>Tms M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VTLREWAVKSHDQVQ---- ------------------------------------------------------------ ---------------QDCELDKPELGTWPPYAFALLLIYFLQQMNNPVLPVLHEMVAPKP GLSEEIVHS--------------------------------------------------- -------------------------------------DNVAQDKT--------------- ------------------------------------------------------------ ------------------------------------LPAFTTL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------YSVSK--- -----------------------EEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVCCSIC HQTGHDFQNCKEDSLEAFAYILPPMEKHFMNAIITFCHQIEEEWAASEEDITIRQQIVAE METFIANEMEGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGKWRTQLFTLGEAFNQGC NKNEILMERAGSGYGLRGPGFDSRRVQIIWEAVGLERKAELNGWSHRCA-----DHMTPS IRKRNMFPLLRLQQLPLPLEQHSPMSHLERPEQPQHVIDGYETYFFEDLKRLPHIWPAYG GNLSTVGELWLQFLKFYVDFDFKSNVVSIRLQEPLSCFEKLWTSKCMAIEDPFELSHNLG AHISKKSILLKHKVYSKTFHSAIARSKASP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PKLTS----------C-------------------- -AETEEF----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >Tsi NRRDGIKGVGITESNTKEGGMCMTLETSILFWKRLVVTGLFYSCLSYLLLVVGLAMSMVA VSSGRGLIRGSDLTVVRGPIMWPDMLLLVRTQPGRKQCLAEPFDNFYTKLRALATPCEFG DQKDKLLRAQIILGVNSKNNHPPNLSSAESVPPSENRIIKKLEQFADADGYSLPPVSVIV FAAFLIAYRRKSTESNRVLKNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTLGGI PFLEYRTYAMKILFPNMDDHAVLQWERPELLRKEKGLRLFGQLIMNKTFLLLFIRTLESN RYFSMRDRVNVASLIMVTLQSKMEYCTDILKTLLAELIEKVMESKSHPKLLLRRGADEGA VDGPGCGSVEGPGWELASTGGRSSGSSAAESAWTAASSLTGCFGTRASTPSPVLGRAMRF HQRTYGWIFCVAFGNALVTHLNKVFYTQLQGRFIDLPLHHGTESVAEKMLSAWFTFLLFK FLRECAGEPLFMLFRAVKQQVDKGPVDAITSEARYSLSEEKLIRQSIDFKPMQFGKLLSF AHWHRPAEKDSCRLLNSEPFHLFTMSLKLTVYVSISQQAVFVSGLDPNTENVPVKVLDCD TISQVKEKALDTIYRATPYSQRPRKDDLDLEWRTGASGRLILYDEDTTTKTEGEWKKRNT LNHYRVPDGGCLNLVSKQSSFYNLSILPEKTDKSHKYETLNLSKFSSASPPLSRATSPLN HDHDGGLKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQALQHGISDPDVVHT WKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSK LLYAKDIPVYKEWVERYYSDIKMMQAISDQDMNAMLAEESRLHTSEFNTNCALHELYTYA VKYNEQLTVTLEEDEFSQKQRLAYKLEQVELEEVNPHLRGVRVENHLGKSTPSSPDRDSN LDLPILSSRAQHDKRVSQLRHRGGYPPHWRSWLRAIHVELDCRGREDRGSNLSRDQLQLQ HSYLSSSEPSTSTAYIGYCVEVSESIPLKSTKRAKALKDILVAAGKGNTVLHKYCGTRWV ERHDAVSVFHECFECIIGALETIMSNEAEANGNASSLHTCLCKFEFIITLTVMSKMVSMT YITSKYLQKESVDISSALDEISMTEKVFADLRKSGKEEFKKLFTKAGDISHKLEVPIKGP RTAGTQRGTEQMLKPKPQKNTTAGFFQQLGDVLIKSPLKLLAGY---GLGEWGTNVHCTR SVKFICLKEGRGELPTQPAARLEDRLCRMVIVQRSVSQTESGLESNENSSVSLKYETEPS QPAGRKKKKKKKKKE-VLDQSVLVTTLEEEIKTTRKLKEDQITKSDNQPLPSPQNTEEFV IPPVLMPFQEKLLEENFIHVLEKKSPKNLKAIYHCSICNYHCNNFAVVQTHIADDRHKNS LEKK------------------ISDMTLQNLPSPTSPQIDAITKLIEDVVAKRGCQIRML GSSASTLALKTSDLNLELFIPPECKAPLMLRTLAEHLEEKDKDYRLCRNNKECSFAARAR SLPSPVPLMFDECAPYKRPSVEEYVTLGRGWDHNIRIIQIYYFYYSFYASCNVSIAVPGS WETHLFLHVQPFRGGGGFGADSWPISAFGLGTVL---SVELVFFQCFAMAEFNEFDPADT VFAAYVT----------------------------------------------------- ----------------DCELDKPELGTWPPYAFALLLIYFLQQMNNPVLPVLHEMVVPKP GLSEEIVHS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VYGGIDQ----------------------------------------VP HL-------------VIIGCGG------------------------------KQTSG--- -----------------------EEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVYCSIC HQTGHDFHNCKEDSLEAFDYILPPMENHFMNTIITFCHQIEVEWAASEEDITIRQQIVAE METFIANEMKGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGK---TLGCVVKRFTNVC DIND-------------------------------ASRGSLSSYAYLLMLIYFLQHCEPP V---------------LPVLQ-----ELERPEQPQHVIDGYETYFFEDLKRLPHIWPGYG ENVSTVGELWLQFLKFYVNFDFKSNVVSIRLQEPLSCFEKLWTSKCMAIEDPFELSHNLG AHISKKMLV----YIINTLRSAYLRFGTPLHYYMSYRNRLEDFFLNREYLTSGEPPNDRG CRICKKIGHMAKDCPSHRPKQNLIKKRFDQPETKEKLPYNIPLISRHQPGKHWGEDYPYV NQKHYFENKINRHSGAYSHLNKYSSNAEKPIIGQIRRYSNTTRALNHRASHSLATGLDRD GNNNVPPSDASAIYERFINARYGIPQTVHPFRSLLNGAECRRNDPVPSDSALSDSALFLH NTQSEITVE-----------------HAEKKETPLSSNLLTSAPNRGMPVSIPPFSLPTN II--PNR--GSSVPSPFPNPTNSIPNRGSSV-----------PSP--------------- ------------------------------------------------------------ -------------------------------------FPNPTN---- >Tcm RA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LHTLS EVHLSERREGGVANTASSEAR-----------RPAILKTESGLESNENSSVSLKYETEPS QPAGRKKKKKKKKKE-VLDQSVLVTTLEEEIKTTRKLKEDQITKSDNQPLPSPQNTEEFV IPPVLMPFQEKLLEENFIHVLEKKSPKNLKAIYHCSICNYHCNNFAVVQTHIADDRHKNS LEKK------------------ISDMTLQNLPSPTSPQIDAITKLIEDVVAKRGCQIRML GSSASTLALKTSDLNLELFIPPECKAPLMLRTLAEHLEEKDKDYRLCRNNKECSFAARA- -LPSPVPLMFDECAPYKRPSVEEYVTLGRGWDH--------------------------- -----------------------------FSTVL---SVELVFFQCFAMAQFNEFDPADT VFAAYVTRIRTTGRSQLGAGTTGRRDNWALGQLGAKSIYITCLYMLPRRGVRAYVDRRSG TCKIFRSSEPEGEEIEDCELDKPELGTWPPYAFALLLIYFLQQMNNPVLPVLHEMVVPKP GLSEEIVHSA----ININVE-GLKLSDSSSPTKHSHFNLEAVGLVYPCLCPGERTNF--- ------------------------------------HSSVKENYTSILSFKRIYY----- ------------------------------------------------------------ -----------------------------RP----SLKIFTL------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VYGGIDQ----------------------------------------VP HL-------------VIIGCGG------------------------------KQTSG--- -----------------------EEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVYCSIC HQTGHDFHNCKEDSLEAFDYILPPMENHFMNTIITFCHQIEVEWAASEEDITIRQQIVAE METFIANEMKGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGK---TLGCVVKRFTNVC DIND-------------------------------ASRGSLSSYAYLLMLIYFLQHCEPP V---------------LPVLQ-----ELERPEQPQHVIDGYETYFFEDLKRLPHIWPGYG ENVSTVGELWLQFLKFYVNFDFKSNVVSIRLQEPLSCFEKLWTSKCMAIEDPFELSHNLG AHISKKRIGEVE-YRESELAFALRESGKPF------------------------------ --------------------------------------------RKNHPTSP-------- ---------------------------------------------------------ERD