>Tge x----------xx------------------------------------- -------------------------------------------------- -----------------------------xKARLQILWVSEDSSMPPEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNTGSSNSEGEGSELC PQEPSRKKQRTTEYQVWSEKYTLGAN-----PKNSASHQSNCQLGPPSDK PTxxNPNSVHRDGSFPRIEQMESNSKHQTNWQETNKIPDDDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAQRCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTMVLIVEGISLYEYLAYESLFPAITSLLTHRV EVVVPAQYNSSLVRELALVPSTALHKKQLISDYGNLEAALKNNEEV---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------YTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASLVNEKLEA-------------------------------------- -------QPAITNNLCRLxxxxxxxxxxxxxxxxxxxxxxVSxxxxxxxQ IRLFWILPDATRRIxxVMYDILVKPDNNITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM TGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLAQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANIFNQAPKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKLxxxxxRLx >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------MYDILVKPDNNITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM TGDRSRKCKLALLCDRLLHESIQSSSKGHSPIEDSQAAMKLAQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANIFNQASKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LCVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKxxxxxxxxx >Tte -------------------------------------------------- -------------------------------------------------- --------------------------------------------MPPEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNTGSSNSEGEGSELC PQEPSRKKQRTTEYQVWSEKYSLGAN-----PKNSASHQSNCQLGLPSDK PTxxHPNSVHRDGSFPRIEQMESNSKHQTNWQKTNKIPDDDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAQRCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTMVLIVEGISLYEYLAYESLFPAITSLLAHRV EVVVPAQYNSSLVRELALVPSTALHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAEVREDGKDKVLGSIPESDNYPRTHLLLSAWQMIEEHYPLLLKG EMQSxLAHIPQPSVL------------------------WLLPSFITRDK LYLSFFLILPIYFTSLSSICTTLSVGTISMAFSLSRRDCRASALGGNNSR xxxxxxxxx------------------------------xxxxxxxxxxx xxxxxx------RYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASLVNEKLE--------------------------------------- -------------------------------------------------- ----------------VMYDILVKPDNNITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM TGDRSRKCKLALLCDRLLHESIQSSSKGHSPIEDSQAAMKLAQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANIFNQASKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKLAxxxxRLx >Tps xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------EKYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVNEKLE--------------------------------------- -------------------------------------------------- ----------------VMYDILVKPDNHITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAVVIAS ESVIREYKLHLGSKEPANTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKLxxxxxRLx >Tms -------------------------------------------------- -------------------------------------------------- -----------------------------xxPRLQILWVSEDSSMPQEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIE------------------ ---------------VWSEKYTPGANHIPVNPKNSVSHLSNCQLGLSSDK PT-LHSDSVHSDGSFPRIEQMESNSKHQTNWQETNKMPDNDYIKLKQE-- -------QVPHFRLKSVGDKASVQLNEAQRCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTIVLIVEGISLYEYLAYESLFPAITSLLTHRI EVVVPAQYNSSLVRELALVPSTSLHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAQVREDGKDQVLASIPESDKYPRTHLLLSAWQMIEEHYPLLLKG EMQS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVNEKLE--------------------------------------- -------------------------------------------------- ----------------VIYDILVKPDNHITDYLTRYSGITEIMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAIVIAS ESVIREYKLHLGNKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQLDDWCGKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKLxxxxxRLx >Tce xxxxVKLTENPIHKLGQSNA------------------------------ GSK--------QLSTSKVQSVFYSPLRKKWSDVHNxIxxxITLPSTTSWx PKPCYSTSATTKATTHDxxxxxxxxxxxx----LQILWVSEDSSMPQEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNAGSSNSEGEGSELC PQEPSRKKQRTTEYQVWSEKYTPGANHIPVIPKNSVSHLSNCQLGLSSDK PT-LHSDSEHKDGSFPRIEQMESNSKHQTNWQETNKMPDNDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAQRCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTIVLIVEGISLYEYLAYESLFPAITSLLTHRI EVVVPAQYNSSLVRELALVPSTSLHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAQVREDGKDKVLASIPESDKYPRTHLLLSAWQMIEEHYPLLLKG