>Tms M------------------------------------------------- --------------------------I-----------GTVHKSHEQxxx ---------------------------------------WMKEFLWTGYK RDLEQSDLYEPLKIxLSENLGDDLER------------------------ -------------------------------------------------- ------VWEEEQSRALQKGKSPSLLRAIFVTFWKQYIFSxxxxxxxxxxx RVAQPLLLGKVIEYFTPNSTMAIEEAYMYGAGMIVNVYLMVIMDHHYN-- -------------------------------------------------- -LSAAAVGMRIRIACCSLIYRKVLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYFLWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSDLREKIAV------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxSEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LLAYVLLGNTTSSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ------------------------------------------------ -------------------------------------------------- -------------------------EFLMQGEITPRKAIPSTVTQNGMKS CSLGVTIKNGCAKWSPSDSQPTLSDVCFHVKPGALCAIIGPVGSGKFFSR QKRSLFxQDPGLFFQSSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKKYQEVVRVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLAR--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------x >Tce x------------------------------------------------- --------------------------xxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LLAYVLLGNTTSSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ------------------------------------------------ -------------------------------------------------- -------------------------EFLMQGEITPRKAIPSTVTQNGMKS CSLGVTIKNGCAKWSPSDSQPTLSDVCFHVKPGALCAIIGPVGSG----- ------xQDPCLFFQSSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKKYQEVVRVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLAR--------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tbi xx------------------------------------------------ ---------------xxxxxxxxxxxx----------------------x -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---QPLLLGKVIEYFTPNSTMTIEEAYMYGAGMIVNVYLMVIMVHHYN-- -------------------------------------------------- -LSAAAVGMRIRIACCSLIYRKVLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYFFWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSDLREKIAV------------------------------------- -----------x-----------xxxxxxxxxxxxxxxxxxxxSAWxxxx xxxxxxxxG----------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LIAYVLLGNTISSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------EFLMQEEITPRKAIPSTVTQNGMKS CSLGVTIKNGCAKWSPSDSQPTLSDICLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLLVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVRVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLAR--------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tte x------------------------------------------------- -------------------------------------------------x xxxxxxxxxKPREDCIGLVRNYSDKSTLGLGQTAPSxxxWMKEFLWTGYK RDLEQSDLYEPQKIxLSENLGDELER------------------------ -------------------------------------------------- -------------------------------------------------- -IAQPLLLGKVIEYFTPNSTMTIEEAYMYGAGMIVNVYLMVIMVHHYN-- -------------------------------------------------- -LSAAAVGMRIRIACCSLIYRKVLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYFFWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSDLREKIAV------------------------------------- -----------x-----------xxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxG----------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LIAYVLLGNTISSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------EFLMQEEITPRKAIPSTVTQNGMKS CSLGVTIKNGCAKWSPSDSQPTLSDICLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLLVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVRVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLARAVYRxxxxYILDxPLSAVDTHVGKHLFDECIGTYLATKT RILVTHQLQxxxxAxxxxILNE---------------------------- -------------------------------------------------- -------------------------------------------xxxL--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tsi x------------------------------------------------- --------------------------x----------------------- ------x--------------------------------WMKEFLWTGYK RDLEQSDLYEPLKIxLSEKLGDDLESTVSYYPFVFYALSTNYANxxxIGM VELEEVSPHLxxGKVENHLGKTTPSSPDRDSNLDLPVRSSRAQHDYSVSQ LRHRGGVWEEEQSRALQKGKSPSLLRAIFVTFWKQYIFxxxxxxxxxxxx