>Tge x----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------EYHTEEERNRNLESRLEELNEKFNIVRHQMGLLY RHHGEEKIMWEGKQREFETEKNVLKDNVARLEAK---------------- ----------------------------------------------MKLL EDSARRVSDMSSSLIIERRKCKALQDQENQLCKENGILKQQLVDMEVEVR ATIGNLRRQKEMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSLMCEGQMAARLQGEVDILLKDKEELQSALQAAREKLHSLEVIVT SLSQDTVTQDTHDNQISLLSKKLAALELKELNEKQRADHADKMYKILKDH ELSDNAVTIAIIDSAIIDSNRDSGFEKQIIQLEERNSELESRNSTLVAEN SSLHQVERELRDDLVTFVSREELEDVTQKLKRVEKQGVELRLEKDKMQEM ADIAQDQIRTLESWKVSQELQFQFMKEQILNLQAHTDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDREMSQLWNQFST RCRTLHQVIQGLRRQYSGAVSLSTQERRSISLHRLVEERREWSEKLRAAE KLAHDATLKTQELEIQTQAVQELRVSLSSTHKHKQLAEWHNKNTELRIKE AKCQRKAEFLELQLVQAEERFRRQEEHICSLEDKQARLEKDWEEAQLLWE QTHIDLCKQLSQYEGQQQHKSPRV--------------VLKSPPTQLKSP PAPQPKIEKDVEPIKEESPRQGKILEAQTSVSTETSNEPGVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEAQERVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALKVLSHVLVVTMxxE-TTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI CQPQASHPAVEQYIKKNQELEDEVSELQTAMSNLGNQLTSCKQESERWRN TAEDRLRNMGELRQSGKNTFPMIHFKWITRNDVGQHFRQQAMWAGRLEEQ HQSELSSYQEESNNCRTACEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVRQLSQNVIDLQIQLKTLVQSAAREASSNSQMMGL QLGAREEEGEEGSTGGEDVNNLRAQLYFARDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADIESRKIKSAEE VxxxxxRKKWQQS------------------------TDKLKQLVKDKSV ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSELEKLELERSK LQVEVTTLKNKLEMQQRxxxxxxxxxxxxxxxxxxxxxxxxxxAK----- ------------------------------------KGNLVVAEELEKLK ESNSTLHKANLRLESENLELRLDHERSRTDTPRLREQIQHLEKYVTLLQT ENLQQKKSSSLDEDTPSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKTDHSNTKESVEKLRVELLSLRVERKKLEDRYLEGVQTTTQLEAE LVTSRKHIKALEDRLQAVRGTSTEQRDSDTQELLLVRTQLIHKSQLLEKV KSLLKRAAMKEKTLQEQV------------------------RLLQSLVP A------------------------------------------------- -----VExxxxxxxxxLKNLQExxxxxNGIEANxxxxxxxYIVVxxxxxE EGGFxxxxxxxxxxxxxxxxxIAxxxxxxxxxxxKINKNESKQN------ ------------KSRTHxxxxxxxCLVQWHIVxxxxxxxSVQAIRLCTFY xxxxxxxxxxxxxxPSIHHCERVNPHSNNDTFLGHAKDEPGTLSSVDGRT TKLQALEKLKxxxxxxxxxxWPRGRLVTGLELSRGQISALLSFYSERFMY SPSMASLVLTDSSQLTVDGFExxxxxxxxxYAEPYDLQKTCx >Tte x----xRWRFESQSVKSRxxxxxxxxxxxxxxxxxxxEExxxxYEKLIWY IPEPNTASKKLFLLLKINQEVxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxHTC---------------QERx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------DKLNTLEEQ NFALRTQVKELVDQKLDRDSRLDHFSEALDTRVQEWKRVMEEKDAEIEEL QSRLSLLAAQAPNIQIDTERSRVALLTQTLQKQEDQIEDLQNKLTQATKE