>Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------MEHFTLSTVLLVALLLSTGLVRSLP--------------- -----------------------VDTGDDLGTIIFSSV------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LFRHGDRAPTGTYPNDIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTYVRSSNIDRTLASARA HLAGLYPPTERNLAQPNINFQVIPIHTTDMVNDKELYNLSVPEWANSYYP QPLGNLFLLESFIAAAGTEELQRLSTGPLLKEIIANTLAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVMIELRSKADEYFIT---- ------------------------xSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPAAAILPEWEHCFQQPTV KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKNHx >Tdi MA------------------------------------------------ -------------------------------------------------- ------------xxxxIDSSQLTSDxQHL--------xxxxxxxEEVNPN LxxxxxxNHLGTPHPPS--------------------------------- -------------------------------------------------- -------SPDRDSNLDLPVx------------------------------ -------------------------------------------------- ----xxxxQHDKREASLHNISSPGVxxxxxxxxxxxxxxx----xxRxxx xxxxxxxxxxxxxxIFSSVCGKYFTLSTVLLVTLLxxxxxxxSLPVDSGD DLDTIIxxSVCGKYFTLSTGLLVALLLSTGLVRSLPVDSGDDxxxxxxxS V-----IFRHGDRTLLGSYRNDPYNNQTKYWPRGYEQLTEIGEDQHFKQG SFFRKRYNHILPETYNVNDLYVRSSNIDRTLESAQAHLAGLYPPTEQNLA QPNIKFQVIPIHTTDMVNDMxxDKEIPSLWPRVIL--------------- -----------------------------------------HSYV----- -KTESVMYVRKSSVIYDRSSKxKLYGLPLPKWTEPYYPQPLENxxLFEIF ITSFATKExxRLSAGPLLKEIIANTKAKVKGTLSPDRKLYIYSAHDSNIV ALLQGLNVFNGFLVPYASAVMIELRSKADEYFIT---------------- -------------------------------------------------- ----------------VSYKNSTETDPHLLQLPGCDALCPLHSFVELTKP LIPDDLTTECAEEVVSGQEYHFEIPAAxxxxxxxxxxxxxxxxxxxxxxx x--------------------------------------------xxxxx x--------------------------------------------TLSPI TSKTLKSPVVMEHFTLSTVLLVALLLSTGLVRSLP--------------- -----------------------VDTGDDLGTIIFSSV------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LFRHGDRAPTSTYPNGIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTYVRSSNIDRTLASARA HLAGLYPPTEQNLAQPNINFQVIPIHTTDMVNDKKLYNLSIPEWASSYYP QPLGNLFLLESFIAAAGTEELQRLSTGPLLKEIIANTQAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVMIELRSKSDEYFITxxxx xSTKTDPYLLQFSGCDAVCPLYSSVSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPAAAILPEWEHCFQQPTV KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKNHx >Tps xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TLKSPVVMEHFTLSTVLVVALLLSTGFVRSLP--------------- -----------------------VDTGDDLGTIIFSSV------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LFRHGDRAPTGSYPNGIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTYVRSSNIDRTLASARA HLAGLYPPTEQNLAQPNINFQVIPIHTTDMVNDKKLYNLSIPEWASSYYP QPLGNLFLLESFIAAAGTEELQRLSTGPLLKEIIANTQAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVMIELRSKSDEYFITxxxx xSTKTDPYLLPFSGCDAVCPLYSSVSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPAAAILPEWEHCFQQPTV KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKNHx >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxIFRHGDRTIISSYRNDPYNNKTKYWPRGYEQLTENGEDQHFNQG SFFRKRYNHILPETYNVNDLYVRSSIFDRTLASALAHLAGLYPPTEQNLA QPNIKFQVIPIHTTDIVNDK------------------------------ -------------------------------------------------- ----------------------KLYGLPLPKWAEPYYPQPLKNxxLFEIF MTSSATKExxRLSAGPILKEIIANTKAKVKGTLRPDRKLYIYSAHDSNIV SLLQGLKVFNGFLVPYASAVMIELRSKADEYFITxxxxNSTKIDPYLL-- --------------------------QISGCDALCPLxxx---------- ----------------VSYKNSTETDPHLLQLPGCDALCPLHSFVELTKP