>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MYVY--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TR------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LGVIVLGRVT-------------ENSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVVSEEVEDLIVHSSKCASKESTPSFPVSEGVFYEESDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNQLSTSNFVYKLVKVLMAGKQ--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQPDDVFGNGTDWRKCEVGDEVLYCSVSSWDRPWAADTLYSQPDCRLQFQEVYLH----- LCEGRGENYFG---------EITLNTPNQDLNLDILIIG---SKVYCKSSTL-------- -------NQVTTEGGANEAESTSAPNDMEGTSFEPAAVEERVAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVAETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPHYVHPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGD DKNLATSEKDDSSSEETEEIGTIEKQKEGSEDIKEVEGELEIGNVSSETTTVYGDQSREV HSEYNANIHQEDHKSEEALDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEEY KNELAQIIVHTLDKLDADDMKRV----------LVDGMLYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQAFIDNSIPKVVESECSSETKDHPLPITRQRRSLLGGKTPIDVN DPKVKTVAAFALTKLDLTDSFPNSQPHVKIVAASKQVVQGSLYHLTLELVEGGSSNENV- ----------ATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNRVSNSLYSHTLITLVNATKQ------------VVAGLKYSLVLEVGE STCTKNEANASTCPLREGSG-----IQICHMVVVEQLWLNKTEVTDFSCNPK-------- -ETSLDPSAHRRRREVGNVGIPGGLTLISTDDPNVQEAASFALSELDHITNSANTQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNTPTQECEVVVWSQPWLNRTE LTESSCGPANSGGRVKRGSEPHILGAPTDSDPEDPYIQELATFALTELDKSSNALFALKK LNIIRATTQVVSGKLVTLTMEVGYTKCRKNKNLVIEECDLKEGS---------------- ------------------SVRSANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKRVEQLQRTEQGTAKYGATQFADLTA----------AEFKKKYLGVNPKLKSENLSP LPTAKIPHIQLPEEFDWRHYNVVTEVKNQ-------------------MLGTGEPTILNQ -----C-----AC----------AFDNTCALQSE-------------------------- ---TSRQLR------------------------------WSL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >Tte MALKNVKHIFCGSLLILLTL---CEYNI--GFNLDTKFPVIFEDPQQNRSGSRLSYFGFS VILQQSMENMHRVLVGAPRGNSSIGNQRNIAEPGLVFTCSLEKPYRRCEEQELDPTGNER SPPYGSIYFDHKDGAWIGGSMDIQTPENGGRVSVCGHRWINDFNQDYLMIGVCYVLPPDS STVVDKLLPLVEPDKKLYTYPDGRTVYNYGLGEAGTSVHFPDTQSGKSEMLIGSPGVFNW KGTVILLTESDSLPGGTNKRQLSLDPLGKVVVADPNQVNLK---------------FFDY FGYQVNSGRFFGKDVLYYVSSAPRAACYKGMVIVFKMTSNGMTFKTKKEGTVIGEYFGAS LAVADITNDGLDDLIVGAPIFSKHYEEGRIYIFHGSTKGEFNNPIVGETIDGYSPGGRFG SAIASLGDLDQDGFDDIVVGAPYEKDRGAIYIYNGRPLGLTPKYSQRILAEEVHPVLRGF GISFSRPTDIDDNKYNDVAVGSFLSGHAVLLRSRPVISLGMSLTSTTTKLQREDQSFNVS VCVWYKGVNILVDKVDVTRTLIIDRNFKRGYVSSPDKILDKFAVYVKKISVGKMISCENI TVHLDQTKTHRSLDAFEMAMNCTLSYIEVPVSPIIVSSTVQGEDHFDRKLPVLHRHYGER EESLTVPYAFDCGEDDVCHSDLSLVCELVGVGMNGAAYVIGSSDSLELVIHVTNKEEPAY VTEVTVILLRPLQLTNLLARCHETRNVSTTVTCRLDDPLRASNKHTCTKGHADKGVSLIL FDLLSELRLTLDTRDVTNTIQNLHINVTVSTKSVETKLDDNSQNLIVPLLTEADITITGD FNYEVSLADSSEQVSIESHEIWLQLMGRSRTSQDVEYNYFKKQSDSTVFIFHHIYEGYQY DTELIYNSDIKFDKQESSPDVSSFSDVDSLVAERTKRWTQDYQGISHTIVANNEGANKGT ------------------------------------------------------------ -----------------------------DSSQCVDLQNVETNLPPSNRTFFLNCSSSYV KYASIKFKTERLTWTQTSARFILRLELDLAKLEKFMEMKDIVYLSTQGHVKITQPDNYNS SMNTRPDLVQVSTMFRINEPRKVAKYIIALSIIAGILLILFIVTGLIKAGFFKREKKEEL KQLMSTEVSDNFRKYSIDNKHNGINIDMSTHMPAEVGWADVQKAADEFNYRETMAEHKGA