>Tge M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------NKEFAGHSIDGLAPSSTKLQGISRNTITSSELGQGVAAPYPVEQ DGTRRYTDI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------NYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQAIDDMNTENKQSLQNIPEECEHID-GNIVGASLPTQ KTSKHVEPTLEGSKEKEPLTNTSLSQDCQHLEENPSEVTLSPIEDYSKTNSIISPCVPER DLTLNEQEVLEHSANNRVEERKGNIVFH----QSAKESLSTTEEHTVHNFETLFNEHSSD SAKTNFATGTPSSSVLECPSIGTEDQSPGYSGNQSVLSNQNTDKIP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SEETHIWPVVVESNMPILDSTQIVIVTEDDEDNTGQIGIENTT PCHETNAVAVPISPEMPCLEPFTLPENVVAICNESDFEMPILNVSENASLV--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQEGFNVDG---------VHPHLHK WIVENHPWCTWPGLNPEFPIFGSLVYCESA-LDHVDTKVI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------- >Tms ME----VDLNGVDI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LVMPMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYNEVQRPRYQDPSSNKSEENYQDPGRYHDAQRKAHTVQFR DLPKQSSQTLNYSEAMNKEFA-----GLAPSSTKLQGISRNTITSSELGQGEVASYPVEQ DGTRRYTDI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------NKASSDLEDSSYVDEHNPNIYNRSPFEDGTGRYLKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPS-NVESVLVLDYRSLGNDG LSSLQADEGIGRPVDSGLIQMTYQEIDDMNTVNKQSLQNIPGECEHID-GNIGEASLPIQ KTSKYVEPTLEDSKEKEPLINISLSQDCQHLEENTSEVTLSPIEDYSKTNSIISPCVSER DLPLNEQEVLENSANNRVKERKGNIVFH----QSAKGSLSTTEEHTVHNFETLFSEHSSD SARTNFATGTPSSSVLECPSIGTEDQSPSYSGNQSVLSNKNTNKIP-------------- ------EQI---------------EENHSKEEVNSR----------NDI----------- ------------------------------------------------IKEKSINLKS-- -TNSPVDCS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------IDSPQIVIITGDDED--------NTT PCYETNAGAVPISPEMPCLEPFTVPENVVAICNESDFEMPILNVSENTSLVVSDGNKMPQ LEVTVSSIISTAENNDNSSETLPHYGEHERHLENVATSLQESIIEPYKSVPHNYTHGSDS ISKPFIFERHCHEESLECSLISNEMRCSLTK---TPEIIPTDSVSNWPYLEEEVPSELQV SDSESTVPLPKYFHGTSNVKVCLTPKSHHERETKNWSVVDPSGSGESSHWSFVEENNNDL ITASQNAKQDELYNNQVPIVLVKKLVLKREADGKIGNECEHLPKFAHSSEDDDDEIKKTD AANAIGRKTLVNTEGRNTTPCSNVSKNADIELNSTSLDIEAIEKNLPSTLAKCLEQGR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------NYEEESIKDSMKNNQTGSKESVENMQSSLLVQDSMSAETLIHSQISRSH IRDDHSHSKVTNSRENSTTDLSEKHIVLKEGS---KECEIKQLKKRSSNSSRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSKKELELNSRKLEESEFKSELKALLGEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQLQLESPATIMSSATP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------- >Tps MGPTKLSGAQGRKRKKQQEADNIVQAKQWQKLGWVKKVDPSTAALPLQQGIESRPSTSTF LENENFTKISRVNEQLQHKDMTVDRAVSHLTGLKDALQDIRDTGIDVILDEASNICAATS LGIDCFFEEKRVKKRKRLTLEERFPIGDAVSKQTSAPPWDYTPQPYNSIPNFSGETHLNH RQVPVIHNQNIPQFDRKENSLNIPGHDNSNPLAHYSTNNNNSHQSIVRPTALVNCHSNCN ACCNHSNRVS-HWNVTSDGRYLDNSSSLPKDLPRYPNISSYSHEESKFVGDFASSLNKLS RFSREKANPNHPGFVSPAVEQDHVSPIVNSSAKALNTSSAVSSDSIPVKKGSCATCQDGC QSSCRFFKHQSSVQFPNQDNIHQDQHSISATQENVVRYMGHTALNNATSNQWHMSNRPQT GMWLPNGHYPPFWVQPDNVRMNASGSVSFWGDRNEEISSNISQPMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYNEVQRPRYQDSSSNKSEENYQDPGRYHDAHRKAHTVQFH DLPKQSSQTLNYSEAMNKEFAGHSNDGLAPSSTKLQGISRNTITSSELGQGVAAPYPVEQ DGTRRYTDISNAHPARSMATHFNTNSQANINFTTGIAQPPSRFSSHVTYTQSKITKTNNY MQCIYPPIETSEKNTNFVPVGSKMAYANSEIVPSNRNQYTSVVKESGSNFEFVTNSVDKN SDVIKYCDSKNSDPGPNYSTLQPCNKMSDSTVLGKTMQVVDCPGLVKTKPYFCNQTLQGS NNFYSDIPRYVQTKVSHSYENLNGSKAYHMFGENNMPANLHSLQQTYQINPIPAQNSSSA ITSNVSILPPDKASSDLEDSSYVDEHNPHIYNRSPFEDGTGRYIKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPSNNVEPVLVLDYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQEIDDMNTLNKQSLQNIPEECEHID-GNIGEASLSIQ KTSNYVESTLEDSKEKEPLTNTSLPQDCQHLKENTSEVTLSPIEDYSKTNSIISPGVPER DLTLNEQEVLENSANNRVEERKGNIVFH----QSAKESLSTTEEHTVHNFETLFSEHSSD SARTNFATGTPSSSVLECPSIGTEDQSPSYSGNQSGLSNKNTNKIPVSDSLLQKSLSTSK NINISNEAIDALLKDCAEFSENILPKLHSQEEVENRCNNVDIDENIDDILQTVN-QDNSS TISQNTIFAPINSENKDVVVSENGL--RTSAIVSTFVKELEKNKEQTQIQPKRIGFKS-E KNTTPTPCHNTFVDSEMGEIPSKSNKLEIKPFSKIVAKQILAPEEETTNLYYTSKEQFIT NVEKQDKEAEVNTSTTSQSSFKNEASFENILGDNIINYSNKENLSSIIG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KEVDTPVFEVCGKDK--------- ------PTIHSI----------------------ELIKNSSPDVIVTGFE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------DKDKINSSD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RGNSTTDLSEKHIVLKEGSKENKECEIKPLKKRSSNSLRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSK-----------------------GKFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQDYIWKRRDMGGSADD-SNIH--- -----EP----------------------------------------------------- ------------------------------------------------------SHDAGT ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STR >Tce M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TLLKFL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ICFF-------------------------------- ------------------------------------------------------------ ----------------------------------------------NVI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------Q-----------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQDYIWKRRDMGGNADD-SNIH--- -----EP----------------------------------------------------- ------------------------------------------------------SHDAGT ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STR >Tdi M-------YNGYK----------------------------------------NPEM--- ------------------------------------------------------------ ----CFNNQTHFDN------QPGFPIGDAVSKQTSAPPWDYTPQPYNSIPNFSGETHLNH RQVPVIHNQNISQFDRKENSLNIPGHDNSNPLAHYSTNNNNSHQSIVRPTALVNCHSNCN ACCNHSNRVS-HWNVTSDGRYLDNSSSLPKDLPRYPNISSYSHEESKFVGDFASSLNKLS RFSREKANPNHPGFVSPAVEQDHVSPIVNSSAKALNTSSAVSSDSIPVKKDSCATCQDGC QSSCRFFKHQSSVQFPNQDNNHQDQHSISATQENVVRYMGHTALNNATSNQWHMSNRPQT GMWLPNGHYPPFWVQPDNVRMNASGSVSFWGDRNEEISSNISQPMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYNEVQRPRYQDSSSNKSEENYQDPGRYHDAHRKAHTVQFH DLPKQSSQTLNYSEAMNKEFAGHSNDGLAPSSTKLQGISRNTITSSELGQGVAAPYPVEQ DGTRRYTDISNAHPARSMATHFNTNSQANINFTTGIAQPPSRFSSHVTYTQSKITKTNNY MQCIYPPIETSEKNTNFVPVGSKMAYANSEIVPSNRNQYTSVVKESGSNFEFVTNSVDKN SDVIKYCDSKNSDPGPNYSTLQPCNKMSDSTVLGKTMQVVDCPGLVKTKPYFCNQTLQGS NNFYSDIPRYVQTKVSHSYENLNGSKAYHMFGENNMPANLHSLQQTYQINPIPAQNSSSA