>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----DCYCKSRNLDTLLLTALINELGKMREHIEANTKESKSELEACCDSY SEEEL-EEE--GKVTHYLETDKVDKTGKEVSTNMANMNQEVSKPKAGDEF VLVEKVIHSSVPTSGSTFVNGLFSPKDSGEIVSTNGSKHWRNACETMGGE SKNIILHDYKHNSGLYFSENIIEVKHLEENYETKSNALGAIKKHTI-GDL TSKETSSKFKRKQKPVISQGEKRHSLKDTVKELKHFQAKFKMDSTEPSQE QSNSDPTVEEPIEVSSSYLETHTKMKSPLCTESSHSAILSNVVEKQAIVG SPDQSKGETSELLGNSNMNFIFSSDTKEFLQSCVREVMKDKEGSKILLEE PMEVYWQYMIEEAKAHMKHSVCRNVTRGRRDTLEMHNPAAPEGCGSHYPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tbi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxCCASA--------------------------------- --------RELNLAQGALRNPRKAEYLMYTLSVAEEKLEEIKEDCVVVMN FPRKLLNHTGKVVAFISPDDGFLECEVKDAKKTVLFSRENIFINGLQALH IVNLRKFLTVDTQVCFDAKLISLVLEDSLWNCKIYKAVVLWVGVRTPxxx EIQLKTSENKALKKLSDHLVGKEFIQNLKTRVNEPVYVSV---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KDVV-----------------EYVDERDPLLFGTRYITDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYQDLYINNIRCTSTKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLVPG SIRDAIVVAFHPPNTALVVANVNDKLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWTKNRLQLIEEAFKVEKENQNLTKLVTLW KLELKKSFDLKEADTFYGFNFFSGDSGVDASLNNRLTQESYCEET----- -------------------------------------------------- -------S----------------xxxxPLPLQTNITKEMSEIEIKMKAA VETAQTKDPCLGAVTESELIIPHVLENHNWHSFNVGTHDTAETHT-RDEY ISLRNVQNNEKAEEKIIYSMEQSTSSNNEENDRLSDNTHLEYKGVVDSVS KVSGTILFKINNQMSKALFYKSKVVIDGCPIGKGNNLCDLISLGTPVTFS VELYSLNNISYRAAAVVVTSDNPNLAHESNGKCNVESSDKTETDKSQASN LQPFDAKLEVDMSNAETTLAGILGLSNEFIKNFDGQSAHLPGLDQTINNM NLKVQTMSDAMQKITQGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSQ NIEENSCEKPHLSVSPCLVTDNIPKSEYLDSLSETILLSENNINLESGSQ CGSEPCKLTSQEKIVDEITHQDMTHTEELDNGPRCDLTSKYDMSKETLNF LNLPSNNVLSLTHKCVSSQDKDTIFDLPSPLYDTRQGYLHHNHNSATKEN SPVNE-----PDPPHTEETPTEQDTQTSPCQELRKQETKPISKKNTSTRT KMEVTVGKTENKVKIPEQFPCLTDAKKEPVTSSKDKKLKKSSTPVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKDAVHFPKKNTGGSL VDFLPVGKEVFFDGEDIRHRVDLGCPGIYVSSIYTGKRPKKLAAYKEMRV PVTFSDKKDLLLQGKAYQGVVSEVRAPMAFVAKVKHESSYYSVFVFSLNF SPGKNANKLVDGESVKLFIDVGDSVFVTVQKADNNKEFEWVATEAWTETN KYNRPWTKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILE--------- -------------------------------------------------- ---xEELHFDYFPMEKDLEAENGNLEEMICAQAWFGSRAAPDSCDTLART MFDLDCYCKSRNLDTLLLTALINELGKMREHIEANMKESKSELEACCDSY SEEEL-EEE--GKVTHYLETDKVDKTGKEVSTNMANMDQEVFKPKAGDEF