>Tge M--------------xx--------------------------------- -----------------------------xxxxCxSTCLLVxxxxCPHVC LSPCLTVPMSAxxxxxxxxxxxxxxxxxxxxxxxLGSQxxxxxxxxxxxx x-----------------------------------------SEPRNSLA NETLEGxxxxxxxxxxxxxxxxDSRDxCxxxxxxxxxxxxxxxxYxVIRK LGWGHxxxxxxxxxxx---------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxLKVV KSASHYTExxxxxxxxxxx------------------------------- ------------------xRESDVSDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ------I---------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx--------------------------------------x xxxxxxASKExxxxxxxxxxxxxxxxxxxxWFDGEVAPPLVIDAIADxxx SEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPREPGTLELRSKVFKSKKRKSNKKSKRQDKPLE ENIKPFQELNCSKRESDISVVSVDLIKLQEGENDSSSDAASDDELDLVEV VTPHTD--ISNVLPT----xHLTDNVFNDTEEKHVKNTTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVNFCNGQHSGPSEGKMEETQGKQRHV LGRSESQAISHSNSATHKYNQNESKPFRRVASCPDAQRLVKPLDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------YHHxxxDIQTRQYRCLEVLLGNGYDTPADIWSTACMAFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLNS >Tpa M--------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPREPGTLELRSKVFKSKKRKSNKKSKRQDKPLE ENIKPFQELNCSKRESDISVVSVDLIKLQEGENDSSSDAASDDELDLVEV VTPHTD--ISNVLPTKTTSVHLTDNVFNDTEEKHVKNTTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVNFCNGQHSGPSEGKMEETQGKQRHV LGRSESQAISHSNSATHKYNQNESKPFRRVASCPDAQRLVKPLDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------YHHxxxDIQTRQYRCLEVLLGNGYDTPADIWSTACMAFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLNS >Tms M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxx----------------xxxxxxx xxxxxxxxxVxxxxxxLPTT---xxxxxxxxxxLxVGxxVAKHFVALKVV KSASHYTExxxDExxxxxx------------------------------- ------------------xRESDASDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ----------------- -------------------------------------------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSLGKFLLQGQEQIRFEYLKRFPAHH VTHHRRNHEGNVALSAAPRDPGTLELRSKVFKSKKRKSNKKSKRQDRPLE ENIKPFQELNDSKHESDISVVPVDLVKLQESENDSSSDAASVDELDLAED VTPDTNNLTSNVLPTNKTSVHLTDNVFNDTEQKHVKNTTEESITKSQIY- --VENRKSFAEMEQADIHHPQQLTVNLCNGQHSGPSEGKMEETQESQRHV LGRSESQAISHSNSASHKYNHNENKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSLGKFLLEGQEQI-----KRFHLHH VIHHHRNHEGHVALSAAPREPGTLELRSKVFKSKKRKSNKKSKRQERPLE ENIKPSQELNDSKRESDISVVPVDLVKLQESENDSSSDAASVDELDLAED VTPDTDTLTSNVLPTKKTSVHLTDNVFNDTEQKHVKNPTEESITKSQIY- --VENRKSFAEMEQADIHHPQQLTVNFCNGQHSGSSEGKMEETQENQRHV LGRSESQAISHSNSASHKYNHNESKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS >Tps M------------xxx---------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxx---------xxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxx---------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSLGKFLLEGQEQI-----KPFHIHH VIHHHRNHEGNVALSAAPREPGTLELRSNVFKSKKRKSNKKSIRQGRPLE ENIKPFQELNDSKRESDISVVPVDLVKLQESENDSSSDAASVDELDLAED VTPDTDTLTSNVLLTKKTSVHLTDNVFNDTEQKHVKNPTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVSFCNGQHSSSSEGKMEETQENQRHV LGRSESQAISHSNSASHKYNHNESKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGDDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS >Tdi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxLTVQSNLxPTDxxSEPRNSLA NETLEGxEDxxxCSDEDEDDQEDSRDYCxGxxxxxxxxxxxxxxxxxxxK xGWxxxxxxxxxxxxxxxxxxxxxxxx---------xxxxxxxxxVKxxx xxxxxxxxxxxxxxExACxxxxxQLLx----------------xxxxxxQ PTHHANSxCVxxVxxxLPTxxxxxx------------------------- -------------------------------------------------- --------------------ESDVSDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ----------------- -------------------------------------------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSLGKFLLEGQEQI-----KPFHIHH