>Tge Mx-------xx-------------xxRTKLEKSGELVAYSEAxxxxNASV VEYCRTSMAALSGGTAGLLGMTGFYGFGFYVFAVVGLWVEYRGxxxxxAW xxxEKPFRKNHPQxxxxxxRTSISPSSAVELNTTSALANYATEFSRPEPL LFHSGILFLDCPHEAEFQIHFLTESRGAPGIExxxSVSVTRNSMSMVExx xxxVxxIFTLSPVTTDHGDTQVLHVHARSAAxxxxDERHGQQDTVVEHQD GPGTRAGSLVPGSNPVxxxxGYLEDNSTWVNCHSWVEWLPGxxxxxxxIx xxxxxxxxxxxxxxx------------------------PNVCVVEEVPG TSHKIWTECKYWRNRDICGQKA---------------------------- ------------------VIRYECCEGFHMVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLDTELAKRGVHTLFAPLDSAFE------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLVGRKLTSQSFKA DLLVESRYEGHKLRINKYSNG-----------------------METVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQVGSIGEHGRLVI LGSTDGRFSELAKAMEKTEFVNKMRN----NRQPCTFLAPSDEAFQKIPQ SRL--------------DKIMANKEAKEALLENHVIQHPMCLPAVLGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDR--------------------------------------------AKS ILQLAEQEKLYTFMQLVRTSGLDDALENFGEYTIFAPSEAAMH------- -------SLAPETLRTLRKNKDLARQFVLYHSTQGRHNTDTI-------- -----------------------------------------TICLCTCD- Q--------------------VVMSLDEQNPLRLQVYRKSIGVEDAMIEK PDIDGMNGCIHVINKxxxxxNTSAGDILRQDGNFS--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------IFLTAMEKVMEKNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTK--------------------------- ----------------------------------------TIKNHLVEDM FASEGFRSDLFYDVQTRQNIVDVVKKNGKLKVNDATMTRCDLLNTNGVIH VINKVLLPDHHIED >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------MVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLDTELAKRGVHTLFAPLDSAFE------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLVGRKLTSQSFKA DLLVESRYEGHKLRINKYSNG-----------------------METVNC VTIARK-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------x >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------LAxxxMNVxxxxxxxxxxxxxxxxxPNVCVVEEVPG TSHKIWTECKYWRNRDICGQKA---------------------------- ------------------VIRYECCEGFHMVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLGTELAKRGVHTLFAPLDSAFE------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLLGRKLTSQSFKA DLLVESRYEGHKLRINKYSNG-----------------------METVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQ------------ ----DGRFSELAKAMEKTEFVNKMRH----NRQPCTFLAPSDEAFQKIPQ SRL--------------AKIMANKEAKEALLENHVIQHPMCLPAVLGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDR--------------------------------------------AKS ILQLAEQEKLYTFMQLVRTSGLDDTLENYGEYTIFAPSEAAMH------- -------SLAPETLRTLRKNKDLARQFVLYHSTQGRHNTDTM-------- -----------------------------------------x------xx Q--------------------VVMSLDEQNPLRLQVYRKSIGVEDALIEK PDIDGMNGCIHVINKALSPVNTSAGDILRQDGNFS--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------IFLTAMEKVMERNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTK--------------------------- ----------------------------------------TIKNHLVEDM FASEGIRSDLFYDVQTRQNVVDVVKKNGKLKVNDATMTRCDLLNTNGVIH VINKVLLPDHHIED >Tbi xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------PNVCVVEEVPG TSHKIWTECKYWRNRDICGQKA---------------------------- ------------------VIRYECCEGFHMVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLDTELAKRGVHTLFAPLDSAFE------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLVGRKLTSQSFKA DLLVESRYEGHKLRINKYSNGVLSPTNKNYGFLLTSTKSMLVFQMETVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQ------------ ----DGRFSELAKAMEKTEFVNKMRN----NRQPCTFLAPSDEAFQKIPQ SRL--------------DKIMANKEAKEALLENHVIQHPMCLPAILGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDR--------------------------------------------AKS ILQLAEQEKLYTFMQLVRTSGLDDALENFGEYTIFAPSEAAMH------- -------SLAPETLRTLKKNKDLARxFVLYHSTxxxxxxxxI-------- -----------------------------------------TTCLCTCD- Q--------------------VVMSLDEQNPLRLQVYRKSIGVEDAMIEK PDIDGMNGCIHVINKALSPVNxSAGDxLRQxxxFSxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxLQM---------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxE------LQVNGx EELRVSCxxxLQxSxxxIFLTAMEKVMEKNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTK--------------------------- ----------------------------------------TIKNHLVEDM FASEGFRSDLFYDVQTRQNIVDVVKKNGKLKVNDATMTRCDLLNTNGVIH VINKVLLPDHHIED >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------MVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLDTELAKRGVHTLFAPLDSAFExxxTLxxxxxxx