VLVEKVIHSSVPTSGSTFVNGLCSPKDSGEIVSTNGSKHWQNACETMGGE SKNIILHDYKHNSGLYFSEKIIEVKHLEENYETKSNALGAIKKHTI-GDS TSKETSSKFKRKQKPVISQGEKRQSLKDAVKELKHFQAKFKMDSTEPSQE QSNSDPTVEEPIEVSSSYLETHTKMKSPLCTESSHSAILSNVVEKQAIVG SPNQSKGETSELLGNSNLNFIFSSDTKEFLQSCVREVMKDKEGSKILLEE PMEVYWQYMIEEAKAHMKHSVCRNVPRGRRDTLEMHNPAVPEGCVSHCPL NRKETDTKYINKGTQTVSTGMILYL----------------GV---R--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------xxELNLAQGALRNPRKAEYLMYTLSVAEEKLEEIKEDCVVVMN FPRKLLNHTGKVVAFISPDDGFLECEVKDAKKTVLFSRENIFINGLQALH IVNLRKFLTVDTQVCFDAKLISLVLEDSLWNCKIYKAVVLWVGVRTPISR EIQLKTSENKALKKLSDQLVGKEFIQNLKTRVNEPVYVSV---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KDVV-----------------EYVDERDPLLFGTRYITDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYQDLYINNIRCTSTKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLVPG SIRYAIVVAFHPPNTALVVANVNDKLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWTKNRLQLIEEAFKVEKENQNLTKLVTLW KLELKKSFDFKEADTFYGFNFFSGDSGVDASLNNRLTQESYCEET----- -------------------------------------------------- -------Sxx-------------xxxxxPLPLQTNIIKEMSEIEIKMKAA VETAQTKDPCLGAVTESELIIPHVLENHNWHSFNVGTHDTAETHT-xDEY ISLRNVQNNEKAEEKIIYSMEQSTSSNNEENDRLSDNTHLEYKGVVDSVS KVSGTILFKINNQMSKALFYKSKVVIDGCPIGKGNNLCDLISLGTPVTFS VEPYSLNNISYRAAAVVVTSDNPNPAHESNGKCNVESSDKTETDKSQASN LQPFDAKLEVDMSNAETTLAGILGLSNEFIKNFDGQSAHLPGLDQTINNM NLKVQTMSDAMQKITQGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSQ NIEENSCEKPHLSVSPCLVTDNIPKSEYLDSLSETILLSENNINLESGSQ CGSEPCKLTSQEKIVDEITHQDMTHTEELDNGPRCDLTSKYDMSKETLNF LNLPSNNVLSLTHKCVSSQDKDTIFDLPSPLYDTRQGYLHHNHNSATKEN SPVNx-----PDPPHTEEAPTEQDTQTSPCQELRKQETKPISKKNTSTRT KMEVTVGKTENKVKIPEQFPCLTDAKKEPVTSSKDKKLKKSSTPVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKDAVHFPKKNTGGSL VDFLPVGKEVFFDGEDIRHRVDLGCPGIYVSSIYTGKRPKKLAAYKEMRV PVTFSDKKDLLLQGKAYQGVVSEVRAPMAFVAKVKHESSYYSVFVFSLNF SPGKNANKLVDGESVKLFIDVGDSVFVTVQKADNNKEFEWVATEAWTETN KYNRPWTKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILESSGNLIYFN RKNAFLFGICLESFDLTNIFFK---------------------------- ---DEELHFDYFPMEKDLEAENGNLEEMIYAQAWFGSRAAPDSCDTLART MFDLDCYCKSRNLDTLLLTALINELGKMREHIEANMKESKSELEACCDSY SEEEL-EEE--GKVTHYLETDKVDKTGKEVSTNMANMDQEVFKPKAGDEF VLVEKVIHSSVPTSGSTFVNGLCSPKNSGEIVSTNGSKHWQNACETMGGE SKNIILHDYKHNSGLYFSEKIIEVKHLEENYETKSNALGAIKKHTI-GDS TSKETSSKFKRKQKPVISQGEKRQSLKDAVKELKHFQAKFKMDSTEPSQE QSNSDPTVEEPIEVSSSYLETHTKMKSPLCTESSHSAILSNVVEKQAIVG