>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------VVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPAPPVQPPASLPFPPTS PYPGMSINGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHVALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTAGGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGR------------------------GTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLH----------- -------------------------------------------KVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYA-------QVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDHETEGGGGGRDPGLNN QCVGGGGSDTNHDDEDAEPPAVVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISV---------QIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPTKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELK-----------VKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQSSQTAFQDQHINGPEFGDELFPSFEHDMPEGIEEMPMDLNEIFAW PETGLGGVQSPTGSPRRDSPSQPGSPSCGMGGTSDQHSPFPCNGTSR------------- -------------VSYVITNR--------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------GL- --N-----------------------------------------------------HALL IS----------------------- >Tsi MK---------------------------------------------------------- ---------------------------------------HSDV----------------- RLERRSPGDVTPLAQVAPVIV-----GNVILKKVGGRNLGR--------RVVIFHD--GA SPRDLFSAATSQYDCFMVNMFRTAT----YGEQGSWESGLSYECRALLFKALHNLIERCL LSRDFVRIGKWFVQPYDGAEKLVGESTHFSFAFAFFVHGESTVCASIDVRMHPLVRNLSR QHLVQAQASSSGAPAVKLNRTSALANYATEAVLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCS------- ------------------------------------------------------------ -KCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRGQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSN-----------QVFSPYP AASSVEAAPKPVDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- YEDEEELHSELLYDY----------STLDAW---LNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPTAKAI VEHYSRSPSTRKRLHTVMEEMVLPVLELIQFVDTRWSSEYNMLSRLHAVRKAVGAELANS ENNIEILTEVEWKQAAGIVEVLGPLADATKEINKALKSRFSFYDSDPIFCPSMLCDPRFR GVLIDDMVAVNTLAIEVKKLSDKSSLEPNVKDEHPSCSSSSSGLWSSFDSIPNTTQPAID NNSEVKDYLNEPREEDKRPTPGSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGPLEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGSVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSPATSTASSYLNKNINSVEPVPTPVMARTPEANSLVVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPAPPVQPPASLPFPPTS PYPGMSMNGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHVALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTASGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGR------------------------GTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLHKVCCLGRHSPF TKVLLLLLLLRRFVVLADSPITKVVLMLLLLRRFVVLADSPITKVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYA-------QVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDHETEGGGGGRDPAMNN QCVGGGGSDTNHDDEDAEPPAIVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISV---------QIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELKGWSWLLSRKALVKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQSSQTAFQDQHINGPEFGDELFPSFEHDMPEGIEEMPMDLNEIFAW PETGLGGVQSPTGSPRRDSPSQPGSPSCGMGGTSDQHSPFPCNGTSRSGGSLGVDSQEEV GTLHQQPLALGYYVSTAPTGRMPRWFWASCPHLENVCPAFLKNSLHLHSPAIQQNSDDLL QQQSTVTVH---PL-DSQYTTDVL------------------------------------ ----------------------------------------------------RYVLEGY- --NALSWLALDSNTRDRLSCLPVHIQALMQLY---------------------HMTSALV ------------------------- >Tms MT-----ALR------------------------QETCSA-------------------- ---------RRQL-YDIV-------------------IHHHDY----------------- -------------------------------QLPATG-----WVS-----------ISSF PASTLLLPPTSI---SNILLYVHWSDCVPDGEQGSWESGLSYECRALLFKALHNLIERCL LSRDFVRIGKWFVQPYDGAEKLVGESTHFSFAFAFFVHGESTVCASIDVRMHPLVRNLSR