>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxCVSVHRADEKxxxxxxxxxxxxxxxxxxxxxxxxxxx xxSWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFIQGGFSLD SDSFLNMAVSTAIEGFNDHTGGNTVHQQSLGNNQFLQSTQKSNPNCDNTS ASSEEQKICKTESH-TSLVTVKTTKKT-----xxxxRRRKEKLLRLRPMA RLAALKVALISRHKKKLKIRETSFQGSDDENSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMD------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLSGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLQRLTT-------------- -------------------------------------------------- -CSPLL >Tms xxxxxxx-x----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --SWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNNLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFIQGGFSLD NDSFLNMAVSTAIEGFNDHTGGNTVHQQSLGNNQFLQSTQKSNPNCDNTS ASSEEQKLCKTESH-TSLVTVKTTKKVKRKL------------------- ------------------------------NSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLSGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tce --------x----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --SWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNNLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFI------- ---------------------------------QFLQSTQKSNPNCDNTS ASSEEQKLCKTESH-TSLVTVKTTKKVKRKL------------------- ------------------------------NSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLSGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tdi --------xxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xSWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFI------- ---------------------------------QFLQSTQKSNPNCDNTS ASSEEQKLCKTESHxTSLVTVKTTKKVKRKL------------------- ------------------------------NSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLPGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQAEY PCMPLF >Tps --------xxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xSWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFI------- ---------------------------------QFLQSTQKSNPNCDNTS ASSEEQKLCKTESHxTSLVTVKTTKKVKRKLIFRRSRRRKEKLLRLRPMA RLAALKVALISRHKKKLKIRETSFQGSDDENSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLPGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tsi xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --SWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFIQGGFSLD NDSFLNMAVSTAIEGFNDHTGGNTVHQQSLGNNQFLQSTQKSNPNCDNTS ASSEEQKLCKTESHxTSLVTVKTTKKVKRKLIFRRSRRRKEKLLRLRPMA RLAALKVALISRHKKRLKIRETSFQGSDDENSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLPGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tcm xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --SWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFI------- ---------------------------------QFLQSTQKSNPNCDNTS ASSEEQKLCKTESHxTSLVTVKTTKKVKRKLIFRRSRRRKEKLLRLRPMA RLAALKVALISRHKKKLKIRETSFQGSDDENSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYGHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCEQCGYSCRTKQNLLAHLRCHTTDRPFKCEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLPGGDRPTNTNHAHQPLPNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tbi xx-----------xxxLPNNPMNFxENQHGNxxxxKLKTQKEQGRFCDVx xxxxGxQFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDIFSCLx xxxxxxxVVIDKNxxxxLLRxANHFLVLKLKxYCAEYLDRYLDVTNCLSV REMAEKYNMxxxxxxATLFVQVHLNKIINQDELLxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xSWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFIQGGFSLD SDSFLNMAVSTAIEGFNDHTGGNTVHQQSLGNNQFLQSAQKSNPNCDNTS ASSEEQKICKTESH-TSLVTVKTTKKVKRKL------------------- ------------------------------NSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCGLCGYVCQWNKDYYSHMKGHFPGPPFKCDSC DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCDQCGYSCRTKQNLLAHLR---------xEIC GRAFSMKNTLEQHLAGHNSDRPYLCDICGFSTKYLSHLIAHKRIHSGDVY RCSYPQCKYSTPKKSQLGSHARTHGAVRPHSCNICGRGFLEKSHLVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLSGGDRPTNTNHAHQPLSNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tpa MA-----------xxxLPNNPMNFTENQHGNAVLEKLKTQKEQGRFCDVT LYVEGKQFKAHRNILASCSPYFDSVFKMHKTVKERLTITCQNSDIFSCLL NYMYTGTVVIDKNNVAELLRLANHFLVLKLKSYCAEYLDRYLDVTNCLSV REMAEKYNMPALSKAATLFVQVHLNKIINQDELLNSPLSKxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xSWTVPQNALLSLIAQWISRDINSRERSMRTLLTFVDWNTLDGAMISEH VDREPLYSSSEISLYFILQALVDNNLLFPKYQGIYQALQDKFIQGGFSLD SDSFLNMAVSTAIEGFNDHTGGNTVHQQSLGNNQFLQSTQKSNPNCDNTS ASSEEQKICKTESH-TSLVTVKTTKKT-----xxxxRRRKEKLLRLRPMA RLAALKVALISRHKKKLKIRETSFQGSDDENSEMMDGYGCHLCPHVSPDT TRLEQHLAEVHSMDVTYKCG------------------------------ DY--------------------------------------------TCER IGQVLTHRMKHSDERPHHCDQCGYSCRTKQNLLAHLRCHTTDRPF----- --------------------------------KYL--------------- --------------------------------------------YVRHER IHLEEKPFKCSQCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx----------------------------MASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMVAQSGANQGQNVGAQHHQGEY PCMPLF >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xCEYASSRRDKLKEHFGRHHGENASAKVPYKARPMRGTG SNSSSSSSGRTNGHKTCQ-------------------------------- -ESGGFGGANNLSGGDRPTNTNHAHQPLSNSGGDMASLMMQHHPPSTTNN PLPSHSQPPAYPGYPPSLDYSHHKSDHQALLHQQASHHMLPSAVRTSQQA VAAMMLDPRFHHPNPGAYHPAPPVSMAAMAAQSGANQGQNVGAQHHQGEY PCMPLF