>Tge MK------------------------------------------------ -----------------------------VxxxxxNKSGxxKxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- --------------xGGESDFKEAKSADSGKKKTTGKIKQ-E-VGQAINT VATKIDGVKGSSIKKTNLLYLQEQNKIRKDKQEERRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNLQDFGSDFEEDLAIVTGKPSSKAKQKSEEV ISDEFSDD-SLQASDWDCSETEQGGGMEDNEKMGYVSDGESSSDNMTTSD LGENRSDENEANTESSTNLKNNKLSRDTFSKVKSKRNTNNLxNLIxQDSI NENIDSPK--------------HIIRKGNKGKSKSGETIILKNKTNKINK LDKKHIVDNGEISEDETDINKGQSCGTKAILTECDSLRTETHQKMSSKVL KRSKTCKAELKSKSVKFTDDLGSDDTSEL-------------DSDSEINT KGSGDELWEDIYGRTRNKQGNIIHSGGKYIPPHLRAQGTETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQFEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLATKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTHMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGVLPGEINAATPDTTTSDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKF------------------ -------------------------------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDIDKPAVRFL RQVLLGVLLCSSEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLEKRAKIADKILSLQESGDYLTIIYLSKRKINKRMYRKCKDA NCQIMVVLEQMGDILMEERNIT >Tpa Mx------------------------------------------------ -----------------------------I-------------------- -------------------------------------------------- ---------------GGESDFKEAKSADSGKKKTTGKIKQ-E-VGQAINT VTTKIDGVKGSAIKKTNLLYLQEQNKIRKDKQEERRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNLQDFGSDFEEDLAIVTGKPSSKAKQKSKEV ISDEFSDDISLQASDWDCSETEQGCGMEDNEKMGYVSD------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xLKSKSVKFTDDLGSDDTSEL-------------DSDSEINT KGSGDELWEDIYGRTRNKQGNIIHSGGKYIPPHLRAQETETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQFEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLATKFEEKEV ELILVVLRSVGLSLRKDDPAALKELILRLQQQAATHTHMHK--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------- >Tbi Mx------------------------------------------------ -----------------------------I-------------------- -------------------------------------------------- ---------------GGESDFKEAKSADSGKKKTTEKIKQ-E-VGQAINT VTTKIDGVKGSSIKKTNLLYLQEQNKIRKDKQEERRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD---LHLATNLGLRGSVPGWYLGYFYQKGExxxxxxGx YLLEVCDEANRQNVVAAEQNMQDFGSDFEEDLAIVTGKPSSKAKQKSEEV ISDEFSDDISLQASDWDCSETEQGGGMEDNEKMGYVSDDESSSDNMTTRD LGENRSDENEANAES----------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------SDDTSEL-------------DSNSDINT KGSDDELWEDIYGRTRNKQGNIIHSGGKYIPPHLRAQEAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQFEELYMLNSRNDMNETLTQLMVESLI APVSTPERLIMEHVLLITVLHANVGTEVGRLNLEEVHLHLRGGRVERHLG GGKNQCTRPGSNPELLVFGILVQHKISALDNIATKAGAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLATKFEEKEV ELILVVLRSVGLSLRKDDPAALKELILRLQQQAATHTHMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELNISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGVLPGEVNAATLDTTTSDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKF------------------ -------------------------------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDVDKPAVRFL RQVLLGVLLCSSEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLEKRANIADKILSLQESGDYL--------------------- ---------------------- >Tce xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------KIKQ-ExVRQASNT ITTKIDDVKGSSIKKPNLQYLQEQNKIRKDKQEERRKKQYNKIRIKQMKE ANVEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNLQDFGSDFEEDLAIVTGKPYSKAKQKSEEV ISDEFSDDNSLQASEWDCSETEQGDGMEDNEKMGYDSDDEFSSDNMATRG LGENRSDENEANTESSTNLKNNKLSKDTFSKVKSKRNIN----------- -------KLxQDNINENTDFSEQIIRKGNKGKNKSDETIILKSKTNKINK