>Tge x------------------------------------xxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxSWLPGLRTSLAVLS LAAGLGNIVRLPRVVFLNGGxxxxGSDDTGIVSGAFLVVYLSISLILGIP LVFLEIGQGQLCQKGTATLWRAVPLFKGVGYVKILSSTLVSVYYPILMTL SLFYVIWIARGPLPFQECQIQGVESEGFVKGQICIQ-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --IFKGADSSHLSMFFVVAPVICCLIALLIDSLLREPTARGLQLLTTVNW NVLANVQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGHSVETPQLTEMFVFTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATMVATAPDCSNVVFPKLGQLYHVCPPQIILV YSLLVALPLxxFGKWQWWHAAGIVSALGFLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFAW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFAILEIWSFVSLPLDGV VGKVRDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLAxVLYMKIG LYKLVFALDSQKFRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKSNSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASANG------xxxxxxMTAVVHATHSFTCCMSVVCLG SMSRVSATVICPLNI >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxKLDASRAGSS NSGIYRLLTERPSSRALKTPPGPLQRPPQQDLPKRRLPLRVEPSAVKLRP VSPGTTTVTTSARLPDYSTVLxRTTQSKRSVAATPGFQPLPDSST----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQ ExxxxxxxxxxxxxxxxxxxxxxxxRQRGPNSWTPHGLEVDNGDTLTEKF IPKVETSEVIVEEPLRLIAAPPGNVSSVEGPGGSGEDTVIAPLSAGDGGA ISxAKAKQSRSPGCSVSVSPDGGSSPELSEATSSEAPMRDTGQQISTRAS SPGSILSSSGYMGSTTRLLQATKQVGLHLVYLYxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- ---------------------xxxxxx----------------------- -------------------------xxxxxxxxxxxSWLPGLRTSLAVLS LAAGLGNIVRLPRVVFLNGGx--VGVDVKGVVSGAFLVVYLSISLILGIP LVFLEIGQGQLCQKGTATLWRAVPLFKGVGYVKILSSTLVSVYYPILMTL SLFYVIWIARGPLPFQECQIQGVESEGFVKGQICIQ-------------- -------------------------------------------------- -------------------------------------------------- ---------------------QTFLVSVDEDAMWFGVNASLLFLIWTLCM LLIFKGADSSHLSMFFVVAPVICCLIALLIDSLLREPTARGLQLLTTFNW DILANIQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGYSVETPQLTEMFVFTVxxDVA------ ----------------------------------------------IILV YSLLVALPLxxLGKWQWWHAAGIVSALGFLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFSW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFTILEIWSFVSLPLDGV VGKARDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKLRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKSNSSPPSTTYSSRIRNKGPFTI ESNGNIEHVCRRASANGTNKAIR--------------------------- --------------- >Tcm x------------------------------------------------- --------------------xxxxxxxxxxxxxxxIKK------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------RT------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------NSWTPHGLEVDSGDTPTEKF IPRVETSEVIVEEPLRLVAAPPGNVSSVEGPGGSGEDTVIAPLSAGDGGA ISxxKAKQSRSPGCSVSVSPDGGSSPELSEATSSEAPMRDTGQQISTRAS SPGSILSSSGYMGSTTRLLQATKQ-------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxSWLPGLRTSLAVLS LAAGLGNIVRLPRVVFLNGG-------------xAFLVVYxSISLILGIP LVFLEIGQGQLCQKGTATLWRAVPLFKGVGYVKILSSTLVSVYYPILMTL SLFYVIWIARGPLPFQECQIQGVESEGFVKGQICIQ-------------- -------------------------------------------------- -------------------------------------------------- ---------------------QTFLVSVDEDAMWFGVNASLLFLIWTLCM LLIFKGADSSHLSMFFVVAPVICCLIALLIDSLLREPTARGLQLLTTFNW DVLANIQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGYSVETPQLTExxxxTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATM-------------------------IILV YSLxxxxPLxxxGKWQWWHAAGIVSALxxLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFSW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFTILEIWSFVSLPLDGV VGKARDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKIRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKSNSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASANGTNKAIR--------------------------- --------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MTL SLFYVIWIARGPLPFQECQIQGVESEGFVKGQICIQ-------------- -------------------------------------------------- -------------------------------------------------- ---------------------QTFLVSVDGDAMWFGVNASLLFLIWTLCM LLIFKGADSSHLSMFFVVAPVICCLTALLIDSLLREPTARGLQLLTTVNW DVLANVQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGHSVETPQLTEMFVFTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATM-------------------------IILV YSLLVALPLxxLGKWQWWHAAGIVSALGFLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFAW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFAILEIWSFVSLPLDGV VGKVRDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKLRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKANSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASANGTNKAIR--------------------------- --------------- >Tdi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-----xxxxxx xxxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxSWLPGLRTSLAVLS LAAGLGNIVRLPRVVFLNGGx--xGxxxxxxxSGAFLVVYLSISLILGIP LVFLEIGQGQLCQKGTATLWRAVPLFKGVGYVKILSSTLVSVYYPILMTL