>Tge --------------------------------------------xx---- -------------------------------------------------- -------------------------------------------xxxx--- ------------------------------------------FRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYVVELKGEIVLPLVCF EESSTVEEPFSLHLILYPMGLLISVPFLVSTMLVYCLIPQLRDLHGKTLS CHVLCLAAAYVLLAIVQLGGRDFNDHLCT--------------------- -----II------------------------------------------- -------------------------------------------------- ------------------AFLTQFTFQACFFxLQVMCFDTxWVIRSSYIN KTSIQLKPYIENKAKEMAGIDNETF-DDVDNSLEMKRVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNLIMFVLSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVLELVQRQLWPQISHYLCKCRKNTAGSSIKPKVMNNNGFPHNVTY SSVSTNEAP----------------------------------------- -------------------------------------------------- --------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MCFDTxWVIRSSYIN KTSIQLKPYIENKAKEMTGIDNETF-DDVDNSLEMKRVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNLIMFVLSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVLELVQRQLWPQISHYLCKCRKNTAGSSIKPQVMNNNGFPHNVTY TSVSTNEAP----------------------------------------- -------------------------------------------------- --------------------------------------- >Tbi --------------------------------------------xx---- -------------------------------------------------- -------------------------------------------xxxx--- ------------------------------------------FRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYIVELKGEIVLPLVCF EESSTVEEPFSLHLILYPMGLLISVPFLVSTMLVYCLIPQLRDLHGKTLS CHVMCLAAAYVLLAIVQLGGRDFNDHLCTxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- ---------------------------------------------SSYIN KTSIQLKPYIENKAKEMAGIDNETF-DDVDNSLEMKRVFCLPPLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNLIMFVLSALMIWKSQWQEGSGRSERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRILELVQQQLWPQISHYLCKCRKNTAGSSIKPKxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- --------------------------------------- >Tte --------------------------------------------x----- -------------------------------------------------- ----------------------------------------------xxxx ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxFRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYIVELKGEIVLPLVCF EESSTVEEPFSLHLILYPMGLLISVPFLVSTMLVYCLIPQLRDLHGKTLS CHVMCLAAAYVLLAIVQLGGRDFNDHLCTxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- ---------------------------------------------SSYIN KTSIQLKPYIENKAKEMAGIDNETF-DDVDNSLEMKCVFCLPPLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNLIMFVLSALMIWKSQWQEGSGRSERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVLELVQQQLWPQISHYLCKCRKNTAGSSIKPKVMNNNGFPHNVTY TSVSTNEAP----------------------------------------- -------------------------------------------------- --------------------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------AFLTQFTFQACFFxLQVMCFDTxWVISSSYTN KTSIQLKPYIENKAKEIVGMDNETF-DGVDNSSEMKNVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNMIMFVSSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVRELVQRQLWPQISQYLCKCRKNTAGSSIKPKVMNNNGFHHNVTY TSVSTNEAxxxxx------------------------------------- ---x---------------------------------------------- --------------------------------------- >Tce --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxx------ ------------------------------------------FRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYVTELEGEIVLPLVCF EDSSTVDEPFSIHLILYPIGLLISVPFLVSTMLVYCLIPQLRDLHGKTLS CHVMCLAAAYVLLAIVQLGGRDLNDHLCT--------------------- -----VI------------------------------------------- -------------------------------------------------- ------------------AFLTQFTFQACFFxLQVMCFDTxWVISSSYIN KTSIQLKPYIENKAKEMSGIDNETF-DDVDNSLETKNVFCLPTLMVGGKL PSKSTERKVFLCYSIYAWCWPIILIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNMIMFVLSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVRELVQRQLWPQISQYLCKCRKNTAGSSIKPK------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLADFRS FRNG---------------------------------------------- --------------------------------------- >Tsi --------------------------------------------x----- -------------------------------------------------- ---------------------------------------xxx---xx--- ------------------------------------------FRLEPHYE DTDEFHVMRNGSLSVPYLYPDYYLTPHNYCLETFYVTELEGEMVLPLVCF EESSTMEEPFSLHLILYPIGLLISVPFLVTTMLVYCLIPQLRDLHGKTLS CHVMCLAAAYVLLAIVQLGGRDLNDHLCT--------------------- -----VI------------------------------------------- -------------------------------------------------- ------------------AFLTQFTFQACFFxLQVMCFDTxWVISSSYIN KTSIQLKPYIENKAKEIVGMDNETF-DDVDNSSEMKNVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNMIMFVSSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVRELVQRQLWPQISQY----------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tdi xxxxxxxxxxxTYSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------FRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYVTELEGEIVLPLVCF EESSTMEEPFSLPLILYPIGLLISVPFLVTTMLVYCLIPQLRDLHGKTLS CHVLCLAAAYVLLAIVQLGGRDINDHLCT--------------------- -----VI------------------------------------------- -------------------------------------------------- ------------------AFLTQFTFQACFFxLQxMCFDxxxVISSSYIN KTSIQLKPYIENKAKEIVGIDNETFxDDVDNSSEMKNVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGHVK CWYSSQEAELNYFYGPIIFVLVTNMIMFVSSALMIWKSQWQEGSGRTERQ TFRLSFSLFFVMGINWIMEVISWAAGGPKHIWYVTDTINTLQGVIIFAIF VLDKRVRELVQRQLWPQISQYLCK-------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxL------------------------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxAFLTQFTFQACFFxLQVMCFDTxWVISSSYIN KTSIQLKPYIENKAKEIVGIDNETFxDDVDNSSEMKNVFCLPTLMVGGKL PSKSIERRVFLCYSIYAWCWPIVLIIVSTMIDLIPTIPSSYIKPNFGH-- -------------------------------------------------- -------------------------------------------------- -----------------------------------PKxxx---------- -------------------------------------------------- -------------------------------------------------- --------------------------------------- >Tms --------------------------------------------x----- ---------------xxxxxxxxxxxxxxxRENRLxxxxxxMTDTAxxxx xxxxxxxRExxxxxQTxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ ------------------------------------------FRLEPHYE DTDEFHVLRNGSLSVPYLYPDYYLTPHNYCLETFYVTELEGEIVLPLVCF EDSSTVEEPFSIHLILYPIGLLISVPFLVSTMLVYCLIPQLRDLHGKTLS CHVMCLAAAYVLLAIVQLGGRDLNDHLCT--------------------- -----VIEGLEKQQHYIIDGKPPTPNTPSPVHQDKIIASTAMSPVFQTIR ERVRNHPQYLRPVLNHDLPVISSLFYYESDALDDVVTKA----------- ------------------AFLTQFTFQACFFxLQVMCFDTxWVISSSYIN KTSIQLKPYIENKAKEMAGIDNETF-DDVDNSLEMKNVFCLPTLMVGGKL PSKSTERRVFLCYSIYAWCWPIILIIVSTMIDLIPTIPSSYIKPNFGH-- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------