LNKKHCLDNGEISEDETDIKKGHSCGTKAILTECDSLRTETHQKMSSKVL KRSKTCKAELKSKSVKFTDDLGSDDASEL-------------DSNSDINT KESGDELWEDIYGRTRNKQGNIIHSGGKYVPPHLRAQEAETDTKKKEQLI RLKKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTYMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGILPGEVNAVTLDTTISDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI IHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKF------------------ -------------------------------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDVDKPAVRFL RQVLLGVLLCSSEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPPNDVQTLEKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------GESDFTEAKSTDLGKKKTTEKIKQ-E-VGQASNT ITTKIDGVKGSCIKKPNLLYLQEQNKIRKDKQEEKRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNMQDFGSDFEEDLAIVTGKPYSKAKQKSEEV ISDEFSDDNSLQASEWDCNESEQEDGMEDNEKMAYVSDDEFSSDN----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxDSNSDINT KESGDELWEDIYGRTRNKQGNIIHSGGKYVPPHLRAQDAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCILMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTHMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGILPGEVNVATLDTAISDRTSSQPSALYS QELMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCNYDRKFxVGPFFGVLAQKLCNYDR KFQVGPFFGVLAQKLCDYDRKF---------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLK------------------------------ ---------------------RTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLQKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tdi MR-----------xxxxxxxxDGTARKxxxxxxxxxxxxVxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- ---------------GGESDFTEAKSTDLGKKKTTKKIKQ-E-VGQASNT ITTKIDGVKESCIKKPNLLYLQEQNKIRKDKQEEKRKKQYNKIRIRQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNLQDFGSDFEEDLAIVTGKPYSKAKQKREEV ISDEFSDDNSLQASEWDCNETEQEDGMEDHEKMAYVSDDEFSSDNIATG- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------ELKSKSVKFTDDLGSDDTSEL-------------DSNSDINT KGSGDELWEDIYGRTRNKQGNIIHSGAKYVPPHLRAQEAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTYMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLRGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGILPGEVNVATLDTAISDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKFxVGSFFGVLAQKLCNYDR KFQVGPFFGVLAQKLCDYNRKY---------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLK------------------------------ ---------------------RTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLQKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------GESDFTEAKSTDLGKKKTTKKIKQ-E-VGQASNT ITTKIDGVKESCIKKPNLLYLQEQNKIRKDKQEEKRKKQYNKIRIRQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLDxxxxx-------------------------------- -----------------EQNLQDFGSDFEEDLAIVTGKPYSKAKQKREEV ISDEFSDDNSLQASEWDCNETEEEDGMEDNEKMAYVSDDEFSSDNMAT-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xDDLGSDDTSEL-------------DSNSDINT KGSGDELWEDIYGRTRNKQGNIIHSGGKYVPPHLRAQEAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTYMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLRGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGILPGEVNVATLDTAISDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKFxVGSFFGVLAQKLCNYDR KFQVGPFFGVLAQKLCDYDRKYQVGLFFGVLAQKLxxxxxx--------- ------------------------CQMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDVDKPAVRFL -----------TEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLQKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tms xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------GGESDFTEAKSADLGKKKTMKKIKQxE-VRQASNT ITTKIDDVKGSSIKKPNLQYLQEQNKIRKGKQEERRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLDCILL--------------------------------- YLLEVCDEANRQNVVAAEQNLQDFGSDFEEDLAIVTGKPYSKAKQKSEEV