TKYDVQESYD-----------------ES------------------------------- ----------------------------------IIISNPCALASGICPVSSSGPQFNPW SEFRLMTFSWNRADTWRAMSSRGATLGPHCS---------YPQHCSIGR----------- -----AVGLITIDGVV-------------ENSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEDLIVHASKCASKESTPSFPVSEGVFYEESDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNQLSTSNFVYKLVKVLMAGKL--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQPDDVFGNGTDWRKCEVGDEVLYCSVSSWDRPWAADTLYSQPDCRLQFQEVYLH----- LCEGRGENYFG---------ETTLYTPNQDLNLDLLIIG---SKVYCKSSTL-------- -------NQVTTE--ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEEAVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVAETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILYNNCTQDDNNDLDN EIIPHYVHPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGD AKNLATSEKDNSSSEETEEIGTIEKQKEGSEDVKEVEGELEIGSVSSETTTVYGDQSREV HSEYNANIHQEDHKSEEALDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEEY KNELAQIIVHTLDKLDADDMKRVVLKIIDAKKQLVDGMLYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQAFIDNSIPKVVESECSSETKDHPLPITRQRRSLLGGKTPIDVN DPKVKTVAAFALTKLDLTDSFPNSQPHVKIVAASKQVVQGSLYHLTLELVEGGSSNENV- ----------ATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAVSTALAHLNRVSNSLYSHTLITVVNATKQ------------VVAGLKYSLVLEVGE STCAKNEANASTCPLREGSG-----IQICYMVVVEQLWLNKTEVTDFSCNPK-------- -ETSLDPSAHRRRREVGNVGIPGGLTLISTNDPNVQEAASFALSELDHITNSANTQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEKPCQLKPNTPTQECEVVVWSQPWLNRTE LTESSCGPANSGGRVKRGSEPHILGAPTDSDPEDPYIQELATFALTELDKSSNALFALKK LNIIRATTQVVSGKLVTLTMEVGYTKCRKNKNLVIEECDLKEGSETQLCHLEVWDQPWRK HREVNNIKCGSSQTFTKRSVRAANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKRVEQLQRTEQGTAKYGATQFADLT-------------------------------- --AAKIPHIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNIEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGESEQCHFNKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HT---------------------------------------------------------- -----YPMFHKTLPFWVIKNSWGPSWGEQVGN---------------------------- --------------------EAMHGNG-LQSL----------PMAT-----------TGC IAAT---------------------ELAE >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MYVY--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TI------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LGVRVLGRVT-------------ENSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEDLIVHASKCASKESTPSFPVSEGVFYEESDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNQLSTSNFVYKLVKVLMAGKL--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQPDDVFGNGTDWRKCEVGDEVLYCSVSSWDRPWAADTLYSQPDCRLQFQ---------- ------------------------------------------------------------ ---------------ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEEAVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVAETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILYNNCTQDDNNDLDN EIIPHYVHPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGD AKNLATSEKDDSSSEETEEIGTIEKQKEGSEDIKEVEGELEIGSVSSETTTVYGDQSREV HSEYNANIHQEDHKSEEALDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEEY KNELAQIIVHTLDKLDADDMKRV----------LVDGMLYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQAFIDNSIPKVVESECSSETKEHPLPITRQRRSLLGGKTPIDVN