SPNQSKGETSELLGNSNVNFIFSSDTKEFLQSCVREVMKDKEGSKILLEE PMEVYWQYMIEEAKAHMKHSVCRNLPRGRRDTLEMHNPAVPEGCVSHCPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxELNLDQGAQRNPRKAEYLMYTLSVAEEKLEEIKEDCVVVMN FPRKLLNHTGKVVAFISPDDGFLECEVKDAKKTVLFSRENIFINGLQALH IVNLRKFLTVDTQVCFDAKLISLVLEDSLWNCKIYKAVVLWVGVRTPISR EIQLKTSENKALKKLSDQLVGKEFIQNLKTRVNEPVYVSV---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KDVV-----------------EYVDERDPLLFGTRYITDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYQDLYINNIKCTSTKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDGKKPSCNQVFEKFLTSLKETVKLVPG SIRDAIVVAFHPPNTALVVANVNDKLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWTKNRLQLIEEAFKVEKENQNLTKLVTLW KLELKKSFDFKEAYTFYGFNFFSGDSGVDASLNNRLTQESYCEET----- -------------------------------------------------- -------------------------xxxxLPLQTNITKEMSEIESKIKAA VETAQTKDPCMGAVTESELIIPHVLENHNWHSFNVGTHNTAETHT-xDEY ISLRNVQNNEKAEEKIIYSMEQSTSSNNEENGRLSDNTHLEYKGVVDSVS KVSGTILFKINNQMSKALFYKSKVVIDGCPISKGNNLCDLISLGTPVTFS VEPYSLNNISYRAAAVVVTSDNPNPAHESNG--NVESSDKTETDKSQASN LQPFDAKLEVDMSNAETTLAGILGLSNEFIKNFDGQSVRLPGLDQTINNM NLKVQTMSDAMQKLTQGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSQ NIEENSCEKPQLSVSPCLVTDNIPKSEYLDSLSETILLSENNINLESGNQ CGSEPCKLTSQEKIVDEITHQYMTHTEEIDDCPWCDITSKYDMSKETLNF LNLPSNNVLSLTHKCVSSQDKETIFDLPSPLYDTRQGYLHHNHNSATKEN SPVNEQTCNKPEPLHTEEAPTEQDTQTSPCQELRKQETKPISKKNTSTCA KMEATVGKTENKVKIPEQFPCLTDAKKEPVTSSKDKKLKKSSTPVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKDAVHFPKKNTGGSL VDFLPVGKEVFFDGEDIRHRVDLGCPGIYVSSVYTGKRPKKLAAYKEMRV PVTFSDKKDLLLQGKAYQGVVSEVRPPMAFVAKVKHESSYYSVFVFSLNF SPGKNANKLVDGESVKLFIDVGDSVFVTVQKADNNKEFEWVATEAWTETN KYNRPWTKESVFSWDKSKCPEPECAFKGTVTKIMPDRGILESSGNLIYFN RKNAFLFGICLESFDLTNIFFK---------------------------- ---DEELQFDYFPMEKDLEAENGNLEEIICAQAWFGSRAAPDSCDTLART MFDLDCYCKSRNLDTLLLTALINELGKMREHIEANTKESKSELEACCDSY SEEEL-EDE--GKVTHYLETDKVDKTGKEVSTNMANMDQEVSKPKAGDEF VLVEKVIHSSVPTSGSTFVNGLFSPKDSGEIVSTNGSKHWRNACETMGGE SKNIILHDYKHNSGLYFSENIIEVKHLEENYETKSNALGAIKKHTI-GDS TSKETSSKFKRKQKPVISQGEKRHSLKDTVKELKHFQAKFKMDSTEPSQD QSNSDPTVEEPIEVSSSYLETHTKMKSPLCTESSHSAILSNVVEKQAIVG SPDQSKGETSELQVNSNVNFKFNSDTKEFLQSCVREVMKDKEGSKILLEE PMEVYWQYMIEEAKAHMKHSVCRNVPRGRRDTLEMHNPAAPEGCGSHCPL NRKETDTKYINKGTQTVSTGMILYLxxxxxxKRPxxxxxxS--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tms xxxxxxxxxxxxxxxxWRLCLHVHQVQYSDNIIPTVLCVSAQHVVREKDD IEQAMQFLKECDMLKIEDIxxxxxxFVTIDHFKDAICTSLQEYNQHIQDL