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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKELPSAVDINVETIKEE DPDEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEPPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIA--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------NKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGxxxNxNFxxIxINIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAG-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------LYxxLILYP -------------------------------------------------- ------------xx >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------FKVNNDWESALKHLQLSLIDTSPCS VTNLE--------------------------------------------- -------------------------------------------------- --------------------------------------------IRFHIA HLFEVQGKYKTAKENYEQLLREKELPTHLKADICRQLGWMYHCVESLGEK IQRETVAIHCLLKSIDADPKSGQSLYLLGRCYASIGKVHDAFIAYRNSVE KSEGNADTWCSIGVLYQQQNQPMDALQAYICAVQLDKSHVAAWTNLG--- ILYESCNQPRDAYACYVNATRGHSSSLGGAVSPNSSSSNFSQHCRVAGGM HPNLGHRIKYLQSHIVNAPMPSITSKRRQLPTIEEAWNLPISAEMSSRAV QQQGPSMVQQRSGTTPSYQKVYGGQPLQYHNGINSHQPQGPPPPYPVQAS NPTKRFK------------------------------------------- -------------------------------------------------- -HGEIMEGGNIVGNSQHRQVPLFYLNQQQMQTLQFLQQNITNLTPQQR-- -------------------------------------------GVMEQLQ HQFRLMQQHQQQLRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- NPCTVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNRSNITKETSDVKPTEDEENVK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKEIPSAVDINVETIKEE DPEEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIA--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xSTAEDxxxxxxxxxxxxxxSxNLSDSDSxxSTGNFVRRKIKGG TGAILSVSKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARV----- --------------------xPGSRTPGHQENNNFCSININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAG-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------Wxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------MEQLQ HQFRLMQQHQQQIRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- IPCTVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMDHSLAVTKSNRSNITKETSDIKPTEAEENVK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKELPSAVDINVETIKED DPDEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEPPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAx-------------------- 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HQFRLMQQHQQQLRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- NPCAVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNRSNITKETSDVKPTEDEENVK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKEIPSAVDINVETIKEE APEELKDTIPLMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAK-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxSxNLSDSDSxxSTGNFVRRKIKGG AGAILSVNKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKV----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx >Tce xxEExxxxxxxxxK------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------AVK AFQQVLYVEPGFSRANEVHLRLGLMFKVNNDWESALKHLQLSLIDTSPCS VTNLEK--------------------------------NxxxxxxxxxMS RHGxxxxxxETHKKIKTLGSLLLVHQ------------------------ -------------------------------------------GVRFHIA HLFEVQGKYKTAKENYEQLLREKELPTHLKADICRQLGWMYHCVESLGEK IQRETVAIHCLLKSIDADPKSGQSLYLLGRCYASIGKVHDAFIAYRNSVE KSEGNADTWCSIGVLYQQQNQPMDALQAYICAVQLDKSHVAAWTNLGKLR ILYESCNQPRDAYACYVNATRGHSSSLGGAVSPNSSSSNFSQHCRVAGGM HPNLGHRIKYLQSHIVNAPMPSITSKRRQLPTIEEAWNLPISAEMSSRAV QQQGPSMVQQRSGTTPSYQKVY---------------------------- -------------------------------------------------- -------------------------------------------------- -HGEIMEGGNIVGNSQHRQVPLFYLNQQQMQTLQFLQQNITNLTPQQR-- ----------------------LANTLVLSSTAKDGEIEIRxxGVMEQLQ HQFRLMQQHQQQLRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQxxxxxxxxxxx------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------------------- -----------------------------xxxxx---------------x NPCTVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNRSNITKEISDVKPTEDEENVK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKEIPSAVDINVETIKEE DPEEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAKx------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTYN AQTFNLGNEEINQLYDSPVVVAPGKLKDIRDLLPYLANTLVVL------- ------SSTAEDxxxxxxxxxxxxxxxxNLSDSDSxxSTGNFVRRKIKGG TGAILSVSKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGxxxNxNFxxININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAG-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------WYxxLILYP xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------FTISLRIRLKNLTLLISLNKHGTYESGFCSDQK GVRAVTLKGQKAYRTIMGSGKENTTVKAFCSVAEAVINMVFDKPKLLNLG GDLAKSLDEFQEEVLEYFEETETGTKYSGVQIARPKNLLGRDAVLLDSTL TTIKPEKET----------------------------------------- -----------------------------------EHLDVPKMDILPRVS VLRSPSSIYLIPIxxxxxxHYTSFLGCGHFGCTLAQVLGCAGVRKKLAHL AHACAYSLLAQACIQSDCSLRLTGQPAGLARSFLPIVCFRVCPALIGKRE SAFPSQVLAHELSIVSNADILVDxxKKGNRRSFxxxxxxxHIxELRRAVK AFQQVLYVEPGFSRANEVHLRLGLMFKVNNDWESALKHLQLSLIDTSPCS VTNLEKRVSLxxxxxxxxxKSFxxxxxSTTVHEAIW-------------- ----------------------------------------------FVxx xCxxxxxxxVSWWxxSKKISxxxxPGSTTLLLATVFKLFTSSEGVRFHIA HLFEVQGKYKTAKENYEQLLREKELPTHLKADICRQLGWMYHCVESLGEK IQRETVAIHCLLKSIDADPKSGQSLYLLGRCYASIGKVHDAFIAYRNSVE KSEGNADTWCSIGVLYQQQNQPMDALQAYICAVQLDKSHVAAWTNLG--- ILYESCNQPRDAYACYVNATRGHSSSLGGAVSPNSSSSNFSQHCRVAGGM HPNLGHRIKYLQSHIVNAPMPSITSKRRQLPPIEEAWNLPISAEMSSRAV QQQGPSMVQQRSGTTPSYQKVYGGPPLQYHNGINSHQPQGPPPPYPVQAS NPTKRFKKGTAGHMKQLNARFMGNKEMNIAMWER---------------- ----------------------------------FVGAWLKGIPVLNHLN EHGEVMEGGNIVGISPHRQIPLFYLNQQQMHTLQFLQQNITNLTPQQRVL GGFVPSGLGRWGSGSxxxxFxxx-------------------AGVMEQLQ HQFRLMQQHQQQLRQHRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSAQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -----xxxxxxxxxxxxxMNKLVxxxxxxxxxxxSLVRQSLxxxxxxxTS RSSWIAxxxxxxxxxxxVSSxxSSSxxxxxxxxxxxxxxxxxxxxxxxxG WVMFRxxxxVxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- NPCAVSPHIVAPVSALRQETLGYQQQTSSPPYQHTSGYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEESNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNKSNITKETSDVKPTEDEENVKSSDSGSSSSPVST ESLAxxxxxPSGDSAGYSKSFSVSSVIVKPQKEAVAKS------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ARKRYQEYLEMEKxERSEEYKKAEKRKLDIxVxxxxxxRKxLxM ATEEKREAIEVELQELKKKxxxxxxxxMEVTSIREIPSAVDIDVETIKEE APEEIKDTIPLMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAK-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxNLSDSDSxxSTGNFVRRKIKGG TGAILSVNKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAGCVxWxQAVGxxxxIAWNVGPLTARQxxxxxxxxxxxxLQSFKSI VPxxxxxxxxxxxxxxxxPKLFELIxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxASxxxxxCExxxxxxxxxxxxxxxxVVHxxxCARKQAPGLE GFVCLEEYRMS--------------------------------x------ -------------------------------------------------- -------------- >Tcm x------------xxxSAVNSVQRALSPQVNLSTKFWSPRKVAVLPSYSG CGLNHFHVASVYVYVLHSRQRKRDLRRLAHILERLVGLSTHWIRETKYFY KLYNG------------------------------------------GSI DIEEVERELHSSSSGGEENTPTWSEVENAFKSIKRVHPTEMRTSISPSSA VELNTTSALANFATEAVFTISLRIRLKNLTLLISLNKHGTYESGFCSDQK GVRAVTLKGQKAYRTIMGSGKENTTVKAFCSVAEAVINMVFDKPKLLNLG GDLAKSLDEFQEEVLEYFEETETGTKYSGVQIARPKNLLGRDAVLLDSTL TTIKPEKETVNGILKQCLGEPFEIFYPQLRVLAMPCEFGDQEDKLLRAQI ILVVKSKHSGNDISCEDHNRGRSFGDDMGELEGLKEHLDVPKMDILPRVS VLRSPSSIYLIPMxxxxxxHYTSFLGCGHFGCTLAQVLGCAGVRKKLAHL AHACAYSLLAQACIQSDCSLRLTGQPAGLARSFLPIVCFRVCPALIGKRE SAFPSQVLAHELSIVSNADILVDxxKKGNRRSFLAxxxxxHIxELRRAVK AFQQVLYVEPGFSRANEVHLRLGLMFKVNNDWESALKHLQLSLIDTSPCS VTNLEKRVSLxxxxxxxxxKSFxxxxxSTTVHEAIWLVx----------- -------------------------xxVVLxxTAEDGxxxxxxSVG---- -----------WWSSSKEISxxxxPGSTTLLLATVFKLFTSSEGVRFHIA HLFEVQGKYKTAKENYEQLLREKELPTHLKADICRQLGWMYHCVESLGEK IQRETVAIHCLLKSIDADPKSGQSLYLLGRCYASIGKVHDAFIAYRNSVE KSEGNADTWCSIGVLYQQQNQPMDALQAYICAVQLDKSHVAAWTNLG--- ILYESCNQPRDAYACYVNATRGHSSSLGGAVSPNSSSSNFSQHCRVAGGM HPNLGHRIKYLQSHIVNAPMPSITSKRRQLPPIEEAWNLPISAEMSSRAV QQQGPSMVQQRSGTTPSYQKVYGGPPLQYHNGINSHQPQGPPPPYPVQAS NPTKRFKKGTAGHMKQLNARFMGNKEMNIAMWERTILKRTSAEDLYKCVE SLVNAILMLPHGNADVEQRFSQNQAGNMTCLSAT---------------- -HGEVMEGGNIVGISPHRQIPLFYLNQQQMHTLQFLQQNITNLTPQQR-- -------------------------------------------GVMEQLQ HQFRLMQQHQQQLRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSAQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -----xxxxxxxxxxxxxxxxLVxxxxxxxxxxxSLVRQSLxxxxxxxTS RSSWIAxxxxxxxxxxxVSSxxSSSxxxxxxxxxxxxxxxxxxxxxYWQG WVMFRxxxxVxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- NPCAVSPHIVAPVSALRQETLGYQQQTSSPPYQHTSGYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEESNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNKSNITKETSDVKPTEDEENVKSSDSGSSSSPVST xxxxxxAILPSGDSAGYSKSFSVSSVIVKPQKEAVAKSEISVVPRRNHNT xVVKDDITKAExIWAM-------------------------NTSNVTDNE VCSLLSLGTCGLHVVHGFLRTGVEFVDWEIISLLRHTYYLF--------- -------------------------------------------------- --------------------IDSPARRSLFTQLTGCASFSLKFxGxRCSE MDYxxxxxxxxxExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxELxxxx-------MEVTSIREIPSAVDIDVETIKEE APEEIKDTIPLMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAK-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxSxNLSDSDSxxSTGNFVRRKIKGG TGAILSVNKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAGCVxWxQAVGxxxxIAWNVGPLTARQYxxxxxxxxxNxLQSFKSI VPMxxxxxxxxxxxxxxxPKLFELIxxxxxxxIRQCALILEFVKSxxxxx xxxxxxxxxASxxxxxCExxxxxxxxxxxxxxxxVVHxxxCARKQAPGLE GFVCLEEYRMSELIEV---------FDHFVLQPVVSCFDFRFHx------ -------------------------------------------------- -------------- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -HGEVMEGGNILGNSQHRQVPLFYLNQQQMQTLQFLQQNITNLTPQQR-- -------------------------------------------GVMEQLQ HQFRLMQQHQQQIRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- NPCTVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMDHSLAVTKSNRSNITKETSDIKPTEDEENVKLAPx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKELPSAVVINVETIKEE DPDEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEPPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIA--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------NKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAGCVxWxQAVGxxxxIAWNVGPLTARQYxxxxxxxxxNxLQSFKSI VxMVHLxxxxxxxxxxxxPKLFELIx------------------------ -------------------------------------------------- ---------------xxxxxxxxxxx------------------------ -------------------------------------------------- -------------- >Tps -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-----------------------------------------xxGVMEQLQ HQFRLMQQHQQQLRQQRATGVVRQSPQYLAYQQQRPVIKTYSMTQNMQGT VTPQTGFVDSGVGYPAATGSSQQSPGMPYKSATSEQQLYQQRQYQFTPTS TQ------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------G WVMxxxxxxxxxLDxxxxxxxxx--------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx NPCAVSPHIVAPVSTLQQETLGYQQQTSSPPYQHTSVYPPSSPNAKDLAV SEQELTALLSQKDLTTSFAENLLKHFETGSEETNSLLEESLTGNTLSSGP FSPSNMEHSLAVTKSNRSNITKETSDVKPTEDEENVK------------- -------------------------------------------------- ---------------xxxxxxxxxxAFTLGGDKAAYFIVHGNTSNVTDNE VCSLLNLGTCGLHVVPGFLRTGVEFVDWEIRSLLRHTYYLFTDLSSSSSI VYPVDRMCIFSIEVLWCADLQQNRLLGETAxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --------------------------xMEVTSIKEIPSAVDINVETIKEE APEELKDTIPLMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEAPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIA--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xVNKPGPKMLKFGTNVDLSDERKWRPQLQELMKLPAFARVVSAGN MLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWF AVPDAYWGVVYNLCERNNINYLHGSWWPSLEDLYDENIPVYRFNQRPGDL VWVNAGCVxWxQAVGxxxxIAWNVGPLTARQYxxxxxxxxxNxLQSFKSI VxMxxLxxxxxxxxxxxxPKLFELIxxxxxxxIRQCALILEFVKSxxxxx xxxxxxxxxASxxxxxCExxxxxxxxxxxxxxxxVVHxxxCARKQAPGLE GFVCLEEYRMSV-------------------------------------- -------------------------------------------------- -------------- >Tbi -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------MEVTSIKELPSAVDINVETIKEE DPDEIKDTIPIMDLTVESPVMEIAELCEPSPEIEYNIDMDAKMVLDSCKG HGINGVSNCSILSDRAPPPQPPEPPQQRLTREQLLPPTPSVYLENKKDAF SPQLQEFCLKHPIAVVRGLAAALKLDLGLFSTKTLVEANPDHSVEVRTQM QQTSDENWDPQQGRKVWACISHRSHTTIAKxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------x------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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