DPKVKTVAAFALTKLDLTDSFPNSQPHVKIVAASKQVVQGSLYHLTLELVEGGSSNENV- ----------ATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNRVSNSLYSHTLITLVNATKQ------------VVAGLKYSLVLEVGE STCAKNEANASTCPLREGSG-----IQICYMVVVEQLWLNKTEVTDFSCNPK-------- -ETSLDPSAHRRRREVGNVGIPGGLTLISTDDPNVQEAASFALSELDHITNSANTQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNTPTQECEVVVWSQPWLNRTE LTESSCGPANSGGRVKRGSEPHILGAPTDSDPEDPYIQELATFALTELDKSSNALFALKK LNIIRATTQVVSGKLVTLTMEVGYTKCRKNKNLVIEECDLKEGS---------------- ------------------SVRAANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKRVEQLQRTEQGTAKYGATQFADLTA----------AEFKKKYLGVNPKLKSEELSP LPAAKIPHIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNIEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGESEQCHFNKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HITSIRHRVM-----------PYWTVKNSW--GPSWGEQVRFAEGLTLH----------F LYFAAYPMFHKTLPFWVIKNSWGPSWGEQLANALV--------------------VLSST SK------DGEIEVQISGYYRVYRGDG-TCGV----------NLMA-----------SSA VIA-------------------------- >Tsi MK----NQLWCLELLAFIRVDSGHKVNLVPGINLDIHLA--------------------- ---------LNIVLIGAPRGNSSLGNQRNIPEPGLVFTCSLERPYRRCEEQELDPTGNER SPPYGSIYFDHKDGAWIGGSMDIQTPENGGRIAVCGHRWINVFNQDYLMIGVCYILPPDT STVVDKLLPLVEPDKKLYTYPDSRTIYNYGLGEAGTSVHFPDTESGKSEMLIGSPGVFNW KGTVILFTESDSLPGGTNKRQLSLDPLGKVVVADPNQNQLSLPQAASSGRETRVMLLVEL QGYQVNSGRFFGKNVLYYVSSAPRAADYKGMVMVFEIASNGLKFKTKKEGTIIGEYFGAS LAVADITGDGLDDLIVGAPIFSKHYEEGRIYIFHGSTKGEFKNPIVGETIDGYSPGGRFG SAIASLGDLDQDGFDDIVVGAPYEKDRGAIYIYNGRPLGLTPKYSQRILAEEVHSVLRGF GISFSRPTDIDDNKYNDVAVGSFLSGHAVVLRSRPVISLGMSLTSTTTKLQREDQSFNVT VCMWYKGVNILVDKVDVTRTLIIDRNFKRGYVSSPDKILDKLAVYVKKISVGKMISCENI TVHLDQTKTQRSLDAFEMSMNCTLSYMEVPGSPIIVSSTVQGEDHFDRKLPVLHRHYGER EESLTVPYAFDCGEDDVCHSDLSLVCFLVGVGMNGAAYVIGSSDSLELVIHVTNKEEPAY VTEVTVVLLRPLQLTNLLARCHETRNVSTTVTCRLDDPLRASNNH--------------- ----SELRLTLDTRDVTNTIQNLHINVTVSTKSVETKLDDNSQNLIVPLLTEADITITGG FN------------------------------------------------------GYQY DTELIYNSDIKFDKQESSLDDSSFSDVDSLVAERTKRWTQDYRERSHTIVKKNEEANKGT VCSKLGEVKRAVRILCQMAIGMSRGQHYIIIVIVIVIVIVIVIVIVIIINSFCPVARLIN KRSGRNKMSFIFCLFEAKKSVARDSHKHQNSSQCVDLQSVETNLPPCNRTFFLNCSSSYV KYASIKFKTERLTWAQTSARFTLRLELDLAKLEKFIGMKDIVYLSTQGQVKITQPENYNS SLNTRPDLVQVSTMFRINEPRKVAKYIIALSIIAGILLVLFIVTGLIKAGFFKREKKEEL KQLMSTE------------------------------------AADEFNYRETMAEHKGA TKYDVQESDDESKVSLSQQINLPVARRERFKSQGSPTHRGSVASWDGMGGDKSPGWWGEA LRSSLKLDETDHHISIYGDVRNMLIRDPLSGSQSIIISKPCALARGICPVSSSGPQFNPW SEFRLMTFSWNRADTWRAMSSRGATLGPHCSTDLEQLEEGNPFYSDVIQFVSNIINDSLI LPSTTSPRISLINVYH-------------ENSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVSEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNKLSSSNFVYKLVKVLMAGKL--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQLYDVFGNGTDWRKCEVGDEVLYCSLSSWDRPWAADTLYSQPDCRLQFQ---------- ------------------------------------------------------------ ---------------ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPHYVGPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNQAASEKEDSSSEETEEIGTLEKPKEGSEDIKEIEGELEIGSVLSETTTVYGDQSLEV RSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIVVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLKVGFTPCKEDGSSKPD CMEGTIPSRICKAQLHQAFISDSKPKVVESECSNEIKDHPLPITRQRRGLLGGRTPIDVN