SLFYVIWIARGPLPFQECQIQGVESEGFVKGQICIQ-------------- -------------------------------------------------- -------------------------------------------------- ---------------------QTFLVSVDEDAMWFGVNASLLFLIWTLCM LLIFKGADSSHLSMFFVVAPVICCLIALLIDSLLREPTARGLQLLTTFNW DVLANIQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGYSVETPQLTEMFVFTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATM-------------------------IILV YSLLVALPLxxLGKWQWWHAAGIVSALGFLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFSW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFTILEIWSFVSLPLDGV VGKARDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKLRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKSNSSPPSTTYSSRIRNKGPFTI ESNGNIEHVCRRASANGTNKAIR--------------------------- --------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxEDMQLIHILDHYVIGRMVIASTILELVGFAW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFAILEIWSFVSLPLDGV VGKVRDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKFRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKANSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASTNGTNKAIR--------------------------- --------------- >Tte x------------------------------------------------- -------------------------------------xxxxHGSPDPGPG KxxxxxxxxxxxPDPDWWATGPTQHTGTRTxxxxLDPFHMDQNMRGPLLH FEVVRIYxRCxRDSQPRSxxxxxxxxxYKRGxxxxxxxxxSKKVSSNCxC SAVCVVxxxxxLSDPQVRLxxSxxxxxxxxxxxxxRxFSLLPTRSWVHKP SPSRKVICIAS--------------------------------------- -------------------------------------------------- AWRENGKTTLSTLDRDSSFDLTVISSLDYLESSALEHASTETG------- ----------------------------VHQIPGDLDHLQPHSLYALAEA LP------------------------PSHVLTLYNPxxxxKLEASRAGSS NSGIYRLLTERPSSKAFKTPSGSLQRPPQQDLPKRRLPLRVEPSAVKLRP VSPGTTTVTTSIRLPDSSTVLPRTTQPSRYATITPGSQPLPDNSTVLxxx xxxxxxx--------------------------xxTPGSQPLPDSSTVLP RTTQSNKHATTTPGSKPMPTPxxxxxxxxxxxxxxRDNKKTSGIExELSQ KLxxxxIxxxxxxxxxxxxxxxxxxxxAQxxxxxAKRxxxxxxxxxxxxx xxxVNKRI------------------------------------------ -------------------------------------------------- ------------------------------NSWTPHGLEVDSGDTPTEKF VPRVETSEVIVEEPLRLVAAPPGNVSSAEGPGGSVEDTVNAPLSAGDGGA ISxAKAKQSRSPGCSVSVSPDCGSSPELSEATNSEAPMRDTGQQISTRAS SPGSILSSSGYMGSTTRLLQARKQ-----------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxMxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- ---------------------------------GAFLVVYLSISLILGIP LVFLEIGQGQLCQKGTATLWRAVPLFKGVGYVKILSSTLVSVYYPILMTL SLFYVIWIARGPLPFQECQIQG---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----GADSSHLSMFFVVAPVICCLIALLIDSLLREPTARGLQLLTTVNW DILANVQVWYYATIQMFFSTHLGFGNIVTCSGGLYPNSNPLRSAVMYMVC NLLLGLLAVCVVYMWLGELELQGHSVETPQLTEMFVFTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATMVATAPDCSNVVFPKLGQLYHVCPPQIILV YSLLVALPLxxLGKWQWWHAAGIVSALGFLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELVGFSW IYGCKAIYTDFEFILGQKLNPVWKIVWVITPVLFAILEIWSFVSLPLDGV VGKVRDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKFRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKANSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASANGTNKAIR--------------------------- --------------- >Tsi MS------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------ASRKTLNPGRGLSSICRAKTDTRGRAKKRRCVTRESVxLSA xxxxxFTNPHARExxxxxxxxxxxEDGVSPHRKRVSAHLYIALILCLTLG AWMENGKTSLSTPDRDSSFDLTVISSLVYFESSALDHASTETGKINRPNR YSNLYxxVNxxSEYCEIDALDHTTIKEGV--------------------- -PIARGGGRSVGWCxxIAISDYGVFEPSHVLTLYNPxxxxKLDASRAGSS NSGIYRLLTERPSSKALKTPPSPLQRPPQQDLPKRRLPLRVEPSAVKLRP VSPGTTTVTTSARLPDSSTVLPRTTQSNRHETTTPGSQPLPDSSTxxxxx xxxxxxxxxxxxxxxxxxxxxxxPxxxxxxxxxxxxxxxxxxxDSSTVLP RTTQSKRHVTNTPGSQPLPTxxxxxxxxxxxxxxxxxxxxxxxxxxELSQ KLxxxxxxLSTSPxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------VDSGDTPTEKF IPRVETSEVIVEEPLRLVAAPPGNVSSVEGPGGSGEDTVIAPLSTGDGGA ISxxKAKQSRSPGCSVSVSPDGGSSPELSEATSSEAPMRDTGQQISTRAS SPGSILSSSGYMGSTTRLLQATKQI------------------------- -------------------------------------------------- ------------------------ARSVAIDQLxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx-------xxxSWLPGLRTSLAVLS LAAGLGNIVRLPRVVVLNGGxxxxxxxxx--------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDDDDDGGDDDDDD DDDDYDYDYxxxxxxxxxxxxQTFLVSVDEDAMWFGVNASLLFLIWTLC- -------------------------------------------------- -------------------------------------------------- -----LLAVCVVYMWLGELELQGYSVETPQLTExxxxTVxxDVAVTCMGA TNQAxSAIAFITITCAGFATM-------------------------IILV YSLxxxxPLxxxGKWQWWHAAGIVSALxxLLGIPCIVP------------ -------------------EDMQLIHILDHYVIGRMVIASTILELIGFSW IYGCKAIYTDFEFILGQKLNPVWKIVWVISPVLFTILEIWSFVSLPLDGV VGKAKDPTWVYTIGWLLYTSMWVIVAAGGMYQVYHQVDYNLA-------- ----------QKLRSALKPSRDWGPMDPTYRHDWVQWRFQNNKTGEKDFT FRRRGTKEYARSVQRTVHTSEPAGTHYKSNSSPPSTTYSSRIRNKGPFTI ESNGDIEHVCRRASANGTNKAIR--------------------------- ---------------