LIPDDLTTECAEEVVAGQEYHFEIPAAx---------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGExxxxxxxxTLSPI TSKTLKSPVVMEHFTLSTVLVVALLLSTGLVRSLP--------------- -----------------------VDSGDDLGTIIFSSV------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LFRHGDRAPTGAYPNDIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTYVRSSNVDRTLASARA HLAGLYPPTEQNLAQPNINFQVIPIHTTDIANDKELYNLPIPEWVNSYYP QPLRNLFLLESFIAAAGTEELQRLSTGPLLKEIIANTQAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVMIELRSKSDEYFITxxxx xNTETDPY----------------------------LLQLPGCDTLCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPAAAILPEWEHCFQQPTV KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKHHx >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LLRHGDRAPTGAYPNDPYNEEAKYWPRGYG QLTEIGEEQHFKQGSFFRERYNHILSETYNVNDTYVRTSYIDRTLASAQS HLAGLYPPTEQNRAQPNIKFQDIPIHMVDQSNDQELYNLTIPEWAKSYYP QPLRNLYLFEQFITAAGTEELKRLSTGPLLKEIITNTQAKVNGTLSPDRG LYIYSAHDNNVVDLLQGLDVFNGILVPYASAVMIELRNKSDEYFIT---- ------------------------VSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPATAILPEWEHCFQQPTL KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKNxx >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxHEISNTxxxxxxxRxIPSTxH IIRSPNVLRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRExxxxxxxNH xxxTTASSPDGDSNFDLPVxxxxxxxxxxxxxxxANEVGSGIxLDxxxxx xxxxxxxxxGxEKVDIxxxxxxxxxxWxxxxxxGVDFQNRTRHYRSSPWx xFxxx-----------------------------------------RWTL PILRVDTGDDxxxIIxxSV------------------------------- -------------YFTLSTVLVVALLLGTVLVRSLSVDTGDDLGTIIFSS V-----IFRHGDRTILGSYRNDPYNNQTKYWPRGYEQLTEIGEDQHFKQG SFFRKRYNHILPEIYNVNDLYVRSTNIDRALASAQAHLAGLYPPTEQNLA QPNIKFQVIPIHTTAPLNDK--------------xxMPTYSCAKYKTLLT NLKASDEYQCVMNTTATVRSEVAELAGYSTFSPIIYDILFIx-------- ----------------------ELYGLPLPKWTKPYYPQPLENxxLFEKF ITSSAIKKxxRLSAGPILKEIIANTQAKVKGTLSPDRKLYIYSAHDSNVV DLLQGLKVFNGFLVPYASAVLIELRIKADEYFITxxxxNSTELDPYLLGL xRETHKAIIPDDLTTEGxxxxxxxxxx----------------------- ----------------VSYKNSTETDPHLLQLPGCDALCPLDSFVELTKP IIPDDLTTECAEEVVAGQEYHFEIPAA----------------------- xMLPEWEHCFxQPxxxxxxxxxxxMPSEPGxxxxxxxxxxxxxxxPTTLV x--------------------------------------------TLSPI TSRTLKSPIEMEHFTLSTVLVVALLLSTxxxxxxxxxxxxxxxxxxxxSV YFTLSAVLVVALLLSTGLVRSLSVDTGDDLGTIIFSSVxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKFxxxxxxxxxxxxxxxxx xxxxxxxxILRDDVVEDGDELVNGAGSYLVAILVHGVDWDILPEDLVRGF LVQGRVKTSQVALGTHQGPVNVRATDVRVVHVVLQRKQGRVTLSPVVMEY LFISTVLVVALLLINGPVRSLSVDSADxxxTIxxSSVLFRHGDRAPTESY PNDPYKDEAKYWPRGxGQLSYIGEEQHFKQGSFFRKRYNHILSETYNVND TYVRTSYIDRTLASAQSNLAGLYPPTEQNRAQPNIKFQDIPIHMVDQSND QLIWNTDNCAKYTTLLAYLKESDEYLCVMNTTATVQEEVSEFAGYSTFKR IVYDILFIDELYNLPLPEWTKPYYPQPLKNLYLFEEFITAAGTNELQRLS AGPLLKEIISNTQAKLNGTLSPDRGLYIYSAHDNNVVEMLQTLKVFNGIL VPYASAILIELRNKSDEYFITVSYKNSTELDPHLLQLPGCDALCPLDSFV ELTKPIIPDDLTTECAEEVVAGQEYHFEIPAAEAKVGVDKSVLTPTMFYG CDASVYPEKHKRKLFYQNGNTVSSNQLSKMDGFIEFPSLLPLTNNAFVNC SEDNGSSDRHLRTKQHVVAGERFNFFGKGNFEILFLGTMSVKHLMWTLQH HHLASATIEKGHPTQHIVVPSGSYSDRKPDIHNINIAEPTTLVxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSSVY FTLSAVLVVALLLSTGLVRSLPVDTGDDLGTIIFSSVYFTLSAVLVVALL LSTGLVRSLPVDTGDDLGTIIFSSVYFTLSAVLVVALLLSTGLVRSLPVD TGDDLGTIIF---------------------------------------- -----------------xxxLLRHGDRAPTGAYPNDPYNEEAKYWPRGYG QLTEIGEEQHFKQGSFFRERYNHILSETYNVNDTYVRTSYIDRTLASAQS HLAGLYPPTEQNRAQPNIKFQDIPIHMVDQSNDQELYNLTIPEWAKSYYP