ITSNVSILPPDKASSDLEDSSYVDEHNPHIYNRSPFEDGTGRYIKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPSNNVEPVLVLDYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQEIDDMNTLNKQSLQNIPEECEHID-GNIGEASLSIQ KTSKYVESTLEDSKEKEPLTNTSLPQDCQHLKENTSEVTLSPIEDYSKTNSIISPGVPER DLTLNEQEVLENSANNRVEERKGNIVFH----QSAKESLSTTEEHTVHNFETLFSEHSSD SARTNFATGTPSSSVLECPSIGTEDQSPSYSGNQSGLSNKNTNKIPLS---IIPNLKSVD NIITSEDHPTSSLNSVA-FREQI-EEQHSKEEVNSR----------NDI----------- ------------------------------------------------IKEKSINLKS-- -TNSPVDC------------------------SIVTKTPEIIPTDSVSNWPYLEEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VPSELQVS DSESTDKAEKIEHVKEHLYHCQQCHIAFNSK-----------------------GKFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQDYIWKRRDMSGSADD-SNIH--- -----EP----------------------------------------------------- ------------------------------------------------------SHDAGT ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STR >Tcm M-------YNGYK----------------------------------------NPEM--- ------------------------------------------------------------ ----CFNNQTHFDN------QPGFPIGDAVSKQTSAPPWDYTPQPYNSIPNFSGETHLNH RQVPVIHNQNIPQFDRKENSLNIPGHDNSNPLAHYST-NNNSHQSIVRPTALVNCHSNCN ACCNHSNRVS-HWNVTSDGRYLDNSSSLPKDLPRYPNISSYSHEESKFVGDFASSLNKLS RFSREKANPNHPGFVSPAVEQDHVSPIVNSSAKALNTSSAVSSDSIPVKKDSCATCQDGC QSSCRFFKHQSSVQFPNQDNIHQDQHSINATQENVVRYMGHTALNNATSNQWHMSNRPQT GMWLPNGHYPPFWVQPDNVRMNASGSVSFWGDRNEEISSNISQPMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYNEVQRSRYQDASSNKSEENYQDPGRYHDAHRKAHTVQFH DLPKQSSQTLNYSEATNKEFAGHSNDGLAPSSTKLQGISRNTITSSELGQGIAAPYPVEQ DGTRRYTDISNAHPARSMATHFNTNSQANINFTTGIAQPPSRFSSHVTYTQSKITKTNNY MQCIYPPIETSEKNTNFVPVGSKMAYANSEIVPSNRNQYTSVVKESGSNFEFVTNSVDKN SDVIKYCDSKNSDPGPNYSTLQPCNKMSDSTVLGKTMQVVDCPGLVKTKPYFCNQTLQGS NNFYSDIPRYVQTKVSHSYENLNGSKAYHMFGENNMPANLHSLQQTYQMNPIPAQNSSSA ITSNVSILPPDKASSDLEDSSYVDEHNPHIYNRSPFEDGTGLYIKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPSNNVEPVLVLDYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQEIDDMNTVNKQSLQNIPEECEHID-GNISEASLPIQ KTSKYVESTLEDSKEKEPLTNTSLSQDCQHLKENTSEVTLSPIEDYSKTNSIISPCVTER DLTLNEQEVLENSANNRVEERKGNIVFH----QSAKESLSTTEEHTVHNFETLFSEHSSD SARTNFATGTPSSSVLECPSIGTEDQSPSYSGNQSVLSNKNTNKIPVSDSLLQNSLSTSK NINISNEAIDALLKDCAEFSENILPKLHSQEEVETRCNNVDIDENIDDILQTVN-QDNSS TISQNTIFAPINSENKDVVVSENSLTTRTSAIVSTFVKELEKNKEQTQIQPKRIDFKS-E KNTTPTPCHNTFVDSEIGEIPSKPNKLEIKPFSKIVAKQILTPEEETTNPYHTSKEQFIT NVEKQDKEAEVNTSTTSQSSFKNEASFENILGDNIINVSNKENLSSIIG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KEVDTPVFEVCGKDK--------- ------PTIHSI----------------------ELIKNSSPDVIVTGFEDK-DKINSSD SEDHPTSSLISVAFQEQIEEHH---------------------SKEEVNSRNDIIKEKSI DLKSTNS---PVDCSI-------------------------------------------- ----------------------------------------------------------D- ------------------QIIR-----TLAK-EDHPDLLP-------------------- --------------GTSNVKVCLTPKSHHERESKTWSVVDPSGSGESSHWSFVEENNNDL ITASQNAKQDEHYNNQVPIVLVKKLVLKREADGKIGNECEHLPKFAHSSE-DDDEIKKTD AANAKGRKTLVINKGRNTTPCSNVSKNADIELNSTSLDIEVIEKNLPSTLAKCLEQERSN IITSTNSPRLCDSSAACSLSGAESCDGSEKHVPRVIIKRTGSGTNYKSFLRESSYSTNFW