LNEGAAIIEQLGSRRSKLNSSEIDAVAAGQLKAVLQQTEERVRLLEGKLK DAEEDAQAKAQEMTEMIVKLREYESGEYGLMEAVDEIKQLRKQRQLRDRQ IEELIQSSNKLQEEATSMEEQNMALREKLGISAENPLRVDGILAQRKKEQ LLVKVLQQQSERLGEDKLHLQLENRRLCKRLSRLCEQLKSLGQSPDVSTL DEQDSVLALPAPEDKELIRADMQLVISEAVSSSAIGRLTSMEAEVKRVKE ERDSLKQGMVYIEEKLLAVTKENEALRTGMHEILDSVRSQDGSSDVRLES QCLERLLEALDSRHISGWYHPAMRLQAQVHTLEGNNTALRDQLRATRLEE NKSREQAQKALLKIEHLEQKLASLEDSKHSSVGVTAYREMGLPPNLSLSS AEVIANLNMHLLRVLNEYHTEEERNRNLESRLEELNEKFNIVRHQTGLLY RHHGEEKIMWESKQREFETEKNVLKDNVARLEAK---------------- ----------------------------VTELDSHWSKVDSDSDTQMKLL EDSARRVSDMSSSLIIERRKCKALQDQENQLCKENGILKQQLVDMEVEVR ATIGNLRRQKEMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSLMCEGQMAARLQGEVDILLKDKEELQSALQAAREKLHSLEVIVT SLSQDTVTQDTHDNQISLLSKKLAALELKELNEKQRADHADKMYKILKE- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLHQVERELRDDLVTFVSREELEDVTQKLKRVEKQGVELRLEKDKMQEM TDIAQDQIRTLESWKVSHELQFQFMKEQILNLQAHTDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDREMSQLWNQFST RCRTLHQVIQGLRRQYSGAVSLSTQERRSISLHRLVEERREWSEKLRAAE KLAHDATLKTQELEIQTQAVQELRVSLSSTHKHKQLAEWHNKNTELRIKE AKCQRKAEFLELQLVQAEERLRRQEEHICSLEDKQARLEKDWEEAQLLWE QTHIDLCKQLSQYEGQQQHKSPRV--------------NLKSPPTQPKSP PAPQQRIEKDVEPIKEESPRQGKIPEAQTSVSTETSNEPAVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEAQERVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALK--------------TTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRAKG-- -------------------LGDEVSELQTAMSNLGNQLTSCKQESDRWRN MAEDRLRNMGELRQSEENTFAMIHFKWVTRNKVGQHFRQQAMWAGRLEDQ HQSELSSYQEESNNCRTTCEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVGQLSQNVIDLQIQLKTLVQSAAREASSNSQMMGV ELVAREEEGEEGSTGGEDVNNLRAQLYFARDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADIEFRKIKSAEE VARWDERKKWQQS------------------------TDKLKQLVKDKSV ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSELEKLELERSK LQVEVTTLKNKLEMQQRHAGGLGAAILEERLEAQxxxIxxxELAK----- ------------------------------------KGNLVVAEELDKLK ESNSTLHKANLRLESENLELRLDHERSRTDTPRLREQIQHLEKYVTLLQT ENSHQKKSSSLDEDTPSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKTDHSNTKESVEKLRVELLLLRVERKKLEDRYLEGVQTTTQLEAE LVTSRKHIKALEDRLQAVRGTSTEQRDSDTQELLLVRTQLIHKSQLLEKV KSLLKRAAMKEKTLQEQV------------------------RLLQSLVP Axxxxxxxxxxxxxx----xEKEILVNPNCPVRVMVDYIRSVMNESNLNQ VTNTDFExxxxxxxxxLKNLQExxxxxNGIEANxxxxxxxYIVVxxxxxE EGGLVKPMPLVARSSRQYNDLIAxxxxxxxxxxxKINKNESKQNKEGSKT AIVKKSGDRVLPK------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------MCEGQMAARLQGEVDILLKDKEELQSALQAAREKLHSLEVIVT