>Tms x------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------VNSNDEDVSVAGVIHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATPxxxxLVGQAGPDILLRYEGWQVIDAMxQE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGEK DREDITNQYKAEE------------------------------------- -GSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDKVNIGDSFxxVxxINN KSDSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KxxxxxxxxxxxxxxxxxExxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxLDIK VSESLPVNQPTIVKFxxxxxxxxxxxxxxxKYEGPGVTKNKTISYRxxxx xxxxxxxxRFTPMRAGxxxDIRAGELVVLEHRFTPMRAGVQKLVATFSST ELLDITGAASIDVYDDTE-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------E >Tps -------------------------------------------------- -------------------------------------------------- ----------------x--------xxxxxxx------------------ -------------------------------------------x------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRSPPDSPVGEWNFE IETKSKVDxxxPASLYKFPSKFYLLFNPWAKGxxxxxxxxxxxxxxxxW- -------------------------------------------------- ------------------DK------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------DDHVYMEDKHLLDEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRGDPIAVTRAISRI THTHARGLDLAPAGRSHRAPEPHPDEAGLRPWPGALAPNRHRLPPRSSVS SGGAHHTVSDASVDKCWGVVIADAPYDxVNSNDEDVSVAGVIHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATP---------------------------QE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEE------------------------------------- -GSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDKVNIGESFxxxxxINN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KxxxxxxxxxxxxxxxxxExxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxLDIK VSESLPVNQPTVVKFxxxxxxxxxxxxxxxKYEGPGVTRNKTIPYR---- -------------------DIRAGELVVLEHRFTPMRAGAQKLVATFSST ELLDITGAASIDVYDDTE-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------E >Tcm -------------------------------------------------- ------xPxxDIVRLIFTFGANPSPVKGxRxVSSVTGRMDYSKDLQEWDV RLLKTDQV---SxxLx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------VRSPPDSPVGEWNFE IETKSKVDxxxPASLYKFPSKFYLLFNPWA-------------------- -------------------------------------------------- -------------------K------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------DDHVYMEDKHLLDEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRGDPIAVTRAISRI -------------------------------------------------- ----------------------------VNSNDEDVSVAGVIHGRWDGEY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATP---------------------------QE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEE------------------------------------- -GSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDKVNIGESFxxxxxINN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KxxxxxxxxxxxxxxxxxExxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxLDIK VSESLPVNQPTVVKFxxxxxxxxxxxxxxxKYEGPGVTKNKTIPYR---- -------------------DIRAGELVVLEHRFTPMRAGAQKLVATFSST ELLDITGAASIDVYDDTE-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------E >Tce MAxVLEVDGVRMYPLENAKRHHTERYELIHEAENPSVILRRGQEFELLVx xRERGFDPxxDIVRLVFTFGANPSPVKGxxxVSSVTGRMDYSKDIQEWDV RLLKKDQVxxxx------------------xx------------------ -------------------------------------------WNRD--- -------------------------------------------------- --TxxxTQYQRHNIKDTGSEAQDQRHRIRDTVSETHEQRHRIKDTVSDTG RETQDQGHRIRDIGSETQEQRHRIKDTVSETQ------------------ --------------------------------------------DQRHRN RDTVKFG--------------HLNYWGNWINASYQVRSPPDSPVGEWNFE IETKSKVDxxxPASLYKFPSKFYLLFNPWA-------------------- -------------------------------------------------- -------------------Kx-------------------------YSxx xxxxxxxxxxxxxxxxxxDDDDDYDDDDDDDDDDDDDxxxxxxxxWTxxx FxxxxxxxxxxxxxPxxxxPSLxxVxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxDDHVYMEDKHLLEEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRGDPIAVTRAISRI -------------------------------------------------- ----------------------------VNSNDEDVSVAGVIHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATPxxxxLVGQAGPDILLRYEGWKVIDAMxQE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGEK DREDITNQYKAEE------------------------------------- -GxxxxxxxxxxAxxGxxxAxxxxxxxxxSREExxFELV----------- -------------------------------DLDKVNIGDxxxxxxxxNN KSDSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx V--------------------------------------------RDF-- ----------------IxxDIRAGELVVLEHRFTPMRAGAQKLVATFSST