DPKVKTVAAFALTKLDLTDSFPNSQPQVKIVAANKQVVQGSLYHLTLELMEGGPSNENV- ----------ATHVCYVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQ------------VVSGVKYSLVLEVGE STCAKTEASVGTCPLREGSV-----DQICHMVVVEQLWLNKSE----------------- ----LDPSAHRRRRELDNVGIPGGLTLISTDDPNVQEAAGFALSELDHITNSANSQCLVR IKRVHSQVVSGLKYHITLEVGESNSKKNDTSEEPCQLKPNTPTQECEVVVWSQPWLNRTE LTESSCGPANSAERVKRSSEPHIIGAPTDSDPEDPYIQELANFALTEIDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKSNNLVREECDLKEGSETQLCHLEVWDQPWRK HREVNKIKCGSSQTFTKRSVRAANKHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKKVDLLQRTEQGTAKYGATQFADLTA----------AEFKKKYLGVNPKLKSEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNVEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGEGEQCHFNKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HT---------------------------------------------------------- -----YPLFHKTLPFWVIKNSWGPSWGEQGYY---------------------------- --------------------KVYRGDG-TCGV----------NLMA-----------SSA VIA-------------------------- >Tcm ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MFTMKKLNP-------------DNSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVSEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNKLSSSNFVYKLVKVLMAGKL--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQLYDVFGNGTDWRKCEVGDEVLYCSLSSWDRPWAADTLYSQPDCRLQFQ---------- ------------------------------------------------------------ ---------------ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPHYVGPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNQAASEKEDSSSEETEEIGTLEKPKEGSEDIKEIEGELEIGSVLSETTTVYGDQSLEV RSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIVVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLKVGFTPCKEDGSSKPD CMEGTIPSRICKAQLHQAFISDSKPKVVESECSNEIKDHPLPITRQRRGLLGGRTPIDVN DPKVKTVAAFALTKLDLTDSFPNSQPQVKIVAANKQVVQGSLYHLTLELMEGGPSNENV- ----------ATHVCYVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQ------------VVSGVKYSLVLEVGE STCAKTEASVGTCPLREGSV-----DQICHMVVVEQLWLNKSE----------------- ----LDPSAHRRRRELDNVGIPGGLTLISTDDPNVQEAAGFALSELDHITNSANSQCLVR IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNAPTQECEVVVWSQPWLNRTE LTESSCGPANSGERVKRSSEPHIIGAPTDSDPEDPYIQELANFALTEIDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKSNNLVREECDLKEGSETQLCHLEVWDQPWRK HREVNKIKCGSSQTFTKRT------------------YMTRYNKNYPSKAEHKRRYHIFR ANMKKVDLLQRTEQGTAKYGATQFADLTA----------AEFKKKYLGVNPKLKSEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQ------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >Tps M----------------------------------------------------------- -----------------------------------------------------NPH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LR-- --------------------GGRVENH---------------LGKTT------------- ------------------------------------------------------------ -----------------------------PSSP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DR----DS-----------NL------------ ------------------------------------------------------------ --------------------------------DL-------------------------- -----SVLSSRAQHDK-------------SNSTESGKYLIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVSEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNKLSSSNFVYKLVKVLMAGKLEKP---PPV HLTEIRTSISPSLAVEI-------NTTNTLANYATELTPGSDSTLSTFDILVASTRCLKV