ISDEFSDDNSLQASEWDCSETEQGDGMEDNEKMGYVSDDEFSSDNMAT-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xDDLGSDDASEL-------------DSNSDINT KESGDELWEDIYGRTRNKQGNIIHSRGKYVPPHLRAQEAETDTKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTYMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELKISLEDLLKG MQRRSHLAGELEGTGGRKRDMSGRVWDHFILTTILEMEDSKLLTMTPMYS LFMKVSDSQEAPFLVEASQVSELTFLGVGSMSTVASVSIEWASVSSVHET QVSAVCSEERGRWWVVGSAWTGILPGEVNAVTLDTTISDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI IHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKFxVGPFFGVLAQKWCDYDR KFQVDPYYGVL----------------------------xx--------- ---xxxxxxxxxxxxxxxxxxxxxVQMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDVDKPAVRFL RQVLLGVLLCSSEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPPNDVQTLEKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFAL------------------ ---------DGLD------------------------------------- YLLEVCDEANRQNVVAAEQNMQDFGSDFEEDLAIVTGKPYSKAKQKSEEV ISDEFSDDNSLQASEWDCNESEQEDGMEDNEKMAYVSDDEFSSDNMATRG LGGNISDENEANTESSTNLKNNKLSKDTFPKVKSKKNINNLxHLKxQGNI NENIDS--------------SEQIIRKGNKGKSKSDETIILKSKT---NK LNKKHSLDNEEISEDETDIKKGHTCGTKAILTECDSLRTETHQKMSSKVL KRSKTCKAELKSKSVKFTDDLGSDDFS---------------DSNSDINT KGSGDELWEDIYGRTRNKQGNIIHSGGKYVPPHLRAQDAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQLEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- ------------------------------------GAYFLQVMIKKFQE MYEECHEVENKLLDNIVLILAHLYNFKVFHCILMFDVLDKLANKFEEKEV ELILVVLRSVGLSLRKDDPAALKDLILRLQQQAATHTHMHNTRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELKISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGILPGEVNVATLDTAISDRTSSQPSALYS QELMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCNYDRKFxVGPFFGVLAQKLCNYDR KFQVGPFFGVLAQKLCDYDRKFQVGPFxxxxxQKLxxxxxxxxxxxxxxx xxxxxx------------xxxxxxVQMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKV---------------VQFVDVDKPAVRFL RQVLLGVLLCSSEEVCVEVFQRTAQSAKLRMFRESLRLFIHHFLLRNTAT LPANDVQTLQKRAKIADRILSLQEAGDYL--------------------- ---------------------- >Tte MI------------------------------------------------ -----------------------------V-------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxGGESDFKEAKSADSGKKKTTEKIKQ-E-VGQAINT VTTKIDGVKGSSIKKTNLLYLQEQNKIRKDKQEERRKKQYNKIRIKQMKE ANEEEDKIIKKLEKQLKLNKRKSKTVPKSFALxxxxPVIMPAKAKTFLFH SNVxxxxRxx---------------------------------------- -LLEVCDEANRQNVVAAEQNMQDFGSDFEEDLAIVTGKPSSKAKQKSEEV ISDEFSDDISLQASDWDCSETEQGGGMEDNEKMGYVSDDESSSDNMTTRD LGENRSDENEANAESSTNLKNNK--------------------------- -------------------------------------------------- -------------------------------------------------- --SKTCKAELKSKSVKFTDDLGSDDTSEL-------------DSNSDINT KGSDDELWEDIYGRTRNKQGNIIHSGGKYIPPHLRAQEAETDSKKKEQLI RLRKQLKGLLNRLAENNMNSIAVQFEELYMLNSRNDMNETLTQLMVESLI APVSTPERLVMEHVLLITVLHANVGTEV---------------------- -------------------------------------------------E MYEECHEVENKLLDNIVLILAHLYNFKVFHCVLMFDVLDKLATKFEEKEV ELILVVLRSVG------------------------------TRVKFMLDI LLAIKNNNVSKIPNYDTSHSEHLKKLLKGFLRKGNYVTELNISLEDLLK- -------------------------------------------------- -------------------------------------------------- ------AEERGRWWVVGSAWTGVLPGEVNAATLDTTTSDRTSSQPSALYS QQLMDLAKKQRMNTDVRRNIFCILMTAEDYLDAFEKLLHLGLKNQQEREI VHVLMHCCLQEKQFNPYYGVLAQKLCDYDRKF------------------ -------------------------------------------------- -------------------------QMTLQFSLWDRLKELSTMKLQQTSN LAKLLTHLLLEKGLPISVLKVxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- ----------------------