>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxx-------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -xxxxxxxxxxx---xxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------VFTDGPLWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSDNRPVVMHDAFDICVLNSLWALLAGH------------ -------------------------------------------RFALNDK RLAELIDIVHASFRMLDMSGGLLNQMPFLRFLAPDKSGYTRIINILERMF NFLR---------------------------------------------- -------------------------------------------------- -------ETITEHRTTLNPDFSRDLIDSFLVEIDKQPDSTFS-------- ---------------------ELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELDREVGRERQPALQDRAR------------------ -----------------------FEHWIFEIISDTRLR------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQ--------- ----------------GATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGV------------------------------------- -----------------------GKRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRGPGCSG---x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------MEVQRHGNVVPVAVAHRATRTADLMGHIIPQ--------- ----------------GATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGV------------------------------------- -----------------------GKRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRGPGC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tms MAAVSLYCRDIDGxSVATVPEVRVELRWFGTATQPAHCSRIAAVSMIWVV ILVLLVLFLAVVDTRRPDNYP--------------------P-------- ----------------------------------------------GPSW LPLVGNYPLLRRELARLKYHYLVWAHLGARYGPVVGLRLGRDLVVLVSGY TAIRAVLTREEFEGRPDGFFFKLRTFGQRLGTLLCPTLFFFKLRTFGQRx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------VFTDGALWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGH------------ -------------------------------------------RFALNDK RLAELIDIVHTSFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIINILERMF NF------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxLSYIEAVLMEVQRHGNVVPVAVAHRATRTANLMGHIIPQ--------- ----------------GATLLVSLHSIHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGV------------------------------------- -----------------------GRRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRRPGCSG---x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tce MAAVSLYCRDxDGSSVATVPEVRVEFSWFRTATQPAHCSRIAAVSMIWVV ILVLLVLFLAVVDTRRPDNYPPEEDITQYLASSWSCYVRVSP-------- ----------------------------------------------GPSW LPLVGNYPLLRRELARLKYHYLVWAHLGARYGSVVGLRLGHDLVVLVSGY TAIRAVLTREEFEGRPDGFFFKLRTFGQRLGTLLCPTPFFFKLRT----- -----------xx---------------xxWPExRYVTVSNPLLxxxxxL WPETRYVxxxxxxxxxxxxLWPETRYVTVSNPLLLQAEELWPETRxxxxx xx------------------------------------------------ -------------------------------------------------- ----------xxxxxxxxxxx----------------------------- ------xxxxxxxxxxxxxxxxxLFLQAEDLWPETRYVTVSNPxxxxxxx xxxxxxYVTxxxxxxxxxxxxxxxTRYVTVSNxxxxxxxxxxxxxRYxTx xxxxxxQAExxxxxTGYYVSVSYFLFQPEDLxxxxxSYFxxPNxxLxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------EVFTDGALWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGHRFL--------- -----------------------HTKSSSATVTVLIQVVVLCPRFALNDK RLAELIDIVHTSFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIINILERMF NFLRVRLQLVSLERMASSQSIVTGFVLYGPCFIETIA------------- ---------SYKLTLSLTRSxxQIWVDFSxTRILKILKTGMTCFDKCKLF VKCLYSQxTITEHRTTLNPDFSRDLIDSFLVEMDKQPDSTFSGECQLNLP LPTTCAQPNMASQEIVIVMLLELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELEREVGRERQPALQDRA------------------- -------------------------------------R------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQVRVVLVKMI SSHPTSKCVMWMYVGNGATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGVVxAPLGS------------------------------ ------------KECQGWLCCVAGRRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRRPGIDNxYQx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------MEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGH------------ ----------------------------SATVTALIQVVVLCPRFALNDK RLAELIDIVHASFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIVNILERMF NFLR---------------------------------------------- -------------------------------------------------- -------ETIREHRTTLNPDFSRDLIDSFLVEMDKQPNSTFSGECQLNLP LPTTCAQPNMASQEVVIVMLLELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELEREVGRERQPALQDRA------------------- -------------------------------------R------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQ--------- ----------------GATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGVV-----xLCGLVxRVPxYRFRGxxxxxxRIFCEPVGL ERGQAxxNxxxxKECQGWLCCAAGRRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRRP---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tps