EQLYDVFGNGTDWRKCEVGDEVLYCSLSSWDRPWAVDTLYSQPDCRLQFQ---------- ------------------------------------------------------------ ---------------ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPHYVRPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNLAASEKEDSSSEETEEIGTIEKPKEGLEDIKEIEGELEIGSVLSETTTVYGDQSLEV RSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIVVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLKVGFTPCKEDGSSKPD CMEGTIPSRICKAQLHQAFISDSKPK---------------------------------- ---VKTVAAFALTKLDLTDSFPNSQPHVKIVAANKQVVQGSLYHLTLELVEGGPSNENV- ----------ATHVCYVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQ------------VVAGVKYSLVLEVGE STCAKTEASAGTCPLREGS----------------------------------------- ----LDPSAHRRRRELDNVGIPGGLTLISTNDPNVQEAAGFALSELDHITNSANSQCLVR IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNAPTQECEVVVWSQPWLNRTE LTESSCGPANSGERVKRSSEPHIIGAPTDSDPEDPYIQELANFALTEIDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKSNNLVREECDLKEGS---------------- ------------------SVRAANRHKGKVTLEMFQEYMTLYNKNYPSKAEHKRRYHIFR ANMKRVDLLQRTEQGTAKYGATQFADLTGKA-------PAEFKKKYLGVNPKLKFEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNVEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEVDYPYEGEGEQCHFNKSEVQVTVSGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HSGAGVPSGLKLALHFFSNIFSYYKSTTSTLPPPTYQPHQRSRHRHTNHINRDLLTYTSF SYFAAYPLFHKTLPFWVIKNSWGPSWGEQVGN---------------------------- --------------------EVMHGNS--------------------------------- ----------------------------- >Tdi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MQGHS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ERGGSK---------------GG---------- -------------------------------------------VRGVGVVTAL------- -----------------------ATTVVHFCTDLEQLEEGNPFYSDVIQFVSNIINDSLI LPSTTSPRISLINVYH-------------ENSTESGKYFIQLDVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVSEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVSTVDKLNKLSSSNFVYKLVKVLMAGKLEKP---PPV HLTEIRTSISPSLAVEI-------NTTNTLANYATELTPGSDSTLSTFDILVASTRCLKV EQLYDVFGNGTDWRKCEVGDEVLYCSLSSWDRPWAADTLYSQPDCRLQFQ---------- ------------------------------------------------------------ ---------------ANEAESTSAPNDMEGTSFEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPHYVRPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNLAASEKEDSSSEETEEIGIIEKPKEGSEDIKEIEGELEIGSVLSETTTVYGDQSLEV RSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIVVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLKVGFTPCKEDGSSKPD CMEGTIPSRICKAQLHQAFISDSKPK---------------------------------- ---VKTVAAFALTKLDLTDSFPNSQPQVKIVAANKQVVQGSLYHLTLELVEGGPSNENV- ----------ATHVCYVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQ------------VVAGVKYSLVLEVGE STCAKTEASAGTCPLREGSV-----DQICHMVVVEQLWLNKSE----------------- ----LDPSAHRRRRELDNVGIPGGLTLISTDDPNVQEAASFALSELDHITNSANSQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNAPTQECEVVVWSQPWLNRTE LTESSCGPANSGERVKRSSEPHIIGAPTDSDPEDPYIQELANFALTEIDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKSNNLVREECELKEGS---------------- ------------------SVRAANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKRVDLLQRTEQGTAKYGATQFADLTGKARQYKILQSAEFKKKYLGVNPKLKSEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNVEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGEGEQCHFNKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HSKICRETCL-----------------------------------LTLH----------F