>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxDSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVAPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNNVFSKNRQQKAFSATPTEFSEAETFSSGFSDETI NKSTQTDGNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKTPPSKVCQHTPLESTAYRDSSEAQNNQCKRKSPHKETILKEESASSF SSPPASVSSQSIKSESQQKFERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQASRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTMMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tte x----------xxxxVVEVVFASDSRGEMxxxxIVRTVTPPSQLPTVCLG ADSHASFTAPNCVxxxxxxxxxxxSQLCVRTVTPRPQLPTVCLGRTVTPR SQLPTVCLGxxxxxxxxxxxxxxxx------------------------- ---xxxxxxxxxxxLQLAAELGKTLLERNKELEASLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQ---------------------- -------------LESKCEELQGNVQDLSSQLGVKDKRSNLPKSPITPTV -QKNGSSAREVSTIGAVQDEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQ--ENTCLEEQLILLKQKQDEMCSLAEVGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVAPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNNVFSKNRQQKAFSATPTEFSEAETFSSGFSDETI NKSTQTDGNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKKAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKTPPSKVCQHTPLESTAYRDSSEAQNNQCKRKSPHKETILKEESASSF SSPPASVSSQSIKSESQQKFERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQASRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTMMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------LQLAAELGKTLLERNKELEASLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQLEVSIQDLERANQRLALENSTD KKHIKNLCVNIDTLESKCEELQGNVQDLSSQLGVKDKRSNLPKSPITPTV -QKNGSSAREVSTIGAVQDEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQ--ENTCLEEQLILLKQKQDEMCSLAEVGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVAPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNNVFGKNRQQKAFSATPTEFSEAETFSSGFSDETI NKSTQTDGNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKKAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKTPSSKVCQHTPLESTAYRDSSEAQNNQCKRKSPHKETILKEESASSF SSPPASVSSQSIKSESQQKFERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQASRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTMMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------LQLAAELGKTLLERNKELEASLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQLEVSIQDLERANQRLALENSTD KKHIKNLCVNIDTLESKCEELQGNVQDLSSQLGVKDKRSNLPKSPITPTV xQKNGSSPREVSTIGAVQDEEVKSLLVQLQDLRAQRSREQSKVAALEDQL TATIQ--ENTSLEEQLILLKQKQDEMCSLAEVGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVAPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNNVFGKNRQQKAFSATPTEFSEAETFSSGFSDETI NKSTQTDGNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKTPPSKVCQHTPLESTAYRDSSEAQNNQCKRKSPHKETILKEESASSF SSPPASVSSQSIKSESQQKFERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQASRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTMMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tms -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxD----------LQLAAELGKTLLERNKELEATLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQLEVSIQDLERANQRLALENSTD KKHIKNLCVNIDTLESKCEELQGIVQDLSSQLGVKDKRSNLPKSPITPTA -QKNGSSPQEVNTIGTVQEEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQ--ENTCLEEQLILLKQKQDEVCSSADDGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVTPSVDNCLSLEEELRQSGDFNSFSGKNYN ETNSEVPENREESGKNSVFRKNGQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKRAAEAKADNEQLQLQLRAENSHTSVATPTETLPTSENKLVNG EEKAPPSKVCQNTPLESTAYRDSSAAQNIQCNRKSSRKETILKEESASCF SSPPASVSSQSIKSESQQKLERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tce M------------------------------------------------- -------------------------------------------------- --------------------------xQHQxxHKYRLLKTxxxxxxx--- ---D----------LQLAAELGKTLLERNKELEATLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQLEVSIQDLERANQRLALENSTD