>Tge xx------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxTADYPSQQLNDHYDSRDSRDSRDNRRGGN YNRxxxxxxxxTLLSCxxxTNPDAQxxxxxxLVLTDSSQLTALKSYQTKL CIPTPNHMICINTCLAAVTSDSQNLxxxxxxxxxxxxVNCxxxxxxxxxx xxxxxxxxxxxxxxxxxxxAIAAGAMMVVSTPTVLIxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- ----------------------GGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAK--------------------- -------------------------------------------------- ----------------------------GFGRRKQYPLGLVLAPTRE--- --------------------YGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQ---------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP-----------------------CM----------- -------------------------------------------------- ----------------xxxxxxxxxxxxx--------------------- ------------------TQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKRFx------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxx------------------- -------------------------------------------------- - >Tsi xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- ------PFADLDLQSERQQSGGRYVPPHLRNKAASTQAAP---------- ----------------------ADYPSQQLNDHYDSRDSRDSRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSR----GGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAS---xxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- --------------------YGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQ---------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP-----------------------CLxxxVVGTxxxx xxxVQIFVxxVKTMIVHSLPEKTCRILYSTCAATGATAGVCTFGxxxxxx xxxxxxxxxxxxxxxxxxxxx----------------------------- ------------------AQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKR--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- - >Tps -------------------------------------------------- -----------------x-------------------------xxxxxxx xxxxxxQFADLDLQSERQQSGGRYVPPHLRNKAASTQAAPVLCDx----- ---------xxxxxxxxRFAVTADYPSQQLNDHYDSRDSRDSRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSR----GGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAS--------------------- -------------------------------------------------- ----------------------------GFGRRKQYPLGLVLAPTRE--- --------------------YGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQ---------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------SQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKR--------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx-----xxx------------------- -------------------------------------------------- - >Tbi -------------------------------------------------- -----------------x-------------------------xxxxxxx xxxxxxQFADLDLQSERQQSGGRYVPPHLRNKAASTQAAP---------- ----------------------ADYPSQQLNDHYDSRDSRDNRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSRxxGGGGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAK--------------------- -------------------------------------------------- ----------------------------GFGRRKQYPLGLVLAPTRELAT QIFDESRKFSYRSRLRPCVVYGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQGLPSVGFAGAASVDHPVMTRTTLFDNQQTPDSALRDPMVQ SLSHVNVKSAxMLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP-----------------------C------------ -------------------------------------------------- --------------------xx------xVLKSDxxxxxxxxxxxxxxxx xxNISPYPDMLxxxxxxxAQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKRY-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx x >Tte -------------------------------------------------- -----------------x-------------------------xxxxxxx xxxxxxQFADLDLQSERQQSGGRYVPPHLRNKAASTQAAP---------- ----------------------ADYPSQQLNDHYDSRDSRDNRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSRxxGGGGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAK--------------------- -------------------------------------------------- ----------------------------GFGRRKQYPLGLVLAPTRELAT QIFDESRKFSYRSRLRPCVVYGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQGLPSVGFAGAASVDHPVMTRTTLFDNQQTPDSALRDPMVQ SLSHVNVKSAxMLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDPxxxxxKPAASHxxxxxIIWxxxx------------- -------------------------------------------------- -----------------------------xLKxxxxxxxxxxxxxxxxxx xxNISPNPDMLITSTSxxAQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKRYL---------------xGSVAALVLE TTASKVVVEVVAVALLEV-------------------------------- -------------------------------------xxxxxxxxExEEG DTAVVDTQAVDIMAA---------------VGVVxxxxALTxxGAEVAQT GGAAVxxxxxxxxxSTFxRSGNEDPCGCRQKQ------------------ - >Tdi x------------xxxxxxxDxxxxxx----------------------- --------xxxxxxxxx--------------------------------- ------QFADLDLQSERQQSGGRYVPPHLRNKAASTQAAP---------- ----------------------ADYPSQQLNDHYDSRDSRDSRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSR----GGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQAS--------------------- -------------------------------------------------- ----------------------------GFGRRKQYPLGLVLAPTRELAT QIFDESRKFSYRSRLRPCVVYGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQ---------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------SQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKSVIxxxxxxxxH----QxAGSVAALVLE TTASKVVVEVVVVALLEVx-xVQxDMx-EVVAEEVDTAVVDTRAEDIMAA VGEGVVAMVALITVGAEVAQTGGAAVRPxxxxxPxxxx------------ -------------------------------------------------- -------------------------------------------------- - >Tcm -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------FADLDLQSERQQSGGRYVPPHLRNKAASTQAAP---------- -------------ANDGxxxxTADYPSQQLNDHYDSRDSRDSRDNRRGGN YNR----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------GGQSRGGDYGGGGGYRSWRNDGGQYANGSDQGGNYRS GGNRDRDRDRDGGDWGSR----GGSRWQDRGNEPPPTRNDRWQEPPPGSR GGGGGRSSDVDWTIPTARDERQEFELFGTGNTGINFNKYEDIPVEATGDN IPTHITTFDDIQMTEIISNNIALARYDKPTPVQKYAIPIIMGRRDVMACA QTGSGKTAAFLVPILNQMYEGGPQQLQASHHVN---------------RP LLIWGVRPSDPQLTPSVLSQLWLYYLFLSLPRSLSLPRHLPPSFPPSLSS ALNSGDQYEIGVTDPRTQIIVNVWVFFxGFGRRKQYPLGLVLAPTRELAT QIFDESRKFSYRSRLRPCVVYGGANVGDQMRELDRGCHLLVATPGRLVDM LERGKIGLENCRYLVLDEADRMLDMGFEPQIRRIVQQDTMPKTGERQTLM FSATFPKEIQ---------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP-----------------------CLxxLVVGTIMxx xxx----------------------------------------------- ----xxxxxxxxxxxxxxxxx----------------------------- ------------------AQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKR--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- - >Tpa xxxxx--------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------MLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRS FLLDLLNAAGLNDP------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------SQESLTLVFVETKKGADSLEEFLHHEGYPVTS IHGDRSQREREDALKRFRGGQTPILVATAVAARGLDIPHVKHVINFDLPS DVEEYVHRIGRTGRMGNLGLATSFFNDKNRNLVRDLVELLVETKQELPPW LDSMAADQRMPQNNRRGGGANKRY---------xxxKISVAGSVAALVLE TTASxxxxEVVAVALLEVxxAVQxDMxxEVVAEEGDTAVVDTQAVDIMAA VGV-VVAMVALTTVGAEAAQTGGAAVRPTPQPGPATLx------------ -------------------------------------------------- -------------------------------------------------- -