LYFAAYPLFHKTLPFWVIKNSWGPSWGEQVGN---------------------------- --------------------EVMHGNRLLQGVSR------RRNLWGK----------SNG IIGRHRLRYIHYPWYS------------- >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MSK-----------LFYD--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------FKQSAPRIRFS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LCNS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PSSTKLVDGMLYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQAFIDNSIPK---------------------------------- ------------------------------------VVQGSLYHLTLELVEGRFFQRECG KVTPRAFSVSATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNRVSNSLYSHTLITLVNATKQ------------VVAGLKYSLVLEVGE STCAKNEANASTCPLREGSG-----IQICYMVVVEQLWLNKTEVTDFSCNPK-------- -ETSLDPSAHRRRREVGNVGIPGGLTLISTDDPNVQEAASFALSELDHITNSANTQCLVK IKRVHSQ--SGLKYHITLEVGESNSKKNVTSEEPCQLKPNTPTQECEVVVWSQPWLNRTE LTESSCGPTNSGGRVKRSSEPHILGAPTDSDPEDPYIQELATFALTELDKSSNALFALKK LNIIRATTQVVSGKLVTLTMEVGYTKCRKNKNLVIEECDLKEGS---------------- ------------------SVRSANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKRVEQLQRTEQGTAKYGATQFADLTA----------AEFKKKYLGVNPKLKSENLSP LPAAKIPHIQLPEEFDWRH----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >Tms ------------------------------------------------------------ ---------------MAP-----------------------------------NPT---- --------------------------------------------------------PPIV S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VFH-------------------------- --LVAL--------------------RLAEYYY----------------LETLCP----- -----------------------GQGH--------------------------------- ------------------------------------------------------------ -------------------MPCQL--IRAPVQPM-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ER------------------------------- ------------------------------------------------------------ ----------------------------------------VPA-NDVLMEPGRHMESYVI PRSH--VGPALLNFYV-------------KNSTESGKYFIQLEVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVNEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVNTVDKLNKLSTSNFVYKLVKVLMAGKL--------- ------------------------------------LTPGSDSTLSTLDILVASTRCLKV EQLYDVFGNGTDWRKCEVEDEVLYCSVSSWDRPWAVDTLYSQPDCRLQFQVGDLG----- --------------------YLALNKRPDSIN-----LG--------------------- ----------IIM--VNEAEGTSAPNDMEGTSSEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPQYVHPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNLAASEKDDSSSEETEEIGTIEKPKEGSEDVKEVEGELQMGSVSSETTTVYGDQSLEV HSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIIVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQPFISDSKPK---------------------------------- ------------------------------------------------------------ ----------ATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQ------------VVAGVKYSLVLEVGE STCAKNEASASTCPLREDSV-----AQICHMVVVEKLWLNKSEVTDFSCNPKARYINLFL QQKKLDPSAHRHRRGLDNVGIPGGLTLISTDDPNVQEAASFALLELDHVTNSANSQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNAPTQECKVVVWSQPWLNRTE LTESSCGPANSGERVKRSSEPHIVGAPTDSDPEDPYIQELASFALTELDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKTNHLVREECDLKEGSETQLCHLEVWDQPWRK HREVNKIKCGSSQTFTKRSVRDANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKKVDLLQRTEQGTAKYGATQFADLTA----------DEFKKKYLGVNPKLKSEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNVEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGEGEQCHFDKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HT---------------------------------------------------------- -----YPLFHKTLPFWVIKNSWGPSWGEQVGNEVMHGNQVKWEGFKKSLVVAAEEVFGGT SDKEKVNGDTMVERLGKGYYKVYRGDG-TCG----------------------------- ----------------------------F >Tce ------------------------------------------------------------ ---------------MAP-----------------------------------NPT---- --------------------------------------------------------PPIV S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VFH-------------------------- --LVAL--------------------RLAEYYY----------------LETLCP----- -----------------------GQGH--------------------------------- ------------------------------------------------------------ -------------------MPCQL--IRAPVQPM-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ER------------------------------- ------------------------------------------------------------ ----------------------------------------VPA-NDVLMEPGRHMESYVI PRSH--VGPALLNFYVKLWVGPLSRLDVLQNSTESGKYFIQLEVSDDCSTSSFTNCIPVK LVCELVASEEVEGLNVHSSKCASKESTPSFPVNEGVFYEENDASDARDIAEFALRQLEDE GSPRRNILEIMSLKKQMEANGTKLYLTVKVTATDGGDSSQLEVCEFEVNQTSEVTLESQG ACFPLGEERTNTPLNGDDILAGAVNTVDKLNKLSTSNFVYKLVKVLMAGKLLTPGSDSTL STLDILVASTRCLKVEQLYDVFGNGTDWRKCEVEDELTPGSDSTLSTLDILVASTRCLKV EQLYDVFGNGTDWRKCEVEDEVLYCSVSSWDRPWAADTLYSQPDCRLQFQATETGTKSSG MQIARLKNLLGQDAVRLYKTLTTIKPEEETVNGILKRLGELFENFYAELRALATPCEFDD QEHKLLRAQIILG--VNEAEGTSAPNDMEGTSSEPAAVEERIAMVEEPAVAVEETVVVAP SYCTGCPTDLNTDNPALGEFTEQALSMIDDSSNQEYIHNIVKILRAQRQVVSGVKYTLLM EVVETSCLKGSGTERQLCEARSGVKTRLCFVEFLEKPWLDQSREILSNNCTQDDNNDLDN EIIPQYVRPDTADRQEIYDYLDAMDEPVPDKVLTRLGVEDIIHIPVHKDPVEPETSVEGN AKNLAASEKEDSSSEETEEIGTIEKPKEGSEDVKEVEGELQMGSVSSETTTVYGDQSLEV HSEYYDNIQQEDHKSEEVLDDSDEDTVISYISTGSRRRRDSLSRPNIGKLIDFDPSEEKY KNELAQIIVRTLDELDADDMKRVVLKILDSKKQLVDGMSYHLTLRVGFTPCKEDGSSKPD CMEGTVPSRICKAQLHQPFISDSKPK---------------------------------- ------------------------------------VVQGSLYHLTLELVEGGPSNENV- ----------ATHVCNVSVWDRPWLNKTELTNSSCSPVQQRTKRELLVGGASPASVSDSG VQRAASTALAHLNSVSNSFYSHTLITLVNATKQVVAGVKYSLVLEVVAGVKYSLVLEVGE STCAKNEASASTCPLREDSGDNPRWLRFATMVVVEKLWLNKSEVTDFSCNPKARYINPFL QQKKLDPSAHRHRRGLDNVGIPGGLTLISTDDPNVQEAASFALLELDHVTNSANSQCLVK IKRVHSQVVSGLKYHITLEVGESNSKKNVTSEEPCQLKPNAPTQECKVVVWSQPWLNRTE LTESSCGPANSGERVKRSSEPHIVGAPTDSDPEDPYIQELASFALTELDKSSNALFALKK LNILRATTQVVSGKLVTLTMEVGYTKCRKTNHLVREECDLKEGSETQLCHLEVWDQPWRK HREVNKIKCGSSQTFTKRSVRDANRHKGKVTLEMFQDYMTRYNKNYPSKAEHKRRYHIFR ANMKKVDLLQRTEQGTAKYGATQFADLTA----------DEFKKKYLGVNPKLKSEDLSP LPAAKIPNIQLPEEFDWRHYNVVTEVKNQGSCGSCWAFSVTGNVEGQWALRRGKLVSLSE QELVDCDTLDQGCGGGLMFNTYTAIKNIGGLENEDDYPYEGEGEQCHFNKSEVQVTVAGG VNITSNETQMAQWLVKNGPISIAINANAMQFYFGGVSHPWSFLCDPESLDHGVLIVGYGV HT---------------------------------------------------------- -----YPLFHKTLPFWVIKNSWGPSWGEQ------------------------------- -----------------GYYKVYRGDG-TCGTTKDGEIEVRISVVGKGGKEVEKLDILSI LLTGGKIRYTLYSFDRFDAKGQKIPEKIF