>Tge -------M-----x-------xxxHLxxxLVLAVYGVxxxxYRLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKEGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDLPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLTTE QPCTWVQQRWDAVVARKxxxxxxxxxxxxxxxxxxxxxxxxxxxxPxxLx xxxxxxxxxxxxHSCYIx-------------------------------- -------------------------------------------------- --------------------DVAAALKASLLLALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIGDLKGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFASVCAPGSKDSDYDRQGLNNGTDLCALCSEA NLKLPTPFASVNGTTDTCSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRAEIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSRTNNGAMLQSTLALLFTLVAVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tms xxxxxxNM-----x-------xxxHLxxxLVLAVCGVxxxxYRLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPNYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDVPSTCEYKAGISSN HLGALECLHRGLGDVAYVDKEIIKTYFGMAGNEGFSFLCRNGTLEPLNTE QPCTWVQQRWDSVVARS--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLSALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIRDLKGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDKDVCPYGASANSLFSSVCAPGSKDTDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLQSTLALLFTLMAVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tce --xxxxxM-----x-------xxxxLxxxLVLAVCxxxxxxYRLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPNYKFESVAVVRSNHTGGLLGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDVPSTCEYKAGISSN HLGALECLHRGLGDVAYVDKEIIKTYFGMAGNEGFSFLCRNGTLEPLNTE QPCTWVQQRWDSVVARS--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLSALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIRDLKGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFSSVCAPGSKDTDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLQSTLALLFTLMVVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tdi -------Mxxxxxx----------------------------RLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDLPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLDTE QPCTWVQQRWDTVVSRN--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLLALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIRDLKGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFTSVCAPGSKDSDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQxxxxxxxLRTYKPPRTY KPPHTHKQLRTYKPPRTYKPPRTHKQLRTYKQLRTYKPPRTHKQLRTYKP PCIYKPPHTYKPPRTQKSSRTYKPPCTCKPPRTYKPPRTYKPPRTYK--- ----------QISTTEDGEIENNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLQSTLALLFTLMTVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tbi -------xxxxxxx----------------------------RLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKEGRSAVENEVYSLSQFFNSTCRPGPWVLNDWLDDKL- ------------------------KRDNSKLCALCDVPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLTTE QPCTWVQQRWDAVIARN--------------------------------- -----------------HATRPDGSLKRCAFSxxxxxxQSPLVAKHPPPP KS----GGEFWAEGANSRNLRAHRPEGRWAGGPVRACLFHPVLFCSCSIQ LTPVTSSSIGFLSVSADFYxDVAAALKASLLLALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKYFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIGDLKGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFASVCAPGSKDSDYDRQGLNNGTDLCALCSEA NLKLPTPFASVNGTTDTCSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRAEIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSRTNNGAMLQSTLALLFTLVAVKYLSGCLVAPFYGKLLHEKTISEEQPG KPAPKKASSTNFSNSQDINYCGSLPTIHGRLEDTANKRS----------- -------------------------------------------------- ---------------------------FGQTDKRAIERASDWVAKLASA >Tte -------Mxxxxxxxxxxxxxx-------------------YRLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVL---- -------------------------------------------------- ------------------------------------------------KE FELAVVETQCEAKEGRSAVENEVYSLSQFFNSTCRPGPWVLNDWLDDKL- ------------------------KRDNSKLCALCDVPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLTTE QPCTWVQQRWDAVIARN--------------------------------- -----------------HATRPDGSLKRCAFSHAVAGRQSPLVAKHPPPP KSVLHFGGGFWAEGTNSRNLRAHRPEGRWAGGPVRACLFHPVLFCSCSIQ LTPVTSNSIRFLxxSADFYxDVAAALKASLLLALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLTKFSYNLTSAGYQESNSYGNNIIVPIIRADSIIGDLKGLVKVKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFASVCAPGSKDSDYDRQGLNNGTDLCALCSEA NLKLPTPFASVNGTTDTCSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRAEIPDGCTLAAVLGGEVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSRTNNGAMLQSTLALLFTLVAVKYLSGCLVAPFYGKLLHEKTISEEQPG KPAPKKASSTNFSNSQDINYCGSLPTIHGRLEDTANKRSSCSGELSDFxC TDESKIxLxxxCDGAMDCPDGSDEVRPLxxxISCPFPRSFQCMYGACVSK TVVCDGKLDCADGSDESHCGHENDxxx---------------------- >Tsi ------------------------------------------RLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTT----------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx---xxxxxxxxxxxxxGKE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKLx ESLNHRYFGVLVALLTSESYPLFTERDNSKLCALCDLPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLDTE QPCTWVQQRWDTVVSRN--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLSALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGRSKFDCFRKIEAGQADIVGINTNL GYLAK--------------------------------------------- ----xxxxxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxAWVAFIESLRS ASLVDRDVCPYGASANSLFTSVCAPGSKDSDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTEVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTDSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLQSTLALLFTLMAVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tcm ------------------------------------------RLCVPKYS GGR----------------------------------------------- ---------------------------------DCVILESGDSNIRCVQV TDSVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVLx--- -----------------------------VNLISVxxxxSPVHPSEIRTS ISPSSxxxxxTTSTLANYATEAGVVKELNSP---PHSQSTKWRNSEHGKE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDLPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLDTE QPCTWVQQRWDTVVSRN--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLSALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGRSKFDCFRKIEAGQADIVGINTNL GYLAK--------------------------------------------- ----xxxxxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxAWVAFIESLRS ASLVDRDVCPYGASANSLFTSVCAPGSKDSDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTEVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTDSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLQSTLALLFTLMAVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tps -------M------------------------------------------ -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- --SVECALKLQSGEVDVGVFTAEEALLASKFIDNSTKVILQIVPQASSET TTTPKYKFESVAVVRSNHTGGLSGLRGKNLCHPGFHRTQYWSDRVLxEKT SLHLTEIRTLIYPVIGxxxxxKSNSLDHVV-------------------- -------------------TEAGVVKELNSPSLSP-SQSTKWRNSEHGKE FELAVVETQCEAKDGRSAVENEVYSLSQFFNSTCRPGPWVLDEWLDDKL- ------------------------KRDNSKLCALCDLPSTCEYRAGISSN HLGALECLHRGLGDVAYVDREIIKTYFGMAGNEGFSFLCRNGTLEPLDTE QPCTWVQQRWDTVVSRN--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------DVAAALKASLLLALPSISANRRLDWTDNLA NVMLKESSYVVQEVVTTNLKSFIQEGRVIPEPANVTDCRSYIRWCTISPL EVQKCEWVRQAGITHGILPELTCVEGSSKFDCFRKIEAGQADIVGINTNL GYLAK--------------------------------------------- ----x-----------xxxx-------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFTSVCAPGSKDSDYDRQGLNNGTDLCALCSEA DLKLPTPFASVNGATDICSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYN--------------------------------- ---ILCRNGTKISIRADIPDGCTLAAVLGGEVIARRNRTDSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEFNGTQGVLLQ----------------- -------------------------------------------------- -------------------------------------------------- ---------------------NNTLALLNVFNKQSSYISSYDDIKRNAYE CSKTNNGAMLKSTLALLFTLMAVKLI------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------SYNLTSAGYQESNSYGNNIIVPIIRADSIIGDLRGLVKAKACFP EFGGL----------------------------------AWVAFIESLRS ASLVDRDVCPYGASANSLFASVCAPGSKDSDYDRQGLNNGTDLCALCSEA NLKLPTPFASVNGATDTCSANASTNPFYGDLGALRCLSTGVADVAIIEAT NISAIIAELGFQAEYYNxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx---------------------------EVIARRNRTNSHTRDIANVI TELDDWFGYAYHNYENIFHIFEEF-------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxx--------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------