQDLACWMYFCSLRRLPA MVRQWWSGEEPRVASLVEKVTTRYMSPLLCSLEMQSVQKENTRTGNMA-- -------------------------------------------------- -------------------------------------------------- ------VKVHPTAREVVAVYHVDEVSLELSIQLPLNHPLGPVIVESSKQM VDTSQWRNWLMQLNVFLTYQNGSLWDGLALWKSNLDKRFEGIEECYICFS VIHGSNFQIPKLCCSTCKKKFHSPCxxxQVxxxxxxxxxxxxxDGLDSMV FTLLxxxxxxxxLxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------MELCHENLDNSAD------DDEIKEDCNHLVSSQSWPLLQSHLL NILYANVIAHTFTEHFKS-------------------------------- -----------------TLHYNSLAHKFELLNLRFCLFQEKSGFERDQLI IATQEK------------------------------------AKQEGDLW VKAALSLTDANFTWLSVEVGETDDSNNTSSPHADQLCKTNEVMSDTDPEL PTLTLERLAVINNCQCQAGAKEESLIVNQLDNVGEAGSVVRVK------- -------------------RCCMCMIKANRTNLLFESHIGKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAGP FSLPLVTSTMNNR------------------------------------- -----------------------------------------------GAS VENSVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEE- -----VYKSLLSIFIYVADHCDIQQLTCHDLLLLEPLCEAVSLMNPEYFL VHNNQAQERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLHLWMLNGALELTQGFVDTLYSDQRL--------------- ------------------------------------------------EE ILRLLDVKVSKISEVLMSGLNLKYGVSSRSETLQDLACWMYFCSLRRLPA MVRQWWSGEEPRVASLVEKVTTRYMSPLLCSLEMQSVQKENTRTGNMA-- -------------------------------------------------- -------------------------------------------------- ------VKVHPTAREVVAVYHVDEVSLELSIQLPLNHPLGPVIVESSKQM VDTSQWRNWLMQLNVFLTYQNGSLWDGLALWKSNLDKRFEGIEECYICFS VIHGSNFQIPKLCCSTCKKKFHSPCxxxQVxxxxxxxxxxxxxxxxxxxx xxxxxxxxxQxFLLxxxxxxxxx--------------------------- -------------------------------------------------- -------------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxSLYKYYTVAL FSITVLMELCHENLDNSADDDESETDDEITEDCNHLVSSQSWPLLQSHLL NIHYANVIAHTFTAHFKSxxxxxxxxxxxxxxxxxxxxxxxxxxxxVPxx xxxxxxxxxxxxxxxxxxx------------------------------- ------------------------------------------AKQEGDLW VKAALSLADANFTWLSVEVGETDDSNNTSSPHADQVCKTNEGMSDTDPEL PTLTSEGLAVVNNCQCRAGAKEESLIINQLDNVGEAGSIVRVKxxxxxxx xxxxxxxxxRWCxxxxxxx------------------HISKLDWSDVQRL SEAARVMADVVNSNPEVLEQEVFDVVHITLTSWLASLEKSKESLLVPAGP LSLPLVTPTMNTR------------------------------------- -----------------------------------------------GAS IENSVDAYKVAVLGANILQLFATLERFYATAEERKQSFYEEWKDVFAEE- -----VYKSLLSIFIYVADHCDIQQLTCHDLLLLEPLCEAVSLMNPEYFL VHSKQGHERLKLVMKYCCHLVCSPIAPLQLVAYHVIKRLSRGLTSLDTVM VAAEADLANLHLWMLNGALELTQGFVDTLYSDQRLGDCCTVQPHTDAYTF TLAYLLLWDIVLDMCGWAGAQLRYHYAAGLSNKGLMQTLLQTVFCLMPEE ILRLLEVKGSKISEVLMSGLNLKYGVSSRSETLQDLACW----------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------