EMQSx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----SICNCALRYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVNEKLE--------------------------------------- -------------------------------------------------- ----------------VIYDILVKPDNHITDYLTRYSGITEIMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHALQPVAQMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAIVIAS ESVIREYKLHLGNKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCGKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------V KKLxxxxxRLx >Tcm M------------------------------------------------- --xxxxxxxxxx-------------------------------------- ---------------------------------LQIPWVSEASSMPPEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNAGSSNSEGEGSERC PQEPSRKKQRTTEYQVWSEKYTPGANNIPVNPKNSVSHLSNFQLGLSSDK ----HSDSVHRDGSFPGIEHMESNSKHQTNWQETNQMPDNDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAERCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTIVLIVEGISLYEYLAYESLFPAITSLLTHRI EVVVPAQYNSSLVRELALVPSTALHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAQFREDGEDKVLGSIPESDKYPRTHLLLSAWQMIEEHYPLLLKG EMQS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVSEKLE--------------------------------------- -------------------------------------------------- ----------------VMYDILVKPDNHITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQxxxxxxxxxxxxED--------------------------------- -------------------------------------------------- ---GEIEVRIxxxxxGxxxxxxxxxxxxxxxVMSFLLPECREEKETIPFD QMTP----------------xVIYxxDFTTVNFNRTNFNxxxxxxxxSxx RVFPHHNHTSVTSACRCRxxGLGLxRLSDLLASRLFNAxDYMPDENNMx- ----------- >Tsi M------------------ASPDRDSNLDLPVLSSRAQHDxRVxxxxxxx x------------------------------------------------- ---------------------------------LQIPWVSEASSMPPEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNAGSSNSEAEGSERC PQEPSRKKQRTTEYQVWSEKYTPGANNIPVNPKNSVSHLSNFQLGLSSDK ----HSDSVHRDGSFPGIEQMESNSKHQTNWQETNQMPDNDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAERCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTIVLIVEGISLYEYLAYESLFPAITSLLTHRI EVVVPAQYNSSLVRELALVPSTALHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAKVREDGEDKVLGSIPESDKYPRTHLLLSAWQMIEEHYPLLLKG EMQSx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----SICNCALRYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVNEKLELMIDDDDDDDEDxxxxxxxxxKTxxxINKExxxxHEVDV DNNMTQxx------------------------------------------ ----------------VMYDILVKPDNHITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQ----------------------------------------------- -------------------------------------------------- -----------xxxxGxxxxxxxxxxxxxxxVMSFLLPECREEKETIPFD QMTPxxxxxxxxxxxxxxxxxVIYFHDFTTVNFNRTNFNxxxxxxxxSFN WVFPHHNHTSVTSACRCR-------------------------------- ----------- >Tdi -------------------------------------------------- -------------------------------------------------- --------------------------------------------MPPEMR PLTTRQQQRIDKKKKKMAAYLEIAKLNDQDIEAKQNAGSSNSEGEGSERC PQEPSRKKQRTTEYQVWSEKYTPGANNIPVNPKNSVSHLSNFQLGLSSDK ----HSDSVHRDGSFPGIEQMESNSK-----QETNQMPDNDYIKLKQEVR NRKNKFNQVPHFRLKSVGDKASVQLNEAERCPLFLNDVQHLLMFALLGHQ SPYVPRWCHMEKYNRLSHTIVLIVEGISLYEYLAYESLFPAITSLLTHRI EVVVPAQYNSSLVRELALVPSTALHKKQLISDYGNLEAALKNNEEVFRAL RAVFPVAQVREDGEDKVLGSIPESDKYPRTHLLLSAWQMIEEHYPLLLKG EMQS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KYTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASVVNEKLE--------------------------------------- -------------------------------------------------- ----------------VMYDILVKPDNHITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM AGDRSRKCKLALLCDRLLHESIQRSSKGHSPIEDSQAAMKLTQMKLANSK IISQxVEFGDAVLMGRTKAEKTLIRTLEKEQAANISNQASKEKTAVVIAS ESVIREYKLHLGSKEPANTCNVKCVVADSNSDVVTQTCQVALEHHMTISH LRVDVSGTLPPDDQLRQVDDWCRKVWEHLAFNGLCVVLFASRPGSVNGAC FVQxxxxxxxxxxxxEDEEIExxxxxxxxxxxxxxxxSxxxxxNNxxxxx xELxxxxxxxxxxxxxxxxxxxxxxxxWTCxxTSSRYEKVPEAQHxxxxx HFSSx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tpa xx-----------------------------------------------x x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------YTEYVFTKSEYKEVTPNSPMFALDCEMCRTTTGELEL TRASLVNEKLE--------------------------------------- -------------------------------------------------- ----------------VMYDILVKPDNNITDYLTRYSGITEKMLSEVTNK LSDVQKDLINLLPPDAILVGHSLNCDLHAL----QMMHPYVIDTSVIYNM TGDRSRKCKLALLCDRLLHESIQKSSKGHSPIEDSQAAMKLAQMKLANT- -----VEFGDAVLMGRTKAEKTLIRTLEKEQAANIFNQAPKEKTAIVIAS ESVIREYKLHLGSKEPASTCNVKCVVADSNSDVVTQTCQVALEHHMTISH IRVD------------------------------xxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------