>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxx--- -----------------------------------LAPPAxxxxDFVYHW RMITKFYVNKDTTTRVVVESTxIPxxxxxx-------------------- -------------------------------------------------- --------------------------------xKLILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPV------------------------------------------QYV ETKRLSVSSTTSSQSSGFEDSKFPPSPQCRPNDNGNLEHPLLNREDALEQ TKPGLMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPGVDPNDID EMQITWG------------------------------------------- ----------------------LDSLAWTDGTKF---------------- ----------PGCRQVAAFLAWLDYFDQ---------------------- -----------------LVREAHPITGTTLAESFRSQFLEGVLGPTLLDT GSSTILVTAFITKCLKQVTAPALLQxxxxxxx------------------ -------------------------------------------------- -----GEGREPELPNVITCPIRRQLFDNCFHEQDEVSLETLRLFEVLLEK PSEHGLHCLVLTYLNSRRYYDTSSSDLIIGSWSDEEEERERNNRDSPTLD FSEGPSPVSRTLAPGNIDKIINSFLLLLPQPLHSATDPGDEGYEQYVQDA DRQYQECVTRCSRHSWPTEATFPDLMEGDDSHSSDSRPEADHDGNGARNF YEGPFLRMLFTRLVRLPYQPYEINLQLTSLVSRLAMLPHPYLHEYLLNPL LPVLPDTNTLFGTLELVAAELVTQIPLFKSYKQALYATRQRLLEGICDPQ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------EETNSILESVIVxxxxxxxxxxxxxxxxx xxx--------------------------- >Tbi xxxxxxxxxxx--------------xxxxxxxxxxxxEEKDxxxxxxxxT ------------GRKKxxxxxxxxxSSDxxxxxxxxx------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- ------------------------------------APPAxxxxxFVYHW RMITKFYVNKDKTTRVVVESTNIPxxxxxx-------------------- -------------------------------------------------- --------------------------------xKLILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPVQRLVAVCSGLLASPSETDEIHFLCTLCAVIGKHPHLINIFNSQYV ETKRLSVSSTTSSQSSGFEDSKFSPSPQYRPNDNGNLEHPLLSREDALEQ TKPGLMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPGVDPNDID EMQITWG------------------------------------------- ----------------------LDSLAWTDGTKF---------------- ----------PGCRQVAAFLAWLDYFDQ---------------------- -----------------LVREAHPITGTTLAESFRSQFLEGVLGPTLLDT GSSTILVTAFITKCLKQVTAPALLQxxxxxxx------------------ -------------------------------------------------- -----GExxEPELxxxxxCPIRRQLFDNCFHEQDEVSLETLRLFEVLLEK PSEHGLHCLVLTYLNSRRYYDTSSSDLVIGSWSDEEEERERNxxxxxxxx xxEGPSPxSRTLAPGNIDKIINSFLLLLPQPLHSATDPADEGYEQYVQDA DRQYQECVTRCSRHSWPTEATFPDLMEGDDSHSSDSRPEADHDGNRARNF YEGPFLRMLFTRLVRLPYQPYEINLQLTSLVSRLAMLPHPYLHEYLLNPL LPVLPDTNTLFGTLELVAAELVTQIPLFKSYKQALYATRQRLLEGICDPQ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------EETNSILESVIVLEEFSKELSAIAFVKYH HSS--------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- --------------------------------xKLILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPVxRLVAVCSGLLASPSETDEIHFLCTLCAVIGKHPHLINIFNSQYV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tpa x------------------------------------------------x xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------LILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPVQRLVAVCSGLLASPSETDEIHFLCTLCAVIGKHPHLINIFNSQYV ETKRLSVSSTTSSQSSGFEDSKFPPSPQYRPNDNGNLEHPLFSREDALEQ TKPGLMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPGVDPNDID EMQITWG------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tps x------------------------------------------------- ------------x-----------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------QLILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPVQRLVAVCSGLLASPSETDEIHFLCTLCAVIGKHPHLINIFNSQYV ETKRLSVSSTTSSQSSGFEDFKFPPSPQYRHNGNENLQHPLLSREDALEQ TKPELMTETFTFQASPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPDVDPNDID EMQITWG------------------------------------------- ----------------------LDSLAWTDGTKF---------------- ----------LGCRQVAAFLAWLDYFDQ--------FEHYIxxxxxxxxx