ELLDITGAASIDVYDDTE-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------E >Tdi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------VNSNDEDVSVAGVIHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATP---------------------------QE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEE------------------------------------- -GSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDKVNIGESFxxVxxINN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKSxxxxxxxxxx xxGDLSKVINSITVVLQVTGDLSKLVTSITVVLQVTGELSKVVTSIKVVL QLTIDLPKLVTSITVVLPVTGDLSKVVTSIAVILQVTGDLSKVGTSITVV LQVTGDLSKVITLVTVVLKGTGDLSKVVSSTSLVLQVTGDLSKLVTSITV VLQVTGDLSKVGTSITVVLQVTGDLSKLVTSTSLVLQVTGDLSKLVTSIT VVLQVTGDLSKVExxxxxxxxxxxxxxxxxExxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxLDIK VSESLPVNQPTVVKFxxxxxxxxxxxxxxxKYEGPGVTKNKTIPYR---- -------------------DIRAGELVVLEHRFTPMRAGAQKLIATFSST ELLDITGAASIDVYDDTE-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------E >Tte MAxVLEVDGVRMYPLENAKRHHTERYEMIHAEENPSIILRRGQEFELLVx xRERGFDPxxDIVRLVFTFGANPSPVKGxRxVSSVTGRMDYSKDIQEWDV RLLKNDQV---SVRLxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxKLNPWSNWINxxxxVRSPPDSPVGEWNFE IETKSKVDxxxPASLYKFPSKFYLLFNPWAKG----------------WS xxxxxxxxxxxxxxxxSRTAVxRIxxxFFFxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxA------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------HDHVYMEDKHLLEEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRSDPVAVTRAISRI -------------------------------------------------- ----------------------------VNSNDEDVSVAGVLHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATP---------------------------QE TSxxxxxxxxxxxxxxxxxxxxxxGFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEExxxxxxxxxxxxxxxxxxxxxxDNIYIMDSLCIKSKR GxSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDRVNIGESFxxxxxINN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KxxxxxxxxxxxxxxxxxExxxxxxx------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxLDIK -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------- >Tsi MAxVLEVDGVRIYPLENAKRHHTERYELIHEAQNPSVILRRGQEFELLVx xRERGFDPxxDIVRLIFTFGK--THVAGxRxVSSVTGRMDYSKDLQEWDV RLLKTDQV---SVRLxx--------------xxxxxxxxxxxxVEAQxxx xxxxxxGTxxQDKSHRIIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxNQxxxxxIQNQGHRNKDTxxxxxxxKHIIRTQxxRHRIRxxESGTQK QRTGSGTQYQRxxIRDLGS------------------------------- -ETQDQGYRIWDLGSETQNQGHRIRDLASETQNQGPRIIDTExGIQDQGL RIRDTExGRQYQRHIITGKDLxxKLHxxxxxxxxxxxxxxxxxxxx---- -----------------------------------VRSPPDSPVGEWNFE IETKSKVDxxxPASLYKFPSKFYLLFNPWA-------------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -----------------------DDHVYMEDKHLLDEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRGDPIAVTRAISRI -------------------------------------------------- ----------------------------VNSNDEDVSVAGVIHGRWDGEY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATP---------------------------QE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEE------------------------------------- -GSATERLALMNAVRGxxxAxxFxxLPSISREExxFELV----------- -------------------------------DLDKVNIGESFxxxxxINN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xx-------------------------------- -----------xxxxx----------------------xxx--------- -------------------------------------------------- -------------------------------xE >Tbi MG------------------------------------------------ -DEIGYDPx----------------------------------------- ---xxxxI---SLR------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------DDHVYMEDKHLLEEYVVNDVGKIWVGP YGTSRGREWVFGQFDDCVLPACMVMLDRAAGAGTLKRSDPVAVTRAISRI -------------------------------------------------- ----------------------------VNSNDEDVSVAGVLHGRWDGDY KDGTAPAAWTGSVAILEEYLTTGKEVKYGQCWVFAGVVTTVCRALGIPSR VVSNLVSAHDANSSLTVDRYYDLNNEELDYDPTNWEGEDSIWNYHVWNDV WMARPDLPLGYGGWQAIDATPQETSLVGRAGPDLPLGYGGWQAIDATPQE TSL---------------------GFFQCGPASLEAIKCGAVGFSYDVPF LLASVNADLFRWKEDPESDRGYTKISSNKYHIGRVIFTKAPWLFDPNGDK DREDITNQYKAEE------------------------------------- -G----------------------------------xxxxxxxxDxxxxx xxxxxxxxxxxxxxxxSNILIPNKLGYCxxxxxx--------------DN KSNSVKTVKAILSAASVYYTGIKAHLIKKASGDFQVQPKS---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- ------------------------------------------IPAG---- -------------------DIRAGELVVLEHRFTPMRAGAQKLVATFSST ELLDITGAASIDVYDDTEDLSSGERKSPEGGQGWSGGGKQPHVSTTMPGM VLRRMLLLLSKWRIEMDDILLGMQHGVLFSMEAIIASRPWCRHSPSLEIV ESAACVFSSPRILPGSGAETQHPHTGGEAGEPKRHELGHVDLNPSPFTLR QLLLRGGHRNGLVGTVRQSVQPLDPHSHIYHRI