xxTxSMSxxxxxxxxxxxxxxxxxxxxxxxxxxxxSMSxxxxxxxxxxxx xxxxxxxxxxxxxxxxSMSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxELPREQKARLENYRGNPDN--PILLYHLLGRKLTSQSFKA DLLVESRYEGHKLRINKYSNG-----------------------METVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQ------------ ----DGRFSELAKAMEKTEFVNKMRH----NRQPCTFLAPSDEAFQKIPQ SRL--------------DKIMANKEAKEALLENHVIQHPMCLPAVLGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDR--------------------------------------------AKS ILQLAEQEKLYTFMQLVRTSGLDDALENFGEYTIFAPSEAAMHxxxxxxx xxxxxxxx------------------------------------------ ------------------------------------------TCLCPCE- QxxxSxxxxxxxxxxVHVSVLVLMSLDEQNPLRLQVYRKSIGVEDALIEK PDIDGMNGCIHVINKALSPVNTSAGDILRQDGNFS--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------IFLTAMEKVMEKNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTK--------------SSTKSLETTTCSG HSTTSSVNSTEAFSSACSASMFVTVTEGNTEDLAD----TTIKNHLVEDM YASEGFRSDLFYDVQTRQNVV----------VNDATMTRCDLLNTNGVIH VINKVLLPDHHIED >Tcm MV-------xSRRPPGTxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------PNVCVVEEVPG TSHKIWTECKYWRNRDICGQKASSLETCFAMAKSRLLCCFANSPPTIGVx xxxxxxxxxxxxxxxxxxVIRYECCEGFHMVPGEQGCTGVKPLKNVLETA RDLGAYKFVQYIEQSGLGTELAKRGVHTLFAPLDSAFE------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLLGRKLTSQSFKA DLLVESRYEGHKLRINKYSNG-----------------------METVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQ------------ ----DGRFSELAKAMEKTEFVNKMRH----NRQPCTFLAPSDEAFQKIPQ SRL--------------AKIMANKEAKEALLENHVIQHPMCLPAVLGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDRVWSETGSRILGDLIKMVDPMKCPEVVLSDLIADFSLELSNTMYKAKS ILQLAEQEKLYTFMQLVRTSGLDDTLENYGEYTIFAPSEAAMH------- -------SLAPETLRTLRKNKDLARQFVLYHSTQGRHNTDTMFxxxxxxx xxxxxPDQIMYPxxxxxxxxNHVFSRCRHVLSGYKCTCPISTTCICPCD- Q--------------------VVMSLDEQNPLRLQVYRKSIGVEDALIEK PDIDGMNG------------------------------------------ -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx-------xxx-------------- -----------------IFLTAMEKVMERNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTK--------------SSTKSLETTKCFG HSITLSANTTEALASECPASMFATETEGNTEDRADMxxxxTIKNHLVEDM FASEGFRSDLFYDVQTRQNVVDVVKKNGKLKVNDATMTRCDLLNTNGVIH VINKVLLPDHHIED >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------FQ------------ -------------------------------------------------- -------------------------------------------------- ----------ELPREQKARLENYRGNPDN--PILLYHLVGRKLTSQSFKA DLLVESRYEGHKLRINKYSNGVLSPTNKNYGFLLTSTKSMLVFQMETVNC VTIARKDQEASNGIVHIVDSLLDPAFTVQRDLTEIVAQ------------ ----DGRFSELAKAMEKTEFVNKMRN----NRQPCTFLAPSDEAFQKIPQ SRL--------------DKIMANKEAKEALLENHVIQHPMCLPAILGEHK VRTMGEDKMVFDCDKRGVTLE-----GKRLRADFTMGENGVIYMVDDVLV PDR--------------------------------------------AKS ILQLAEQEKLYTFMQLVRTSGLDDALENFGEYTIFAPSEAAMH------- -------SLAPETLRTLRKNKDLAR------------------------- ---------------------------xxxxxxxxxxxxxSTTCLCTCD- Q--------------------VVMSLDEQNPLRLQVYRKSIGVEDAMIEK PDIDGMNGCIHVINKALSPVNTSAGDILRQDGNFSVREELQMSGQEELQV SGQxxxQVSSKKELQVSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxLxVSxxxE------LQVNGQ EELRVSCRDKLQVSYSIIFLTAMEKVMEKNPQTLELQKPGSSYTFFVPTD QAFNKLGSARLHRIMGDSTYLTKxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------- >Tms MN------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------x------------- -------------------------------------------------- -------------------------------------------------- ----------RxPNAxxxxxxxxxxVFDSSRPII-------RLCRxxxxx xxxxxxxxxxxxxxxxx----------------xxxxxxxxxxxxxxxxx ------xxxxxxxxxxxxxxxxxxxxxxxxxxPxxxxx------------ ----xxxxxx-------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------ -xxxxxxxxxxxxxxxxxYxxxxxxxGKKTFNAIELASNLILPVIGSTVY HER--------------------------------------------xxx xxxxxxxxxxxxxxxx--TMGLVSGKLEDGGMPLFA-------------- --------------RASFKNK----------------------------- ------------------------------xxxxxxx------------- -------------------------------------------xx----- --------------------xxxxxx---xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- ----------xxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxx-xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxKxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxx-- -------------x