>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxx--xxxxxxxxxxxxxxxxxVKDKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLKQDGASEEKSKKQEKSLFLRDYERKLILEKGGKFTDDE------ -------------------------------------------------- ---------------------------DDAHYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQL------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------xxxLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNKELGFKDEDLEGEFNPAEYDKRMKELFSDEYYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEDMS QVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQEELIESTRR RKKGRRRSKLAQLLAKKKPVFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------EKNEEKTPEPGKKKKRRKR KKNxSTAETSEKAFKIQR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------x- -DSELMQTELPSEIQVNKIPTHATKQITGARKKENEPTIAIQSKSQVKEK ANNLLINKDEIETSPSNELNIKSGELKQTARKPSVLPMSASVSTKGLKKK KSKKIKETVKDSSSNHSKLKLKRKKHKNENLGGKMLHxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- --------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxF LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEYYKE EDYSQKPEFPDIDDELEIVLKHAHALLLFVMNVFLLPIENWERWRGEDMS QVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQEELIESTRR RKKGRRRSKLAQLLAKKKPVFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKANNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------EKNEEKTPEPGKKKKRRKR KKNxSTAETSEKAFKIQR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxEIQANKIPTHATKQITxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxNELNxxxGELKQTARKxxVLPMxxxxxxxxxxxx xxKEIxxxxxxxxxxxxxxKxKRKKHKNENLGGKILH------------- ------------------------xxxxxxNSQELAISDTRLRAYGIRPK TFKNKLKYGKQQNMx >Tte M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVKDKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLKQDGASEEKSKKQEKSLFLRDYERKLILEKGGKFTDDEEEDSSN VNQKRPPSPTLVEEELAIRDSFKNVLNDDDEDVKDLGGLFQKRQKSKQEL xVALRISHSSLMNADRMKPRSVDWAEKDDAHYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQLDESEQFLRDYILNKNLWEDTLHFCQSSVVFVMAMFM YVKERKTYFERRVLSRCKELMRFETNDCTKANSELCCTAMHNVAKHLKDP YDFEDLEQGGDEDEFVEEEVGTEIYENNATKVCxxxxxxxI--------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEYYKE EDYSQKPEFPDIDEELEIVLKHAHALLLFVMNVFLLPIENWERWRGEDMS QVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQEELIESTRR RKKGRRWSKLAQLLAKKKPVFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKANNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------EKNEEKTPEPGKKKKRRKR KKNxSTAETSEKAFKIQR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------x- -SSQLMQTELPSEIQANKIPTHATKQITVATKKENEPTIAIQSKSQVKEK ANNLLINKDEIETSPSNELNIKCGELKQTARKPSGLPMSTSVSTKGVKKK KSKKIKETVKDSSSNHSKLKLKRKKHKNENLGGKILH------------- ------------------------NGKSSGNSQELAISDTRLRAYGIRPK TFKNKLKYGKQQNMY >Tms xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------KNKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLKQDGASVEKSKKKEKSLFLRDYERKLILEKGGKFTDDEEEDGSN VNQKRPPSPTLVEEELAIRDSFKNVLNDDDEDVNNLGGLFQKRQKSKQEL -------------------------EKDNANYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQLDESEQFLRDYILNQK--------------------- -------------------------------------------------- -------------------------------------------------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------EKNEEKTPEPGKKKKKRKR KKS-STAETSEKAFKIQRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MES ELKPLHDFWNDPQLDESEQFLRDYILNQK--------------------- -------------------------------------------------- -------------------------------------------------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDETPNYCVHTF---------------QILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYS----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x >Tdi xxx---------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxPTxxxPCHRxxxxxxxxxxxxxxxxxxxxx xxxxxxxVSxxxxxxxxxxxKxxxxxxTDxxxxxxxxxxxxxxxxxxxxx