>Tge M-----------xxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xIGLGMVAPSS YLAFNSYFLERRGLAMGLCQAGIGLGFIVAPPLVQYLLEDYGYRGTMLIL SGIALNGVVGAVLYQPVRYHLVRKAPKIVDKESEMVEISLRPTNGSVSL- -VEDTRLSIDVVPEEEDDLANKSETHPHNGYSNQFRTQEPDGTTNTVDYG GPEWEVALRVSHSYL---------MSSDRM-------------KPRSGEW VDIRHRGLSSTMMICQVSCLRSKFTTHTQLRGKSQPADNRSKQKTACISC HDTECDEHVVISRRGSYVMSAMLDCRTNLLLLPLEEEGDDSSSRNYDPTT PIIESPPDFNRQISATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVEQQKSLLHQPTQRDDLREEETPSPGPPDITx GGHRLSRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIIGPLVGGFTPYLVERGVVARVPDSGDRAGMYYN LALTL--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxGQGxVNxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tbi x-----------xxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IGLGMVAPSS YLAFNSYFLERRGLAMGLCQAGIGLGFIVAPPLVQYLLEDYGYRGTMLIL SGIALNGVVGAVLYQPVRYHLVRKAPKIVDKESEMVEISLRPTNGSVSL- -VEDTRLSxxxxxEEEDDLANKSETHPHNGYSNQFRTQDPDGTTNTVDYG GPE----------------------------------------------- ------GFSSTMMIRQVSCLRVEFTTHTQxxxxxxPxxxxxxxxxxxISC HDTECDEHVVISRRGSYVMSAMLDCRANLLLLPLEEEGDDSSSRNYDPTT PIIESPPDFNRQISATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVEQQKSLLHQPTQRDDLREEETPSPGPPDIT- GGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARS------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------xxxxDRSGSFPxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------x >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------ISC HDTECDEHVVISRRGSFVMSAMLDCRANLLLLPLEEEGDDNSSRNYDPTT PIIESPPDFNRQISATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVEQQKSLLHQPTQRDDLREEETPSPGPPDITx GGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARS------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tms Mxxxxxxxxxxxx------------------------xxxxxxxxxxxxx xx------------------------------------------------ ---------------------------------------------LVTNH LLRSMSYRMxSVIGALLFTLGVMLTxFAQSMTHIVITYSIISxTLSQLVK YQSNISFTRTRYAINLLRRQPGLRIGPLVSLASVSRSDTYLRRAVNNTQD PRTLTSEQHNKLLTTTVRLTQTTHKFASQIACPLERFSSRYWLVVRRNTG LGCFKHLPTSDGKDRAKTPLSVPRTGVMRSTSRIRPNTRRIGLGMVAPSS YLAFNSYFLERRGLAMGLCQAGIGLGFIVAPPLVQYLLEDYGYRGTMLIL SGIALNGVVGAVLYQPVRYHLVRKAPKMLDKESEMVEISLRPTNGSVSLA xVEDTRLSMDVVPEEEDDLANKSETHPHNGYSNQ---------------- -------------------------------------------------- -----------------------------------------------ISC HETECDEHVVISRRGSYVMSAMLDCRANLLLLPLDEEGDDSSSRNYDPTT PIIESPPDFNRQMSATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVELQKSLLHQPSQRDDLREEETPSPGPPDIT- GGHRLRRWIGAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFSGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIVGPLVGGFTPYLVERKNVARVPDSGVGSGLYYN LALTLAIELGxxxx------------------------------------ --------------xxSGSFPFCIHALSILMLLxxxxxxLEYL------- -----------xxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxx >Tps xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------EMVEISLRPTNGSVSLA xVEDTRLSMDVVPEEEDDLANKSETHPHNGYSNQ---------------- -------------------------------------------------- -----------------------------------------------ISC HDTECDEHVVISRRGSYVMSAMLDCRANLLLLPLDEEGDDSSSRNYDPST PIIENPPDFNRQMSATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVELQKSLLNQPSQRDDLREEETPSPGPPDIT- GGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARS------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xx >Tte xx------------------------------------------------ -xxxxSGNGVTRxxxxxQYEGHNGQVQDWEQPLQPPEGGWGWMVAFGMAL