x------------------------------------------------- -----------------------------------------x-------- ----------------------------------------------x--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------DVFTDGALWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGHRNLxRFVCRNWV FGSKPCYQVTLIIDGMCGRDxxxNTKSISATVTALIQVVVLCPRFALNDK RLAELIDIVHTSFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIINILERMF NFLRVRLQSVSLERMASSQSIVTGF------------------------- -------------------------------------------------- -------ETITEHRTTLNPDFSRDLIDSFLVEMDKQPNSTFSGECQLNLP LPTTCAQPNMASQEVVIVMLLELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELEREVGRERQPALQDRARDEEGSILDVTYPHLRRRV RNHLAEITFSKPDQDSNLDLLVIS-------------R------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQVRVVLAKMI SSHPTPKCVTWMYVGNGATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGV------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tdi M------------------------------------------------- -----------------------------------------P-------- ----------------------------------------------SPSW LPLVGNYPLLRRELARLKYHYLVWAHLGARYGSVVGLRLGRDLVVLVSGY TAIRAVLTREEFEGRPDGFFFKLRTFGQRLGTLLCPTPFFFKLRTFGQRx ------------xxxYVTVSNPLLLQxxxxWPExxxxTVSNPLLLQVEDL WPETRYVTVSNPLLLQVEDLWPETRYVTVSNPLLLQVEDxxxxxxYVTVS NP---------LLLQx---------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxLWPETRYVxxxxxLLLQxxxxxxxTRYVTVSNPLLLQVED LWPETxxxxxxxxxxxxxxxxxxxxxxxxVSNPLLLQVEDLWPExxxxxx xxxxxxxxxxxx-------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxVEDLWPETRYVTVSNPLLLQxxxxxxxxxxxxxSNPL LLQVxxxWPExxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxSNPLLLQVEDxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxPExxxVTVSNPLLLxxxxxxxxxxxVTVSNPLLLQVEDxxxE TRYxxxxxPLLLQVEDLWPExxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVSNPLILQTEDLRPE xxxxxxxxxxxxxxxxxxxxxxxxTVPNPxxxxVEDLWAMTRLIxxxxxx xxxxxxxxxxxxSVFTDGALWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGHRNLxRFVCRNWV FGSKPCYQVTLIIDGMCGRDxxxNTKSISATVTALIQVVVLCPRFALNDK RLAELIDIVHTSFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIINILERMF NFLRVRLQSVSLERMASSQSIVTGF------------------------- -------------------------------------------------- -------ETITEHRTTLNPDFSRDLIDSFLVEMDKQPNSTFSGECQLNLP LPTTCAQPNMASQEVVIVMLLELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELEREVGRERQPALQDRARDEEGSILDVTYPHLRRRV RNHLAEITFSKPDQDSNLDLLVIx-------------R------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQVRVVLAKMI SSHPTPKCVTWMYVGNGATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGVVxxxxxx------------------------------ ------------KECQGWLCCAAGRRRCLGETLARSTLFLFFTTLLHNFT LSVPPEGSLPSTKGYDGVTISPRPFFAVLTPRRPGIDNxYPxxxxxxxxx xxxxGSIEGGFVPGADxxxxxxxxPVKKRKMEFLAKVSPMHRLRPDNTML SLSAGSELGEGEEPITGHESTIVIQEPLGTEHVRIPPMLGVHKKTDRLYN QCKVDDPHLRNMVVVQCRVSQHPPGTAKGHHMGGRTVMPNHSVYFCVNxx xNIxxxDHCQEGEVEGVTCGLGAPDEQGKPPSVHPTEIRTSISPSSAAEL NTTSVLANYATxxxxxCLNQGYRLSVPPNRSNARILLPISSKSRSRCSPL MRFPAVRTHSTFSTLGAKQELNVTPLVEHLLLLSRRTSEASSESIMASMS QDMGPIALGQFLEHQVLVAELLGETCSQPLCWRDAFQYTAVKKFPHTTTA RGAHVGAPADGALNADDIGWTVSCIDNQVQIRPxxxxxCRCTPRTPLSPR IRTSLVRRSGWSDSSSQACMHRLVTGRPLLLVSCFAASMSRR-------- -------------------------------------------------- ----------------------------------------LVRSRDDDDD DDDDDKSPARVSHTQAKKAFDxxxRYIKQNESSTPMDIFFESxIPVVGIQ TENFKKASISKSLVLEGPRKEHRERACSSxxxxxxxxxxHDQKNIRRITP LGTKSFCWEYx >Tcm M--------------------------------------------xxx-- -----------------------------------------xxxxxxxxx xRGASFNMxPLALTxxxxxxxxxxxxASRVTPSHRTVGDYWTTVHxGPSW LPLVGNYPLLRRELARLKYHYLVWAHLGARYGSVVGLRLGRDLVVLVSGY TAIRAVLTREEFEGRPDGFFFKLRTFGQRLGTLLCPTP-xxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------LVFTDGALWQEQRRFSLVHLRNLGLGKSSMEAQIQAEA EELVVSLRDKGSGNRPVVMHDAFDICVLNSLWALLAGH------------ -------------------------------------------RFALNDK RLAELIDIVHASFRMLDMSGGLLNQMPFLRFLAPDKSGYTCIVNILERMF NFLRVRLQLVFLERMASSQSIVTGFVLYGPCFMETMAWLANALVMLSSTA EDGEIVVRIS---------------------------------------- -------ETIREHRTTLNPDFSRDLIDSFLVEMDKQPNSTFSGECQLKLP LPTTCAQPNMTSQEVVIVMLLELQLLALCLDLFMAGSETTSNTLGFATAY MLLHPDIQDRVHQELEREVGRERQPALQDRA------------------- -------------------------------------R------------ --LSYIEAVLMEVQRHGNVVPVAVAHRATRTADLMGHIIPQ--------- ----------------GATLLVSLHSLHMDPTHWGDPDTFRPERFLDAQG KLLQDDWFLPFGVV-----------xRVPGYRFRGxxxxxxxxxxxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xx------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTRxxxx xxxxxTNLRNNKSRVVGGSVPKCDVSLVTSFKETGFMTxHL--------- -------------------------------------------------- -------------------------------------------------- -----------