QPLRNLYLFEQFITAAGTEELKRLSTGPLLKEIITNTQAKVNGTLSPDRG LYIYSAHDNNVVDLLQGLDVFNGILVPYASAVMIELRNKSDEYFIT---- ------------------------VSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPATAILPEWEHCFQQPTL KDGRxxxxxxxxxxxxIGSESKALEHVATEVSPYEKLKPQQxxxxxxxxx xDLExxxxxxxxxxxxxxxxxxRDDGLCQFxxGVQWTQG----------- -------------------------------------------------- -------------------------------------------------- ------------------------VTSRQLQQVRFYHDSRSVRNKYAIED IQSLQQIDDxxxxx------------ >Tce xxx----------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------x-------------------------------------- ------IFRHGDRTILGSYRNDPYNNQTKYWPRGYEQLTEIGEDQHFKQG SFFRKRYNHILPETYNVNDLYVRSSNIDRTLASAQAHLAGLYPPTKQILA QPNIKFQVIPIHTTDLLNDK------------------------------ --------------------------------------------xxxxxx xx------------------------------------------------ --------------GPILKEIIANTKAKVKGTLNPDRKLYIYSAHDSNIV DLLQGLKVFNGILVPYASAVLIELRSKADD-------------------- ------------------------xxx----------------------- ----------------VSYKNSTETDPYLLQLPGCDALCPLDSFVELTKP LIPEDHTTECAEEVVAGQEYHFEIPAAx---------------------- -IxxxWEHCxxxxxxxx---------------------------xxxxxx F--------------------------------------------TLSPI TSRTLKSTVVMEHVTLSTVLLVALLLSTGLVRSLP--------------- -----------------------VDTGDDLGTIIFSSV------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LFRHGDRAPTGTYPNDIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTYVRSSNIDRTLASARA HLAGLYPPTERNLAQPNINFQVIPIHTTDMVNDKELYNLSVPEWANSYYP QPLGNLFLLESFIAYAGTEELQRLSTGPLLKEIIANTQAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVMIELRSKADEYFIT---- ------------------------VSYKNSTELDPHLLQLPGCDALCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYHFEIPAA--------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxPGELGRxxxVPIINDILGGSITLELANxxxxxxxxxxxx YPGVYDTNRTHVAQQGLACLDxxGSKxxxxxxxILSCSGFLQVTSLISQP LxxxxxQVSNxxxxxxGVPPWFNPV------------------------- -------------------------- >Tsi Mx------------------------------------------------ -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxRxxxxxEKVDIxxxxxxxxxxx----------------------- ---------------------------------------xxxxxxxRWNP P------------------------------------------------- ---------------------------------xxxxxxxxxxxxxIFxN V-----IFRHGDRTIISSYRNDPYNNKTKYWPRGYEQLTEIGEDQHFKQG SFFRKRYNHILPETYNVNDLYVRSSNIDRTLASAQAHLAGLYPPTEQNLA QPNINFQVIPIHTTDIVNDK------------------------------ --------------------------------------------xxxxxx xx------------------------------------------------ --------------GPILKEIIANTKAKVKGTLSPDRKLYIYSAHDSNIV SLLQGLKVFNGFLVPYASAVMIELRSKADEYFITxxxxNSTKIDPYLL-- --------------------------QISGxxxxxxxxxFVELTKTIIPD DLIPEGxxxxxxxxxxVSYKNSTETDPHLLQLPGCDALCPLHSFVELTKP LIPDDLTTECAEEVVAGQEYHFEIPAA----------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxLxxxTxxxxxxx--------------- -----------------------xxxxDDLxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxGTRKVEFKGLGKFAWRENGKPFRENHPQYIRLESNSDIH VIDSPVYLESDALKHVAxxxLFRHGDRAPTGAYPNDIYNDEAKYWPRGYG QLSEIGEEQHFKQGSFFRKRYNHILPETYNVNDTY--------------- ----------------------------------ELYNLPIPEWVNSYYP QPLRNLFLLESFIAAAGTEELQRLSTGPLLKEIITNTQAKVNGTLSPDRG LYIYSAHDSNVVDLLQGLDVFNGILVPYASAVLIELRSKSDEYFIT---- ------------------------xSYKNNTETDPYLLQLPGCDTLCPLD SFVELTKPIIPDDLTTECAEEVVAGQEYLFEIPAAAILPEWEHCFQQPTV KDGR---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------FHRISFTTKHHx