xxxxxxxxxxxxxxxxxLVREAHPITGTTLAESFRSQFLEGVLGPTLLET GSSTILVTAFITKCLKQVTAPALLQ------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tcm -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------QLILEEQCSLEEGATGP CLEYLLQNHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPV------------------------------------------QYV ETKRLSVSSTTSSQSSGFEDFKFPPSPHYRHNGNENLQHPLLSREDALEQ TKPELMTETLTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPDVDPNDID EMQITWG------------------------------------------- ----------------------LDSLAWTDGTKF---------------- ----------LGCRQVAAFLAWLDYFDQxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------NSQYV ETKRLSVSSTTSSQSSGFEDSKFSPSPQYRPNDNGNLEHPLLSREDALEQ TKPGLMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSA-------- -------------------------------------------------- ---xxWN------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tdi x---------xxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxYV ETKRLSVSSTTSSQSSGFEDFKFPPSPQYRHNGNENLQHPLLSREDALEQ TKPELMTETFTFQASPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPDVDPNDID EMQITWG------------------------------------------- ----------------------LDSLAWTDGTKF---------------- ----------LGCRQVAAFLAWLDYFDQ---------------------- -----------------LVREAHPITGTTLAESFRSQFLEGVLGPTLLET GSTTILVTAFITKCLKQVTAPALLQ------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tms M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxTLILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPV------------------------------------------QYV ETKRLSVSSTTSSQSSGFEDFKFPPSPQYRHNDNENLEHPPLIREDALEQ TKPELMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLVALYEGIVPDVDPNDID EMQITWG------------------------------------------- ----------------------LDSLVWTDGTKF---------------- ----------LGCRQVAAFLAWLDYFDQ---------------------- -----------------LVREAHPITGTTLAECFRSQFLEGVLGPTLLET GSSTILATAFITKCLKQVTAPALLQ------xxxxxxxxxxxxxxxxxxx xxxHGAKPSxxxxxESETRVNRRSMQPDALGAMRPCAASCAQLEGGRExx xxxxxGESREPELPNVITCPIRRQLFDNCFHEQDEVSLETLRLFEVLLEK PSEHSLHCLVLTYLNSRRYYDTLSSDLVIGSWSDEEEERERNNRDSPTLD FSEGPSPVSRTLAPGNIDKIINSFLLLLPQPLHSATDPGDEGYEQYVQDA DRQYQECVTRCSRHSWPNEATFPDLMEGDDSHSSDSRPEADHDGNGARNF YEGPFLRMLFTRLVRLPYQPYEINLQLTSLVSRLAMLPHPYLHEYLLNPL LPVLPGTNTLFGTLELVAAELITQIPLLKSYKQALYATRQRLLEGICDPQ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxYICSSxYxGxxxIxxxxxxxxxxxxxxAPPAxxxxDFVYHW RMITKFYVNKETATRVVVESTNxxxxxxxxxxVSPLxSVSYDNLMPMVDI ECSNPSPISAGTNSVHIEEMGETLGFLIEMTEKEEEDDNNGASPAVGLPP ACDENPPPSPSQxxxxxxxxxx-------------ILEEQCSLEEGATGP CLEYLLQHHILDLLATLACTDSPPGMKSLTLCFMKKLLTQLREPVLPHVS VYAPV------------------------------------------QYV ETKRLSVSSTTSSQSSGFEDFKFPPSPQYRHNDNENLEHPPLIREDALEQ TKPELMTETFTFQSSPETKSPNWGSTNKFPLLDALLSFLHSADSRVTVKA CEGIMLLAALPSDSFARSLARHSNLCAELAARLAALYEGIVPDVDPNDID EMQITWGxYYQMTQLARVYRLYAQMTQLAGVYRFYAQISQLVRIYRFYAQ LYQLARVYRFYAQLYQLARVYSLDSLAWTDGTKFxxxxxxxxxxxxxxxx xxCLAAxxxxLGCRQVAAFLAWLDYFDQ---------------------- -----------------LVREAHPITGTTLAECFRSQFLEGVLGPTLLET GSSTILATAFITKCLKQVTAPALLQ------------------------- --------xxxxxxESETRVNRRSMQPDALGAMRPCAASCAQLEGGRExx xxxxxGESREPELPNVITCPIRRQLFDNCFHEQDEVSLETLRLFEVLLEK PSEHSLHCLVLTYLNSRRYYDTLSSDLVIGSWSDEEEERERNNRDSPTLD FSEGPSPVSRTLAPGNIDKIINSFLLLLPQPLHSATDPGDEGYEQYVQDA DRQYQECVTRCSRHSWPNEATFPDLMEGDDSHSSDSRPEADHDGNGARNF YEGPFLRMLFTRLVRLPYQPYEINLQLTSLVSRLAMLPHPYLHEYLLNPL LPVLPGTNTLFGTLELVAAELVTQIPLLKSYKQALYATRQRLLEGICDPQ xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPLQDTRGPGWHP LEHVETAVQGALSAGTQLRGVSVNQTKGLYALKKLKVLMKTCVVKCLSQG YGGNQIDSNPPSSxxxSHNKFxxxxxLxxxxxxxxCPLAFLIPSVSMxxx xxxxxxxxxHWGCEAALRDYLRPDNVGKFVAGAARGLIYVLSIAGLTGLL FxxxxxxxxxECLExxxxxxxx---------------------------- ------------------------------