RVAQPLLLGKVIEYFTPNSTMTIEEAYMYGAGMIVNVYLMVIMDHHYN-- -------------------------------------------------- -LSAAAVGMRIRIACCSLIYRKVLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYFLWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSNLREKIAV------------------------------------- -----------xxxxxxxxxxxxx-------------------------- --------G----------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LLAYVLLGNIISSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ--------------------------------RVALCxxxVLCPLEFV TESIxxKRYELAxxISLREN------------------------------ -------------------------EFLMQEEITPRKAIPSTVTQNGTKS CSLGVTIKNGYAKWSSSDSQPTLSDVCLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVKVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLARAVYRxxxxxxMDxPLSAVDTHVGKHLFDECIGTYLATKT RILVTHQLQxxxxxxxxxILNExxxxIDxxxxKVPSSxTLTCLPIDLNTL PIFQDLILTTRK-------------------------------------- -------------------------------------PFFSPLVTHL--- -------------------------------------------------- -LQSSDHSPVTCDPQFLLLPVESPPDFNYHHVNSPGFHARLVYVVLSAPS IRY----------------------------------------------- -------------MRCGSDTGHKLYGSGLTSIEPGRSKESSTPTVGSYFG GGEIGASLEVNPFLSDHQFSFQKDLSMIHAVAKVVDLVTGAFNARAPMGF MVLDVKGALDSTNHRGLLTPLIRASFALPIIHLLFSFLGDRSFRFADDTA ILAQSPEASMVWAKLTFTLRGLSAYIQSPSLTIQSQKMQSKLSTRWIMGP LRIHGVSERYFSWVLASSNQIIRVIGDYDYPAHPYCRIRDGVVNPFVDGV VVNKGTFEEVLKSGLDFAKLLPSANEDEPEEDPPLIRKLRSRQSSTITVN SIQDDADVLDPEESEEFQTKGAVKWVTYWRYTRAGGNICFLSFVFFMLCF SQVTTNAVDFWLTFWYVADNTPEHDPQT >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------MTIEEAYMYGAGMILNVYLMVIMDHHYNxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxPDCLLFxxxxxxxxxxxxxxxx x--------------------KVLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYFLWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSNLREKIAV------------------------------------- -----------xxxxxxxxxxxxx-------------------------- --------G----------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LLAYVLLGNIISSDKVYSMAQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ--------------------------------RVALCxxxxxCPLEFV TESIxxKRYELAxxISLREN------------------------------ -------------------------EFLMQEEITPRKAIPSTVTQNGTKS CSLGVTIKNGYAKWSSSDSQPTLSDVCLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVKVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLARAVYRxxxxxxMDxPLSAVDTHVGKHLFDECIGTYLATKT RILVTHQLQxxxxxxxxxILN----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tps xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQExxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------VLKLSMVSSGKTTTGWLVNLLSNDVNRF DMVTLFLHFIWIAPLQVLLVTYCLWQYVGVAAFIGVAFIFLQTIPVQSYM SKLTSNLREKIAVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- --------G----------------------------------------- -------------------SEIDLVRSTSYLRGVYMSFMVFTERTSLFVT LLAYVLLGNIISSDKVYSMSQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ--------------------------------RVALCxxxxxCPLEFV TESIVxKRYELAWxFSLRENxASxxxxxxxxxxxxxxxxxPSHLVEWxxx xxxCIVICVGLGKGAFxxxxxxxxxEFLMQEEITPRKAIPSTFTQNGMKS CSLGVTIKNGCAKWSSLDSQPTLSDICLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVKVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLARAVYRxxxxYIMDxPLSAVDTHVGKHLFDECIGTYLATKT RILVTHQLQxxxxAxxxxILNE---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MSFMVFTERTSLFVT LLAYVLLGNIISSDKVYSMSQFYNVLNLSLAIFYPMALSTGAEAMVSVDR IQ--------------------------------RVALCxxxxxCPLEFV TESIVxKRYELAWxFSLRENxASxxxxxxxxxxxxxxxxxPSHLVEWxxx xxxCIVICVGLGKGAFxxxxxxxxxEFLMQEEITPRKAIPSTFTQNGMKS CSLGVTIKNGCAKWSSLDSQPTLSDVCLHVKPGALCAIIGPVGSGK---- ---------------SSLLQAVLGELPLETGSLQVDSDISYASQEPWLFV GSVRQNILFGQPYEKKRYQEVVKVCALERDLQLFPYGDKTIVGERGVSLS GGQRARINLARAVYRxxxxYIMDxPLSAVDTHVGKHLFDECIGTYLATKT RILVTHQLQxxxxAxxxxILNE---------------------------- -----------xxxxxxxxxxxxLCWKVTTMIGTHLGDMLHLHxxxxxxx xRxxxxxxxxxxxxxxxxxxxxxxxSYFPRPHFDHEEPFFSPLVTHLS-- -------------------------------------------------- --QSSNHSPVTCDPQFLLLPVESPPDFNYHHVDSPGFHARLVYVVLSAPY IHYVKELDHHARLFASSLLSAFVLLLQIIHAILTLLYFPKQWKAAFVVHI YKVAERINLARLGLR----------------------------------- ------------------WSFQKDLSMIHAVAKVVDLVTGAFNARAPMGF MVLDVKGAFDSTNHRGLLTPLIRESFALPIIHLLFSFLCDRSFRFADDTA ILAQSPEASMVWAKLTFTPRGLSAYIQSPSLTIQSQKMQAKLFTRWRMGP LRIHGVVERSFSWVIASSNQIIRGIGDNDDPAHPYCRIRDGVVNPFVDGV VVNKGTFEEVLKSGLDFAKLLPSANEDEPEEDPPLIRKLHSRQISTITVN SIQDDVDVLDPEESEEFQTKGAVKWVTYWRYTRAGGNICFLSFVFFMLCF SQVTTNAVDFWLSFWY------------