>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxTITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPSKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPTTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQVDKQGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNPDSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------- >Tce xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxx------------------------------------------ ---------------------xx--------------------------- -xTITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSM-------------------- ------MSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------- >Tte xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --TITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSM-------------------- ------MSNQYSSIPSKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPTTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRMVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNPDSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxx---------- xxTITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPSKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKNDTNAPVWDEHFLFDVSPTTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGNREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNPDSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIELxxxxxx- ------------xxx----------------------------------- --------------------xQ--------LLHYKSPHGQEAVPVEEWLD SKTDTTLSPRYGITIHCDSKGPPQANTPWKKTYGLMELGFYKLLYNVMFQ VL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------WSRS------x >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --TITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSM-------------------- ------MSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQVDKQGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- ---------------------QxxxxxxxWLLHHKSSHGQEAVPVEEWLD SKTDTTLSPRDGTTIQCDSEGPPQANTLWKKTHGLMELGFYKLMYNVMFQ Vxxxxxx------------------------------------------x xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xSxxxxSHPGFMx---------- >Tcm x------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- --TITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGAELVCVLFLARCVVLKIC VLFPTLYTVTEPLTNGEDVVTDSALRELEAKNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQVDKQGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxx >Tps Mxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --TITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADI----------------NIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- ---------------------QxxxxxxxRLLHHKSPHGQEAVPVEEWLD SKTDTTLSPRYGTTLQCDSEGPPQANTLWKKTHGLMELGFYKLMYNVMFQ ------xxxxxxxxxxxxxxxQNLVPDWxxLYSARTQRIFPQYGAARIDD -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------- >Tdi x------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxx------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- --TITCDFEATPALQLKAFRQKGEKVEVSHYRVNVNRFRARLNIICVTEK MLADIKCDGWPDIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKN------------------------------------GTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- -------------------------------------------------- ---------------------Qx-----xxLLHHKSPHGQEAVPVEEWLD SKTDTTLSPRYGTTLQCDSEEPPQANTLWKKTHGLMELGFYKLMYDVMFQ Vx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx------x >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------KIKIALAPVGSIKNNMDEQQLQDVITEIVVVAMRNSTAH LNLGQYPTCPRLVRQTASQGYNLPLHYDSMSGNASFDLNAKTEVREYHRR QDITSEMSNQYSSIPTKTAVEKRLLVKVVKAIGLGGKKGCSDPYCVVEMD EPSQKNQTSIKKDTNAPVWDEHFLFDVSPNTAELLFEIYDHVNKEKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQVDKQGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNADSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIELx----xx xxxxxFMxxxxxx------------------------------------- ------------------------------LLHHKSPHGQEAVPVEEWLD SKTDTTLSPRYGTTIHCDSKGSPQANTLWKKTHGLMELGFYKL------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxAQAxxxxxxLFDHSLALKLTE FGGRTNWEGQIIGSEPAFAWRESGKPFRKNHPPVHPTEIRTSISLSSAVE LNTTSGLANYATEAGFSTVNANSNPVNVDISMNIKGCxxxxxxxxxxxxx xxxxxxxVHHTMITTxxxxHICxxxESCFRxxxxxxxVxxxxxxxxx--- ----------------------- >Tpa x------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- ------------------------xxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------KRKRFLG LGIVGMEELLINPSQRQTISLQSRPFERDEVSGTLTVEFLFIEGADIPQL GDKPYKLKETLRTVSPTGGVVTTTKTVFEKPGA----------------- --------VTEPLTNGEDVVTDSALRELEARNRGGPAQTSKSTLIIHSVH RVEQSDSGEWHEVSEQ---QGTREQLGQLDGTDNTAPNGTLDDRSRSRRK KRDIFGTIKKRLGRSKARSKSMDPGDKEDTLNPDSSINRSISADRARDPS AHSTGYLSVPGMRGIDGNSTRSSLSEASGVSGASTRTYVNEASTLVLETV ENGVKKHYLVPLSMAQKSKWRKKGTKLHIFNDHTFIAKHLSGGTPCHVCT KPVARRLGKQGYECRDCQLKCHKHCHIKVDTTCTSSTIQSIEL------- --------------xxxxxxxxKPVARRLGKQGxxxRDCQLKCHKHCHIK VDTTCTSSTIxxxxxxxxxxxx--------LLHHKSPHGQEAVPVEEWLD SKTDTTLSPRYGTAIHCDSKGPPQANTPWKKTYGLMELGFYKLLYNVMFQ VL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------WSRS------S