SLSQDTVTQDTHDNQISLLSKKLAALELKELNEKQRADHADKMYKILKE- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLHQVERELRDNLVTFVSREELEDVTQKLKRVEKQGVELRLEKDKMQEM ADIAQDQIRTLESWKVSQELQFQFMKEQILNLQAHTDDKATI-------- --------AKKRSHQLSSEVTRLRALNLRLDSRLEEKDREMSQLWNQFST RCRTLHQVIQGLRRQYSGAVSLSTQERRSISLHRLVEERREWSEKLRAAE KLAHDATLKTQELEIQTQAVQELRVSLSSTHKHKQFG-----------RE AKCQRRAEFLELQLVQAEERLRRQEEHICSLEDKQARLEKDWEEAQLLWE QTHIDLCKQLSQYEGQQQHKSPRV--------------VLKSPPTQPKSP PAPQQRIEKDVEPIKEESPRQGKIPEAQTSVSTEIx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxDGAVRVGSVECGEVGTPEHVVLECARTVEIRRPNQQEM QGRLVGGVLRDPTKW-------------------xxxxRxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRxxxWLEIHPLGN KRSEIRSRMGLLRQDEDRRLPRSPLVPSGQMDYPRVLKGAM--------- -------------------------------------xxxxDKLNTLEEQ NFALRTQVKELVDQKLDCDSRLDHFSEALDTRVQEWKRVMEEKDAEIEEL QSRLFLLAAQAPNIQIDTERSRVALLTQTLQKQEDQIEDLQNKLAQATKE LNEGAAIIEQLGSRRSKLKSSDIDAAAASQLKAVLQQTEERVRLLEGKLK DSEEDAQAKALEMTEMIVKLREYESGEYGLMEAVDEIKQLRKQRQLRDRQ IEELIQSSNKLQEEATSLEEQNMALREKLGISAETPVRVDGILAQRKKEQ LLVKVLQQQSERLGEDKLHLQLENRRLCKRLSRLCEQLKSLGQSPDVSTL DEQDSFLALPAPQDRELVQADMQLVISEAVSSSAIGRLTSMEAEVKRVEE ERDSLKQGMVYIEEKLLAVTKENEALRTGMHEILDSVRSQDGSSDVRLES QCLERLLEALDSRHISGWYHPAMRLQAQVQTLEGNNTALRDQLRATRLEE NKSREQAQKALLKIEHLEQKLALLEESKHSSVGVTAYREMGLPPNLSLSS AEVIANLNMHLLRVLNEYHTEEERNRKFESRLEELNEKFNIVRHQTGLLY RHHGEEKITWESKQREFETEKNVLKDNVARLEAK---------------- ----------------------------VAELDGHWSTVSSDSDTQMKLL EDSARRVSDMSSSLIIERRKCKALQDQENQLCKENGILKQQLVDMEGEVR ATIGNLRRQKEMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSLMCEGQMAARLQ-------------------------------- ------------------------------------------------D- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLHQVERELRDDLVTFVSREELEDVTQKLKRAEKQG--LRLEKDKMQEM ADIAQDQIRTLESWKVSQELQFQFMKEQILNLQAHSDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDRERSQLWNQFST RCRTLHQVIQGLRRHYSGSVSLSTQERRSISLHRLVEERKEWSEKLRAAE KLAHDATLKTQELEIQTQAVQELRVSLSLTQKHKQLAEWHNKNTELRIKG AKCQRSAEFLELQLVQAEERLRKQEEHICSLEDKQARLEKDWEEAQLLWQ QTHIDLCKQLSQYEDQQQHKSPRVILKSPPTQPKSPRAILKSPPTQPKSP PAPQQRIEKDVEPSKEESPRQGKIPDAQTSVSTETSNEPGVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEVQESVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALKVLFRVLVLTMxxEVTTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI RQPQAFHPAVEQYIKKNQELEDEVSELQTTVSNLGNQLASCKQESERWRN MAEDRLRNMGELRQ-------------------------------RLEEQ HQSELSSYQEESNNCRTACEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVGQLSQNVIDLQIQLKTLVQSAAREASSNSQMVGL