>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxTKHTANDANLHTTDDSIKKG PHTxxxxxxxxxxxxxxxxxI---------------------------SQ IHATKRDL--------------------xHSRERSFQCVCCDECFPKAST LxxH-FITHTAKRNHGCGLCKRMFFTAISADLHRRIHKRKNYYKCPNCPK VFLSKGGINYHKEVVHTAEQQVQCDVCNKWFYSQPAFK------------ -------------------------------------------------- ----MHRKFSCGDRTV---------------------------------- ---------------------------PC---PL---------------- -------------------------------------------------- --------------CGKLFTTHLLLKRHQVIHDLVRPYTCDLCGHGFNQI NGLKLHQSLHSPL--------MDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHDKNLRYHCDTCGKKFQLKYRL LQHTYIHTGVKVHQCDKCNKVFSLKSNLEKHQKWVHVKQEPVNCMICNKV FKKNTSLQSHIKNH------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxx >Tms xxxPDESTLRxxxLLAFNLFIQANAAISCSSVSADLAYVKSNFGNIPGTI TALEARDLPLVKTEKIxxxIEENLNQASGSVG------------------ ----------------TAIVDKFNRVLQRNPGWKSVFFYVEQLVQIxR-- ----------------------------------VIGDMSKCVTVFKSHE ARTASRDQQALGDTNINLETQ----------V------------------ -------------------------------------------------- -----------------------------------------xxxSWPLFx xxxCYALSxxLDYGPRLVMTNILRAQRKD-GPVQSTTYQLVIKHIQCEEY R-----ITTESSPKKRQTSIRFNEVNSNTQSTVSFKKKLT---------- -------PxxKxxxxx----------------xSKKKSAPxxxRRSTVNS KKQNTLGTKxxxxxNSKKQSTLVAKTQSIFxSKTHKPKNNAVRSKMGLTP VSSETQSTAISKMRIAKVDSKAEASSFSSKTRPTAIEANVQSTDDSIKKG PHTCSICQRNFVSVHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASN LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR VFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLKRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNLRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHHCDTCNKVFSLRSNLKKHQVGVHGSQEPVHCVLCDKV FKNKTSLHRHISKHVKIEKDxxxxQD------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xx---- ------------------------------------ >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------MSKCVTVFKSHE ARTASRDQQALGDTNINLES------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------------------------QCEEY R-----ITTESSPKKRQTRIRFNEVNSNTQSTVSFKKKLTxxxxxxxxxx xxxxx-xxxxxxxxxx----------------xxxxKSAPxxxRxxxxxx xxxxxxxxxxxxxxNSKKQSTLVAKTQSIFxSKTHKPKNNAVRSKMGLTP ISSETQSTAxxxxxxAKVxxxxEASSFSSKTRPTAIEANVQSTDDSIKKG PHTCSICQRNFVSVHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASx LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR VFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLKRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNLRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHHCDTCNKVFSLRSNLKKHQVGVHGSQEPVHCVLCDKV FKNKTSLHRHISKHVKIEKDx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------MSKCVTVFKSHE ARTASRDQEALGDPNINLETQ----------xxxxxxTIHxxxxxWLNTL VKNExxxxxxxxS------------------REEDYDSLLYKPWTGEELM YSQLTIKKDSSISLYHPWTNxTFLYSQIDxxxxxxxxxLVLx-------- --------------PGLVMTNILRAQGKD-EPVQSTTYQLVIKHIQCEEY R-----ITTESSPKQRQTRIRFNEVNSNTQSTVSFKKKLT---------- -------PxxKxxxxx----------------xSKKQSAPxxxRRSTVNS KKQNTPGTKxxxxxNSKKQSTPVAKTQSIFxSKTHKPKNNAVQSKMGLTP VSSERQSTAISKMRIAKVDSKADASSFSSKTRPTAIEANVQSTNDSIKKG PHTCSICQRNFVSIHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASN LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR MFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLQRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNFRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHQCDTCNKVFSLRSNLKKHQVGVHDSQEPVHCVLCDKV FKNKTSLHRHISKHVKIEKNxxxxQDx----------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxGxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------Txxxxxxxxxxxxxxxxxx xxxxxxxxxxxxGxRDxxxxxxxxxxx-------xx >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------MTNILRAQGKD-EPVQSTTYQLVIKHIQCEEY R-----ITTESSPKQRQTRIRFNEVNSNTQSTVSFKKKLT---------- -------PxxKxxxxx----------------xxxKQSAPxxxRRSTVNS KKQNTPGTKxxxxxNSKKQSTPVAKTQSIFxSKTHKPKNNAVQSKMGLTP VSSERQSTAxxxxxxAKVDSKADASSFSSKTRPTAIEANVQSTNDSIKKG PHTCSICQRNFVSIHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASN LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR MFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLQRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNFRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHQCDTCNKVFSLRSNLKKH------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ >Tps -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MLS ILQRNNLKQIVTPLTCTAQKQIAKYLNCIGNLxVVIGDMSKGVTVFKSHE ARTASRDQQALGDPNINLETQxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ---------------GLVMTNILRAQGKD-EPVQSTSYQLVIKHIQCEEY R-----ITTESSPKQRQTRKSFNEVNSNTQSTVSFKKKLT---------- -------PxxKx------------------------QSAPxxxRRSTVNS KKQNTPGTKxxxxxNSKKQSTPVAKTQSIFxSKTHKPKNNAIHSKIGLTP VSSETQSTAISKMRIAKVDSKTEASSFSSKTRPSAIEANVQSTDDSIKKG PHTCSICQRNFVSIHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASN LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR VFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLQRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNFRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHHCDSCNKVFSLRSNLKKHQVGVHGSQEPVHCVLCDKV FKNKTSLHRHISKHVKIEKNxxxxQDQxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ >Tdi xG------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------VIGDMSKGVTVFKSHE ARTASRDQQALGDPNINLETQ----------V------------------ -------------------------------------------------- -----------------------------------------xxxSWPLFL xxACYALSxxLDYGPRLVMTNILRAQGKD-EPVQSTSYQLVIKHIQCEEY R-----ITTESSPKQRQTRKSFNEVNSNTQSTVSFKKKLT---------- -------PxxKx------------------------QSAPxxxRRSTVNS KKQNTPGTKxxxxxNSKKQSTPVAKTQSIFxSKTHKPKNNAIHSKMGLTP VSSETQSTAIAKMRIAKVDSKAEASSFSSKTRPSAIEANVQSTDDSIKKG PHTCSICQRNFVSIHNLQNHLFLHTGSFQYHCSTCGRGCASRGRLHSHEK IHMTKRDFKCDQCDKTFLNKTVLKEHSRKHSRERPFHCLLCNERFLYASN LxxH-VITHTGERTHSCDFCKRMFLTASSAQLHRQIHERKNSYKCPDCPR VFLSKGGMNYHKEVAHTAELQVQCDVCSKWFYSQLAFK------------ -------------------------------------------------- ----MHRKVQCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGKLFTTHRLLQRHQVIHDLVRPYTCDVCGHGFNQI NGLKLHLSVHRPL--------TDRPN------TCD-----------ICGQ SF--------------RRKDVLYNHRRLHNKNFRYHCDTCGKKFHLKYYL LQHTRIHTGVKDHHCDSCNKVFSLRSNLKKHQVGVHGSQEPVHCVLCDKV FKNKTSLHRHISKHVKIEKNxxxxQDQ----------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxPRKILSNFLxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxNxxxxxxxxxIxMDPTxxxxxxxxxCVHKKH YICxxxxxKVxxxxxxxxxxxxxxxxxxxKRxxxxxGYTYTGxxxRPTLP DLTGPESPPAxxxxTLVPTLDxxENSLTRDLx------------------ ------------------------------------ >Tbi -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------DSIKKG ----------------------LHTGSFQYYCSTCGLGCASRGRLHSHEK IHITKRDSR--------------KEHSRKNLPLRLFHCLLCKERFLY--- LxxxxIITHKGECTHGCGFCKRMFLTAIAARLHRRIHERRNYYKCPDCPK VFLSKGGMNYHKEVTHTAEQQVQCDVCNNWFYSQLAFK------------ -------------------------------------------------- ----MHRKVPCGERTV---------------------------------- ---------------------------PC---PI---------------- -------------------------------------------------- --------------CGNLFTTHRLLKKHQVIHYLVRPYTCDVCGHGFNQI NGLKLHQSLHSPL--------MDRPN------TCD-----------ICGQ SF--------------RRIDGLYNHRRLHDKNLRYCCDTCGKKFHHKYRL LQHTHIHTGVKVHQCDKCNKVFSLKSNLKKHQIRVHVKQEPVPCMICNKV FKKNTSLQRHIKNH------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxx >Tte MR--------QExxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------x------------------ ----------xxxxxxxxxExxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------SNMSSSEEED-RPMQSTNYEVVIN------x xxxxxxITAESSLVEWKTRIHI---------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxISAPxx-xxxxxxx xxxxxxxxxx-xxxxxxxxxxxxxx------------------------- -------------------------------------------------- -----------------------------------GSTVNSRGRLHSHEK IHITKRDSR--------------KEHSRKNLPLRLFHCLLCKERFLY--- LCxHxVITHKGECTHGCGFCKRMFLTAIAARLHRRIHERRNYYKCPDCPK VFLSKGGMNYHKEVTHTAEQQVQCDVCSNWFYSQLAFK------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxx--xxx--------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxx---------------- ----------------------------------xxxxxx---------x xxxxxxxxxxxxxxxx----------------xxxxxxxxxxxxxxxxxx xxxx----------------TPVAKTQSIF-------------------- ------------------DSKAEAGPSSSKTKHTANDANLHTTDDSIKKG PHTxxxxxxxxxxxxxxxxxI---------------------------SQ IHATKRNL--------------------xxxxxQSYQCLVCNECFLNASx LRxH-FITHTPKRNHGCGICKRMFFTAISAELHRRIHKRKNYYKCPKCPK VFLSKGGMNYHKEVVHTAEQQVQCDVCNKWFYSQPAFKxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxS LxxxMYDSFPCVQKIVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx------------------------------- ---xxxxxxxxxxxxxGLLxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx----------------------------xxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- 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