>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------AKKL NMPLFGKK-NKCVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGSLQDLSLLQVLDIHSNNFIFLPEDITLLRSLRILNVSSNNLKSLPE ALGSLQKLRVLNVSFNNLRAIPSSMGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRDLMVDPTGFVHPPTSVVQMGTVEIIKFLCIELGVGYVSPCESPE EGAFASNSSCRANSPDADDKEKVFQ------------------------- ------EQRQLERIALEKELEEHHRRELELQHGVRANKNRV--------- -------------------------------------------------- -----VELTADAVISQLLALSEISRDSSQLQHLLEQELKEEERLLNMRQE EYQSLRRKEVLxxxxxxxxLDKLGPKHN---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVYGAIHCLPFLAQW------------ -------------------------------------------------- --AGVTLAQDRAAILEAVNSFLExxARQLAVPEDSGASAPTLEAEGTMSV AECAVCLDDTCEVIFVPCGHMCCCIKCAELMGQCPLCRADINQK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRVIQP--------- --- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MPLFGKK-NKCVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGSLQDLSLLQVLDIHSNNFIFLPEDITLLRSLRILNVSSNNLKSLPE ALGSLQKLRVLNVSFNNLRAIPSSMGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRDLMVDPTGFVHPPTSVVQMGTVEIIKFLCSELGVGYVSPCESPE EVAFASNSSCRANSPDADDKEKVFQ------------------------- ------EQRQLERIALEKELEEHHRRELELQHGVRANKNRV--------- -------------------------------------------------- -----VELTADAVISQLLALSEISRESSQLQHLLEQELKEEERLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQI------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --- >Tbi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAKKL NMPLFGKKENKCVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGSLQDLSLLQVLDIHSNNLIFLPEDITLLRSLRILNVSSNNLKSLPE ALGSLQKLRVLNVSFNNLRAIPSSMGKLCYLHTLDLRGNTFLNTLPNNLC QATGLRDLMVDPTGFVHPPTSVVQMGTVEVIKFLCSELGVRYVSPCESPE EGAFASNSSCKANSLDADDKEKVFQ------------------------- ------EQRQLERIALEKELEEHHRRELELQHGVRANKNRV--------- -------------------------------------------------- -----VELTADTVISQLLALSEISRDSSQLQHLLEQELKEEERLLNMRQE EYQLLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQI------------ --------------------------------EKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVYGAIHCLPFLAQWVYSTQDLHQLND HKLREASYLS----------------------xxxxxxxxxxxxPYENLD YQAGVTLAQDRAAILEAVNSFLE----xxAAPEDSGASAPTLEAEGTMNV AECAVCLDDTCEVIFVPCGHMCCCIKCAELVGQCPLCRADINQKxxxxxx TDTQIDGIAKTTFKGPGGHETSTSINISDLKCCMDRVSNEWVLKECGLKG NPIGHCERSVLRWFGHDKKSVDRGRKQIYEGRRFNKAIKFCLFQSLEHVV CTQGLAVILHCDPISSRSHVEHKYRRRLGQNSSGLLSDADSVGQGLFGYS CYHSIGQLFAIATLTLYPHIIHSPMAVAVIGEANLDAFNHEKPYINIECI RTALTGFAQGPATxxxxxxxLPNTLTRAFRGPILTVQ------------- --- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MPLFGKKDNKRVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGNLQDLSLLQVLDIHSNSFIFLPDDITLLRSLRILNVSSNNLKSLPE ALSSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPTSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCNANSPDADDKDKFFQ------------------------- ------EQRQLERIALEKELEEQHRRELELQHGARANKNRV--------- -------------------------------------------------- -----VELTADAVISQLLALSEISRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLFSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQWxxxxQDLHQLxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxx >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MPLFGKKDNKRVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGNLQDLSLLQVLDIHSNSFIILPDDITLLRSLRILNVSSNNLKSLPE ALSSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPTSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCNANSPDADDKDKFFQTFWREDNHESRNKTYHSIDILSYGG LPIAIVEQRQLERIALEKELEEQHRRELELQHGARANKNRV--------- -------------------------------------------------- -----VELTADAVISQLLALSEISRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLFSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQWxxxxQDLHQLxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxx >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MPLFGKKDNKRVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGNLQDLSLLQVLDIHSNSFIFLPDDITLLRSLRILNVSSNNLKSLPE ALCSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPSSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCKVNSPDADDKDKFFQTFWREDNRESRNKTYHSIDILSYGG LPIAIVEQRQLERIALEKELEEQHRRELELQHGARANKNRVGTECNTDTH TSEVH--------------LLExLAVxQSHLESEIMRVQMDRETDRxxLI xQIQQVELTADAVISQLLALSEISRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLSTLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQWAYSTQDLHQLND HKLREASYISxxxxxxxxxxxxPPARLSYQIPA----------------- --AGVTLAQDRAAILEAVNSFLExxARQLAAPEDSGASAPTLEAEGPMSV AECAVCLDNTCEVIFVPCGHMCCCIKCAELVGQCPLCRADINQK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRVIQP--------- --- >Tte M------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxLCNKxxGNCDGVNYRKxxxKxx xxxRCANTTVLPDTQxxLYxxxxxxxxxxxxxxxxxxDSxxxxxxxxxxx xxxxxxxxxxxxRLVALTTVxxNTMATSLxxxxxxxxxxIGLQDKAVEGx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx-------------------------------x------------- ----------------------------------------------Q--- -----------------------------------------FLESSAKKL NMPLFGKKENKCVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGSLQDLSLLQVLDIHSNNLIFLPEDITLLRSLRILNVSSNNLKSLPE ALGSLQKLRVLNVSFNNLRAIPSSMGKLCYLHTLDLRGNTFLNTLPNNLC QATGLRDLMVDPTGFVHPPTSVVQMGTVEVIKFLCSELGVRYVSPCESPE EGAFASNSSCKANSLDADDKEKVFQ------------------------- ------EQRQLERIALEKELEEHHRRELELQHGVRANKNRV--------- -------------------------------------------------- -----VELTADTVISQLLALSEISRDSSQLQHLLEQEFKEEERLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQI------------ ----------------------------VRYTEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVYGAIHCLPFLAQW------------ -------------------------------------------------- --AGVTLAQDRAAILEAVNSFLE----QLAAPEDSGASAPTLEAEGTMNV AECAVCLDDTCEVIFVPCGHMCCCIKCAELVGQCPLCRADINQK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRVIQP--------- --- >Tsi MxxxxxxxxxxxxxxxxxxxxxxHWRKDxxKNCWAxxDDGHWAELSCKNx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxIxxxxxxxxxxxxx xxxxxxxxxxxFRIREHVVxxxxEGTDDGxxxxQGxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxAREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQENQLRSL AGGGNLQDLSLLQVLDIHSNSFIFLPDDITLLRSLRILNVSSNNLKSLPE ALSSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPTSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCKVNSPDADDKDKFFQ------------------------- ------EQRQLERIALEKELEEQHRRELELQHGARANKNRVGTECNTDTH TSE----------------LLExLAVxQSHLESEIMRVQMDRETDRxxLI xQIQQVELTADAVISQLLALSEVSRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMEALLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLSTLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQWxxxTQDLHxxND HKLREASYIS---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxx >Tms M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxE--- -----------------------------------------FLESSAKKL NMPLFGKKDNKRVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQ------- ------------------------------------ILNVSSNNLKSLPE ALSSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPTSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCKANSPDADDKEKLFQ------------------------- ------EQRQLERIALEKELEEQHRRELELQHGVRANKNRVGTEWNTDTH TSGVHx-------------------------------------------- -----LELTADAVISQLLALSEISRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------N---------------------- ------------------------GMETLLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQW------------ -------------------------------------------------- --VGVTLAQDRAAILEAVNSFLExxARQLAAPEDSGASAPTLEAEGPMSV AECAVCLDNTCEVIFVPCGHMCCCIKCAELVGQCPLCRADVNQK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRVIQP--------- --- >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- ----------------------------------------------E--- -----------------------------------------FLESSAKKL NMPLFGKKDNKRVDYKARLEHKLYL------------------------- -------------------------------------------------- -------------------------------------------------- -----AREDPEPVFDLSDCALKSVPAGIYSLCKVFRKDALYLQ------- ------------------------------------ILNVSSNNLKSLPE ALSSLQKLRVLNVSFNNLRAIPSSVGKLCYLHTLDLRGNKSLNTLPNNLC QATGLRELMVDPTGFIHPPTSVVQMGTVEVIKFLCSELGVGYVSPCESPE EGAFASNSSCKANSPDADDKEKLFQ------------------------- ------EQRQLERIALEKELEEQHRRELELQHGVRANKNRVGTEWNTDTH TSGVHxCYxxxxxxxxxxxF------------------------------ -----LELTADAVISQLLALSEISRDSSQLQHLLEQELKEEDRLLNMRQE EYQSLRRKEVL----------------NxxxxxxxxxxxxxxxxxxYEEG RAEATRTLLSQRGDDNNNNNNITxGMETLLEEECRREAKLREYEEGRAEA TRTLLSQEVETDKQLATLLLSQGQAQSELVGRLQKDEELQRAAVAALLER GDARSWALVHQVAVVESQLASLTALEMERKKLEMNEQIFDLSEKRVALSA MLVDLLSQQADRRRQLLNTLDEMERRRWISDQEKGEKSDEDFWLLQYQRL LDSRPYSLVEMERSLDPMLAQHLVVHGAIHCLPFLAQW------------ -------------------------------------------------- --VGVTLAQDRAAILEAVNSFLExxxxQLAAPEDSGASAPTLEAEGPMSV AECAVCLDNTCEVIFVPCGHMCCCIKCAELVGQCPLCRADVNQK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRVIQP--------- ---