QPVVRIQRNKDLDNLSRSLVKSDCPKKVVHLNRLRLVIRRQSSFEREKVMKNNVHQVAFV TNVDPT-MNEYENIPSVKQCKESLEKKEIYTYAVENNAKKNKLTSHRQRNELNTRVHDTE IRHLKHNKPQSYGQLCFVKEKQRLKCSTIPEQNKVRAHNEIKKKHSETNHISQSSQSHSY DGMKDQCIDEKNERKGRRYSECSHNILGYHIAKVSRKRISEGSIDINEKGKNSNAFADNI PYYKKRFAMGSDYEEESIKDSIKNNQTGSKESVENMQSSLLVQDSMSTETLIHSQISRSH RRDDHSHSKVTNSRGNSTTDLSEKHIVLKEGSKENKECEIKQLKKRSSNSSRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSK-----------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQVCI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------- >Tte A------------------------------------------------------SL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVSDG----------------------------------------- ------------------------------------------------------------ -------------------------------------------------------NR--- ------------------------------------------------------------ ------------------------------------------------------------ -MP------------------------------QLEATMSSIISTAE------------- ---------------------------------------------------------NN- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DNSSETLPQSG---EHERHLEYDATFQESI---IEPYKSVPHNYTHGSDS LSKPFIFERHCHEESLECSLISNEMRC----SLTKTPEIIPTDSVSNWPYLE-------- -------------------------------------EEVPSELQVSD------------ -----------------------------------SECTV-PLPKYF------------- ---------------------HGII----------------------------------- ----------DSNGILTAPPL-----SP----------------IPSSD----------- ------------------------------EE---------------------------- ------------------------------------------------TLPRQTNFKM-- ---------------------------------------------------------MLS SAYRKTN----NEKRKSLNFFKCRKSLKS--EHFAVNPHNGLKCQLSWN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RIFALSKIDECKKLK--------- -------------------------------------------------TNK-IKQKRDV SKG--------------------W------------------------------------ ------------------------------------------------------------ ----------------------PYYGKSPMRW----TRIKRKETDEYKS----HLVTTD- ------------------QIIR-----TLSK-EDHPDLLP-------------------- --------------GTSNVKVCLTPKSYHEREDKTWCVVDPSGSGESSHCSSVEENNNDL VTASQNTKQDELYNNQVPIVLVKKLVLKREADGKIANECEHLPKFTHSSE-DDDEIKQTD VANAIGRKILVNTEGRNTTSCSNVLKNVDIELNSMSLDIEAIEKNLPSTLAKRLEQGRSN IITSTNSPRMCDSTAGCSLSGAESCDGSEKHVPRVIIKRTGSGTNYKSFLRESSYSTNFW QPVVRIQRNKNLDNLSRSLVKSDCPKKVVHLNRLRLVIRRQSSFEREKVIKNNVHQEAFV TNIDPTSVNEIENVPSIKKREESLEKKEIFTYAVENNAKKNKLTSHRQRNESKTRVHDTE IRYLKH---------------------------KVRAHNEIKKKHSEINCISQSSQSHSY DGMKDQCIDEKNERKGRRYSECSHNILGYHIAKVSRKRISEGGIDINEKGKHSNAFADNI PYYKKRFAMGSDYELESTKDSIKDNQTGSKESVKNIQSSLLVQDSMSTEKLIHSQISRSH RRDGHSHSKVTNSRGNSTTILSEKHLVLKEGSKENKECEIKQLKKRSSNSSRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSK-----------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQDYIWKRRDMGGSADD-SNIQ--- -----EP----------------------------------------------------- ------------------------------------------------------SHDAGT ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STR >Tpa M-------YNGYK----------------------------------------NPEM--- ------------------------------------------------------------ ----CFNNQTHFDN------QTGFPIGDAVSKQTSAPPWDYTPQPYNSIPNYSGETHLNH RQVPVIHNQNIPQFDRKENALNITGHDNNNPLVHYST-NNNTHQSIVRPTALVNCHSNCN ACCNHSNRVSHHWNVTSDGRYLDNSSSLPKDLPRYPSISSYSHEESKFIGDFASSLNKLS RFSREKANPNRPGFVPPAVEQDHVSPIVNSSAKALNTSSAVSSDSIPVKKDSCATCQGGC QSSCRFFKHQSSVQFPSQDNIHQDQHSLSTTQENVVRYMGHTTLNNVTSNQWNMSNRPQT GMWLPNGHHPPFWVQPDSVRMNASGSVSFWGDRNEEISSNISQPMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYHEVQRPRYQDPSSNKSEENYQDPGRYHDAQRKAHSVQFH DLPKQSSQTLNYSEAMNKEFAGHSIDGLAPSSTKLQGISRNTITSSELGQGVAAPYPVEQ DGTRRYTDISNAHPARSMATNFNTSSQANINFTTGIAQPPSRFSSHVTYTQSKITKTNNY MQCIYPPIETSEKNTNFVPVGSKMAYANSEIVPSNRNQYTSVVKESGSNFEFVTNSVDKN SDVIKYCDSKNSDPGPNYSTLQPCNKMSDSAVLGKTMQVVDCPGLVKTKPYFCNQTLQGS NNFYSDIPRYVQTKVSHSYENLNGSKAYHMFGENNMPANFHSLQQTYQMNPIPAQNSSSA ISSNVSILPPDKASSDLEDSSYVNEHNPNIYNRSSFEDGTGRYIKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPSNNVEPVLVLDYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQAIDDMNTENKQSLQNIPEECEHID-GNIGGASLPTQ KTSKHVEPTLEGSKEKEPLTNTSLSQDCQHLEENPSEVTLSPIEDYSKTNSIISPCVPER DLTLNEQEVLEHSANNRVEERKGNIVFH----QSAKESLSTTEEHTVHNFETLFNEHSSD SAKTNFATGTPSSSVLECPSIGTEDQSPSYSGNQSVLSNQNTDKIPVSDSLLQKSLSTSK NINISNEAIDALLKDCAEFSESGLLKLHSQEEVETQCNNVDIDENIDDILQTVNHQDNTS TSSQNTIFTPINSENKDVVVSENSLTTRTSAIVSSFVKELEKNKEQTQIQPKRIDFKSLE KNTILTPCHNTFVDSEICEIPSKQNKLEIKPFSKIVSKQILTPEEETTSPCHTPKEQFIT NVEKQDKEAEVSTSKTSQSSFKNESSIENILGDSTISYSNKENLSSTIDINNVKTYNKLT MQSHSQLVGDKNISEPESETMERGNIRLFSEEILNFDSKGALNLKMKKENETSTPDIYFE CQPSSINKDATSVIMELTSTDTNKCNETSICDQGTLETSNSKELQANIIQNLSHKQTLAT NSEEKSITLLESPVINEVSHMCVNQHSHIVHCCNTEQHSLKCCEDTDLETLANKHISSHT ASITACEEPLDNVSVTNVLDISTNGTVSSINTEAIPQENDLTITRTCSKDKFVIDLPGTD ENKTKESTLHSICSHKKFKCDSPKLLRIQADTHTSVFESKAMEVQENGFENNFDNNTNSA NVTELSLQYEGTEFVEQSEETHIWPVVVESNMPILDSTQIVIVTEDDEDNTGQIGIENTT PCHETNAVAVPISPEMPCLEPFTLPENVVAICNESDFEMPILNVSENASLVVSDGNRMPQ LETTMSSIISTSENNDNSSETLPQSGEHERHLEYDATSFQESIIEPYKSVPHNYTHGSDS LSKPFIFERHCHEESLEYQIIR-----TLSKEEDHPDLLP-------------------- --------------GTSNVKVCLTPKSHHEREGKTWCVVDPSGSGESSHCSFVEENNNDL VTASQNTKQDELYNNQVPIVLVKKLVLKRGADGKIANECEHLPKFTHSSE-DDDGIKQTD AANAIGRKILINTEERNTTPCSNVLKNADIELNSMSLDIEAIEKNLPSTLAKRLEQGRSN IITSTNSPRMCDSSAGCSLSGAESCDGSEKHVPRVIIKRTGSGTNYKSFLRESSYSTNFW QPVVRIQRNKDLDNLSRSLVKSDCPKKVVHLNRLRLVIRRQSSFEREKVMKNNVHQVAFV TNIDPTSMNEIENVPSVKKREESLEKKEIFTYAVENNAKKNKLTSHKQRNELNTRVHDTE IRYLKHNKPQSYGQLCFVREKERLKCPTIPERNKVRAHNEIKKKHSEINCISQSSQSHSY DGMKDQCNVEKNERKGRRYSECSHNILGYHIAKVSRKRISEGGIDINEKGKNSNAFADNI PYYKKRFAMGSDYEEESTKDSTKDNQTGSKES---------------------------- ------------------------------------------------------------ ------------------------------------------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQVLLN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------- >Tbi M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QSH-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -SQLVGDNNISEP-----------------------------ESETMERGNI-------- ------------------------------------------------------PLFSEE