>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------GRLG----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------HI YLVMYQYLSSHTQEAEIEHLKPNMESCLKTLLKLIVDVETPPYISAALLK ILKRVNSESILMNLVPLGLRVLSISQQMDRELDVNHSIILRNVLGKLEQT TSDCLKHDKCWELVESALKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIFLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPTWKRGVTLLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPEGE PIDSDLFVPERTFNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISSVG DHELTCTIARVLSVFTVALLDIPEHRRLPLFYKLLSTVDPDRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLATMFPVDTVMRSCISLM x------------------------------------------------- -----------xYYWLNLYWRQLSSLFCxxxxEGTLxxVVRQTSWEA--- ----QQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGDMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGSIGAGDKGQEGELELNQQTA LLSLKLMARFLGLEHPSRFQECVDVMAK---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MLKNNVPQGNVLASMVLCIADMTTSLKANIIVSIPL IMPALINILRKHQTL----------------------------------- -----------------ESPSLMMLSIITAVHKIVENLTKFLSPYIHNVL WEICTLSAKWVNDTDPKIAPIIHKLQ------------------------ ---LTRE----------------------------------------KIS TSLSPRVLVPAVSTCFTQLLRNGQHAAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRTDSSEGLEAVAIVEGHIVDALVALVLKLSESSFRP LYFKLFHWATSSESHKDRTITFYRLSSSIAEHLKGLFVLFAGHFLKNAAG LLDANNLAKTDTLYFGSGKLAKTKANLLLQQILKTLHRVFMYDRQKFINK ERFDVLMQPIVDQxANALVMLSLTVEDREIQVRISLENTLGGVEGLQSRA SSFVQPCIAEFAVAIADDALWKDLNYQILLKTSHNMPExTHGIHPTLAAV ESVLIASMWRGLAGQQLGSPSKKSHRELVDSPILEYFFVNHKRSAEPSVG LKDGGRMRSPTEWWGERINDEKGGVRASAQQGKSPRRRRREACTDKGRQT VVRLAALQTLCEVAHKLGEDFLPFLPETVPFLAERLEDEEEEVEKEAKRV VQELEEVLGESLQKYF--------- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------MNLVPLGLRVLSISQQMDRELDVNHSIILRNVLGKLEQT TSDCLKHDKCWELVESALKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIFLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPTWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPEGE PIDSDLFVPERTFNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISSVG DHELTCTIARVLSVFTVALLDIPEHRRLPLFYKLLSTVDPDRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLAAI-------------- -------------------------------------------------- -----------xYYWLNLYWRQTSSLFCxxxxEGTLxxVLRQTSWEA--- ----QQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGDMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGSIGAGDKGQEGELELNQQTA LLSLKLMARFLGLEHPTRFQECVDVMAK---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MLKNNVPQGNVLASMVLCIADMTTSLKANIIVSIPL IMPALINILRKYQTL----------------------------------- -----------------ESPSLMMLSIITAVHKIVENLTKFLSPYIHNVL REICTLSAKWVNDTDPKIAPIVHKLQ------------------------ ---LTRE----------------------------------------KIS TSLSPRVLVPAVSTCFTQLLRNGQHAAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRTDSSEGLEAVALVEGHIVDALVALVLKLSESSFRP LYFKLFHWATSR-------------------------------------- LLDANNLAKTDTLYFGSGKLAKTKANLLLQQILKTLHGVFMYDRQKFINK ERFDVLMQPIVDQ----------------------LENTLGGVEGLQSRA SSFVQPCIAEFAVAIADDALWKDLNYQILLKTSHNMPE------------ -------------------------------------------------- -------------------------------------------------- -VRLAALQTLCEVAHKLGEDFLPFLPETVPFLAERLEDEEEEVEKEAKRV VQELEEVLGESLQKYF--------- >Tms M------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxQTYPPPVHLKGA xxHSLRAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTGFHH xxxxFHIHLYNRDDLLLLIFPYYDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAADPSFLKFVCDGALAAVKEHSGDAHCLTTALGF FCTTIVGALEHNAATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIENLTKNPQPSLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASVPTFPTTLGELSASGGHVTPLLVPLLAETLRSIQSQIDDTGLR KLAINLVSQVGLEDDSVEEIIRMAVENFDINGLLSEQSDPVEQVANNSKE IIEWYTMFMRSLERKYPTQYDK---------------------------- ----------------------------------------------EKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKIQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLQ CTLEVLQSKFAQQNHMLMLVKKDLGDLQRVKNPAQVNSAVWRCLTSACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSRVVPENDPHTSLLVLNKAIKC VEDSHMYVEQNIPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL PEHLKKAIWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDCSDCALIPSLLIVLAYPLAPFRTTALDCLNSVSRL FGSALNSDNWGPLVTVLLSRREELIMDHKxxxxGKVxxxxxxxxxxxxx- -----------IQESEIEQLKPNMESCLKTLLNLIGDVETPPYISAALLK ILKRVNSESVLMNLVPLGLRVLSISQQMDRELDVHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LTSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKISLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE LIDTDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DHELTCSIARVLGVFTVALLDIPEHRRLPLFYKLLSTVDPNRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLAAMFP------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGEMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGTIGAEGKGQEGDLELNQQTA LLSLKLMARFLGSEHPTRFQE----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LIRE----------------------------------------KIS TSLSPRVLVPAVSTCFSQLLRNDRHTAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRSDSSEGLEVVALVEGHIVDALVALVLKLSESSFRP LYFKLFHWATNSESHKDRTITFYRLSSSIAEHLKGLFVLFAGHFLKNAAG LLDANNLAKTDTLYFGSGKLAKTKADLLLQQILKTLHGVFMYDRQKFINK ERFDVLMQPIVDQ----------------------LENTLGGVEGLQSRA SSFVQPCIAEFAVAIADDALWKDLNYQILLKTSHNMPE------------ -------------------------------------------------- -------------------------------------------------- -VRLAALQTLCEVAHKLGEDFLPFLPETVPFLAERLEDEEEAVEKEAKRV VQEMEE----------xxxxxxx-- >Tsi x------------------------------------------------- -------------------------------------------------- ----------------------------xR-------------------- -------------------------------------------------- ----FHIHLYNRDDLLLLIFPYYDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAADPSFLKFVCDGALAAVKEHSGDAHCLTTVLGF FCTTIVGALEHNAATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIENLTKNPQPSLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASVPTFPTTLGELSASGGHVTPLLVPLLAETLRSVQSQIDDTDLR KLAINLVSQVGLEDDSVEEIIRMAVENFDSNGLLGEQSDPVEQVANNSKE IIEWYTMFMKSLERKYPTQYDK---------------------------- ----------------------------------------------EKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKVQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLL CTLEVLQSKFAQQNHMLMLVKKDLGDVQRVKNPAQVSSAVWRCLTPACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSKVVPENDPHASLLVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL SEHLKKAIWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDRSDCALIPSLLIILAYPLAPFRMTALDCLNSVGRL FGSALNSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSTDIQESEIEQLKPNMESCLKTLLKLIGDVETPPYISAALLK ILKRVNSESVLLNLVPLGLRVLSISQQMDRELDIHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPNKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIILDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE LIYSDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DQELTCSIARVLNVFTVALLDIPEHRRLPLFYKLLSTLDPNRSLWLLLCL VVESHVSCWSEGDLPKGHSKDETPKRLEFCLSLAAMFP------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGEMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADSSSKCDPESYFNLLPPLMAVVGTIGAESKSQEGELELNQQTA LLSLKLMARFLGLEHPTRFQE----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxTARE----------------------------------------KIS TSFSPRVLVPAVSTCFSQLLRNNQHAAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRSDSSEGLEAVALVEGHIVDALVALVLKLSESSFRP LYFKLFHWATSSESHKDRTITFYRLSSSIAEHLKGLFVLFAGHFLKNAAG LLDANNLAKTDTLYFGSGKLAKTKADLLLQQILKTLHGVFMYDRQKFINK ERFDVLMQPIVDQ----------------------LENTLGGVEGLQSRA SSFVKPCIAEFAVAIADDALWKDLNYQILLKTSHNMPE------------ -------------------------------------------------- -------------------------------------------------- -VRLAALQTLCEVAHKLGEDFLPFLPETVPFLAERLEDEEEKVEKEAKRV VQELEEVLGESLQKYF--------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------MSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKVQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLL CTLEVLQSKFAQQNHMLMLVKKDLGDVQRVKNPAQVNSAVWRCLTPACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSRVVPENDPHASLLVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL PEHLKKAIWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDWSDCALIPSLLIILAYPLAPFRMTALDCLNSVGRL FGSALNSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSTDIQESEIEQLKPNMESCLKTLLKLIGDVETPPYISAALLK ILKRVNSESVLLNLVPLGLRVLSISQQMDRELDVHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPNKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIILDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE LIDSDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DQELTCSIARVLNVFTVALLDIPEHRRLPLFYKLLSTVDPNRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLSAMFPVDTVMRSC---- -------------------------------------------------- -------xxxxEx---------------------------------xxxx xxxxEQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGEMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADSSSKCDPESYFNLLPPLMAVVGTIGAESKSQEGELELNQQTA LLSLKLMARFLGLEHPTRFQECVDVMAK---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MLKNDIPQGNVLASMVLCIADMTTSLKANIIISIAL IMPALINILRKHQTL----------------------------------- -----------------ESPSLMMLSIITAIHKIVENLTKFLSPYIHNLL REICALSAKWVNETDPKIAPIVHKLQ------------------------ ---LTRE----------------------------------------KIS TSLSPRVLVPAVSTCFSQLLRNNQHAAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRSDSSEGLEAVALVEGHIVDALVALVLKLSESSFRP LYFKLFHWATSSESHKDRTITFYRLSSSIAEHLKGLFVLFAGHFLKNAAS LLDANNLAKSDTLYFGSGKLAKTKADLLLQQILKTLHGVFMYDRQKFINK ERFDVLMQPIVDQ------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ -------------xxxx-----xxx >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------MSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSNKVQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLL CTLEVLQSKFAQQNHMLMLVKKDLGDVQRVKNPAQVNSAVWRCLTPACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSRVVPENDPHASLLVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL PEHLKKATWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDWSDCALIPSLLIILAYPLAPFRMTALDCLNSVGRL FGSALNSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSTDIQESEIEQLKPNMESCLKTLLKLIGDVETPPYISAALLK ILKRVNSESVLLNLVPLGLRVLSISQQMDRELDVHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPNKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIILDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE PIDSDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DQELTCSIARVLSVFTVALLDIPEHRRLPLFYKLLSTVDPNLSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCL------------------- -------------------------------------------------- -------------------------------------------------- ----xQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSQEVGRNANQPSAKYWKIMLNQSCDILDK xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----FHIHLYNRDDLLLLIFPYYDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAADPSFLKFVCDGALAAVKEHSGDAHCLTTALGF FCTTIVGALEHNAATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIENLTKNPQPSLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASMPTFPTTLGELSASGGHVTPLLVPLLAETLRSIQSQIDDTGLR KLAINLVSQVGLEDDSVEEIIRMAVENFDINGLLSEQSDPVEQVANNSKE IIEWYTMFMRSLERKYPTQYDKLANTLVxxxxxAEDGEIEVRI------- ---------------------------------------------SEKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKIQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLQ CTLEVLQSKFAQQNHMLMLVKKDLGDLQRVKNPAQVNSAVWRCLTSACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSRVVPENDPHTSLLVLNKAIKC VEDSHMYVEQNIPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL PEHLKKAIWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDWSDCALIPSLLIVLAYPLAPFRTTALDCLNSVGRL FGSALNSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSSHIQESEIEQLKPNMESCLKTLLNLIGDVETPPYISAALLK ILKRVNSESVLMNLVPLGLRVLSISQQMDRELDVHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTIVWADNGTPTCPAIVTLTQLSQVPLEH LTSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKISLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE LIDTDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DHELTCSIARVLGVFTVALLDIPEHRRLPLFYKLLSTVDPNRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCL------------------- -------------------------------------------------- -------------------------------------------------- ----xQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQxxxxxxxxxxxxxxxxxxxx---------------------------- -----------------------------------------------xxx xxxxxxxxNLxxxVLSSRAQHNxRVSQLRHQGGFPGTQLKLIAALSDVDT NLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGEMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGTIGAEGKGQEGDLELNQQTA LLSLKLMARFLGSEHPTRFQE----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tbi x----------xxxLADxxxxxxxxxxSAFSQEKKRASLxxxxKExxxxx xxxxxEIGLKGxxELKKFNSKFDKFATxLFDLxSQSLExSVESEKANKKL NKHIRSFILLLSPYFxxxxxHQALEWLINR-------------------- -------------------------------------------------- ----FHIHLYNRDDLLLLIFPYHDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAVDPSFLKFVCDGALAAVKEHSGDAHCLTTALGF FCTTIVGALEHTSATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIVNLTKNPQASLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASVPKFPTTLGELSASGGHVTPLLVPLLAETLRSIQSQIDDTGLR KLAINLVSQVGLEEDSVEEIIRMAVENFDINGLLGEQPDPVEQVSNNSKE IIEWYTMFMRSLERKYPTQYDK--------------------VIHKMYAS KKTRNLLEKxxGFHNSDNIFEKLNHPNSKIRGQAVQYVVSNFYQIEEKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSSVSTKVQVQVLKCLCSSDLSQPGLIEDRILLAVLPYLFPLDDLDLL CTLEVLQSEFAQQNHMLMLVKKDLGDLQRVKNPAQVNSAVWRGLTPACLP NKHLWEAIDQAPHLEGDFSPHLLAITLLSRVVPENDPHTSLMVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGDARMGRLAVPGFINCLTRLMHKTPL PEHLKKTMWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLIMKRLYV DALKEFNDVYFPSLKEQVQFLYKLTVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDWSDCALIPSLLIVLAYPLAPFRMTALDCLTSVGRL FGSALTSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSSHTQEAEIEQLKPNMESCLKTLLKLIVDVETPPYISAALLK ILKRVNSESVLMNLVPLGLRVLSISQQMDRELDVNHSIILRNVLGKLEQT TSDCLKHDKCWELVESALKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIFLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPTWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPEGE PIDSDLFVPERTFNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISSVG DHELTCTIARVLSVFTVALLDIPEHRRLPLFYKLLSTVDPDRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLAAMFPVDTVMRSCISLM xxxxxxxxxxxxxxxxxxxxxxxxNRGEEEACxxxxxxxxxxxxxxxxxx xxCCDCVxx----------------------------------------- ----EQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ-------------------xGxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxLRVMExxxxWRELLQCWVCHLVLLLVKLVILKDVFKPQVPDIDQK-- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGDMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGSIGAGDKGQEGELELNQQTA LLSLKLMARFLGLEHPTRFQECVDVMAK---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MLKNNVPQGNVLASMVLCIADMTTSLKANIIVSIPL IMPALINILRKHQTL----------------------------------- -----------------ESPSxMMxxxxxAVHxxVENLTxxLSPYIHNVL REICTLSxxxVNDTDPxxAPxxxxxx------------------------ ---LTRE----------------------------------------KIS TSLSPRVLVPAVSTCFTQLLRNGQHAAIGPLLHILSDSFTAMSPEERVHH QPYLITFFLEALQFRTDSSEGLEAVALVEGHIVDALVALVLKLSESSFRP LYFKLFHWATSRx----------RLSSSIAEHLKGLFVLFAGHFLKNAAG LLDANNLAKTDTLYFGSGKLAKTKANLLLQQILKTLHxxxxxDxxxxIxx ERFDVLMQPIVDx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -VRLAALQTLCEVAHKLGEDFLPFLPETVPFLAERLEDEEEEVEKEAKRV VQELEExxGESLQKYF--------- >Tpa MxxxxxxxxxxG-------------------------------------- --------LKGxxELKKFNSKFDKxxxxxxxxxSQSLERSVESEKANKKL NKHIRSFLLLLSPYFLLKPAHQALEWLINR-------------------- -------------------------------------------------- ----FHIHLYNRDDLLLLIFPYHDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAVDPSFLKFVCDGALAAVKEHSGDAHCLTTALGF FCTTIVGALEHTSATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIENLTKNPQASLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASVPKFPTTLGELSASGGHVTPLLVPLLAETLRSIQSQIDDTGLR