KEEMEEATKSAEVIRGEIQTFRNRCSFVHSHDVCSLCDxxxxxxxxxxFP CGHRFxxxxxxxxxxxMLPPGKRNKMLELQxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxEKLSLxxxxxxALT QQRxxxxPPxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- ----------------AQQNPRKAEYLMYTLFVAEEKLKEIKEDCVVIMN FPRKLLNHTGKVVGFISPDDGFLECEVKDVKKTVLFSRENIFLNGLQALH VVNLRNILTVNTQVCFDAKLISLVLEDSLWNCKIYKAMVLWVGARTPISR EIQLKTSENKALKKLSDQLVGKQFIQNLKIRANEPVYVSV---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KDVV-----------------EYVDERDPLLFGSRYIIDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYQDLYINNIKCTSTKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLVPG SIHDAIVVAFHPPNTALVVANVNDKLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELEKSFDFEEINTFYDFNFSSVDGGVDDSLNNRLTQESYCEET----- -------------------------------------------------- -----------------------xxxxxLLPLQTNITNKMSGIENKIKVV VETAQTKDPCLEAITESELINPHTLENHNWHSFNVGTHDSAKTHTGDDEH ISLRNVQNNKKAQEKIIYSMEHSTSSNNEENDGLSDMTHLEYKGVVDSVS KVSGTILFKINNKMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAAAVVVTSE----------ECNVEYSDKTDTDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDGQSVRLPGLD------ ----xTMSDAMQKIAPGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSH NIEENSCEEPHLSVSPCLVTDIIPKSENLNSLSETILLSE-NINIGSGNQ SGSESCKLTSQEKIVDEITHQDMTQTDELDNSLR---------------- --------LSLTHKCVSSQDKETIFDPPSPLYDTHQGDLHHNHHSASKEN GPFNKQTCTEPVPPHADGAPTEKDTQTSPCQELRKQETKSIIKKNT-xxM KMEATVGKTRHKVKNLEQFPCLTDAKREPVASSKDKKLKKSSTLVDNTGS TIQLKGQPGKVKEISEDGGTIELIIADKVLQVAFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHTVDLGCSGIYVSSIYTGKRPKKLVAYKEMRV PVTFSDKKDLLLQGKAYQGVVSEIRPPKAFVVKVKHKSSYYSVFVFGLNF SPGKNANKLVDGESVKLFIDVGDYVFVTVQKADNNKEFEWVATEAWTETN KYNRPLTKESLFSWDKSKCPEPECAFKGTVTKIVPDLGILE--------- -------------------------------------------------- ---xEELHFDYFLMEKDLEAENGNLEETVCAQAWFGSRTAPDSCDALART MFDLDCYCTSRNLDTLLLTALINELGKMREHIEANMKESKSEMETCDDSS SEEEL-EKE--GKVTRYLKTDKVDKTGKEVSTNMAYMDEEVSKPKTGDEF ALVDKVIH----TSSSTFIDGLCSPKDNGEIVSANGSKHWRNTCETTAGE LKNNILHDPKQNSGLYFRDNIIEVKHLEENCETKSNALGAIKKCTI-GDS TSKETFSKLKRKQKPVISQGEKQQSLKDAVKELKNFQDKFKMDSTEPSQE QAISDPAVKEPIEVSSSYSET----------------------------- ------GETSELPKNSNMNFIFSSDTKEFLQSCVREVMKDKVGSKILLEE PMEVYWQYMIEEAKAHMKDSACRNVTEGRRDTLEMLNPSVPEGRVSQHPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxGxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxKDVV-----------------EYVDERDPLLFGSRYITDTLVTVGG