>Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------SRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNGPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGQPASNCKLGxSAKYPFLCASTIENT GPNKPFx------------------------------------------- -------------------------------------------------- -----------------------------------------------QDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGTPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKISVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYN---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------- >Tce MxxAELCGFDSQYNIKSFARPNILSEVCSVSGNFSNNLELALPPFTDPAV KLSQFSHDEHGKKIKIHFDHGTTTLGFQYQxxxxxAVDSRATGGQFIGSx DMKKIVEINDYLLGTLAGGAADCVYWDRVLAKQCRMYELRNRERISVAAA SKLMANMVYNYKG------------------------------------- ------------------------------------------MGLSMGMM IAGWDKRGPGLYYVDSEGTRTKGKVFSVGSGSVYAFGVLDSGYNWDLTDD EAYELxxxxxxxxxxxxxxSGGIIRVYHMKSTGWVNISNEDCKDLHYKYQ EEKDDKFVTLVNDANLTGMDxxxxxxxDGVYTxxxxALLTIVCVIICFNI STCSSQQQDYCRICTDHTMCKFQSRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNGPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKLGxxxxxxxxxxxxxxxx GxxKPFNE---------------------------------------LSI NTDLSTDGDIEDNTTYLISYSDYSHLGNIEELNNN--------------- -----xxQDVAKxxxYxxxxxxx----------------------xxQDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGTPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKISVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINENDNPNVPIIVAELPSPADIVET LQSKKQFRKFQRKAKFLKKLLGSDxSVKPVVSQVNSLQTNNYAQISGSNL PYVGAFNKSPFNSIHPLSVP-----PITTPPQLIHNVYTNPSISQPQ--- ---------------------------MISNVFNSPPSAVTISHPHLVAN IFNKPAYMSTSPPx-------------------------------SEQSS VNRVSYYNQNKGNLTNDITSIAKMVTNTTTNLTRVPSGLLNITSVLKVDI NSTIKLPVIVIGHQSTRSNFTKTTNSEQMFMDNIMSDSYSGENIITNATV ISRSNTTITRNITSFLIxxxxxxxxxx----------------------- ---------------xxxxxxxxxxRxTVTPISFTPNQLKISKPVSGGTH IVHKINRGSFSYGTVPQEKRPQRRKKKKQYLMIKEPD------------- -------------------------------FKNVPLEEVVVQLLK---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------x >Tte M------------------------------------------------- -------------------------------------------------- DFK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ALLTIVCVIICFNI STCSSQQQDYCRICTDHTMCKFQSRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNGPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKLGxSAKYPFLCASTLENT GPNKPFNE---------------------------------------ISV NTDLSTAGDIEDNTTYLISYSDYTNVRNIEELNNNTGxxxATxIMYALNx IYDRTx-----------------------------------------QDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGTPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKISVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINENDNPNVPIIVAELPSPADIVET LQSKKQFRKFQRKAKFLKKLLGSDxSVNPLV------------------- -------------------------------------------------- -------------------------------------------------- ------------PQNVxxxxxxNNPKEIxxxxxxxxxxxxxCSSRSEQSS VNRVFYYNKNKGNLTSDITSISKMVTNTTTNLTRVPSGLLNITSVLKVDI NSTIKLPVIAIGHQSTRSNFTKTSNAEQMSMDNIMSDSYSGENIITNATV ISQSNSTITRNITSFLI--------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxEMxQ------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx >Tcm M------------------------------------------------- -------------------------------------------------- GSK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------ALLAIVCVVICFNI SSCSSQQQDYCRICTDHTMCKFQSRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNSPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKLGxSAKYPFx-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------QDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGAPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKMYVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINDNDNPNVPIIVAELPSPADIVET LQSKKQFRKFQRKAKFLKKLLGSD-------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xSEQSS VNRVSYYNQNKENLTSDITSISKMVTNTTTNLTRVPSGLLNVTSVLKVDI NSTIKLPVIVIGHKSTRSNFTKTSNTEQMSMDNIMSDSYS---------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxFxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxTIVCVIICFNI STCSSQQQDYCRICTDHTMCKFQSRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNGPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKLA---------------- -------------------------------------------------- -------------------------------------------------- -----x-----------------------------------------QDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGTPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKISVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINENDNPNVPIIVAELPSPADIVET LQSKKQFRKFQRKAKFLKKLLGSDxxVNPLVPQVNSLQTNNYAQIPGSNL PYVGAFNKLPFNSNHPISVPxxxNNxxxAQPQLIQNVYTNPSISQPQLIQ NAYTNxxxSQPQLIQNAYTNPFISQPHMISNVFNSPPSAVTISHPPLVAN IFNKPAIMSTSPPx-------------------------------SEQSS VNRVFYYNKNKGNLTSDITSISKMVTNTTTNLTRVPSGLLNITSVLKVDI NSTIKLPVIAIGHQSTRSNFTKTSNAEQMSMDNIMSDSYSGENIITNATV ISQSNSTITRNITSFLI--------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------ERAII QSYEMN-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxLxxxxxxxxxxxxxxxGLVQWKKRxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------SRDPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNSPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKLA---------------- -------------------------------------------------- -------------------------------------------------- -----x-----------------------------------------QDP GKSEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGAPASECRSAVPSKKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKMYVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINENDNPNVPIIVAELPSPADIVET MQSKKQFRKFQRKAKFLKKLLGSD-------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xSEQSS VNRVSYYNQNKENLTSDITSISKMVTNTTTNLTRVPSGLLNVTSVLKVDI NSTIKLPVIVIGHNSTRSNFTKTSNTEQMSMDNIMSDSYSDEN-ITNATV ISQSNTTTT----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------- >Tdi x------------------------------------------------- -------------------------------------------------- xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xLxDxxxxxxxxALLTIVGVVICFNI SSCSSQQQDYCRICTDHTMCKFQSRAPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAEL--------TWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNSPDWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPIYKT-------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLSI DTDLSTDGDIEDNTTYLISYSDHSHLGNIEELNNNTD------------- -------QDMEKIRx--------------------------------QDP GKPEWGHYTQVVWAKTTKVGCGRSLFHSTESGYPVRMEFLVCNYGPGGNF NGRVVYKSGTPASECRSAVPSRKYPGLCEISKEEEDVQLIINQRHKKKKS SFIWRKKMYVGAPGLGPIKTFTVDQTASGKTNYSIMTGSHVAKDYNTFLG MFMDGHGKIAAKNVLNTLGIPYKTTINENDNPNVPIIVAELPSPADIVET LQSKKQFRKFQRKAKFLKKLLGSD-------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xSEQSS VNRVSYYNKNKENLTSDITSISKMVTNTTTNLTRVPSGLLNVTSVLKVDI NSTIKLPVIVIGHKSTRSNFTKTSNAEQMSMDNIMSDSYSGENIITNATV ISQSNTTITHNITSFLI--------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------ARAFI QSYAVNVxxxxxxxxxxxxDPTQIERDLKTxxxxxxxxKxTxATHTMQSN EIKxxINHENESxxxxxxxxxxxxxxxxxxIxxxxxxxxKIIENDMKQSA TSNTQNTTDEDRKVEDTEKRxITNxxxIKEExxxETSTNERFTEKRPHRR KRKKQYLMIKEPDFKNVPLEEVVVQLLK----------L >Tps xxx-----------------------------------------xx---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- ------xx------------------------------------------ ----------------------QSRAPGPMCTDYQPLPLTAKEKVSILHD HNFYRSIVASGNETRGSPGPQPSASNMAELVSIIDTLTTWDTELEEVAQR WADQCMIDDHDACRDVARFHVGQNMLAGGDTGPVFNSDVPDLVQKWYDEV DIFDSSVVQRYHMPPRNGADWGHYTQIVWANTLNVGCARAMFLSNSDNPP LRMEFLVCNYGPGGNFQKRPVYKTGRPASNCKL----------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------