>Tge -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxx------------------------------VSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKELNEPQGTLNELEKDPDKLHFK HDHGDFDVKDEIMDLPLDVTLDSDLDNHIDTISADSTSEEQSTSEVVLSP ASSPLPKKGARYHQDRRRKMLQPKKKPRGSSR-AQSTLVTRRRGRPRRAP PPSLLEHDSEEEEGREFEEGDHQDMMKWKEDEDMLTLNHFKDAGLGEDEE EDEEEYEEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGK----------------------------------------- -----------------------xFAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQEYQHNHQ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------AQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNSENNSATMMGGYSHQ TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQxxxSxxxxxxxxxTTRS ANAMPFLLPPLTPANTTNVSVPPPxxxxF--------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxG >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------MKELNEPQGTLNELEKDPDKLHFK HDHGDFDVKDEIMDLPLDVTLDSDLDNHIDTISADSTSEEQSTSEVVLSP ASSPLPKKGARYHQDRRRKMLQPKKKPRGSSR-AQSTLVTRRRGRPRRAP PPSLLEHDSEEEEGREFEEGDHQDMMKWKEDEDMLTLNHFKDAGLGEDEE EDEEEYEEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGK----------------------------------------- -----------------------xFAEKSHLNRHYSFHSEKRPF------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------- >Tbi -------------------------------------------------- -------------------------------xDVxxxxxxxxxxxxxxxx xxxxx------------------------------VSKDDILPKKICELC HGQLEDCHKFAEKANKVQHTLDLLIQMKELNEPQGTLNELEKDPDKLHFK HDHGDFDVKDEIMDLPLDVTLDSDLDNHIDTVSADSTSEEQSTSEVVLSP ASSPLPKKGARYHQDRRRKMLQPKKKPRGSSR-AQSTLVTRRRGRPRRAP PPSLLEHDSEEEEGREFEEGDHQDMMKWKEDEDMLTLNHFKDAGLGEDEE EDEEEYEEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGK----------------------------------------- -----------------------xFAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQExxxxxx -----------------------xxxxxx--------------------- ---------------------------xSTRVNNLTEAILGLCRVMLPIR IL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------HQVLKAMLQEAQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNSENNSATMMGGYPHQ TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQ----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------VGx >Tte -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxx-------------------VSKDDILPKKICELC HGQLEDCHKFAEKANKVQHTLDLLIQMKELNEPQGTLNELEKDPDKLHFK HDHGDFDVKDEIMDLPLDVTLDSDLDNHIDTVSADSTSEEQSTSEVVLSP ASSPLPKKGARYHQDRRRKMLQPKKKPRGSSR-AQSTLVTRRRGRPRRAP PPSLLEHDSEEEEGREFEEGDHQDMMKWKEDEDMLTLNHFKDAGLGEDEE EDEEEYEEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKWSVFKYLCLVLxWTLFEFGCGCHKATYLHEFLPWSCHFEFC FSPFPMSTKPPLHLQKYCKIIVVxFAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPDHQ------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------AQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNSENNSATMMGGYPHQ TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQxxxSxxxxxxATETTRL KNVVPFRLPPLTPANTTNVLVPLPPSPNFxxxxLLAPLLPASQDPVILSE YEKDKMYTKxxxPFVPISNEWNxFCLVLPYHIIYxxxxxxLTxEVFPLAR KVSNFTIAISIQEVMREAIYMEDLxxxxTGSxETxxxAGIPSPHRKxxxx xxxxNGxDSVGQCV------ >Tms -----------------------------------------------xxx xxxxxxxxxxxx-------------------------------------- -----------------------------------VSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKKLNEPQGTLNELEKDPNKLNFR HDPEDFDVKDEIMDLPLDVTLDSDLDNHIDTVSADSTSEEQSTSEAVLSP SSSPLPKKGARHHQDRRRKMLQPKKKPRGGSRAAQSTVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE EDEEEYEEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEG--RCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKWSVFKYLLLVL------------------------------ -----------------------NFAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQEYQHNHQ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------AQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNNENNSAAMLGGYPHQ TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQ----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------- >Tps -------------------------------------------------- -------------------------------x------------------ --------------xxxxxxxxxxxxxxxxxxxxxVSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKKLNEPQGTLDELEKDPNKLNFK HDPEDFDVKDEIMDLPLDVTLDSDLDNHIDTISADSTSEEQSTSEAVLSP ASSPLPKKGARHHQDRRRKMLQPKKKPRGGSRAAQSAVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE ED-EEYDEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDIHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKx---------------------------------------- ------------------------FAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQ------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xx >Tcm -------------------------------------------------- -------------------------------x------------------ --------------xx-------------------VSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKKLNEPQGTLDELEKDPNKLNFK HDPEDFDVKDEIMDLPLDVTLDSDFDNHIDTVSADSTSEEQSTSEAVLSP ASSPLPKKGARHHQDRRRKMLQPKKKPRGGSRAAQSAVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE EDEEEYDEEDEEMDEIDKKAQEEWKTHWGIKCDRCDAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGK----------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------x >Tdi x------------------------xxxxxxxxxxxxxxxETxxxxxx-- ----------xxxxxxxxxxxxxxxxxxxxx------------------- -----------------------------------VSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKKLNEPQGTLDELEKDPNKLNFK HDPEDFDVKDEIMDLPLDVTLDSDLDNHIDTVSADSTSEEQSTSEAVLSP ASSPLPKKGARHHQDRRRKMLQPKKKPRGGSRAAQSAVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE EDEEEYDEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDIHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKx---------------------------------------- ------------------------FAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQEYQHNHQ xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- ----------------------------xTxxNNLTATILGLGRVMLSIR IL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------HQAVKAMLLKAQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNNENNSATMMGGYPHH TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQ----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxx >Tce -------------------------------------------------- -------------------------------------------------- -----------------------------------VSKDDILPKKICELC HGQLEDCHKFAEKASKVQHTLDLLIQMKKLNEPQGTLNELDKDPDKLNFR HDPEDFDVKDEIMDLPLDVTLDSDLDNHIDTVSADSTSEEQSTSEAVLSP SSSPLPKKGARHHQDRRRKMLQPKKKPRGGSRxAQSTVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE EDEEEYEEEDEEMDEIDKKTQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKxSVFKYLCLVL------------------------------ -----------------------NFAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASG------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxELQEIFRPCDQFSDEVGLDTIYxxFLIGEANxxx xxxxxxxxxxxxxxxxxxxxxxxxxxSLLVENMHEKTVIxxxxxxxxxxx xxxIKNIxIxxxxxxxxxxxRKRYHEYLxxxxxxxxxxxxxxxxxxxxxx xxxxLEGERxxLxMATEExxxxxxxxxxELxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------- >Tsi xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------DELEKDPNKLNFK HDPEDFDVKDEIMDLPLDVTLDSDFDNHIDTVSADSTSEEQSTSEAVLSP TSSPLPKKGARHHQDRRRKMLQPKKKPRGGSRxAQSAVVTRRRGRPRRAP PPSLLEHDSEEEERRELEEGDHQDMMKWKEDEDMLTLNHFKD-GLGEDEE EDEEEYDEEDEEMDEIDKKAQEEWKTHWGIKCDRCEAVFPFKSQFDNHYR SSYNARPTYTCSYCNKTMEKYSTFRSHCYRHVTEGRYRCEYCQKGFSLRS MLHVHILAKHTMVKPYICEECGKGFVTRPGLNIHLKKHKTDEKLEYPCSE CGKVLHTRGGLTAHQNVHKLGRRFMCDVCGKTFTQKVNMQQHVKHHTGER PYACEKCGKx---------------------------------------- ------------------------FAEKSHLNRHYSFHSEKRPFECKTCN KMYKTERCLKVHAMVHAEARPHVCTYCSKGFLSTTKLKQHYNIHTGERPY VCKFCERTFTNYPNWLKHTRRRHKTDPRTLRLAQASGVLPVQQE------ --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxDTRVNNLTAAILGLGRVMLPIR IL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------HQATKAMRLKAQE QPQPEVIISEVQQPDEEERLSVHSQQSQMSVMCLNNENNSATMMGGYPHQ TQSHLHQASQQTHPHLLQAIAGDMRMQAPLQLQ----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------Vxx