FVSPSYGILLLDNQGVKQGVLFHYRDLYINNIKCTSMRPLDEYIKVGKAL HCTAGKLREVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLAPG SIRDAVVVAFHPPNTALVVANVNDNLVPLLLFVDQLHLGKDELKLSRDSW IEDYLEVDDILEVKIAVLAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELKKSFDFEEIYTFNDFNFSSVDGGVDDLLNNRLTQESYCEET----- -------------------------------------------------- -------Pxxxxxxxxx------------LPLQTIITNKMSGIENKIKVV VETAQTKDPCLGAITESELINPHALENQDWHSFNVGTHNTAKTRTRDDEN ISIRNVQNNKKAQEKIIYSMEHSTSSNNEENDGLSDITHLEYKGVVDGVS KVSGTILFKINNKMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAASVVVTSGNTNHAHESNGECNLKSSDKTDTDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDGQSVHLPGLDQTINNM DLKVQTMSDAMQKIAPGELYQVVADIFKDY-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------AKKERVASSKDKRLKKSSTLVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHRVDLGCSGIYVFSVYTGKRPKKLAAYKEMRV PVTFSDTKDLLLQGKAYQGVVSEVRPPMAFVVKVKHESSYHSVFVFGLNF SPGKDANKLVDGESVKLFIDVGDYVFVTVQKADNNKEFEWVATEAWTETD KYDRSLAKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILESSGNLIYFN RKNAFLFGICLESFDLTNIFFK--------------AVELNTTSALANYA TEADEELHYDYFPMEKDLEAENDNSEETVSVQAWFGSRAAPDSCDALART MFDLDFYCTSRNLNTLLLTALINELGKIREHIEANMKESKSEMETCSDSY SEEELxxxExxGKVTRYSETGKVDKTGKEVSTNMTNMDGEVSKPKTGDEF ALVDKVIHTSVKTSGSTFVNGLCSPKDNREIVSTNGSKPLQNTCETTRGG LKNTILRDPKHNSGI-------------------SNALGAIKKCTI-GDS TSKKTFSKFKRKQKPVIGQGEKQHLLKDNVKELKYFQAKFKMDSTKPSQE EANSDPAVKEPIEVSSSYLET----------------------------- ------GETSELPGNSNVNFIFSSDTKEFLQSCVREVMKDMVGSKILLEE PLEVYWQFMIEEAKAQMKDSACRNVTAGRRDTSEMHNPSVPEGSVSHRPL NRKETDTKYINKGTQTVSTGMILYL----------------GVTSDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxDxMQ DKFAHxxxxxxNTTxxxxxxxx-----------Gxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx-------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx---------------------YVDERDPLLFGSRYITDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYRDLYINNIKCTSTRPLDEYIKVGKAL YCTAGKLREVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLAPG SIRDAVVVAFHPPNTALVVANINDNLVPLLLFVDQLHLGKDELKLSRDSW IEDYLEVDDILEVKIAVLAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELKKSFDFEEIYTFNNFNFSSVDGGVDDSLNNRLTQESYCEET----- -------------------------------------------------- -------Pxxxxxxxxxx---PPxxxxLLLPLQTIITNKMSGIENKIKVV VETAQTKDPCLGAITESELINPHALENQDWHSFNVGTHNTAKTHTRDDEN