EFVAREEEGEEGSTGGEDVKNLRAQLSFARDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADVESRKIKSAEE VARWDERKKWQQS------------------------TDKLKQLVKDKSI ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSEMEKLELERSK LQVEVTTLKNKLEMQQRHAGGLGAAILEERLEAQxxxIxxxELAK----- ------------------------------------KGNLVVAEELEKLK ESNSTLHKANLRLESENLELRLDNERSRTDTPRLREQIQHLEKYVTLLQT ENLNQKKSSSLDEDTTSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKADHSNTKESVEKLRVELLSLRVERKKLEDRCLEGVQTTTQLEGE LATSRKHIKALEDRLQAVQGTSTEQRNSDTQELLLVRTQLVHKSQLLEKV KSLLKRAATKEKTLQEQVxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tdi xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx TTxxxxxxxxxxxxxxxxxxxxxRDxxxxxxxRExxxxxxxNNVVPARxx xxxxxxxxxxxxxxxxxCGxxxxVC---------GPGYLAVxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxARxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQLEGEQxY----KLNTLEEQ NFALRTQVKELVDQKLDRDSRLDHFSEALDTRVQEWKRVMEEKDAEIEEL QSRLFLLAAQAPNIQIDTERSRVALLTQTLQKQEDQIEDLQNKLAQATKE LNEGAAIIEQLGSRRSKLKSSDIDAVAASQLKAVLQQTEERVRLLEGKLK DSEEDAQAKALEMTEMIVKLREYESGEYGLMEAVDEIKQLRKQRQLRDRQ IEELIQSSNKLQEEATSLEEQNMSLREKLGISAETPIRVDGILAQRKKEQ LLVKVLQQQSERLGEDKLHLQLENRRLCKRLSRLCEQLKSLGQSPDVSTL DEQDSVLALPAPEDRELVRADMQLVISEAVSSSAIGRLTSMEAEVKRVEE ERDSLKQGMVYIEEKLLAVTKENEALRTGMHEILDSVRSQDGSSDVRLES QCLERLLEALDSRHISGWYHPAMRLQAQVQTLEGNNTALRDQLRATRLEA NKSREQAQKALLKIEHLEQKLASLEESKHSSVGVTAYREMGLPPNLSLSS AEVIANLNMHLLRVLNEYHTEEERNRKLESRLEELNENFNIVRHQTGLLY RHHGEEKITWESKQREFETEKNVFKDNVARLEAK---------------- ----------------------------VAELDAHWSTVNSDSDTQMKLL EDSARRVSDMSSSLIIERRKCKALQDQENQLCKENGILKQQLVDMEGEVR ATIGNLRRQKEMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSLMCEGQMAARLQGEVDILLKDKEELQSALQAAREKLHSLE---- ---------------ISLLSKNLAALELKELNEKQRADHADKMYKILKD- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLRQVERELRDDLVTFVSREELEDVTQKLKRAEKQGVELRLEKDKMQEM ADIAQDQIRTLESWKVSQELQFQFMKEQILNLQAHSDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDRERSQLWNQFST RCRTLHQVIQGLRRHYSGSVSLSTQERRSISLHRLVEERKEWSEKLRTAE KLAHDATLKTQELEIQTQAVQELRVSLSLTQKHKQLAEWHNKNTELRIKE AKCQRSAEFLELQLVQAEERLRKQEEHICSLEDKQARLEKDWEEAQLLWE QTHIDLCKQLSQYEDQQQHKSPIVILKSPLNQPKSPRVILKSPPTQPKSP PAPQQRIEKDVEPIKEESPRQGKIPDAQTSVSTETSNEPGVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEVQESVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALK--------------TTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI RQPQAFHPAVEQYIKKNQELEDEVSELQTAVSNLGNQLASCKQESERWRN MAEDRLRNMGELRQ-------------------------------RLEEQ HQSELSSYQEESNNCRTACEHLKQELASVRHELRQRVDELGQGPSAILKN SVAILKAQLQEKDARVGQLSQNVIDLQIQLKTLVQSAAREASSNSQMVGL ELVAREEEREEGSTGGEDVKNLRAQLSFARDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADIESRKIKSAEE VARWDERKKWQQS------------------------TDKLKQLVKDKSV ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSELEKLELERSK LQVEVTTLKNKLEMQQRHAGGLGAAILEERLEAQxxxIxxxELAK----- ------------------------------------KGNLVVAEELEKLK ESNSTLHKANLRLESENLELRLDHERSRTDTPRLREQIQHLEKYVTLLQT ENLHQKKSSSLDEDTTSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKADHSNTKESVEKLRVELLSLRVERKKLEDRCLEGVQTTTQLEAE LATSRKHIKALEDRLQAVQGTSTEQRNSDTQELLLVRSQLVHKSQLLEKV KSLLKRAAMKEKTLQEQV------------------------RILQSLVP A------------------x------------------------------ ------ExxxxxxxxxLKNVQExxxxxNGIEANxxxxxxxYIVVxxxxxE EGGLVKPMPLVARSSRQYSELISxxxxxxxxxxxKINKNESKQT------ ------------KVK----------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tbi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------TTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI RQPQVSHPAVEQYIKKNQELEDEVSELQTAMSNLRNQLTSCKQESDRWRN MAEDRLRNMGELRQ-------------------------------RLEEQ HQSELSRYQEESNNCRTTCEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVGQLSQNVIDLQ----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------EMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSL------------------------------------------- ---------------xxLLSKNLAALELKELNEKQRADHADKMYKILKD- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLHQVERELRDDLVTFVSREELEDVTQKLKRAEKQG--LRLEKDKMQEM ADIAQDQIRTLESWKVSQELQFQFMKEQILNLQAHSDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDRERSQLWNQFST RCRTLHQVIQGLRRHYSGSVSLSTQERRSISLHRLVEERKEWSEKLRAAE KLAHDATLKTQELEIQTQAVQELRVSLSLTQKHKQLAEWHNKNTELRIKG AKCQRSAEFLELQLVQAEERLRKQEEHICSLEDKQARLEKDWEEAQLLWQ QTHIDLCKQLSQYEDQQQHKSPRVILKSPPTQPKSPRAILKSPPTQPKSP PAPQQRIEKDVEPSKEESPRQGKIPDAQTSVSTETSNEPGVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEVQESVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALKVLFRVLVLTMxxEVTTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI RQPQAFHPAVEQYIKKNQELEDEVSELQTTVSNLGNQLASCKQESERWRN MAEDRLRNMGELRQ-------------------------------RLEEQ HQSELSSYQEESNNCRTACEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVGQLSQNVIDLQIQLKTLVQSAAREVSSNSQMVGL EFVAREEEGEEGSTGGEDVKNLRAQLSFARDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADVESRKIKV--- ------------xxxxNSxxxxxxxxxxxxxxxxxxxTDKLKQLVKDKSI ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSEMEKLELERSK