>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------SNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYAN--------------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRT-------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxM------------ELDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLKx---------------------------- -xxx--------------------------xxx----------------- -------------------xxxxxxxxxxxx------------------- -xxxxx-------------------------------xxxxxxxxxxxxx xxx---------------xxxxxxxxxxxx-------------------- -------------------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------SNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLT------------------------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLT-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tbi x--------------------------------xxxTLQFFITRHIxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxx--------- --------------------xxxxxxxxxxxxxxxxxxxxx--------- ---xxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xSNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVIDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFMATVGNTTYSFLDMTSSLGSALFVVPLLAILEDVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRTxx-xxxxxxWTLNVREIRKVEAMRMKFMRRMLTVTRRN -RIRNEVI------------LEIVxxxxxEYVKGENxxxxxxxxxxxxxx xxETREEMxxxxxxxxxx----------------------------LDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLK----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------Exxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQGMGFTVHSxxxxRx >Tms xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------SNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACMxxxxxxxxxxxxSDHILGFACMAILLLLGWVYPSDHILGx ARVAILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRT-------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxM------------ELDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLK----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- >Tsi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xGQxxxxxVxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxLVxxxxxxxxxxxxxxxxxxx-xSNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQLGRYTLHYCLIQRFSTWGPGPQIHGGSRGLLRGFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRT-------------------------------------- -------------------------------------------------- -----------------x---------------------------KLDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVNVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLKGxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tcm M------------------------------------------------- -----------------------------xxxEExxECKDRxxWRKA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxHSNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQLGRYTLHYCLIQRFSTWGPGPQIHGGS----RGFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------RxxxxxSLCxxxKAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRT-------------------------------------- -------------------------------------------------- -----------------x---------------------------KLDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVNVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLKG---------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- --xxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- >Tte x------------------------------------------------- -------------------------------------------xxxAxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xDSNGSVAVSLP PPADPSNPRDGVKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFMATVGNTTYSFLDMTSSLGSALFVVPLLAILEDVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRTxx-xxxxxxWTLNVREIRKVEAMRMKFMRRMLTVTRRN -RIRNEVI------------LEIVIWTSNEYVKGENTKENIxxxxWxxxx xxETREEMxxxxxxxx----------------V------------KLDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAK------------------------------ -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------SNGSVAVSLP PPADPSNPRDGEKSAWYSRANHDERMRRVVDRARRGCTKKLLYKRIPVLT WLPQYNLSVAASDLVAGFTVGLTVIPQAIAYANVAGLPPQ-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLLxxxxxxxxxxxxx---------------------------- -------------------------------------------YVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVF--- ------------SDGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRT-------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxx------------ELDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVT------ ------------SSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLK----------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ ------------------x------------------------------- -------------------------------------------------- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxYGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLDVWEQLFEHISETRL WDTLLGFACM---------------------------------------- ---AILLLL------------R-----------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVFxDS LLCLHFLVLSNAADGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRTx------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxELDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVTxGSICS YQFTLSESHIFQSSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLK----------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxx------------ ------------------x------------------------------- -------------------------------------------------- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------x-------YGL YSSFMACFVYTIFGSCKDSPVGPTAIAAILTRENLHGLGPEFAVLMCFLC GCVVMLMGILQL-------------------------------GFLIDFI SGPVSVGFTSAAAIIIATTQIKDLLGLSFPGSKFLD-------------- -------------------------------------------------- ---------------------------------KAKDIPVGPADTNKRTT LQKVLGQMLWLISTGRNILVVVVCAVMAYTFKLHDVEPFLLTGYVKPGLP PFQPPPFTATVGNTTYSFLDMTSSLGSALFVVPLLAILENVALAKVFxDS LLCLHFLVLSNAADGRAIDATQEMLAIGACNILSSFVSSMPVSGALSRGA VNHASGVATTFGGIYTGILVILSLYLFTPYFAYIPKASLAAVIVAAVVFM VEFHVVKPMWRTxxxxxxxxxWTSNIRVTRRVEAMRMKFVRSMLAVTRRN xRIRNEVxxxxxxxxxxxxxx----------------------------- -----------------x---------------xxxxxxxxxxxxELDLI PAIATFLSCLFIRLELGIVIGIGINILFLLYASARPSVHVEKVTxGSICS YQFTLSESHIFQSSSGCEYLLITPDRSLVFPSVEYVRNLVTKAGMKEGSS CTPVVIDSRHIQGADFTAAKGIKSLIEDFVKRNQPILFYNLKPSVVEVFQ GVQPKEFKHCHNEAELNELLK----------------------------- -------------------------------------------------- ------------------------------x------------------- -----xxxxxxxxxxxx--------------------------------- -------------------------------------------------- --------------------------------------------------