LNLNFPVL---------------------------------------------------- --------------------------GIKANNTSVLANYTTKA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >Tps M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LNDSSSPTKHS------ -----------------------------------HFNLEAVGLVYPCLCPGERTNF--- ------------------------------------HSSVKENHT--------------- ------------------------------------------------------------ -----------------------------QPGLNHDLPVISSL----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------FYCKSRA----------------------------------------LD HV-------------AA-----------------------------------EACHM--- -----------------------EEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVCCSIC HQTGHDFHNCKEDSLEAFAYILPPMENHFMSAIITFCHQIEVEWAASEEDITIRQQIVAE METFIANEMKGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGK---------------- ------------------------------------------------------------ ---------------------------LERPEQPQHVIDGYETYFFEDLKRLPHIWPGYG ENVSTVGELWLQFLKFYVNFDFKSNVVSIRLQEPLSCFEKLWTSKCMAIEDPFELSHNLG AHISKKICVGTF-LLTQTFTALVIGDGNEI------------------------------ ----KRLGIL----------------------LKRKV-YSKTFHSANACSKA-------- ------------------------------------------------------------ ----------------------SLPKLTS----------C-------------------- -TETEEF----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >Tdi MP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ENS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------YGVTFLVDYTADDK EIEVQIL----------------------------------------------------- ----------------DCELDKPELGTWPPYAFALLLIYFLQQMNNPVLPVLHEMVVPKP GLSEEIVHSASADLLNPSCSLALVPADIPNPSTAQMSSLHSTHSSRPTVETSEQGNW-WK LNANV-------TEC---------ETLWCIQTMVH-HNSLRNAESSVRLFKRMFHDSSTA TDMRLGKDKISYSIVRRGTYMAVTCSSTFPMKFCNVRWLENVDVAKRAMETFDNLKKFVD YISTHKTMKATASSASFKVISCSLKDKLLRP----KLAFFLSLAEDLEPFLKEFQSDSPM SPFLHGNLLNILKTCMGRVVKDDVLGSTLLQKIDLKKEENLKGARDIDIGYATCSALRKC HGVKDLYVLLFQQDCRTCLKNVVDKLLERSPLKFPLTEALTYLNPYKIGFNQDEAVQQMT SAMDILVTSNLIPASVAQNADREYKELQPTGQELNESCTYASSPLAIERGLSINGEVIVE HLKEDSIVAQRIVYDAVMDAGGINNFVVPRDLLLSMRSANMRWKQALENQRLKQTAEDKA KAEKRKAGLLAKELEAKKQRLLLEEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVCCSIC HQTGHDFHNCKEDSLEAFAYILPPMENHFMSAIITFCHQIEVEWAASEEDITIRQQIVAE METFIANEMKGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGK---------------- ------------------------------------------------------------ ---------------------------LERPEQPQHVIDGYETYFFEDLKRLPHIWPGYG ENVSTVGELWLQFLKFYVNFDFKSNVVSIRLQEPLSCFEKLWTSKCMAIEDPFELSHNLG AHISKKICVGTF-LLTQTFTALVIGDGNEI------------------------------ ----KRLGSL-----------------------------GTNLVALQCMIKM-----DVR IVHTDLYDTFTL-----------------EMSLLVIRRSSRTSCL--------------- ---TLPTVSLSVL-------VKGYPDLSSYFSDVMQHLKCE-----------------CH STHTEQLVASLPDGLGWLQLVLSP---VRADKTRALPMLVGRGEG---------VHASSG NIIE-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------- >Tce