ISIRNVQNNKKAQEKIIYSMEHSTSSNNEENDGLSDITHLEYKGVVDGVS KVSGTILFKINNTMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAASVVVTSGNTNHAHESNGECNVKSSDKTDTDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDGQSVHLPGLDQTINNM DLKVQTMSDAMQKIAPGELYQVVADIFKDCENDFMIGDVLK--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------TCTEPVPPHADVAPTEKTTQTSPCQELRKQETKSIIKKNTSTRA KMEVTVGKTRHKVKNQEQFPCLTDAKKERVASSKDKRLKKSSTLVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHRVDLGCSGIYVFSVYTGKRPKKLAAYKEMRV PVTFSDTKDLLLQGKAYQGVVSEVRPPMAFVVKVKHESSYHSVFVFGLNF SPGKDANKLVDGESVKLFIDVGDYVFVTVQKADNNKEFEWVATEAWTENN KYDRSLAKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILESSGNLIYFN RKNAFLFGICLESFDLTNIFFK---------------------------- ---DEELHYDYFPMEKDLEAENSNSEETVSVQAWFGSRAAPDSCDALART MFDLDFYCTSRNLNTLLLTALINELGKIREHIEANMKESKSEMETCSDSY SEEEL-EEExxGKVTRYSETGKVDKTGKEVSTNMTNMDGEVSKPKRGDEF ALVDKVIHTNVKTSGSTFVNGLCSPKDNGEIVSTNGSKPLRNTCETTRGG LKNTILRDPKHNSGI-------------------SNALGAIKKCTI-GDS TSKETFSKFKRKQKPVIGQGEKQHSLKDNVKELKYFQAKFKMDSTKPSQE EATSDPAVKEPIEVSSSYLET----------------------------- ------GETSELPGNSNVNFIFSSDTKEFLQSCVREVMKDMVGSKILLEE PLEVYWRFMIEEAKAQMKDSACRNVTAGRRDTSEMHNPSVPEGSVSHRPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxEYVDERDPLLFGSRYIVDTLVTVGG FVSSSYGILLLDNQGLKQGVLFHYQDLYINNIKCTSTKPLDEYIKVGKAL HCTAGKLEEVHQTGACYKASCVWDKKKPSCNQVFEKFLTSLKETVKLVPG SIRDAIVVAFHPPNTALVVTDVNDNLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELEKSFDFEEIYTFKDFNFSSADGGVDDSVNNRLTQESYCEET----- -------------------------------------------------- -------PxxxxxPTxxxxxxPxxxxxxLLPLQTIITNKMSEIENKIKVV VETVQTKDPCLGAITESELINPHTLENQNWHSFNVGTHNTAKTHTGEDEN ISIRNVQNNKKAQEKIIYSMEHFPSSNNEENDGLSDITHLEYKGVVDSVS KVSGTILFKINNKMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAASVVVTSDNTNHARESNGECNVESSDKTDTDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDVQSVHLPGLDQTINNM DLKVQTMSDAMQKIAPGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSH DIEENFCEESHLSVSPCLVTNNILKSENLDSLSETILLSE-NIDLGSGNQ SSSESCKLTSQEKIVDETTHQDMTQTEELDDSLR---------------- --------LSLTHKCVSSQDKETTFDPPSPLYDTRQGDLHHNHHLTSKEN GPLNEQTCTEPVPPHADEAPTEKTTQTSPCQELRKQETKSIIKKNTSTHA KMEATVGKTKHKVKNPEQFPCLTDAKKERVASYKDKKLKKSSTLVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHRVDLGCSGIYVSSVYTGKRPKKLAAYKEMRV PVTFSD-KDLLLQGKAYHGVVSEVRPPMAFVVKVKHESSYHSVFVFGLNF SPGKDANKLVDGESVKLFIDVGDYVYVTVQKADNNKGFEWVATEAWTETN KYDRPLTKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILENSGNLIHFN RKNAFLFGICLESFDLTNIFFK---------------------------- ---DEELHFDYFPMEKDLEAENGNLEEMVCVQAWFGSRAAPDSCDALART MFDLDCYCTSRNLNTLLLTALINELGKIREHIEANTKESKSEMETGSDSY SEEEL-EEExxGKVTRYLETGKVDKTGKDVTTNTTDMDGKVSKPKTGDEF ALVDKVIHTSVQTSGSTFVNGLCSPKDNGEIVSTNGSKPLRNTCETTRGE LKNNILRDPRHNSGI-------------------SNARGAIKKCAIxGDS TSKETFSKSKRKQKPVINQGEKQQSLTDVVKELKHFQAKFKMDSTKPSRE EANSDPAVKEPIEVSSSYLET----------------------------- ------GEISELPGNSNRNFIFSSDTKEFLQSCVREVMKDMVGSKILLEE PMEVYWQFMIEEAKAQMKDSACRNVTAGRRDTLEMHNPSVPEGSVSHRPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IKEVCVVIMN FPRKLLNHTGKVVAFISPDDGFLECEVKDVRKIVLFSRENIFINGLQALH VINLRNILTVDTQVCFDAKLISLVLEDSLWNCKIYKAVVLWVGVRTPISR DIQLKTSENKALKKLSDQLVGKQFIQNLKSPANEPVYVSV---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KDVV-----------------EYVDERDPLLFGSRYIVDTLVTVGG FVSSSYGILLLDNQGLKQGVLFHYQDLYINNIKCTSTKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDKKKPSCNQVFEKFLTSLKETVKLVPG SIRDAIVVAFHPPNTALVVTDVNDNLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELEKSFDFEEIYTFKDFNFSSADGGVDDSLNNRLTQESYCEETxxxxx xxxxxXXXxXXXXXXXXXXXXXXXXXXXXXXxxxXXXXXXXXXXXXXXXX XXXXXxxPxxxxxx-------PxxxxxLLLPLQTIITNKMSEIENKIKVV VETAQTKDPCLGAITESELINPHTLENQNWHSFNVGTHNAAKTHTGDDEN VSIRNVQNNKKAQEKLIYSMEHSTSSNNEENDGLSDITHLEYKGVVDSVS KVSGTILFKINNKMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAASVVVTSDNTNHARESNGECNVESSNKTDTDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDGQSVHLPGLDQTINNM DLNVQSMSDAMQKIAPGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSH DIEENFCEESHLSVSPCLVTNNILKSENLDSLSETILLSE-NIDLGSGNQ SSSESCKLTSQEKIVDETTHQDMTQTEELDDSLR---------------- --------LSLTHKCVSSQDKETTFDPPSPLYDTRQGDLHHNHHSTSKEN GPFNEQTCTEPVPPHADEAPTEKTTQTSPCQELRKQETKSVIKKNTSTRA KMEATVGKTKHKVKNPEQFPCLTDAKKERVASYKDKKLKKSSTLVDNTGF TIQLKGQPGKVKEISEDGGTIELIIAEKVLQVVFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHRVDLGCSGIYVSSVYTGKRPKKLAAYKEMRV PVTFSD-KDLLLQGKAYHGVVSEVRPPMAFVVKVKHESSYHSVFVFGLNF SPGKDANKLVDGESVKLFIDVGDYVYVTVQKADNNKGFEWVATEAWTETN KYDRPLTKESLFSWDKSKCPEPECAFKGTVTKIMPDLGILENSGNLIHFN RKNAFLFGICLESFDLTNIFFKVHPAEIRTSISPSSAVELNTTSALANFA TEADEELHFDYFPMEKDLEAENGNLEEMVCVQAWYGSRAAPDSCDALART MFDLDCYCTSRNLNTLLLTALINELGKIREHIEANTKESKSEMETCSDSY SEEELxxxExxGKVTRYLETGKVDKTGKAVTTNTTDMDGEVSKPKTGDEF ALVDKVIHTSVQTSGSTFVNGLCSPKDNGEIVSTNGSKPLRNTCETTRGE