>Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxAG-------------------- ----------TSPVMSFLSTYARQLGFSSIIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFVVQFVPEITTESQVSLDCDGLTIF KICGQDSLDQCSDDTLSTQIGLKTIVKCE--------------------- ----------------------FNCDLRNSSLAEEVCKTWNITKYCRNNE EFFPSTSSDQQEWDSSDFTLHEMGDEFSETLTFTADVPMEHVLWE----- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xx------------------------xSTAKCDVKCDSEAVNEVITRTTT DDSDVSSLYQFWTFFLLLILSWVGMAVVVSVGDAICFGMLGDKPSQYGRQ RLWGAVGWGIFSVLSGALVDKFSQGQVKKNYTSIFYLMLVMISLDFGVSL KLKHSQTTLSTSIMHDICKLLKNVRVVVFMLWCVAVGLSTGLLWQFLFWH LEDLASANEGCEMRAWIKTLQGLVSGVQCFGGELPFLFIS------G--- ------------------------------------------------AV LKKIGHAHAMSLVLGAFGIRFLLYSFLYNPWWCLPIELLQGVTFG----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxAG-------------------- ----------TSPVMSFLSTYARQLGFSSIIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFMVQFVPEIATESQVSLDCDGLTIF KICGQDSLDQCSDDTLSAQIGLKTIVKCE--------------------- ----------------------FNCDLRNSSLAEEVCKTWNITKYCRNNE EFFPSTSSVQQVWDSSDFTLHEMGDEFSETLTFTADVPMEHVLW------ -------------------------------------------------- -------------------------------CDVKCDNEAVNEVITRTTT DDSDVSSLYQFWTFFLLLILSWVGMAVVVSVGDAICFGMLGDKPSQYGRQ RLWGAVGWGIFSVLSGALVDKFSQGQVKKNYTSIFYLMLVMISLDFGVSL KLKHSQTTLSTSIMHDICKLLKNVRVVVFMLWCVAVGLSTGLLWQFLFWH LEDLASANEGCEMRAWIKTLQGLVSGVQCFGGELPFLFIS------G--- ------------------------------------------------AV LKKIGHAHAMSLVLGAFGIRFLLYSFLYNPWWCLPIELLQGVTFGLFYAT MASYASIVAPPGTEATVQGLVGAIFEGVGVSLGSLIGGTLYDQQGGSFTF RMFGIGSLVLCLLHFIIQRLLGKSLNYAIKAK------------------ -------xxxxxxxxxxxxxxxxxxxx----------------------- ---x >Tdi xxRYREWDLSCKLYVGNLGSSASKHxxxxAFTKYGPLRNVWVARNPPGFA FVEFEDPRDAEDAVRGLDGTRLCGTRVRVEMSSGRSRRGGGGGGGGGGRR NSGPTSHPRHLLLLRVxxxGHLTTTNQPQQNKSALLYAAxxxxxVLR--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xI xxxxxxxxQTLPHQVSxxxxxxxxxxxxxxxxT----------------- -------------------------------------------------- -------------------------------------xxxFNTTSALAxx xxx-------------------------AG-------------------- ----------TSPVMSFLSTYARQLGFSSIIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFMVQFVPEIATESQVSLDCDGLTIF KICGQDSLDQCSDDTLSAQIGLKTIVKCE--------------------- ----------------------FNCDLRNSSLAEEVCKTWNITKYCRNNE EFFPSTSSVQQVWDSSDFTLHKMGDEFSETLTFTADVPMEHVLW------ -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxFSTAKCDVKCDNEAVNEVITRTTT DDSDVSSLYQFWTFFLLLILSWVGMAVVVSVGDAICFGMLGDKPSQYGRQ RLWGAVGWGIFSVLSGALVDKFSQGQVKKNYTSIFYLMLVMISLDFGVSL KLKHSQTTLSTSIMHDICKLLKNVQVVVFMLWCVAVGLSTGLLWQFLFWH LEDLASANEGCEMRAWIKTLQGLVSGVQCFGGELPFLFIS------G--- ------------------------------------------------AV LKKIGHAHAMSLVLGAFGIRFLLYSFLYNPWWCLPIELLQGVTFGLFYAT MASYASIVAPPGTEATVQGLVGAIFEGVGVSLGSLIGGTLYDQQGGSFTF RMFGIGSLVLCLLHFIIQRLLGKSLNYAIKAKDFDMSARYAAPTDAxHML EDQQELVTT----------------------------------------- ---- >Tcm xxRHREWDLSCKVYVxNLGSSASKHxxxxAFSKYGPLKNVWVARNPPGFA FVEFEDPRDAEDAVRGLDGTRLCGxRVQVEMSSGRSRRGGGG-------- ----------------------------------------------Rxxx