xxxxxVxLxxxxxxxxxx-------------------xxxxxxxxx---- -------------------------------------------------- --------------------------------------VKNKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLRQDGSSEEKSKKQEKSLFLRDYERKLILEKGGKFTDDEEEYSSN VNKKRPPSPTLVEEELAIRDSFKNVLNDDDEDVNNLGGLFKKRQKSKQEL -------------------------EKDNANYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQLDESEQFLRDYILNQK--------------------- -------------------------------------------------- -------------------------------------------------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------EKNEEKTPEPGKKKKKRKR KKS-STAETSEKAFKIQR-------------------------------- -------------------------------------------------- ----------------------------x--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -DxxxxxxELPTEIQANKIPTHTSKQITxxxxxENELTITxQSKSQVxE- -NNLLINKDKIETNPSNELNIKSEELKQTARKLFVLPTxAxx----xxxx -------------------------------------------------- -------------------------------------------------- -------------xx >Tcm Mx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- --------------------------------------VKNKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLKQDGSSEEKSKKQEKSLFLRDYERKLILEKGGKFTDDEEEDSSN VNKKRPPSPTLVEEELAIRDSFKNVLNDDDEDVNNLGGLFKKRQKSKQEL -------------------------EKDNANYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQLDESEQFLRDYILNQK--------------------- -------------------------------------------------- -------------------------------------------------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRMMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLVGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSR---- -------------------------------------------------- -------------------------------EKTEEKTPEPGKKKKKRKR KKS-STAETLEKAFKIQR-------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxx- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xx-------------------xxxxxxxxx---- -------------------------------------------------- --------------------------------------VKNKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLRQDGSSEEKSKKQEKSLFLRDYERKLILEKGGKFTDDEEEYSSN VNKKRPPSPTLVEEELAIRDSFKNVLNDDDEDVNNLGGLFKKRQKSKQEL -------------------------EKDNANYLEWLKGQKEELLDKKMES ELKPLHDFWNDPQLDESEQFLRDYILNQK--------------------- -------------------------------------------------- -------------------------------------------------F LETEDDDHIPTYEEIVHDSDEGLSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFNVRVQYAIRHLSSVGSMSLYLAKGPGCRQDPEL LGMGRELIYSSESGRVCCFPKRVFLVFQQMDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSGLPLH RFLAGMSWASEETVGRFKQAYTCSFRMSTTLGLDLGISQSTAGRILCKRL KIKSFKLELLQGLSVGDKKVCLYFCFEMVEREKTEEKTPEPGKKKKKRKR KKS-STAETSEKAFKIQR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------x- -DxxxxxxELPTEIQANKIPTHTSKQIxxxxKKENELTITxQSKSQVKE- -NNLLINKDKIETNPSNELNIKSEELKQTARKLFVLPTSASVSMKGSKKK KNKKIKETLNDSSSNHSKLKLKRKKHKNENSGGKILH------------- ------------------------NGKSLDNSQELAISDTRLRAYGIRPK TFKNKLKYGKQQNMY >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------MDCDYDPKAQFQKELIESTRR RKKGRRRSKLAQLLAKKKPVFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE--------VGSTMFYLNNFYSNIIKILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- --------------------------------------VKNKYGEDAVNK LDDNDESSSDEENENAKELTEEFERDFLKTLSYLKKKDPCIYDKDTKFFE EYKSTLKQDGASEEKSKKKEKSLFLRDYERKLILEKGGKFTDDE------ -------------------------------------------------- -------------------------------------GQKEELLDKKMES ELKPLHDFWNDPQLDES--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LSGDEHTLGQQEEFERKFNFRFEEPDSE FTKRYPRVMEHSLRKKDDRRKLKREELKKRKQEEKVRKREELKRLRAMKR KEIETKLEKLKEITGNAELGFKDEDLEGEFNPAEYDKRMKELFSDEFYKE EDYSQKPEFPDIDEELE--------------------IENWERWRGEVTS EVDNGNEYQPHCEDPDFN-------------------------------- -----------------------------MDCDYDPKAQFQAELIETTRR RKKGRRRSKLAQLLAKKKPIFEPNERTFDEYVNEYYKMDFEDVIGDLPCR FKYRNVVPNSFGLTTDE-------------------------ILSAKDKE LNQWVSLGKAVQYRPETKELYDVKAYQNKAKNIKLKEKCLASLYSG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------