MD-------NVT---------C--------------------SC---------------- ------------------------------------------------------------ ---------------NIVEDHPPSITK--------------------------------- ------------------------------------------------------------ -------------------------DQPE------------------------------- --------------------------------------------GSQPSL---------- ------------------------------------------------------------ --------------------ANKTFY---------------------------------- ------------------------------------------------------------ --------------LN-------------------------------------------- ------------------------------------------------------------ -------------------------------DKQNKHVV--------------------- -----------------MFE---------------------------------------- -----------------------------------------------------------Q FLYSRQCRIKGE------------------------------------------------ -----------------------------GLQELQP------------------------ ------------------------------------------------------------ ------GDPAGSEA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ RPSSTSRPTRQTPRAQASEEPIGGCAHLTSPEIIGWLRPWGMGYSLLALARAQNNLALAL LAPAPKPSEGSLSKPTMSSEEIKNSKC------LSSLKTESGLESNENSSVSLKYETEPS HHAGRKKKKKRKKKDVVLDQSVLVTDLEEEIKTTQKLKENQITNSDNQSLPSPQYTEEFV IPPVLMPFQEKLLEDNFMHVLKKKSSKNLKAIYHCSICNYHCNNFGVVQTHIEDDRHKKS LEERYIQRKCIRICMEDDWKTILGKTTLGTLDQDSNLDLPVISSL---VYCESSCQIRML GSSASSLALKTSDLNLELFIPPECKAPLMLRTLAEHLEEKDKDYRYVRK----LFSA--- ----------------DHPSIE-------------------FISLPLNITCAIVITNQNA YQLAVLLH--------DYVSFDERVRILGLMIRIFAASVRMVTLREWAVKSHDQVQ---- ------------------------------------------------------------ ---------------QDCELDKPELGTWPPYAFALLLIYFLQQMNNPVLPVLHEMVAPKP GLSEEIVHSDP----------YLPKRNVSRTVAH----IECFDYAMKCLRAAYKYYAIPQ ITSNIPLFTQITSQCNPINKHISKEIYHILETNPYFQDNVAQDKT--------------- ------------------------------------------------------------ ------------------------------------LPAFTTL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------YSVSK--- -----------------------EEALLLVKKLNSKYLGYTYSSSKFAGEQGLPVCCSIC HQTGHDFHNCKEDSLEAFAYILPPMEKHFMNAIITFCHQIEEEWAASEEDITIRQQIVAE METFIANEMEGAQLNVFGSSCNGFGLRKSDLDICLTFVNNKTGKWRTQLFTLAEAFNQGC NKNEILMERAGSGYGLGGPGFDSRRVQIIWEAVG-------------------------- -------------------LE-----RLERPEQPQHVIDGYETYFFEDLKRL-------- --------------DFFLN------------REYLTSGEPPNDRGCRICKKIGHMAKDCP SHRPKQNPIKKH-F---------------------------------------------- ----------------------------DQPETKGKLPYNIPLISRHHPVPS-----PFP NPTNSLPNTHS------------------PLSTPLPRRTSSTRLT--------------- --SSVPPT----I----VQIERSRPSPVNSFRTPFQ------FPPPPKVVHPSYNSEILP TTQPVTTVHS-----RFYQNSVTPSSHVTQKATRTPTSLSSKADT-NIPTSTATAHIPSS TILEPTRLFGSPVPSGQLDNCGVLSDNESEVVDTPCFVCDWDPTPVSSDDPWHEGWVIQG MLTELLTDLGTMLLLFGAKMEPIAMLISEQTSNSMIARTRDLQRACLEPYDLSTSGTMQE EMQPSKRNQEWTYNAGNVRTVQAHVQTIPSDVEAIENYPEDTEKTIF