>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLPFNHLVST------------------------------------ -----------------------------------------xxxxxxxxx xxxxxxxxxxxx----------xxxxxxxxxWTSFQPPGEYIxxPFNHLV RVMDCFFNEGIKVFYRVSMAVVLLFYKHSSPQNSEWMAEILAKGVDSALN RFCKQLP--------------VTPTKLLRTAFGIRALSSAYIQRVFVKTE MTQKSRQVITGSRQLVRSRSSDNLPTSQSQVNIQMMSRTLTIRE------ -------------------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxx---- -------------------------------------------------- ----------------------------------------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLxxxx---------------------------------------- -------------------------------------------------- -------xxxx--------------------GTSFQPLGEY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx----------------------------xxxxx >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLxxxx---------------------------------------- -------------------------------------------------- -------xxxx--------------------WTSFQPPGEYIxxPFNNLV RVMDCFFNEGIKVFYRVSMAVVLLFYKHSSPQNSEWMAEILAKGVDSALN RFCKQLP--------------VTPTKLLRTAFGIRALSSAYIQRVFVKTE MTQKSRQVITGSRQLVRSRSSDNLPTSQSQVNIQMMSRTLTIRE------ -------------------------------------------------- -------------------------------------------------- -----------xx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxx----------------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLPFNHLVST------------------------------------ -----------------------------------------xxxxxxxxx xxxxxxxxxxx--------------------RTSFQPPGEYIxxxxxxxx xVMDCFFxxxxxxxxxxxxxxxxLFYxxSSPQNSEWMAEILAKGVDSALN RFCKQxx--------------xTPxxxxxxAFGxxALSSAYIQRVFxKTE MTQKxxxxxxxSRQLVRSRSSDNxxxxQSQVNIxxxSRTLTIREL----- --------------------------------xxxxxxxxxxxxxREPMK AxLxxxxxxxxxGLE-------------------------SKYKLACAIE RTKLPTCPPVIKxxRFSSVSLVFLAMVVGGSSTRRPGAPARVSxLLVGGG GDGNWGLCLFCGCCSAKGSRSPGARVPSMGAFPIHNIRSQVLDQNELFAL WSWLPVRITMYQPRLLYTTEEHGCSLTTFYVRVEMYEPTLLMIKTCNNEV FGAYCSSRWYERNLKDDHGNRQAYFGTGESFLFSLYPERAKYPWVGIDSS QDDPSLGHSAELFMAADTKMLTIGGGEGQAIWM-----------DENIRF GKTDHCVTFNNPPLCESGDFEIRVLEVYGFVGV----------------- ----------------------------------------------- >Tte xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxx---------- -------------------------------------------------- --------------------KEDCYNSMACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLPFNHLVST------------------------------------ -----------------------------------------xxxxxxxxx xxxxxxxxxxx--------------------WTSFQPPGEYIxxPFNHLV RVMDCFFNEGIKVFYRVSMAVVLLFYKHSSPQNSEWMAEILAKGVDSALN RFCKQLP--------------VTPTKLLRTAFGIRALSSAYIQRVFVKTE MTQKSRQVITGSRQLVRSRSSDNLPTSQSQVNIQMMSRTLTIRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x----------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxDRVGVLFCxxxxxx xxxxxxxxxxxxxxxxxxxxEEECYNSMACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLPFNHLVSTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- ------------------xxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxx------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x----------------- ----------------------------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------Ax--------- --------------xxxxxxxxxxxxxxxFxxxxLEDRVGVLFCxxxxxx xxxxxxxLDWxxxxxxxxxxEEECYNSMACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS T---GLPFNHLVSTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x----------------- ----------------------------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxNIYxxxxxxxxxx----------------------------------- --------------------KEDCYNSMACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFNHLVS Txxxxxxxxx---------------------------------------- -------------------------------------------------- ------------------------------------------------xx RVMDCFLNEGIKVFYRVSMAVVLLFYKHSSPQNSEWMAEILTKGVDSALN RFCKQLPxxxxxxxAxxHCLxVTPTKLLRTAFGIRALSSAYIQRVFVKTE MTQKSRQVITGSRQLVRSRSSDNLPTSQSQVNIQMMSRTLTIREIxxxxx xxxKSLMAQATYANxIxxxxxxxxxxxxxxNVV----------------- ------------------------------------------YKLACAIE RTKLPTRPPVIKCLSFSSVSPVFLAMVVGGSSTWRPGAPARVS-LVVGGG GDGNRGLCLFCGCCSAKGSRSPGARVPSMGAFPIHNIRSQVLDQNELFAL WSWLPVRITMYQPRLLYTTEEHGCSLTTFYVRVEMYEPTLLMIKTCNNEV FGAYCSSRWYERNLKDDHGNRQAYFGTGESFLFSLYPERAKYPWVGIDSS QDDPSLGHSAELFMAADTKMLTIGGGEGQAIWM-----------DENIRF GKTDHCVTFNNPPLCESGDFEIRVLEVYGFVGV----------------- ----------------------------------------------- >Tms Mx-----------xxxxxxxxxxxxxxxxxxxxxDTSGISTANDLGGSPP LGGKGLVLKTFAExxxxxQTGRKRELKTAVRDNAWPVNSPVRPQLWPLLC RQHANDKSLQEGFYWDMVNQLYGTT-------DISDKPIMLPPFVEPSHC MAYQLTRRGRAQADRVVSVLGYACPxxxxxxxxxxITALLLHFMS----- --------------------GQEINNWPINTELRLLWRWPVWGLRPAVIP ATNKVKLSVVSPLPPxSQGTGNSLCSEKLVYWRAHLLGSWTKxxxxxxxx xxxxxxxxxxxxxxxxDKVSTSSG---------------xxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- --------------------KEDCYNSMACIVASKGKMFCTQTKQLWEVT WRTVALITKKYCKSAAVHLTRHCEGSRAERIYSDWLWWILKGLPFxx--- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx RVMDCFLNEGIKVFYRVSMAVVLLFYKHSSPQNSEWMAEILTKGVDSALN RFCKQLPxSPLSEAAGVHCLKVTPTKLLRTAFGIRALSSAYIQRVFVKTE MTQKSRQVITGSRQLVRSRSSDNLPTSQSQVNIQMMSRTLTIRE------ -------------------------------------------------- --------------xxxxxxxxxxxxExxxxxxxxxxxxxx--------- -------------------------------------------------- ------LCLFCGCCSAKGSRSPGARVPSMGAFPIHNIRSQVLDQNELFAL WSWLPVRITMYQPRLLYTTEEHGCSLTTFYVRVEMYEPTLLMIKTCNNEV FGAYCSSRWYERNLKDDHGNRQAYFGTGESFLFSLYPERAKYPWVGIDSS QDDPSLGHSAELFMAADTKMLTIGGGEGQAIWM-----------DENIRF GKTDHCVTFNNPPLCESGDFEIRVLEVYGFVGV----------------- ----------------------------------------------- >Tdi Mx-----------xxxxxxxxxxxxxxxxxxxxxDTSGISTANDLGGSPP PGGKGLVLKTFAExxxxxQTGRKRELKAAVRDNAWPVNSPVRPHLWPLLC RLHANDKSLQEGFYWDMVNQLYGTTxxxxxxxDISDKPIMLPPFVEPSHC MAYQLTRRGRAQADRVVxxxxYACPxxxxxxxxxxxxxxxxxxxxxxxxx xxxxRGDAAPQPxCKExAxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------