>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MRIKW------------------------------------------------------ ---------------------------------------AKVVTLAVI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ILNL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---IGLYYIWKLLSYVNIDKHYDQLRSNTDSSLHNEISHVVKDLTIVIRNFEYFENDIPE TIQSLMSVFPKVPILIVSDILPYPPLNLKQLNKNGTFVKLINLSFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKGQPDRLISTPFLNSKVRDCLKLKLELKEWYLEY ILTRDSDLCDVVK--GKQVILLETGTLRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVRETGAVEWYGCTRETSRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFISRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKSYGEQTLDCFCGLSSSIQMSQLYEG------------- RLEKSPSLHQIRIRTSISLSLAVVQQECDASDHVTTEAGTMGK--SGGLVKTGGSRTNAS EPCQFVSSLGHNILDANG---LVLVDVQVKDVKLTVG----SDRAKNGAREGRPAHVAHR GSQ----- >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MRIKW------------------------------------------------------ ---------------------------------------AKVVTLAVI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------IFNL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---IGLYYIWKLLSYVNIDKHYDHLRSNTGSSLHNERSHVVKDLTIVIRKFEYFENDIPE TIQSLMSVFPKVPILIVSDTLPYPPLNLKELNKNGTFVKLINLNFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKVQPDRLISTPFLNSNVKDCLKLKLELKEWYLEY ILTSDSDLCDVVK--GKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLRNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLEKGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPVIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFVTHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPEQLEFTHKEKVPDVKLQSD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YDY-- >Tte M------------H---------------------------------------------- --------------LSDRC----------------------------------------- ------------------------------------------------------------ -------------GH--------------------------------------------- ------------------------------------------------------------ ---------------------------------------------ATS------------ ------------------------------------------------------------ --------------------VETCVRIQVGE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SAGDVAESLDTCILR--------------------------LSPTKAEV DEKMYINSQLERKLCNLDDTLPLQEKQIQNISQIYENSNFTM-IFVSQIASLYAQEKCVD MNKIQWQQTKAEIVAAKEEEYEEKYFQTTKKLKVMETTFTDGD----------------- ------------------------------IPIQNEIRKKKVLKLKTILQEKKMSKLDDL KAKKDEMANNLSQEVARVERENSVLKKK---NIAFLLRTQKQ-------------LK--- -EEEFAYQHLALRWNSM----STIHHCFNCILADKEAC-PNLL----------------- -------------------------------------ALLSAPASKQEK----------- ----------------HLFPALSNLADIIKDTSTQTVHLIFSLRFTHFRLLKKDIHLKVN VPAFMWKKSEKSFSKKHVRPPGKDSKPNLI----------TE------------------ ---------KPELMSQTPWLSYTPP----------------------------------- --RLRLYYIWKLLSYVNIDKHYDQLRSNTDSSLHNEISHVVKDLTIVIRNFEYFENDIPE TIQSLMSVFPKVPILIVSDILPYPPLNLKQLNKNGTFVKLINLSFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKGQPDRLISTPFLNSKVRDCLKLKLELKEWYLEY ILTRDSDLCDVVK--GKQVILLETGTLRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVRETGVVEWYGCARETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFISRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKLHSD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YEY-- >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VKLLQNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVRETGAVEWYGCTRETSRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDREFPEHFLRPISSIDFISRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKLHSD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YEY-- >Tsi