LKNNILRDPRHNSGI-------------------SNARGAIKKCTIxGDS TSKETFSKSKRKQKPVINQGEKQQSLTDVVKELKHFQAKFKMDSTKPSRE EANSDPAVKEPIEVSSSYLET----------------------------- ------GDTSELPGNSNRNFIFSSDTKEFLQSCVREVMKDMVGSKILLEE PMEVYWQFMIEEAKAQMKDSACRNVTAGRRDTLEMHNPSVPEGSVSHRPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxx-------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxKDVE-----------------EYVDERDPLLFGSRYIIDTLVTVGG FVSSSYGILLLDNQGVKQGVLFHYQDLYINNIKCTSMKPLDEYIKVGKAL HCTAGKLKEVHQTGACYKASCVWDRKKPSCNQVFEKFLTSLKETVKLVPG SIHDAIVVAFHPPNTALVVANVNDKLVPLLLFVDQLHPGKDELKLSRDSW IEDYLKVDDTLEVKIAALAGKWNKNRLQLIEEAFKVKKENQNLTKLVTAW KLELEKSFDFEEINTFYNFNFSSVDGGVDDSLNNRLTQESYCEET----- -------------------------------------------------- -------Sxx-----------xxxxxxxLLPLQTNITNKMSGIENKIKVV VETAQTKDPCLEAITESELINPHTLENHNWHSFNVGTHNSAKTHTxxDEH ISLRNVQNNKKAQEKIIYSMEHSTSSNNEENDGLSDMTHLEYKGVVDSVS KVSGTILFKINNKMSKALFYKSKVVIGGCPIGKGNDLCDLISLGTPVTFS VEPYSLNNISYRAAAVVVTSD----------ECNVESSDKTETDKSPASN PQPFDARLEVDLSNVETTLAGILGLSNDFVKNFDGQSVRLPGLN------ ----xTMSDAMQKIAPGELYQVVADIFKDCENDFMIGDVLKVNHSQTLSH NIEENSCEEPHLSVSPCLVTDNIPKSENLNSLSETILLSE-NINIESGNQ NGSESCKLTSQEKIVDEITHQDMTQTDELDNSLR---------------- --------LSLTHKCVSSQDKETIFDPPSPLYDTRQGDLHHNHHSASKEN GPFNKQTCTEPVPPHADGAPTEKDTQTSPCQELRKQETKSIIKKNTSx-M KMEATVGKTKHKVKNLEQFPCLTDAKREPVASSKDKKLKKSSTLVDNTGS TIQLKGQPGKVKEISEDGGTIEIIIADKVLQVAFKKEAVYFPKKNTGGSL VDLLPVGKEVFFDGEDLRHKVDLGCSGIYVSSIYTGKRPKKLVAYKEMRV PVTFSDKKDLLLQGKAYQGVVSEIRPPKAFVVKVKHKSSYYSVFVFGLNF SPGKNANKLVDGESVKLFIDVGDYVFVTVQKADNNKEFEWVATEAWTETN KYNRPLTKESLFSWDKSKCPEPECAFKGTVTKIVPDLGILESSGNLIYFN RKNAFLFGICLESFDLTNIFFK---------------------------- ---DEELHFDYFLMEKDLEAENGNLEETVCAQAWFGSRTAPDSCDALART MFDLDCYCTSRNLDTLLLTALINELGKMREHIEANMKESKSEMETCDDSS SEEEL-EKE--GKVTRYLETDKVDKTGKEVSTNMANMDEEVSKPKTGDEF ALVDKVIH----TSSSTFIDGLCSPKDNGEIVSANGSKHWRNTCETTAGE LKNNILHDPKQNSGLYFRDNIIEVKHLEENCETKSNALGAIKKCTI-GDS TSKETFSKLKRKQKPVISQGEKQQSLKDAVKELKNFQDKFKMDSTKPSQE QANSDPAVKEPIEVSSSYSET----------------------------- ------GETSELPKNSNTNFIFSSDTKEFLQSCVREVMKDKVGSKILLEE PMEVYWQYMIEEAKAHMKDSACRNVTEGRRDTLEMLNPSVPEGRVSQHPL NRKETDTKYINKGTQTVSTGMILYL----------------GVASDDxTV SRSGEQxQLSFFSSTCALRSRRENARDVKMVRWGNVPRCLGVSQQHQFRE QIKDGCEITTCSFVTAPLTLHSQPVPDRRKELFLFVTGQRIKYMLEQVRS NPVPRLCHRQRCNRSRATSFLYAPEIFWSSRTVKRKWMLYVLVTALSSEQ MNQTVLSEVGMGCEIxTGSFVTAPMMPHSQPVPDRRKELFLFVTGLRIKY SLQRCNRSGATSFLYAPEVFWSSRTVEKx