>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------x------ -------xxxxxxxxxxxxxxxxxxxxxx---HFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLN-EQTMPLMVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDKYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVIFFLQQRSPVLPSLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEHNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGFNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNM------- -------------------------------------------------- --F------------------------------------------xxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------- >Tte x------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxGxxSxxxxxxxxxxxSSKVQNVSTLNxxPLESFETMLKNRRDE ARRSxxxxVHSEQSCAELNxxxTQYGSVKxxxxxxxxSSx---------- --------------------------------HFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMPLMVSSGNTSP NQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTEVYTYKDDKYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVIFFLQQRSPVLPSLKQLVAQAxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxQNKDSLETLLLNFFEFYSSFDFSSRAISIVEGPD DRRITPDGVNCTFIRDLKKLTEHNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGFNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNMxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------x------- ----xxxx--------------------xxxxHFVVVEFAKEDDVKSILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMPLIVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITVLPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQDFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILMVVFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNESKKQNKDSLETLLLNFFEYYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAAWVLESTWEKHDSASSKSKIEPWGLVAIYEAAQLSAKGRNI------- -------------------------------------------------- --FYTSAASRNVxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxx-------------------------xxHFVVVEFAKEDDVKSILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMPLIVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITVLPFGSSVSGFGKVGCDLDLVLHLGPEHTEVYTYKDDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQDFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILMVIFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNESKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAVWVLESTWEKHDSASSKSKIEPWGLVAIYEAAQLSAKGRNI------- -------------------------------------------------- --FYTSAASRNV----------------Q--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxx---------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------- >Tbi xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxx------- --------------------------------HFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMPLMVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTEVYTYKDDKYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVIFFLQQQSPVLPSLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEHNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGFNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNM------- -------------------------------------------------- --FYTSAASRNV----------------Q--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxx---------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxGVIxxxxxxxxxxxxxxxxxxxxRRx---- -------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxx-------------------------xxHFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTLSLMVSSGNTSP NQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTNIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVVFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNETKKQNKDSLETLLLNFFEFYSSFDF SSHAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNI------- -------------------------------------------------- --FYTSAASRNV----------------Q--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------- >Tps x---xxxxxxxxxxxxxxxxxxHxDxxxLTxKS----------------- -------------------------------------------------- -------------------------------------------------- -----------------------SKVQNVSTLNxxPLESFESMLKNRRNE ARRSxxVxVHSEQSCAELNxxxTQYGTVKxxxxxxxxSS----x------ --------------------------------HFVVVEFAKEDDVKTILS ASGHVNNSQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMSLMVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPA PGRWITNFSLILLVVFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSATGRNI------- -------------------------------------------------- --FYTSAASRNV----------------Qx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- -------------------------x >Tcm M---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAFxxxxxxxxxxxKP xxxxxxxxxxxxxxxSPVGLSTTSVLANY--------------------- -----ATKAE---------------------------------------- ----------------------SSKVQNxxxxxxxPLESFESMLKNRRNE ARRSxxxxVHSEQSCAELNxxxTQYGSVKxxxxxxxxxx----x------ --------------------------------HFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMSLMVSSGNTSP NQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTNIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVVFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNETKKQNKDSLETLLLNFFEFYSSFDF SSHAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNI------- -------------------------------------------------- --FYTSAASRNV----------------Qxxxxxxxxxxxxxxxxx---- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxNNDIx xxxIPQCITNDLALxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxE MENVxxxxxVESLxxxxxxxxxxxGSNEVRLNRCLEDTEKLKTTIKQVKQ EEKEVRDQxRKKVEELTSTIKKLERQKMELIHGFKKQLQLIDNLKKQKxH LEAGRVIQFTEDE-----FLKLLxWTPDDEKNx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------- >Tdi x---xxxxxxxxxxxxxxxxxxHxDxxxLTxKS----------------- -------------------------------------------------- -------------------------------------------------- -----------------------SKVQNVSTLNxxPLESFESMLKNRRNE ARRSxxVxVHSEQSCAELNxxxTQYGTVKxxxxxxxxSS----x------ --------------------------------HFVVVEFAKEDDVKTILS ASGHVNNSQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMSLMVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDNYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIK------ -----------TAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPA PGRWITNFSLILLVVFFLQQRSPVLPPLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLTEQNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGLNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEPWGLVAIFEAAQLSAKGRNI------- -------------------------------------------------- --FYTSAASRNV----------------Q--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------x---- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx >Tpa x---x------------------------------------xxxxxxxxx x--------------------------xxxxxxxxxxxxxxNxxVYxxxx xxxxxxxxxx---------------------------------------- ----------------------SSKVQNVSTLNxxPLESFETMLKNRRDE ARRSxxxx------------------------------------------ --------------------------------HFVVVEFAKEDDVKTILS ASGHVNISQVIPVHSPFLWFRAKEKSRKKGAQLNDEQTMPLMVSSGNTSP TQDELRLSMLSAESLSEQMNILYCSSALDDLGIRLRFLTALQLELALNGL FPLITALPFGSSVSGFGKVGCDLDLVLHLGPEHTE-----DDKYRLVFHA KTSMGNGRTQVQRHMETIGDMCQMFLPGCTHIKRILQARVPIIKYKQEFT GVECDLSMTNMTAVYMGELLYIMGSLDDRVKPLVFAVRMWAREVGLTNPT PGRWITNFSLILLVIFFLQQRSPVLPSLKQLVAQA--------------- -----------------------------------------------GPD DRRITPDGVNCTFIRDLKKLIEHNETKKQNKDSLETLLLNFFEFYSSFDF SSRAISIVEGMTIPKPEHAPLYIVNPLERGFNVSKNVSHEETERLRIELR NAAWALESTWEKHDSASSKSKIEP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxx------------------------------- -------------------xxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- --------------------------