KKHIKNLCVNIDTLESKCEELQGIVQDLSSQLGVKDKRSNLPKSPITPTA -QKNGSSPQEVNTIGTVQEEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQCHENTCLEEQLILLKQKQDEVCSLAEDGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVTPSVDNCLSLEEELRQSGDFNSFSGKNYN ETNSEVPENREESGKNSVFRKNRQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFAVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSENKLVNG EEKAPPSKVCQNTPLESTAYRDSSAAQNIQCNRKSSRKETILKEESASCF SSPPASVSSQSIKSESQQKLERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNNxxxQEKERDNSEAEEHELAEEDGVSPTLKEEVALLVSRSSLSS DRMKPREDRMSDWIMKRVIKKKGKQLEVLQVYDPQAGCNLEEKQKFEELE RHTSGENKTKKERDSLNCTQEMDTAGLRRAGIRYGSKGKHRCALKNWRPA STSWAARPTDGCGIHQLPSLHPLESHRPPQLSLAELTWRLDTTILCPTGG APSTAMGPLGLAAAVATPRIPIERGAGTVVSKRAFNSELILPVESGRQMS TSSSSESISAGSLSLLADADNFLLIQVIIDADHLLPILPITDADHLLQIL PITDADHLLPILPITDADHLLPILPITDVDHLLPILLITDADHLLPILPI TDADHLLQILPITDADHLLPILPITDVDHLLPILLITDADHLLPILPITD ADHLLQILPITDADHLLPILPITDVDHLLPILLITDADHLLPILPITDAD HLLQILPITDADHLLPILPITDVDHLLPILLITDADHLLPILPITDADHL LQILPITDADHLLPILPITDADHLLPILLIKDADHLLPILLITDADHLLP ILPITDADHLLPITDADHLLPILPITDADHLLPILPITDANHLFVTCITL LSYFSKLVACICHLLTRILDDTLPSISNWSNVCVPLDSQVATPVHLYRVP TGFIVASVCPTSRSFTTPAQTVLSMASEQVLKNLCSSLESTKATERKKSM NELSSILMAHCPSKEELCGKCGKEGHKxxxCKSREEVCIPCVARKRSEKC KKPN >Tsi xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -----------------------xxxxx---------------------- ---D----------LQLAAELGKTLLERNKELEATLKSHQNIIDDQAQEI EYLTKQTAALREVNDSRL-----RIYEQLEVSIQDLERANQRLALENSTD KKHIKNLCVNIDTLESKCEELQGVVQDLSSQLGVKDKRSNLPKSPITPSA -QKNGSSPQEVNTVGTVQEEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQ--ENTCLEEQLILLKQKQDEVCNLAEDGSGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQATPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNGMFRKNRQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFEVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKAPPSKVFQHTPLESTAYRDSSAAQNIQCNRKSPHKETILKEESASCF SSPPASVNSQSIKSES-QKSERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --KNGSSPQEVNTIGTVQEEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQ--ENTCLEEQLILLKQKQDEVCNLAEDGPGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQATPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNSMFRKNRQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFEVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKAPPSKVFQHTPLESTAYRDSSAAQNIQCNRKSPHKETILKEESASCF SSPPASVNSQSIKSES-QKSERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QKNGSSPQEVNTIGTAQEEEVKSLLVQLQDLRAQRSREQSKVTALEDQL TATIQCHENTCLEEQLILLKQKQDEVCSLAEDGSGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVTPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREESGKNGMFRKNRQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFEVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKAPPSKVFQHTPLESTAYRDSSAAQNIQSNRKSPHKETILKEESASCF SSPPASVNSQSIKSES-QKSERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------SGQSYICARCLKKVCYE DDDMSVVNSSTSETHRSTVMMQIW------------DSPDEDASQDNPYQ TLVEKYEALLRMQQNTPVKQVTPSVDNCLSLEEELRQSGDFNSFNGKNYN ETNSEVPENREENGKNSMFRKNRQQKAFSTTPTEFSEAETFSSGFSDETI NKSTQTDVNLPPGSFLLSIADGDDCKFSIYDEISPVESRFRKTPEYRQLF REIFEVLKRAAEAKADNEQLQLQLRAENAHTPVATPTETLPTSANKLVNG EEKAPPSKVFQHTPLESTAYKDSSAAQNIQCNRKSPHKETILKEESASCF SSPPASVNSQSIKSES-QKSERDILKPKHDILEYLSIGVAIRKKSNSRKN SPSKGNKSGERVERLESMSAVGSCVAKLQANRMSQGGAGRKRRETRIFEN QSYKDRSQQKVESWDFQPFVSSASQEVAKLKRLEKSYAEVLRLGPKKPTN RGTIMNS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YR-- -------------------------------------------------- -------------------------------------------------- ---N