>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------F--------------- -------------------------------------------------- --------------------QDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHSKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tps M------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxTVxLELSxxxxxxxxxxxxxxxxxxSVELxxxxS---------- -------------------------------------------------- -------------------------------------------------- -----------TEPVMPMIPLGLKETKEIDFREPF--------------- -------------------------------------------------- --------------------KDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHGKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tdi M------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxLELSxxxxxxxxxxxxxxxxxxSVELxxxxS---------- -------------------------------------------------- -------------------------------------------------- -----------TEPVMPMIPLGLKETKEIDFREPF--------------- -------------------------------------------------- --------------------KDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHGKDSVLD HNVILRxxxxxxSxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xGSPHAxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxx----------------------------------- -----x >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxx-------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ----------xTEPVMPMIPLGLKETKEIDFREPF--------------- -------------------------------------------------- --------------------KDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHGKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tsi xxxxxxx----------------------------xxxQLTADGFEKxxx Qxxxxxxxxxxxxxx------xxxxxxxxxxxxxQNKRSKLxxxxxxxxx xxxxxxxxxx-------------------------------------xxx xxxxxxTVxLELSxxxxxxxxxxxxxxxxxxSVELxxxxS---------- -------------------------------------------------- -------------------------------------------------- -----------TEPVMPMIPLGLKETKEIDFREPF--------------- -------------------------------------------------- --------------------KDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRILxxxx xxxxxxxx------------------------------------------ ----------xPTxxxASTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHGKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tms x------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxQNKRSKLxxxxxxxxx xxxxxxxxxx-------------------------------------xxx xxxxxxTVxLELSxxxxxxxxxxxxxxxxxxSVELxxxxx---------- -------------------------------------------------- -----CFVGDKRARTSYHLHTPQRGLWIYREGRKTRVAYERLWRVVKQSH LGSCVxxxxxxTEPVMPMIPLGLKETKEIDFREPFxxxxxxxxxxxxxxx xxxxTRYIASEMILxxxxxxxxxxxxxTxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxRKDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFE------------ -------------------------------------------------- CCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHGKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tbi xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xx------- -------------------------------------------------- -------------------------------------------------- -----------TEPVMPMIxxxxKETKEIDxxxxF--------------- -------------------------------------------------- --------------------KDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARExxxxxxxxxxxxGTITV xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -------------VSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHSKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxARTIxxxxxLG GAQLIKLSEKSPPLCSDNIGLEITPTDNVTSVQARSRSIDHETRPCLIVE FLARVSTFRTWAQYxDAQSRPFPPPPSPETPASRxQARVGLRGxxxSKFx xxxxx--------------------------------------------- ------ >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------F--------------- -------------------------------------------------- --------------------QDFILEHYSEDGSQYEDPIAEFMDTRQ--- --------------------------------------xxxxxxxxxxxA HTSQRQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxYDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKLELQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLL----------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRILxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxWTNPAFKPSVLCTGISEMxxxx xxxxxxxxxxxx----ASTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAHSKDSVLD HNVILR-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tce x-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------QDFILEHYSEDGSQYEDPIAEFMDTRQAMR TPLRDSSGVGLLFQYYNQLYFVERRFFPPDRSLGIYFEW----------- ------------------------------------------YDSLTGVP SCQRTVAFEKACVLFNMGAVYTQIGTKQDRLASKGLDSAVDSFLRASGTF RYILENFTNAPSMDLGPEMLDMLVQLMLAQARE----------------- ----------------------------------CLFEKxxLQSRDRKQD VDVCLDLAQEAAQVSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRExxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxGFxxxxxxxxxxxxxx------------------------- -------------------------------GRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- ----------------PSTKFQLSLTPPDFSQYRVEDLFRALGPVAIFSA KHHWTAPRSIQLQRLGGEGFGFSVRGDAPVIVAGVDQGSLADFGGMKEGD FIVAIGDKDVKWFPHEDVVKLIKLAGDSLSLKLVTPMDKNYLKQPKGGPK GSVSTSSSSSSGVSSGQPSPAGSMAAHSHKKLTWNPFRKTSAH------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxNRIRKEIT KELKVSDPVCVDLYIVQIRCVLTCTRRRxxxxxxVDLYTVQRRGSxxxxx xxALLAGDxxGxxxxDELWLWxxxxxGDLLYIGQEVRRxxxxxxxxxxCG xxxxxxxxxxxxxxxxxxxxxxxxxxxSGYAPTPFxxxxFADxxSLEVIT xxxxxxxFCYxxxxxAFxKYLxxxxxxCLVIIGPGExxxxxxCPTPFNPP LDEMVxRRQSYQELGTTGDFVAVYxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------VSEVYGKVHTLISCQPVKDYVPYSWVCLAQVKREHYT ALSHYHTALGVMGARMGDMSAQTRD------------------------- ------------------------TLQFLHAEDENKTRLEIRVPQDDDER KLLGxxxxxxxVxxxxQSMCxxxxxxxxxxxGRAHLRESLLLHEESQRLH RMCRELRGKAALSGVLKKCHTRALDAYTAAEEEDDFREVLDPPRIL---- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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