VIHHHRNHEGNVALSAAPREPGTLELRSNVFKSKKRKSNKKSTRQGRPLE ENIKPFQELNDSKRESDISVVPVDLVELQESENDSSSDAASVDELDLAED VTPDTDTLTSNVLLTKKTSVHLTDNVFNDTEQKHVKNPTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVSFCNGQHSSSSEGKMEETQENQRHV LGRSESQAISHSNSASHKYNHNESKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGDDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS >Tcm Mxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------RESDVSDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ------VS--------- -------------------------------------------xxxxxxx xxxxxxxxx----------------------------------------- ----------xxxxxxxxxxxxxxVLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPREPGTLELRSKVFKSKKRKSNKKSKRQERPLE ENIKPSQELNDSKRESDISVVPVDLVKLQESENDSSSDAASVDELDLAED VTPDTDTLTSNVLPTKKTSVHLTDNVFNDTEQKHVKNPTEESITKSQIY- --VENRKSFAEMEQADIHHPQQLTVNFCNGQHSGSSEGKMEETQESQRHV LGRSESQAISHSNSASHKYNHNESKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS >Tbi xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------RESDVSDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ------VSx-------- -----------------------------------xxxxxxxxx------ -------------------------------------------------- -----------------------xxLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPREPGTLELRSKVFKSKKRKSNKKSKRQDKPLE ENIKPFQELNCSKRESDISVVSVDLVKLQEGENDSSSDAASDDELDLVEV VTPDTD--ISNVLPTQTTSVHLTDNVFNDTEEKHAKNTTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVNFCNGQHSGPSEGKMEETQGKQRHV LGRSESQAISHSNSATHKYNQNEIKPFRRVASCPDAQRLVKPLDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLNS >Tte M-------xxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------SEPRNSLA NETLEGEEDxxxCSDEDEDDQEDSRDYCxG-------------------- --------------------------xxxxxxxxxxxxxxxxxxxVKSSC HSNRCTLSDFLTVTExxCxxxxxELQx----------------xxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- ------------------VRESDVSDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ----------------- -------------------------------------------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPREPGTLELRSKVFKSKKRKSNKKSKRQDKPLE ENIKPFQELNCSKRESDISVVSVDLVKLQEGENDSSSDAASDDELDLVEV VTPDTD--ISNVLPTQTTSVHLTDNVFNDTEEKHAKNTTEESITKSQILI SDVENRKSFAEMEQADIHHPQQLTVNFCNGQHSGPSEGKMEETQGKQRHV LGRSESQAISHSNSATHKYNQNEIKPFRRVASCPDAQRLVKPLDPVLDVC DIKVKIADLGNSCWS----------------------------------- -------------------------------------------------- ------------------------------------------AFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKG--- -----------------------------------------------ELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLNS >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxVAxxxPxLPxx---xxxxx------------xKHFVALKVV KSASHYTExxxDExxxxxCxIVxxxxxxxxxxxxxxxxxVxxxxxxxxxx xxxxxxxxxxxxxxxxxxVRESDASDPKRDKTVQLLDDFKISGVNGTHVC MVFEVLGHNLLKLIVRSNYQGIPLPNVKCIIRQ------VSxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ------------------------VLEGLDYLHTKCKIIHTDIKPENILL C------------------------------------------------- VEESYVRKLATEAAQWRKMGLKLPCSL----------------------- -------------VSAAPRDPGTLELRSKVFKSKKRKSNKKSKRQDRPLE ENIKPFQELNDSKHESDISVVPVDLVKLQESENDSSSDAASVDELDLAED VTPDTNNLTSNVLLTNKTSVHLTDNVFNDTEQKHVKNTTEESITKSQIY- --VENRKSFAEMEQADIHHPQQLTVNFCNGQHSGPSEGKMEETQESQRHV LGRSESQAISHINSASHKYNHNENKPFRRVASCPDAQRLVKALDPVLDVC DIKVKIADLGNSCWSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxDLLxxxITRNCALKKMCVNMYLSLNPSFTILVSTVDSTA LGxxxxxxxx-------------------------------QAFELATGD YLFEPHSGEDYSRDEDHLAHIIELLGTIPKHLIFSGKYSREYFNKKGxVN RHLTLNGQRDLQSIIIGGAKIQAQCYSVLDATDIVCLQGSASLPPSSELR HITKLKPWRLREVLTEKYEWNNADAKAFADFLTPMLAFELSERVTAQECL KHPWLSS