IFISTTxxxxxFGLLFDDxxxxxxxxxxxxTLIMNAxxxxxxxxxLVTNH LLRSMSFRMxSVIGALLFTLGVMLTxFAQSMTHIVITYSIISx------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IGLGMVAPSS YLAFNSYFLERRGLAMGLCQAGIGLGFIVAPPLVQYLLEDYGYRGTMLIL SGIALNGVVGAVLYQPVRYHLVRKAPKIVDKESEMVEISLRPTNGSVSL- -VEDTRLSIDVVPEEEDDLANKSETHPHNGYSNQFRTQDPDGTTNTVDYG GPEW---------------------------------------------- -----------------------------------------------ISC HDTECDEHVVISRRGSYVMSAMLDCRANLLLLPLEEEGDDSSSRNYDPTT PIIESPPDFNRQISATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVEQQKSLLHQPTQRDDLREEETPSPGPPDIT- GGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIIGPLVGGFTPYLVERGVVARVPNSGDRAGMYYN LALTLVIxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxx >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxx------ -----------------------------------------------ISC HETECDEHVVISRRGSYVMSAMLDCRANLLLLPLDEEGDDSSSRNYDPTT PIIDSPPDFNRQMSATNRPSSVFLANFASNVLMFDNTMNIPEPTSPESED NGSVIGRRKRQAPRPIVNVELQKSLLHQPSQRDDLREEETPSPGPPDIT- GGHRLRRWIGAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFSGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIVGPLVGGFTPYLVERKDVARVPDSGVGSGLYYN LGLTLAIELGCI-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxx >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIVGPLVG--------------------------- -----------xxx------------------------------------ --------------xxSGSFPFCIHALSILMLLxxxxxxLEYLLxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tdi -------------------------------------------------- -------------------------------------------------- ---------xxxxxLFDxxxxxxxxxxxxxxxxMxxxxxxxxxxxLVTNH LLRSMSYRxxxxxxALLFTLGVMLTxFAQSMTHIVITYSIISG------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IGLGMVAPSS YLAFNSYFLERRGLAMGLCQAGIGLGFIVAPPLVQYLLEDYGYRGTMLIL SGIALNGVVGAVLYQPVRYHLVRKAPKMVDKESEMVEISLRPTNGSVSLA xVEDTRLSMDVVPEEEDDLANKSETHPHNGYSNQ---------------- -------------------------------------------------- -----------------------------------------------ISC HDTECDEHVVISRRGSYVMSAMLDCRANLLLLPLDEEGDDSSSRNYDPST PIIENPPDFNRQMSATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED IGSVIGRRKRQAPRPIVNVELQKSLLHQPSQRDDLREEETPSPGPPDIT- EGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIVGPLVG--------------------------- -----------xxx------------------------------------ --------------xxSGSFPFCIHALSILMLLxxxxxxMEYLLxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------ >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxx----------------------------- --------------xxxxxxxxxxx------------------------- ---------------------------------------------xxISC HDTECDEHVVISRRGSYVMSAMLDCRANLLLLPLDEEGDDSSSRNYDPST PIIESPPDFNRQMSATNRPSSVFLANFASNVLMFDNTMNIPEPSSPESED VGSVIGRRKRQAPRPIVNVELQKSLLNPPSQRDDLREEETPSPGPPDTT- GGHRLRRWIRAVSDFLDLSLLGDLVYVNIVLGLSVSFLSDTNFFTVFPFF LQSEELGFTGQDTALCMSIAAGADVVSRLVLPWFATRIGLGSRMTYLVGC LTSAIARSIFACVHGFVAIAVMSAxxxxxxxxxxxxxxLTIAEHCRLDQF AAAYSLYMVINGLITVIVGPLVGGFPPYLVERGVVARVPDSGDRAGMYYN LALTLVTELGxVxx------------------------------------ --------------xxSGSFPFCIHALSILxxxxxxxxxxxxxx------ ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxLPRxxxx KxxxxxxxxYPARMGSLTxxxxVxPKFWVCRGVLGLDDGSPSRALDVLLI ITNESLTQLMKQERSVTSDGSNQLGNxxxxxxxxxxxxxxxxxxxRLASN PFTPSPHKLDERALTSSHNSRSERANLGSNKSQRVPDFPEHPRVYDVGAE GGEVETAGNRRLFNHDGGNQTIVRVYVYSVYARGKMSRPSLDEKKIELSQ TSEIDRSESEVPEGGWGWMVAFGMALMFIVMVGPLSAFGLIFGDFLEDLG GxTEAITVINGVLGSSVSFT----------