M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------R------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S EPAFAWMESGKPFRKNHPQFTRPRFEPRSP----------RP------------------ ---------QQSSFNTTSALANYAT----------------------------------- --EAGLYYIWKLLSYVNIDKHYDHLRSNTGSSLHNERSHDVKDLTIVIRKFEYFENDIPE TIQSLMSVFPKVPILIVSDNLPYPPLNLKELNKNGTFVKLINLNFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKVQPDRLISTPFSNSNVKDCLKLKLELKEWYLEY ILTSDSDLCDVVK--GKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLEKGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRHTARHVFDQLDAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQAHSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKLQPD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YDY-- >Tcm M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------WPSTH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------WT-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TLARYTPTADVSLVSG YTETSSECPVRQQRTDPSRKEPGLVRCVCLLDVDTQHRWRLVSAHKLVYP------RAEV DEKMYSNSQLERKLCNFDDTLPLLEKQIQNISQIYENLNFTISYFVSQIASLYAQEKCVE MNKIQWQQTKAEIVAAKEEEYEEKYIQTTKKLKVMGTTFTDGD----------------- ------------------------------IHIQNETRKKKVLKLKTILQEKKMSTLDEL KAKKDEMANNLSQEVARVERENSVLKVELEEVNPHLRGESGKPTPSSPDRDSNLDLPILS SRARHNKRVSQLRHRGIPNGLSEGDRSLDERRGLGAGYEPPSTVD-----LGLVKISRPL ISTATGVLTAVAWRTRGCPEDGSRRVGRRVGRMVLCGNSRISPGGVCRLLGGPYTVSETR YTGLKWQPTVLMNRRPSPHSPESNRVTP---------------------------RLRGS EPAFAWMESGKPFRKNHPQFTRPRFEPRSP----------HP------------------ ---------QQSSFNTTSALANYTT----------------------------------- --EAGLYYIWKLLSYVNIDKHYDHLRSNTGSSLHNERSHDVKDLTIVIRKFEYFENDIPE TIQSLMLVFPKVPILIVSDNLPYPPLNLKELNKNGTFVKLINLNFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKVQPDRLISTPFSNSNVKDCLKLKLELKEWYLEY ILTSDSDLCDVVK--GKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLERGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLDAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKLQPD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YDY-- >Tps M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------YVL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ELE------------------------------------------------- ---------------------------------------TDGD----------------- ------------------------------IQIQNETRKKKVLKLKTILQEKKMSTLDEL KAKKDEMANNLSQELARVERENSVLKTG---ATIYLFKQ----------------LLICS CEAEFDRVPDPLLYRKI----LEAPKIKSRTYGQGHGVHPTEI----------------- -------------------------------------RTSISPSSAVEL----------- ----------------NTTSTLANYATE-----------------------------AGS EPAFAWMEGGKPFRKNHPQFARPRFEPRSP----------RP------------------ ---------QQSSFNTTSALANYAT----------------------------------- --KAGLYYIWKLLSYVNIDKHYDHLRSNTGSSLHNERSHDVKDLTIVIRKFEYFENDIPE TIQSLMSVFPKVPILIVSDNLPYPPLNLKELNKNGTLVKLINLSFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKVQPDRLISTPFSNSNVKDCLKLKLELKEWYLEY ILTSDSDLCDVVK--GKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLEKGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKSYGKQALDCLCGISSLIQMSQ----------------- -----------------------VQFLC---------PGTMGK--SGGLVKTGGSRTNAN IP---------------------LLDAHQEDLRIEWV----ERYGRTAACNN------FT FQEDDYGL >Tms MVAVIKVNMRLPSHGPRGRFLAGCMTVGVNVEVDVYHAINRKRQRRGRSSSLPPKQGHRE KPKGNNCSLETWRLLAHKCHKPPPCTIRFYTTCASMPGIRKLLVDKWAVPSCQRQNSLKG