LQVEVTTLKNKLEMQQR---------------------------xxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKGNLVVAEELEKLK ESNSTLHKANLRLESENLELRLDNERSRTDTPRLREQIQHLEKYVTLLQT ENLNQKKSSSLDEDTTSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKADHSNTKESVEKLRVELLSLRVERKKLEDRCLEGVQTTTQLEGE LATSRKHIKALEDRLQAVQGTSTEQRNSDTQELLLVRTQLVHKSQLLEKV KSLLKRAATKEKTLQEQVxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------ >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------ETPIRVDGILAQRKKEQ LLVKVLQQQSERLGEDKLHLQLENRRLCKRLSRLCEQLKSLGQSPDVSTL DEQDSVLALPAPEDRELVRADMQLVISEAVSSSAIGRLTSMEAEVKRVEE ERDSLKQGMVYLEEKLLAVTKENEALRTGMHEILDSVRSQDGSSDVRLES QCLERLLEALDSRHISGWYHPAMRLQAQVQTLEGNNTALRDQLRATRLEE NKSREQAQKALLKIEHLEQKLASLEESKHSSVGVTAYREMGLPPNLSLSS AEVIANLNMHLLRVLNEYHTEEERNRKLESRLEELNEKFNIVRHQTGLLY RHHGEEKITWESKQREFETEKNVLKDNVARLEAKEVALHVSHSSLMSSDI MKPRLGDWAVMINFLKEAAITSLSIGSxVAELDGHWSTVNSDSDTQMKLL EDSARRVSDMSSSLIIERRKCKALQDQENQLCKENGILKQQLVDMEGEVR ATIGNLRRQKEMLTYQVSALQSSLQDSVPLTTLETTNRQYNELTSKYRDL LQNENSLMCEGQMAARLQGEVDILLKDKEELQSALQAAREKLYSLE---- ---------------ISLLSKNLAALELKELNEKQRADHADKMYKILKD- ---------------------------QIIQLEERNSELESRNSTLVAEN SSLHQVERELRDDLVTFVSREELEDVTQKLKRAEKQGVELRLEKDKMQEM ADIAQDQIRTLESWNVSQELQFQFMKEQILNLQAHSDDKATIAKLSHDMM LARLDEAAAKKRSHQLSSEVTRLRALNLRLDSRLEEKDRERSQLWNQFST RCRTLHQVIQGLRRHYSGSVSLSTQERRSISLHRLVEERKEWSEKLRAAE KLAHDATLKTQELEIQTQAMQELRVSLSLTQKHKQLAEWHNKNTELRIKE AKCQRSAEFLELQLVQAEERLRKQEEHICSLEDKQARLEKDWEEAQLLWE QTHIDLCKQLSQYEDQQQHKSPRVILKSPPNQQKSPRAILKSPPTQPKSP PAPQQRIEKDVEPIKEESPRQGKIPDAQTSVSTETSNEPGVSFTEQLIQA MSLIRSQSQSLLKYEGELAQLRTKLSSSSHEVQESVDQITVKDKLITELR SHLAMVQESAAAMHESTDKLALKVLSRVLVLTMxxEVTTVESLQNIVSQK EETIARYQQLLKDARTEHSEAARRFQEEIQSQQMTIINHEQAYSRLKGRI RQPQAFHPAVEQYIKKNQELEDEVSELQTAVSNLGNQLASCKQESERWRN MAEDRLRNMGELRQSGENTFPLIHF--------GQNFRQQASWASRLEEQ HQSELSSYQEESNNCRTACEHLKQELASVRHELRQRVDELGQGPSAILKN NVAILKAQLQEKDARVGQLSQNVIDLQIQLKTLVQSAAREASSNSQMVGL ELMAREEEGEEGSTGGEDVKNLRAQLSFSRDKIKKLQEQLSARLRVPARR DGSADRRISAKEELLQKRIKTLEGLLQEKTREQDKEKADIESRKIKSAEE VARWDERKKWQQS------------------------TDKLKQLVKDKLV ELDKLESTITSLKDTVTRLEREKLVLASRLKSTKGSESSELEKLELERSK LQVEVTTLKNKLEMQQRHAGGLGAAILEERLEAQxxxIxxxELAK----- ------------------------------------KGNLVVAEELEKLK ESNSTLHKANLRLESENLELRLDHERSRTDTPRLREQIQHLEKYVTLLQT ENLHQKKSSSLDEDTTSDVPTKGKKSSSELEKTIVVLKRVVEKLQSENKR LREGKKADHSNTKESVEKLRVELLSLRVERKKLEDRCLEGVQTTTQLEAE LATSRKHTKALEDRLQAVQGTSTEQRNSDTQELLLVRSQLVHKSQLLEKV KSLLKRAAMKEKTLQEQV------------------------RILQSLVP Axxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------