xxxxxxVLRVSCIVDDKVRGKGxxxxxxxLSHGVTTICRAHSTxxxPLxx xxxxxxFMxxxxxxxDALVPDLVPxxVQLGALVQIPxxxxxxxxxxxxxx xxWDxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------LRNV WVARxPPGFAFVEFExxxxAEDAGAAAVVVVVVEEEAVVVGTLDxxxxxx LLLNHHQPPSTxxxTSCxxxxxxxxxxxxxxxxxxxxxxxxxxxxYFAxI xxxxxxxxQTLPHQVSxxxxxxxxxxLRFQGQTL---------------- ---------------------------------------------ANALV VLSSTAEDGEIEVRISVGKNHxxxxxxxxxxxxPRPxxxxFNTTSTLAxx xxx-------------------------AG-------------------- ----------TSPVMSFLSTYARQLGFSSIIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFVVQFVPEIATESQVSLDCDGLTIF KICGQDSLDQCSDDTLSAQIGLKTIVKCExxxxxxxxxxxxxxxSPSSAV xxxxxxxxxxxxxxAGSRLYxCFNCDLRNSSLAEEVCKTWNITKYCRNNE EFFPSTSSDQQEWDSSDFTLHEMGDEFSETLTFTADVPMEHVLWxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- ----------------------------TAKCDVKCDSEAVNEVITRTTT DDSDVSSLYQFWTFFLLLILSWVGMAVVVSVGDAICFGMLGDKPSQYGRQ RLWGAVGWGIFSVLSGALVDKFSQGQVKKNYTSIFYLMLVMISLDFGVSL KLKHSQTTLSTSIMHDICKLLKNVRVVVFMLWCVAVGLSTGLLWQFLFWH LEDLASANEGCEMRAWIKTLQGLVSGVQCFGGELPFLFIS------GSLR xxMNNHRFDTNHKDPDKPVPIxxGTHNQDFQTCYTTKILRAFPNQxxRAV LKKIGHAHAMSLVLGAFGIRFLLYSFLYNPWWCLPIELLQGVTFGLFYAT MASYASIVAPPGTEATVQGLVGAIFEGVGVSLGSLIGGTLYDQQGGSFTF RMFGIGSLVLCLLHFILQRLLGKSLNYAIKAKDFDMSARYAAPTDAxHML EDQQELVTT----------------------------------------- ---- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxx-------------------------xxxxxxxxxxxxNCxxxxxxxx xxxxxxxxxxTSPVMSFLSTYARQLGFSSLIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFMVQFVPEIPTESQVSLDCDGLTIF KTCGQDSLDQCSDDTLSAQIGLKTIVKCE--------------------- ----------------------FNCDLRNSSLVEEVCKTWNITKYCRNNE EFFPSPSSVRQDWDSSDFTLHEMDDEFSETLTFTADVPMEHVLWE----- ----------------------------SSCLNFRINHTYFGxHTxxxxC NK------------------------LSTAKCDVKCDSEAVNEVLTRTTT DDSEVSSLYQFWTFFLLLILSWVGMAVVVSVGDAICFGMLGDKPSQYGRQ RLWGAVGWGIFSVLSGALVDRFSQGQVKKNYTSIFYLMLVMISLDFGVSL KLKHSQTTLSTSIMHDIWKLLKNVRVVVFMLWCVAVGLSTGLLWQFLFWH LEDLASANEGCEMRAWIKTLQGLVSGVQCFGGELPFLFISGESKHPG--- ------------------------------------------------AV LKRIGHAHAMSLVLGAFGIRFLLYSFLYNPWWCLPIELLQGVTFGLFYAT MASYASIVAPPGTEATVQGLVGAIFEGVGVSLGSLIGGTLYDQQGGSFTF RMFGIGSLVLCLLHFIIQRLLGKSLNYVIKAKDFDMSARYAAPTxAxHML EDQQELVTT----------------------------------------- ---- >Tte xxx----------------------------------------------- -------------------------------------------------- -------------------GHLTTTNQPQQNKSALLYAAxxxxxVLR--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xI xxxxxxxxQTLxxxxxxxxxxxxxxxLRFQRQTxxxxVFWPTTLSTRCLx xxxxxxxxxxxxxNCxxxxNxxxxxxxxxxxxLHxxxxxxxxxxxx---- -------------------------------------xxxxNTTSALAxx xxx-------------------------AG-------------------- ----------TSPVMSFLSTYARQLGFSSLIVGTIFTVLPVCGMLAKPIF GAVADHFRLQKTLFVAFQVLTALAFFMVQFVPEIPTESQVSLDCDGLTIF KTCGQDSLDQCSDDTLSAQIGLKTIVKCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------GKNP------ -----------------------------------------------VSM KLQGSx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxx-----------------xxxxxxxxxxxxxxxxxxxxxxxx xxxx