>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------MEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKPVPFEQHWRKHTLTTMDVATGQV--------------- ---------xxx---- >Tms MNF-----xxxVxxRHNTPNRLDHxLQGSKE------------------- -----------------------------LDA------------------ ---------------------------------------GVMLLFSNRSR HHQFPSNFLSNLVGILNKL-----CITVVYLGRFAAPFPAHSLSISCQTV PKDEKQHTSASKKYSTVDHVHDVVIVGAGAAGLRVALTLASEGFKTAVVT KMFPTRSHTVAAQGGINAAIGSMGEDNWQWHMYDTVKGGDWLGDQDAIHY MTKEAPSVIVELENY-------------------------------GMPF SRTAEGKIYQRKFGAQSLKFGKGPPAHRTCCVSDFTGHSLLHTLYSQTLR YPIDYFIEYFALDLLMENGTCKGIIALRLEDGKIHRFQAKNTIVCCGGAG RCYFSTTGAHTLTGDGTAMASRARLPLQDMEFIQFHPTGIYGSGILVTEG SRGEGGFLLNSEGERFMERYAPIAKDLASRDVVSRAMSCEILDGRGVGPE KDHLHLQLHHLDKDVIKKKLPGIRKTVYTFVGVDICKEPVPVIPTVHYTM GGIPTNYKGQVLSQDKCGEDYIVPGLYAAGECSSVGVHGANRLGANSLLE TVVFGRSCARNIIKTCRPGDKMPELLERTGEVSIANLEWLRSTTGAVPVA TLRADMQKLMHKYAGIFRSQDLLKEGCQKLELLYKNLDDLRVGDRSLVWN TELVEALELQNLMINATQILHSAENRKESRGAHAREDFKFRIDEFDYLKP LDSQKMRELADHWRKHTLSWVDEExxx-----------------xxxxxx LNLGSE-----------------------IVLVSxxxVFYLQLKISLYSL xxxWDHYCAEKSS----------------RKVKFTYRTVNDCTLDxxxxx xVPPV--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxAxxxxxxxx-------- ----------------------------xxxxMQTxxxxxxxxxxxxxxx xxxKTKGKLLTPIKKGNNCTQMKHLxxxxxxxxxxSSVIGR--------- ---------------------SAIAARKIHFTVDGRQSDAKVSDAVSRDY PVVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQG GINAAIGSMEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEETLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTTGQVEIxYRPxIDETLDQK ECATVPPAIRSY---- >Tdi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxSAIAARKIHFTVDGRQSDAKVSDTVSRDY PVVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQG GINAAIGSMEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHSKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEETLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTTGQVxxxYRPxIDETLDQK ECSTVPPAIRSY---- >Tce x------------------------------------------------- -------------------------------xxxxxxxxxxxWYLSGxxx VGYxxxxxxxxxxxMKTxxxxxxELLVxxxxxYSKELYAGVMLLFSNRSR HHQFHCNFLSNLVGILNKLCSNLLCITV---------------------- ---------ASKKYSTVDxxxxVVIVGAGAAGLRVALTxASEGFKTAVVT KMFPTRSHTVAAQGGINAAIGSMGEDNWQWHMYDTVKGGDWLGDQDAIHY MTKEAPSVIVELENYVHPTEIRTSISPSSAVELNTTSVLANYATEAGMPF SRTAEGKIYQRKFGAQSLKFGKGPPAHRTCCVSDFTGHSLLHTLYSQTLR YPIDYFIEYFALDLLMENGTCKGIIALRLEDxxxxxxQAKNTIVCCGGAG RCYFSTTGxxTLTGDGTAMASRARLPLQDMEFIQFHPTGIYGSGILVTEG SRGEGGFLLNSEGERFMERYAPIAKDLASRDVVSRAMSCEILDGRGVGPE KDHLHLQLHHLDKDVIKKKLPGIRKTVYTFVGVDICKEPVPVIPTVHYTM GGIPTNYKGQVLSQDKCGEDYIVPGLYAAGECSSVGVHGANRLGANSLLE TVVFGRSCARNIIKTCRPGDKMPELLERTGEVSIANLEWLRSTTGxxxVA TLRTDMQKLMHKYAGIFRSQDLLKEGCQKLELLYKNLDDLRVGDRSLVWN TELVEALELQNLMINATQILHSAENRKESRGAHAREDFKFRIDEFDYLKP LDSQKMRELADHWRKHTLSWVDEExxxxLSCKLITWVCDSITTML----- -------------------------------------------------- -------------------------------VKxTYRTVNDCTLDxxxxx xVPPVxxxxxxxLRWxxxxGMMIGLTAVxxxxxxxxCxxxxNxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxKLKVWPVSVKRERTRATTVTSH DWPAVASQLNSEFHHNEMCRAHNYSKTWQWPWVHQxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxTxxxxxxxxxxxxxxxNVWTADLxxxxLIA VQxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -----------------------------------SSVIGR--------- ---------------------SAIAARKIHFTVDGRQSDAKVSDAVSRDY PVVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQG GINAAIGSMEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNTEVA LHVSHSSLMSSDIMKP------------RSWDWSVTIDSRQEATITSLSS GSSVLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDKxCHVVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEETLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTTGQVEIxYRPxIDETLDQK ECATVPPAIRSY---- >Tte Mxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xSSVIGR--------- ---------------------SAIAARKIHFTVDGRQSDAKVSDAVSRDY PVVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQG GINAAIGSMEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLK--------------------------------------------V- -------------------------------------------------- ---------------------------------------xx--------- ---------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --VAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDL--------------------------SAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLK--------------------------------------------V- -------------------------------------------------- ---------------------------------------xx--------- ---------------- >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------YDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDYKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTTGQVDIxYRPxIDETLDQK ECSTVPPAIRSY---- >Tsi x-----------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------YDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDYKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTTGQV--------------- ---------xxxxxxx >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFALDLLMEDGECRGVIALCLEDGTIHRFHAKNT--- -------------------------------------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVQGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEDTLQEGCKKTEEIYKQM SDLKHxxYHVDLEQNPPHEEENLTSASDDSEQKQDFRGFGPDAEPLVPLS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKPVPFEQHWRKHTLTTMDVATGQV--------------- ---------xxx---- >Tps M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxEPVARLR-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----HPSVxxxCRLELRxxxTGQMGPAQR--------------------- -----------------------------------------LDAVWPRNV WTGDIxxxxLTAVQxxxxxxxxxxxxxxx--------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxxxSAIAARKIHFTVDGRQSDAKVSDTVSRDY PVVDHTYDAVVVGAGGAGLRAAFGLVAEGFKTAVVTKLFPTRSHTVAAQG GINAAIGSMEQDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELEN YGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLY GQSLRYDCNYFVEYFAL--------------------------------- --------------xxxxxxxxxxxxxxx--------------------- ---VLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNEDLEFVQFHPTG IYGAGCLITEGCRGEGGYLINSEGERFMERYAPVAKDLASRDVVSRSMTI EIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTREP IPVLPTVHYNMGGIPTNYKGQVLTVKGGQDK---VVSGLYACGEAACSSV HGANRLGANSLLDLVVFGRACAKTIAEEDKPGDKIGPLKPSAGEASVANL DWVRHAKGNISTAALRLNLQKAMQTHAAVFRTEETLQEGCKKTEEIYKQM SDLK--------------------------------------------LS DHSMVWNSDLVETLELQNLMLNARQTIVGAENRKESRGAHAREDFKDRVD ELDYARPLEGQKRVPFDQHWRKHTLTTMDVTSGQV--------------- ----------------