>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLELKEVKTIPDIIQVYPNHVKNFSTPLIIDNGSYNC RAGWGINKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPVIITEAFLNPNYSRH -----------------------LMSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAExxxxxxxxxKDSKWFACTLYHRRTCSLLQSLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNSGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVEESKVKQIKQGLRPKEQEDFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRNDPEFE GSTLGRASSSADTAETYQLHVGIERIRAPEILFQPSMVQIMxxxxxx--- -----------------------xxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxx--- -------------------------------------------------- ----------------------xxxxxxxxxx------------------ -QVGSPEAGLAETIEYVLKGYSVDVQSLLVSNIFLTGGCASMPGLVPRLD KELREMRPFESQFHLTVAADPVLDAWHGAQELIASVSLSRCFVTRAEYEE KGGEFFKEHSASNHYFPSPVPLVQAEIVPAPACVEEVEIDV--------- -------------------------------------------------- -------------------------------------------------- ----------------F >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAExxxxxxxxxKDSKWFACTLYHRRTCSLLQSLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNSGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVE---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------- >Tte M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLELKEVKTIPDIIQVYPNHVKNFSTPLIIDNGSYNC RAGWGINKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPVIITEAFLNPNYSRH -----------------------LMSELLFECYKIPSLCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-------------WFACTLYHRRTCSLLQSLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNSGLTIEQQKE RRKELARRLTEINARKxxxxxxxxxxxxxxxx----------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVEESKVKQIKQGLRPKEQEDFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRNDPEFE GSALGRASSSADTAETYQLHVGIERIRAPEILFQPSMVQIVxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------- >Tsi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLEMKEVKTIPDVIHVYPNHVKNFSTPLIIDNGSYNC RAGWGVNKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPVIITEAFLNPNYSRH -----------------------LMSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNGGDLQKMISSIQARIERTRQKIVAANTADD PIAEESKVKQIKQGLRPKEQEEFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSMVQIVxx--xxxxx xxxxxxxxxxxxxx-----xxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------- >Tps M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLEMKEVKTIPDVIHVYPNHVKNFSTPLIIDNGSYNC RAGWGVNKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPIIITEAFLNPNYSRH -----------------------LMSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REERxxxxxx-------- NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIAEESKVKQIKQGLRPKEQEEFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKxLELEEVLxRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSMVQIVxx--xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------- >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQQWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- -------------------------------------------------- -------EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVEESKVKQIKQGLRPKEQEEFESWIEGLKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSMVQIVxx--xxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xQVGSPEAGLAETIEFVLKGYSVDVQSLLVSNIFLTGGCASMPGLVPRLE KELREMRPFESQFHLTLAADPVLDAWHGAQELIASMSLSRCFVTRAEYEE KGGEFFKEHSASNHYFPSPVPLVQAEIVPAPACVEEVEIDV--------- -------------------------------------------------- -------------------------------------------------- ----------------F >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLEMxxxKTIPDVIHVYPNHVKNSSTPLIIDNGSYNC RAGWGVNKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPVIITEAFLNPNYSRH CMYEWVLMKKPPNxxxxxxxxxxMMSELLFECYKIPSVCYGVDSLFSFHH NNPERSSGLVVDLGYHATHVLPVIEGRVDPNRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-------------WFACTLYHSRTRSLLQSLV HEQCFLAVDYQAELQQWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEExx----xxxxxxxxxxxxxxxxxExLQLxxxxxx xxxxxxxKxxEFQxxxxxxxxxxxxxxxxxxxxxxQDGEQLNQLLAVQDx xxxxxxxEFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVEESKVKQIKQGLRPKEQEEFESWIEGLKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSMVQIVxx--xxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xQVGSPEAGLAETIEFVLKGYSVDVQSLLVSNIFLTGGCASMPGLVPRLE KELREMRPFESQFHLTLAADPVLDAWHGAQELIASMSLSRCFVTRAEYEE KGGEFFKEHSASNHYFPSPVPLVQAEIVPAPACVEEVEIDV--------- -------------------------------------------------- -------------------------------------------------- ----------------F >Tdi MxxxxxxxxxxxxxxxHxxxxxxxxTVTRGERKxxxxxRKRKKSQGTPQE QQHSRLxxxxxxRSRPFQLLGDAARTCVRFIMLVSLPYSSGCxxxxxxxx xG---------------------KLFREHHPSSTExxxxxxxxxxxxxxx xxxxxxxxxxxxx--------------------------------GSYNC RAGWGVNKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTE--------------------- -----------------------VMSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEE---------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxx--EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIAEESKVKQIKQGLRPKEQEEFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSMVQIVxx--xxxxx -------------------------------xxxxxxxxxxGTSPVDKLx xxxxxxxxxLGSWFxxxxxxxxxICxxxxxxVSxxxLPFHIMSxxxxxxx xxxxQxxxxxxxxxxxxxxxxxxxxxxxxxTPxxxxxxxxxxxxxxxxxx xxxxxxxxRxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- --VGSPEAGLAETIEFVLKGYSVDVQSLLVSNIFLTGGCASIPGLVPRLD KELREMRPFESQFHLTLAADPVLDAWHGAQELISSSSLSRCFVTRAEYEE KGGEFFKEHAASNHYFPSPVPL-QAEIVPAPACVEEVEIDVxSQECQLRP LGHQYILQVSERVVGNQVDGGHVSGKHIIRIRMGHEEHMFYSVLVVGTEV EHGRRPQKAPSDETGGPDRATGRCGPSARELRVESVDEVVVLQTTVLHVM TQPIPKCWDLLQFLRGI >Tcm M------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------VMSELLFECYKIPSVCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGGAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNPGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEExx----xxxxxxxxxxxxxxxxxx---------- ---------xxx-------QILAAQDLLDEGxxx---------------- ----x--EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIAEESKVKQIKQGLRPKEQEEFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKE----- -----------------------CGDSDSDEEQKLLELEEVLRRHDPEFE GSALGRASSSADTAETYQLHVGIERIRTPEILFQPSM------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDS xxxTHMxxxxxxxxExxxxxxxx--------------------------- --VGSPEAGLAETIEFVLKGYSVDVQALLVSNIFLTGGCASIPGLVPRLD KELREMRPFESQFHLTLAADPVLDAWHGAQELIASSSLSRCFVTRAEYEE KGGEFFKEHSASNHYFPSPVPL-QAEIVPAPACVEEVEIDV--------- -------------------------------------------------- -------------------------------------------------- ----------------F >Tbi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------TTLELKEVKTIPDIIQVYPNHVKNFSTPLIIDNGSYNC RAGWGINKDPSLIFKNLIAKPRKERGKKDGDLQVGNDITNIEAVRFQLKS QFDRNVVTHFEAQEHVLDYIFTHLGVDTEGCVNHPVIITEAFLNPNYSRH -----------------------LMSELLFECYKIPSLCYGVDSLFSFHH NNPEGSSGLVVDLGYHATHVLPVIEGRVDPSRSRRINVGAAHIINYLHRL LQLKYPAHFNSITLSRAE-----------------------------SLV HEQCFLAVDYQAELQHWSDSEHYESHVRRIQLPYTMPVVNSGLTIEQQKE RRKELARRLTEINARK----------------REER------LAEDEEQL NQLLAAQDLLDEGEEExxxxxxxxxxxxxxxxxxxxxxx----------- ---------EEFQDEExLNQLLAAQDLxxxx--x---------------- ----x--EFQNVLESYELSNVGDLQKMISSIQARIERTRQKIVAANTADD PIVEESKVKQIKQGLRPKEQEDFESWIEGVKQKRQELLDRRNARRQRRQD MAKRRTAAAQERMRIISQLARKEKRDDNFGMRDEDWDVYKVINKExxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------RNDPEFE GSALGRASSSADTAETYQLHVGIERIRAPEILFQPSM------------- -------------xxxxxxx---xxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxx--- -------------------------------------------------- ----------------------xxxxxxxxKx------------------ -QVGSPEAGLAETIEYVLKGFSVDVQSLLVSNIFLTGGCASMPGLVPRLD KELREMRPFESQFHLTMAADPVLDAWHGAQELIASGSLSRCFVTRAEYEE KGGEFFKEHSASNHYFPSPVPLVQAEIVPAPACVEEVEIDV--------- -------------------------------------------------- -------------------------------------------------- ----------------F