KLAINLVSQVGLEEDSVEEIIRMAVENFDIDGLLGEQPDPVEQVSNNSKE IIEWYTMFMRSLERKYPTQYDK--------------------VIHKMYAS KKTRNLLEKxLGFHNSDNIFEKLNHPNSKIRGQAVQYVVSNFYQIEEKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKVQVQVLKCLCSSGLSQPGLIEDRILLAVLPYLFPLDNLDLL CTLEVLQSEFAQQNHMLMLVKKDLGDLQRVKNPAQVNSAVWRCLTPACLP NKHLWEAIDQAPQLEGDFSPHLLAITLLSRVVPENDPHTSLLVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGDARMGRLAVPGFINCLTRLMHKTPL PEHLKKTMWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLIMKRLYV DALKEFNDVYFPSLKEQVQFLYKLTVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDWSDCTLIPSLLIVLAYPLAPFRTTALDCLTSVGRL FGSALASDHWSPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSSHTQEAEIEQLKPNMESCLKTLLKLIVDVETPPYISAALLK ILKRVNSESILMNLVPLGLRVLSISQQMDRELDVNHSIILRNVLGKLEQT TSDCLKHEKCWELVESALKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPSKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIFLDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPTWKRGVTLLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPEGE PIDSDLFVPERTFNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISSVG DHELTCTIARVLSVFTVALLDIPEHRRLPLFYKLLSTVDPDRSLWLLLCL VVESHVSCWAEGDLPKGHSKDETPKRLEFCLSLATMFPVDTVMRSCISLM -------------------------------------------------- -----------EYxxxxLYWRQLSSLFxxxxxEGTLxxxVRQxSxEA--- ----QQMKKNSHPVSEVLFNIEKHTAKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGDMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADLSSKCDPESYFNLLPPLMAVVGSIGAGDKGQEGELELNQQTA LLSLKLMARFLGLEHPTRFQECVDVMAK---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MLKNNVPQGNVLASMVLCIADMTTSLKANIIVSIPL IMPALINILRKHQTLxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tcm xxx----------------------------------------------- -------------------------------------------------- -----------------------------R-------------------- -------------------------------------------------- ----FHIHLYNRDDLLLLIFPYYDTRMFVRVLQLLDVKSKSSPWHWLRPL QKPGVPLSKTALLNHCAADPSFLKFVCDGALAAVKEHSGDAHCLTTVLGF FCTTIVGALEHNAATTELQLVHILKPLLKGLPSPVLDFAAASFMITAQLA DKAQLSENVLHQIIENLTKNPQPSLDLEKVLLLVLLYQSQSSTLTSFPHK ALLRLASVPTFPTTLGELSASGGHVTPLLVPLLAETLRSVQSQIDDTDLR KLAINLVSQVGLEDDSVEEIIRMAVENFDSNGLLGEQSDPVEQVANNSKE IIEWYTMFMKSLERKYPTQYDK---------------------------- ----------------------------------------------EKEK QSIKHTLSARLRDDKMSVVSKLLELPLPELVSLLGLDVVLEQLLWLASKC CKSSNVSTKVQVQVLKCLCSSDLSQPGLVEDRILLAVLPYLFPLDNLDLL CTLEVLQSKFAQQNHMLMLVKKDLGDVQRVKNPAQVSSAVWRCLTPACLP NKHLWEAIDQAPHFEGDFSPHLLAITLLSKVVPENDPHASLLVLNKAIKC VEDSHMYVEQNVPNVTEETFPVLLGAARMGRLAVPGFINCLTRLMHKTPL SEHLKKAIWWNLAKNVVTSDDAAMLFVTRLFEVLITGCSLENLDMKRLYV DALKEFNDVYFPSLKEQVQFLYKLSVGSEMTPTSLVVNPELRLRALRLTA ALLQKTSEPLGWCLDRSDCALIPSLLIILAYPLAPFRMTALDCLNSVGRL FGSALNSDNWGPLVTVLLSRREELIMDHK-------------------HI YLVMYQYLSTDIQESEIEQLKPNMESCLKTLLKLIGDVETPPYISAALLK ILKRVNSESVLLNLVPLGLRVLSISQQMDRELDIHHSVILRNVLGKLEHT TSDCLKHDKCWELVESTLKDSHTVVWADNGTPTCPAIVTLTQLSQVPLEH LPNKLQQKLVTLLIEISTDTDLADVLSACRHFMKKIILDASIVVEELTKM RDVQGNEITPTGRSKRLRRSVNLAPSLSLLQSPIWKRGVTMLEFVQNKKK LNSVHLMLPVLFDILKKSLEFETQAPVEYTKQLVLSSILNCCQKLSPDGE LIYSDLFVPERTLNVELIVHCIRATQNPQTHHHALLVLAHLAGMIPEQVL HNMMSIFTFMGYSVLRHDDAFSFQVISKIMETIIPVLIKASQSDKISLVG DQELTCSIARVLNVFTVALLDIPEHRRLPLFYKLLSTVDPNRSLWLLLCL VVESHVSCWSEGDLPKGHSKDETPKRLEFCLSLAAMFPVDTVMRx----- -------------------------------------------------- -------------------------------------------------- -------------------------SKQLRHFKYTLTSFLSSLLSLPALV NQ------------------------------------------------ -------------------------------------------------- -----------------------------------------IAALSDVDT HLMEPLYISMIELMLKFISRVSREVGRNANQPSAKYWKIMLNQSCDILDK ----------------VNCLLPGEMVIPVVRRLLDNKLSTVRRKTMELLN NHLQHQADSSSKCDPESYFNLLPPLMAVVGTIGAESKSQEGELELNQQTA LLSLKLMARFLGLEHPTRFQE------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxMVLCIxxxxxxxxxxxxxxxxx xxxxxxxxLRKHQTL----------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ ---xxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------