>Tge -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- ------------------------------SPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKQNPIQL LYQAYVTANQAAQNDSALGAKAREIFQSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIRSVLDQLEEKGILKLEEDGRKVVN LNNNRRATLVKSDGTTLYLTRDIAAALHRYGRHGFDRLLYVVENGQNDHF TALMGTMKQMDLLWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSASDTTSDILGVSAxxxNDLKQKRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVIEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNIL---- ----xxxxxxxxSLESEVPLxKKHKFxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxAQTEVx >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAQNDSALGAKAREIFKSLEEGSFADIKKWENYRKYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIKSVLDQLEEKGILKSEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDIAAALHRYGRHSFDRLLYVVENGQNDHF TALMGTMKQMDLPWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSADDTTSDILGVSAxxxNDLKQKRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVVEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tsi xxxxxxxxxxxxxxxxxxxxESxxxxxxxxxxxLFISLNKNxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxNKTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxVLEDILDNSKGxxxxxxxxxPSFDEKIVVEY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAQNDSALGAKAREIFKSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIKNVLDQLEEKGILKLEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDIAAALHRYDRHSFDRLLYVVENGQNDHF TALMGTMKQMDLFWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxRVSDTTSDILGVSAxxxNDLKQRRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVVEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tps xxxxxxxxxxxxxxxxxxxxESxxxxxxxxxxxLFISLNKNxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxNKTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxILEDILDNSKGxxxxxxxxxPSFDEKIVVEY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAQNDSALGAKAREIFKSLEEGSFADIKKWENYRNYTVDE LRRIYKRLGVTFDEYEWESMYSTVQIKSVLDQLEEKGILKLEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDVAAALHRYDRHSFDHLLYVVENGQNDHF TALMGTMKQMDLFWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSVSDTTSDILGVSAxxxNDLKQRRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVVEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHVASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tdi xxxxxxxxxxxxxxxxxxxxESxxxxxxxxxxxLFISLNKNxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxNKTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxILEDILDNSKGxxxxxxxxxPSFDEKIVVEY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAQNDSALGAKAREIFKSLEEGSFADIKKWENYRNYTVDE LRRIYKRLGVTFDEYEWESMYSTVQIKSVLDQLEEKGILKLEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDIAAALHRYDRHSFDHLLYVVENGQNDHF TALMGTMKQMDLFWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSASDTTSDILGVSAxxxNDLKQRRQ RxxxFDWNKALQLQGDTGPKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVVEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAENDSALGAKAREIFKSLEEGSFADIKKWENYRKYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIKSVLDQLEEKGILKSEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDIAAALHRYDRHSFDRLLYVVENGQNDHF TALMGTMKQMDLPWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESPxxxxxx------------------------------------ ---------xxxxxxxxx-------------------------------- ------------LQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVVEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tte -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxSSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKQNPIQL LYQAYVTANQAAQNDSALGAKAREIFQSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIRSVLDQLEEKGILKLEEDGRKVVN LNNNRRATLVKSDGTTLYLTRDIAAALHRYGKHSFDRLLYVVENGQNDHF TALMGTMKQMDLLWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSVSDTTSDILGVSAxxxNDLKQKRQ RxxxFDWNKALQLQGDTGSKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVIEVARFGEVLNKSHEELEACILVTYLFRLC------------- -----NLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILGLKP LNEx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tbi -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxSSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKQNPIQL LYQAYVTANQAAKNDSALGAKAREIFQSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIRSVLDQLEEKGILKLEEDGRKVVN LNNNRQATLVKSDGTTLYLTRDIAAALHRYGRHSFDRLLYVVENGQNDHF TALMGTMKQMDLLWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------Sx------------------------------ ---------------------------LYSLEQNCGAQLPTECDPSVLQE TEAVLLVIEVARFGEVLNKSHEELEACVLVSYLFRLCxRMGQGITLAVDW SVDEGNLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tcm xx----------xxxxxxxxESxxxxxxxxxxxLFISLNKNxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxVLExxxxxxKGHRxNxxxxxPSFDEKIVVEY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKHNPIQL LYQAYVTANQAAQNDSALGAKAREIFKSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIKNVLDQLEEKGILKLEEDGRKVVN LDNNRRATLVKSDGTTLYLTRDIAAALHRYDRHSFDRLLYVVENGQNDHF TALMGTMKQMDLFWAERMRHVKFGRIRGMSTRKGSVVFLKDVLDETRDLM HKKQLESP------------------------------------------ ------------------NTRIxxxSVSDTTSDILGVSAxxxNDLKQRRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE IEAVLLVVEVA--------------------------------------- ----xNLTNQAFKVLRIKDQDPHIASQRLLLFHSSRRVLQQGMNILG--- ----------------------------xxxxxxxxxxxxxxxxxxxxxQ FVQGRDVQRGVAVLVPxxxxxxxxxQxFDYVEREQRLTxYRVQGRAMRSR RSHRLSVVSQxxxxxxSSPPDAAGFDHGSSLHQPPPLSLRGxxxxxxxTP AFVDQ---------------------------------QLDAFHGVGFDR RxxRAPVETIPVxxxxxVYQPGHIGSVSKRGAVKGRVGLHPQVDGGPFVD xxxxTxxxxxxxxxxxxxxTFRRFAESDVRPTIxxTVHDVFEYEVRAPEQ GDVLLHLASRREHPPDVIACHLSGLYLLQQLVVTRGxxxxxxxxxxxxx- -------- >Tpa ------------xxxxxxxxESxxxxxxxxxxxLFISLNKxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxNTTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxILEDILNNSKGHRxxxxxxxxxxxxxxxxxY--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SSPNIAKPFHMGHLRSTIIGN FISNLHEHLGGKVVRINYLGDWGTQFGLLQVGLNMSNYTDEMIKQNPIQL LYQAYVTANQAAQNDSTLGAKAREIFQSLEEGSFADIKKWENYRNYTVDE LQRIYKRLGVTFDEYEWESMYSTVQIRSVLDQLEEKGILKLEEDGRKVVN LNNNRRATLVKSDGTTLYLTRDIAAALHRYGRHGFDRLLYV--------- -------------------------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx-------YxRIxxxSVSDTTSDILGVSAxxxNDLKQKRQ RxxxFDWNKALQLQGDTGTKLQYTHCRLYSLEQNCGAQLPTECDPSVLQE TEAVLLVIEVARFDEVLNKSHEELEACVLVSYLFRLC------------- -----NLTNQAFKVLR---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRFETSQ----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------