ILNFDSKGALNLKMKKENETSTPDIYFECQPSSVNKDATNISTNGTVSSINTEAIPQEND LTITR--TCSKDTFVIDLPGT--------------------------------------- ------------------------DENKTKESTLHT----------N------------- ------------------------------------------------VTELSLQYEG-- -TE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FVEQSEETHIWPVVVESSMPILDSTQIVIVTEDDEENTGQISIENTT PCHETNAVAVPISPEMPCLEPFTIPENVVAICNESDFEMPILNVSENASLVVSDGNRMPQ LEATMSSIISTAENNDNSSETLPQSGEHERHLEYDAT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FQEKGSKENKECEIKQLKKRSSNSSRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSK-----------------------GEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQRGLSRG----------NNYYYYY YY-------------------------------------------------YYYYYY--- ------------------------------------------------------------ ------------------------------------------------------------ --------YYY------------------------------------------------- ------------------------------- >Tsi M---------GMN----------------------------------------------- ------------------------------------------------------------ ---ECF------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GPIPPLTTQLY LSVREKANPNHPGFVSPAVEQDHVSPIVNSSAKALNTSSA-------------------- ------------------------------------------------------------ -------------------------------------------PMRSSFHGMARYKSHMM NQKVVRLHEAEQKKIQDIARYNEVQRPRYQDASSNKSEENYQDPGRYHDAHRKAHTVQFH DLPKQSSQTLNYSEATNKEFAGHSNDGLAPSSTKLQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DKASSDLEDSSYVDEHNPHIYNRSPFEDGTGRYIKKRRSRLKGISKKSQN L------HSNKNNQTLRQYLANWDEECDDVTTNPKLPDVVPSNNVEPVLVLDYRSLGNDG LSSLQADVGIGRPADSGLIQMTYQEIDDMNTVNKQSLQNIPEECEHID------------ ------------------------------------------------------------ ------------------------VAFQ-------------------------------- ------------------------------------------------------------ ------EQI---------------EEHHSKEEVNSR----------NDI----------- ------------------------------------------------IKEKGIDLKS-- -TNSPVDCS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------IG------------W------------------------------------ ------------------------------------------------------------ ----------------------PYYGKSPMRW----TRIKRKETDYYKS----HLVTTD- ------------------QIIR-----TLAK-EDHPDLLP-------------------- --------------GTSNVKVCLTPKSHHERESKTWSVVDPSGSGESSHWSFVEENNNDL ITASQNAKQDEHYNNQVPIVLVKKLVLKREADGKIGNECEHLPKFAHSSE-DDDEIKKTD AANAKGRKTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LKKRSSNSSRVPETCQVC GSHYKDKAEKIEHVKEHLYHCQQCHIAFNSKKELESNSRQLEESKFKFELKALLGEFVRH RSSRHPRTKEQHHCLLCQRTFPTLQRHQLHLSGHLHRHLETAQRRTIHTLFRLFTGNDCP ALTPLSEEEASGVSWFPAEGGAIHFYHQAPPLQIAVQLHLELPATIMSSATLWSNMV--- -----SPILSLQILNLEFPGFSSLVYCESSTLDHVDTKTRNMFSTSPVSVQYYLYLLRTQ RNATISGSVETWAEVPTTQIYMNPHMMQGRLQDEMHTRGPFLLRWSLQAEFLTSSDDAGS HIGGANSSHQRPGNGRGGGVPKAALTRAHLAGGGSGGLTLKSSSHQEKLFANMLPLFWKQ NTILAETPYSHQMATVTRDTELVLLPQDTRLIELCTNHLHDAMSHESHPHSMLHPISCQR SRHKSPLVTFLFQENEDKDKNAFAGPSHSKR