QHLVQAQASSSGAP-----------------VLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCSKRKC--- --ELQNKVCLIPPLPLTFFYPDIGLRNNCIYCLRPHNRVSTIQENRGTS----WEFEVIG NKCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRCQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSNQLLVKCVLLNVQVFSPYP AASSVEAAPKPVDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- YEDEEELHSELLYDY----------STLDAWEGLLNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPTVS-- MEGFKRN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------NSVKEEDKRPTPGNGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGALEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGGVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSPATSTASSYLNKNINSVEPVPTPVMARTPEANSLVVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPTPPVQPPASLPFPPTS PYPGMSMNGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHVALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTASGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGRVSHQVVRLCTNYANKLEMRKGGGLGTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLH----------- -------------------------------------------KVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYAQVSHFSPQVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDH--------------- ------GSDTNHDDEDAEPPAIVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISV---------QIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELK-----------VKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQSSQTAFQDQHINGPEFGDELFPSFEHDMPEGIEEMPMDLNEIFAW PETGLGGVQSPTGSPRRDSPSQPGSPSCGMGGTSDQHSPFPCNGTSRSGGSLGVDSQEEV GTLHQQPLALGYYVSTAPTGRMPRWFWASCPHLENVCPAFLKNSLHLHSPAIQQNSDDLL QQQSTVTVH---PL-DSQYTTDVLSKKD-------------------------------- ------------------------------------------------------------ --GVMFANSLDKALKSRFS-----------FYD-SDPI----------FCPF-HAMRPKI ------------------------- >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MHPLVRNLSR QHLVQAQASSSGAP-----------------VLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCS------- ------------------------------------------------------------ -KCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRCQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSN-----------QVFSPYP AASSVEAAPKPVDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- YEDEEELHSELLYDY----------STLDAW---LNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPTVS-- MEGFKRN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------NSVKEEDKRPTPGSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGALEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGGVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CHL------ ---HCLLLPQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >Tcm ML-----SRRKRKAKSRAERTTPTSLKSCGWLGCRRTCDSTVTSALMEKLKKQDSFVLLF YESLNRKLQEKQLDYHIRHWEADKVQ---------SCYMHSDFLGR-------------A TAEDMCRNDSNCKIQIVSLATLCNTRGLVVQREPARGDTSRTWMRYMTLFIIIFQPLAGF PPPPLLSPPPST---LAQSSPPHSS----YGEQGSWESGLSYECRALLFKALHNLIERCL LSRDFVRIGKWFVQPYDGAEKLVGESTHFSFAFAFFVHGESTVCASIDVRMHPLVRNLSR QHLVQAQASSSGAP-----------------VLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCSKKWLGGV GEKVDNLNIGIKP-------STYGSVHQCHILVMLNTTTSEYKTNQDGSLVAHWH---IN PRCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRGQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSN-----------QVFSPYP AASSVEAAPKPVDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- YEDEEELHSELLYDY----------STLDAW---LNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EEDKRPTPGSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGPLEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGSVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSPATSTASSYLNKNINSVEPVPTPVMARTPEANSLVVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPAPPVQPPASLPFPPTS PYPSMSMNGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHVALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTASGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGR------------------------GTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLHKVCRLGQHSPI TKV------------------------LLLLRRCVVLADSPIIKVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYA-------QVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDHETEGSGGGRDPAMNN QCVGGGGSDTNHDDEDAEPPAIVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISV---------QIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPIQEPAEKGLGSACRLAEAHGLCS GCDLAKCAALEISRGPYRQDSSPMASLVLIDSSQLTSDSQHLGWSWLLSRKALVKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQSSQTAFQDQHINGPEFGDELFPSFEHDMPEGIEEMPMDLNEIFAW PETGLGGVQSPTGSPRRDSPSQPGSPSCGMGGTSDQHSPFPCNGTSRSGGSLGVDSQEEV GTLHQQPLALGYYVSTAPTGRMPRWFWASCPHLENVCPAFLKNSLHLHSPAIQQNSDDLL QQQSTVTVH---PL-DSQYTTDVLSRPSARKRFHTVMEEMGLPVLELIQFVDTRWSSEYN MLSRLQAVMKAVGAKLAYSENIELLTAVEWKQSAGIVEVLRPLADYQGDQWSQYVLEGY- --NALSWLALDSNTRDRLSCLPVHIQALMQLY---------------------HMTSALV ------------------------- >Tps ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SY-C-------------RCL LSRDFVRIGKWFVQPYDGAEKLVGESTHFSFAFAFFVHGESTVCASIDVRMHPLVRNLSR QHLVQAQASSSGAP-----------------VLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCS------- ------------------------------------------------------------ -KCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRGQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSNQLLVKRVLLNVQVFSPYP AASSVEAAPKPLDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- ----------------------------------LNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EEDKRPTPGSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGPLEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGSVRCKQEGVPQYGQPS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >Tdi MVISVAGARQKWQSYLEANRRG------------KETA---------QKDSKRKSFTGEI DE-LKAKKQRLQADVDTVTKSADRLSEQAETTGNLTFVSKSNSFRRTAREKTAAMADINK QLSDRCRNDSNCKIQIVSLATLCNTRGLVVQREPARGDTGRTWMR-------PFSEAHSL PMASLVLADSSQ---LTSDSQHLSVYIVPDGEQGSWESGLSYECRALLFKALHNLIERCL LSRDFVRIGKWFVQPYDGAEKLVGESTHFSFAFAFFVHGESTVCASIDVRMHPLVRNLSR QHLVQAQASSSGAP-----------------VLLAPFGLSGALTGQVYKAVDLHTQRLLE DWRQFYPIGGGGEEGAALPPAVEVVVGGVKMRYPTCYVLATDMDDCASPVKSPPAPPLSP SLAVHLPEHVWQDSILNPTQHVAAEGDGTANQQPPVGHWDFVEPARKTSCSCS------- ------------------------------------------------------------ -KCNPPGGVKNKGAVSSVKPGKGEKGSRGVVAPFHRR----LPPDMEHSRC----VGIGT PSGGPSSYPRGQSMTPNPLPTLHDSLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMP TLSPHPPAPPQPSTPLEAQDKVTPAATPSDLNGPKSVSSVSNQLLVKRVLLNVQVFSPYP AASSVEAAPKPVDTMVGSQGPASTHSVAAPNPVAPPEPPVLKRPNLSSKE---------- ----------------------------------LNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPCLMEMDDNVQPNKGSDPYDFDVENDMLAPTVS-- MEGFKRN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------NSVKEEDKRPTPGSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGPLEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGSVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSPATSTASSYLNKNINSVEPVPTPVMARTPEANSLVVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPAPPVQPPASLPFPPTS PYPGMSMNGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHVALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTASGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGR------------------------GTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLHKVCRLGRHSPF TKV------------------------CRLGRH------SPFTKVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYA-------QVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDHETEGGGGGRDPAMNN QCVGGGGSDTNHDDEDAEPPAIVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISV---------QIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELKGWSWLLSRKALVKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQSSQTAFQDQHINGPEFGDELFPSFEHDMPEGIEEMPMDLNEIFAW PETGLGGVQSPTGSPRRDSPSQPGSPSCGMGGTSDQHSPFPCNGTSRSGGSLGVDSQEEV GTLHQQPLALGYYVSTAPTGRMPRWFWASCPHLENVCPAFLKNSLHLHSPAIQQNSDDLL QQQSTVTVH---PL-DSQYTTDVL------------------------------------ ----------------------------------------------------RYVLEGY- --NALSWLALDSNTRDRLSCLPVHIQALMQLY---------------------HMTSALV ------------------------- >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MSTYPPNKGGK-------AAENVSGKMKI----------------------------- -------------------------SSGKSEK-----HREF------------------- ------------------------------------------------------------ --CN-----------------------KEIVATLTQREFSNLIYQLECQQCTAQYVGL-- --------------------TLRERI-----------------NEHRHD----------- ------------------------------------------------------------ --TKIKTPEKPVSAH------ASNHNLNFEDCYTVQSLKYFQTVQLISYTIFTMNSKRGF YEHSSKVNSETWFVFGVGIAILALLSIVDCGR-RLNHPVKRFKPSDLRPAEPVRPRPQRQ SSTDHQPSPTNPNLVQTIKQEIKQEPC--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TEEDKRPTPNSGIPPFDPVITNGPINMNTSGNLFTNEGLQASYKDLDQ IFDNSDDTSNDETLQVSTPPGSNKPGGPLEDPTTTVVVVKPPRNSGGNTSLNSCGGTNTL RPEELVKMFPTPPSMEHNPIASPCGHMSPHGPTTDLMIDSGSVRCKQEVYPNMGSPQEES IDDWSYVFRPPAICKMVGSSKYAPLTNLPSQTLPLVALPLNCVYKPSWVHPPVPPAAAKS PALPCPPRPGPPLSAPHPSHLPHPRAGLSPISPAAHFPPSPMTVAAMGGVGLPIHLQQQY RGGGGGGGVRTPCPPPPAYELPSPATSTASSYLNKNINSVEPVPTPVMARTPEANSLVVN ILLGDTSLNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGIYLPAPPVQPPASLPFPPTS PYPGMSMNGPPPPYGMMGSSPGHHRGTQLDEDPIRCNCGFSAVVNRRLSHRSGLFYEDEL EITGLAEDPSDRRKGSLSAYLLTNSKNSQENASELVDILPQNVIELLREQCVIVQSMSNS LCRASRQFRGSAGPGAVPYGTTVNMLEFSDGNEVTHLALDQGRQALLESTTVAMCKVEEM QQRQQMMQHTAGGGKGAAGPCVHRWPYLRARGPLCNQDIVRVMKILQPLLQDAIQKKCTT RLWDAPYTVSGPLTWRQFHRLAGR------------------------GTDDRCEPQPIP SLVVGYDKDWLSLSPYAIQYWEKLLLEPYSYARDVAYIVVAPENDYVLH----------- -------------------------------------------KVCRLGRHSPITKVLRE GILRVGKSAATKLAKEPVDDWFNLLGDNPTTNMLKLYA-------QVCRHHLAPHLSQMP MDRTLLDPPEGSQAPRSSLDRSMPSPMPPPSTPEDKAPSTPKSDHETEGGGGGRDPGLNN QCVGGGGSDTNHDDEDAEPPAVVVYLVDPFTMGSDSTDLQRLACLGLLRCFTTVLAALPD NIRNNISVQIGNPVFSLQIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLTHTS NIKALTGFGTAAMADLFLKSKDEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELKGWSWLLSRKALVKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQVSR------------------------------------------ ------------------------------------------------------------ -----------------------RW---KC---TNIC---LCHSITVTEP---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------TQISDRID----------------------------------------- ------------------------- >Tte ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------LVVGRIGRIGHGELK-----------VKASKHL KEICGQCGLMYPNDVPCVLSACLVSLEPDSALRLMPDQFTPDERFSQASVNCQLSTPQDV SCTHILVFPTSATTQVCR----------------------HHLAPHLSQMPMD-RTLLDP PE----GSQAPRSSLDRSMPSPMPPPST----PEDKAPSTPKSDHETEGGGGGRD----- ------------------------------PGLNNQC---------VGGGGSDTNHDDED AEPPAVVVYLVDPFTMGSDSTDLQ------------------------------------ ----------------------------------------------------RLACLGLL RCFTTVLAALPDNIRNNISVQIISLESIVELGKLRDRIRHSDHMRAQAFSVFSQCRRMLT HTSNIKALTGFGTAAMADLFLKSKD >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MQEKNRAPYRLYTPPYVLAPAKEKIESSESFGQCSTEHGS VLYVSYCLSEDQHWLLAVATDEKGEIFETSTINIDIPNRSRRKKASARRVGLQKLMDFVL G-------VISQSVQPWR---------FSRG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PY---------------------------------------------- ------------------------------------------------------------ --------------------------------------RQDRSWRTQ------RCVRAIN -------------------------