>Tge x------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xHRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSEEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKTLKEEKTKNAVEVEEIA------------------------------- ------------------EKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGEVRKENTR EEGEEEGVAREEGERKEEEEELKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAAKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGRx xxx------------------------S >Tcm MADSEDEYDRKRRDKFRGERTESYQRxxxRRxGASEERRRDDWIDRESWG SRSRPRTEYREYRGGGGRERYSAAHSQDIVQPMKRMKTEW---------- -------------------------------------------------- ---------EDRRGGGYSHDNSGGYNYRNQWMQESYVPQHNYSGNFNNQK ELQTDTQPPMMSFKAFLQTQDDNITDDEAIRKYNEYKLEFKRQQLNEFFM AHKDEE----------------W--------------------------- -------------------------------------------------- -------------------------------------------------- -------FKIKYHPEDSVRRKDEQSASLKHRLEVFLEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEVVPEPELKPNTEV KKTLKEEKTKNAAEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGKVRKENAR EEGEEEEVAREEGERKEEEKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYxMGRRVIAYNDLDAPEIPEVFS >Tce MADSEDEYDRKRRDKFRGERTESYQRxxxRRxGASEERRRDDWIDRESWG SRSRPRTEYREYRGGGGRERYSAAHSQDIVQPMKRMKTEW---------- -------------------------------------------------- ---------EDRRGGGYSHDNSGGYNYRNQWMQESYVPQHNYSGNFNNQK ELQTDTQPPMMSFKAFLQTQDDNITDDEAIRKYNEYKLEFKRQQLNEFFM AHKDEE----------------W--------------------------- -------------------------------------------------- -------------------------------------------------- -------FKIKYHPEDSVRRKDEQSASLKHRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEATPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKTLKEEKTKNAAEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGTVRKENTR EEGEEEEVAREEGERKEEDKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKVxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------x >Tbi xxxxxxxxxxxxxxxxxxxxxESYQxxxxxxxxxxxxxRRDDWIDRESWG SRSRPRTEYREYRGGGGRERYSAAHSQDIVQPMKRMKTEW---------- -------------------------------------------------- ---------EDRRGGGYSHDNSGGYNYRNQWMQESYVPQHNYSGNFNNQK ELQTDTQPPMxxxxxxLxxxDDNITDDEAIRKYNEYKLEFKRQQLNEFFx xxxDEE----------------W--------------------------- -------------------------------------------------- -------------------------------------------------- -------FKIKYHPEDSVRxKDEQSASLKHRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTELDLQILEAPPPEPPVEDKVDSTTGDKP ESKEGEI-SDDEDKKSEEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKTLKEEKTKNAVEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGEVRKENTR EEGEEEGVAREEGERKEEEEELKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGEEKVVEQVAAKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYNKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGRx xxx------------------------S >Tte MADSEDEYDRKRRDKFRGERTESYQRxxxRRxGASEERRRDDWIDRESWG SRSRPRTEYREYRGGGGRERYSAAHSQDIVQPMKRMKTEWxDVNQSPDNL YKIASDFGLMGNWSPPDD-------------------------GFYYDF- ----IDLVKEDRRGGGYSHDNSGGYNYRNQWMQESYVPQHNYSGNFNNQK ELQTDTQPPMMSFKAFLQTQDDNITDDEAIRKYNEYKLEFKRQQLNEFFM AHKDEExxxxxxxxxxxxxxxxWxxRLYS--------------------- -------------------------------------------------- ----------------------------------------xYIRLLxxxx RGLIPVxFKIKYHPEDSVRRKDEQSASLKHRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTELDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSEEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKTLKEEKTKNAVEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGEVKKENTR EEGEEEGVAREEGERKEEEEELKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGEEKVVEQVAAKKDSGPI---------------------------- -----------------------------------WTKDSKSFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDMYPYKDITRPCQT ILLELIIVHVYLDSRLSEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYNMGRRVIAYNDLDAPEIPEVFS >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- ----------------------------xHRLEVFLEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEVVPEPELKPNTEV KKTLKEEKTKNAAEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGKVRKENAR EEGEEEEVAREEGERKEEEKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNMIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYNMGRRVIAYNDLDAPEIPEVFS >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------HRLEVFLEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEVVPEPELKPNTEV KKTLKEEKTKNAAEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPIPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGKVRKENAR EEGEEEEVAREEGERKEEEKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYNMGRRVIAYNDLDAPEIPEVFS >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------HRLEVFLEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEVVPEPELKPNTEV KKTLKEEKTKNAAEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE APHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGKVRKENTR EEGEEEEVAREEGERKEEEKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVGVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYNMGRRVIAYNDLDAPEIPEVFS >Tms xx------------------------------------------------ -------------------------------------------------- ---------------------------------------------xxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------HRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEATPPEPPAEDKVDSTTGDKP ESKEGEI-SDDEDKKSDEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKPLKEEKTKNAAEVEEIAGGCAPLGITQSPDCRIDCQQEFARARLVASF LLFLSLSLCQCSLLSKVVEKDNKGDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGTVRKENTR EEGEEEEVAREEGERKEEDKEPKPRPLHRTASIFLRNLAPTITKQEVEA- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --MCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAVKKDSGP----------------------------- -----------------------------------------SFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGR- --SPTYxMGRRVIAYNDLDAPEIPEVFS >Tpa x------------------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------HRLEVFIEFLESDRLDAVSVD AHQQEQLITLLDAVVIRLEGGTDLDLQILEAPPPEPPAEDKVDSTTGDKP ESKEGEIxSDDEDKKSEEGDKDSEISDKEAAEPKLDEIVPEPELKPNTEV KKTLKEEKTKNAVEVEEIA------------------------------- ---------------EVVEKDNKDDEPPPPGLEAPAVGSPTPASEPEEEE TPHGEKRKRSLSEDMDLDTTNEMEDISDKEDSSLKLDKPEDGEVRKENTR EEGEEEGVAREEGERKEEEEELKPRPLHRTASIFLRNLAPTITKQEVEAA FTAREYIKHNVNSQKTEPYPSESNKKQASSDIPLTTQYYEGLESNKKQAS SDIPLTTQYYEGLESNKKQASNDIPPTTQYWEGLDKLGYILNIGYNILIS SPLTQNILNNAPRITFKPPSPISATFWFILNCLTQPQTTNISPMFLPCNK YxMCKRYPGFLRVAIADPQQDRRWFRRGWVTFQRSVNIKEICWNLNNIRL RDCELGAIVNRDLSRRIRTVNGITAHRQVVRHDIKLSARIVHNLDARSGL WSESGDEKVVEQVAAKKDSGPVLVLRTFPAVVERIPPFLRISLLFCELKG RGKEGSLFFGESVQRGILDTLAVCHNEYIICFISCC---SRSFGLLSKNP VMKNITDYLIEEASAEEEELLGHGGDHEDGQLADDAATFDRDEGLIKV-- -LDKLLLYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHARSIPPISKVSQQ EISDYCRMFEQKVASFLQPNTIVTDEDYSKLGYKDPDI------------ -----------------EVEKFVQANTQELAKDKWLCPLSGKKFKGPEFV RKHIFNKHAEKVEEVKKEVEYFNNYLRDPKRPQLPEHPGKRPQRGEGTPE SQGFSAPAPYLPHYQYNSFARHGGYGGHPYGGYGYNQGYGRGRGYNRGRx xxx------------------------S