EQLHRTSRSRPEIKSYQPSGRRLLAKSKQPHRTSRSIPEIKSYQPSGRRLLAKSKQPHRT SRSRPEIKSYQPSGHRLLAKSKQPHITSRSRPEIKSYQPSGRRLLAKSNQPHRTSRSRPE IKSYQPSGRRLPEIEPYRPSGRRLLAKSKQPHRTSRSRPKIKSYQPSGRRLLAKSKQPHR NSRSRPEIKPYRPSGHRFLTKIVLTVVSLDTLTLFRTHCCTENLDATGSEPVNFGYVAGN SDQSYTELATGSLEPTPRSSKRGLRFAARPNTYPLRADEDLIKVWTRLKADKDLIQVWTR LREDEDLIQVWTRLKADEDLIQVWTRLKAGEDLIQVWTRLKAGEDLIQVWTRIRTDEDLI QVWTRLKADKDLIQVWTRLKADKDLIQVWTRLKAGEDLIQVWTRLKAGEDLIQGSEVQPP LLLCINLAGNRNCVKEDGVLVSVDSSSVLIWLETETASSKMGSWSVFRFCGGNGLSSSRG NAVFTPPTPQNTPQSITKGTGTGEMR---LLEVDRQHRWRLVSAYKLVYPWGMLPTKAEV DEKMYNNSQLERKLCNLDDTLPLQEKQIQNISQIYE-------------------EKCVE MNKIQWQQTKAEIVAAKEEEYEEKYFQTAKKLKVMETTFTGMEGLILKKFICICVEGEQK TNLSVLMIRFGPWDEKRWTAMPLTIRLPVHIEIQNETRKKKVLKLKTILQEKKMSTLDDL KAKKDEMANNLSQEVARVERENSVLKLGTPDSKVATNHRARWTGWCLAGRGSNPDSP--- ------------------------------RADQGTGTRPARTADPDHGEAKMVKKGTPR VHTRS-------------------------------VRQCTDISAYQQS----------- ----------------RNIHRHTKRHES-----------------------------PGR PKLVARSPERPKLVARSPE--RPKLVARSPERLREVHDPSRPALLHGACHGLAHDLCHAP SSGRERDFHRDDDFYAVDNCALHSASDVVIDCCAHVHIGEGWGGRWDCQVKRALLLSQCR LWRDGLYYIWKLLSYVNIDKHYDHLRSNTGSSLHNERSHVVKDLTIVIRKFEYFENDIPE TIQSLMSVFPKVPILIVSDTLPYPPLNLKELNKNGTFVKLINLNFNFNRLFEEKNPLFHI KTNFVLIIPDSTRINSKLFNVMLKELKVQPDRLISTPFLNSNVKDCLKLKLELKEWYLEY ILTSDSDLCDVVK--GKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLRNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLEKGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPVIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFVTHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPEQLEFTHKEKVPDVKLQYT--MD-------EIPLSQRYVA------------- ------------------------------------EKGIIN------------------ ------------------------------------------------------------ -------- >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MRIKW------------------------------------------------------ ---------------------------------------AKVVTLAVI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ILNL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---IGLYYIWKLLSYVNIDKHYDQLRSNTDSSLHNEISHVVKDLTIVIRNFEYFENDIPE TIQSLMSVFPKVPILIVSDILPYPPLNLKQLNKNGTFVKLINLSFNFNRLFEEKNPLFHI KTNFVLIIPDSTRISSKLFNVMLKELKRQPDRLISTPFLNSKVRDCLKLKLELKEWYLEY ILTRDSDLCDVVK--GKQVILLETGTLRRLPDPFMLPFPEALYIQTSSKNIKVKFLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVRETGAVEWYGCARETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFISRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKRYGEQTLDCLYGLSSLIQMSQELWVNQEVWSKQEVLAL MQENPPPVHPTEIRTSISPSSAVELNTTSTLANYATEAASYLPDYAAMLV---ADRVTLV LRCP-----GRQVDVVNGHIAVVLADHHQTNFHSGSSVPSSSRYSSDGS----------- ---SQY-L >Tdi M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------Y---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RSTAKGTGTA---------------------------------KAEV DEKMYSNSQLERKLCNFDDTLPLQEKQIQNISQIYE-------------------EKCVE MNKIQWQQTKAGIVAAKEEEYEEKYIQTTKKLKVMETTLTDGD----------------- ------------------------------IQIQNETRKKKVLKLKTILQEKKMSTLDEL KAKKDEMANNLSQEVARVERENSV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LKEKP-----PPVHPTEIRTSISPSSAVE------ -LNTTSTLANYATEAGKQVILLETGILRRLPDPFMLPFPEALYIQTSSKNIKVKLLHNQV LRDGKPLFETTHAQWKVRQAEQGRRRHMYQTLGFKKVVLEKGAVEWYGCTRETPRCFGTV TNDMPQYLWEGKWTPPCCLEGLRRTARHVFDQLEAAGVRYWLEGGSLLGAMRMGDILPWD YDIDVGIYRDDIPLCSWLNQARSQPIIDDKGFVWEKANEGDFYRVQFSQVNRLHVDLFPF YKKNSTMTKDTWFITHKQDKEFPEHFLRPISSIDFIGRKVSAPNNIRDFLELKFGKGAIE NPEYPDPDQLEFTHKEKVPDVKLQSD---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---YDY--