>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxSNLDISxxxxxVQQESDAFEHATSDAERECVSPYIC ACxxxxxxxIxHVNTIITKxxxxxxxxxxxxxxNYSRVPEKAAISGVVYQ xxxxPTPAFRAAQYAFIxxERTLAPAADDGSGTHDQDSNPNLHVIGSLLY RESDALDRAATQ----PLLWRRMDVEDFREHGKEMVEYICEYLSTLEERR VTPSVEPGYLSKLLPQQAPQEPEDWATIMADVDSKIMPGVTHWQHRRFHA YFPSGNSFPSILGDMLADAIGCIGFSWVRIFLEQSQEAASPACTELETIV LDWLGKAIGLPEEFLAFPKGSKGGGVIQTSASECVLVxxLAARAQAIKKL KQLHPSVEEGMLLSKLMAYCSKEAHSCVEKAAMICFVKLRILEPDEKCCL RGDTLKQAMEEDEAMGLTPFFVSTTLGTTSCCSFDNLPEVGPVCKRFPAV WLHVDGAxxxxxxxxPELKPMLGGIEYADSFNTNSNKWLLVNFDCSTMWV RDRFRLTSALVVDPLYLQHGYSDAAIDYRHWGVPLSRRFRWAPYTFNTCS FQQEVQVGSLYFQHLWFVLRSYGISGLQSYIRHHIRLAKRFEALVNRDRR FQVCNEVKLGLVCFRLKGSDELNQKLLSNINESGRLHMVPASVNEKYVIR FCAVAQNATEDDMLDRKKKEGLAYKRSFFVRMVSDPKIYNPKIAKSLASS RVExKQTEx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----DTEEFRVRGKEMVDYICDYMNGLGSRPVYPSIEPGFLTNLIPSQA PDEPEDWDAIMADVDSKIMQGVCHWQHPRFHAYFPSGNSYPSIIADMLSD AIGSIAFSWVx------xxxxxxxxxxxxxxxxxxxxxxQLSENVLP--- ------LDYCSILVCVVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSPF FNLFHEINQQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKLxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- ---------------------------------xKALALPEEFLASPQGS RGGGVI------------------QGSASECILVSMLAARNQAVKYLKKD VPDAEDSSFLPRLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEANGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRTYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVIND--MGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDIGE AISSSSNxxxx-------------------xxx----------------- -------------------------------------------------- -------------------------------------------------- ------- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxSPGVEx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KQTEx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----DTEEFRVRGKEMVDYICDYMNGLGSRPVYPSIEPGFLTNLIPSQA PDEPEDWDAIMADVDSKIMKGVCHWQHPRFHAYFPSGNSYPSIIADMLSD AIGSIAFSWVSxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGKALALPEEFLASPPGS RGGGVI------------------QGSASECILVSMLAARNQAVQYLKKD VPDAEDSSFLPLLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEAKGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRMYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDIGE AISSSSNxxxx-------------------xxx----------------- -------------------------------------------------- -------------------------------------------------- ------- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------GKALALPEEFLASPPGS RGGGVIxIASHPCEKCAVNFRFCPQGSASECILVSMLAARNQAVQYLKKD VPDAEDSSFLPLLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEAKGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRMYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDID- ----------------------------------HAWEVIQEFASDLLES MKIAEPPTKPLPDTTK----------------PLSRKLTRRLSFTRSVSR DVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGMSLGSLSISGLP IVDEKDC >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxx-------------- -----NTEEFRVKGKEMVDYICEYMEGLGSRRVQPTVEPGYLRDIIPTEA PNEPEDWDDIMADVDNKIMKGVCHWQHPRFHAYFPSGNSYPSIIGDMLSD AIGSIAFSW----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------ALALPEEFLASPPGS RGGGVI------------------QGSASECILVSMLAARNQAVQYLKKD VPDAEDSSFLPLLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEAKGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRMYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDID- ----------------------------------HAWEVIQEFASDLLES MKIAEPAIKPLPDATK----------------PLSRKLTRRLSFTRSVSR DVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGMSLGSLSISGLP IVDEKDC >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----NTEEFRVKGKEMVDYICEYMDGLGSRRVQPTVEPGYLRDIIPTEA PNEPEDWDDIMADVDTKIMKGVCHWQHPRFHAYFPSGNSYPSIIGDMLSD AIGSIAFSWAA----------------------------------xxxxx xxxxxVLD------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------WF- -------------------------------------------------- -------------------------------------------------- ---------------------------------xKALALPEEFLASPPGS RGGGVI------------------QGSASECILVSMLAARNQAIQYLKKD VPDAEESSFLPRLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEANGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRTYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDID- ----------------------------------HAWEVIQEFASDLLES MKIAEPPVKPLPDTTK----------------PLSRKLTRRLSFTRSVSR EVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGLSLGSLSISGLP IVDEKDC >Tte xxxxxxCTxxxxxxxxxxWxxxERNxxxxREGxxxxxxGGECxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxNSSPSSWTSEExxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxLLLRYNARHALExxxxxxxxEIEGCIYRExxxIxxxxxxxKN L------------------------------------------------- -------------------------------------------------- -------------------------------STHDKDSNPNLPVIGSLLY RESDALDHVATQALIHPLLWRRMDVEDFREHGKEMVEYICEYLSTLEERR VTPSVEPGYLGKLLPQQAPQEPEDWATIMADVESKIMPGVTHWQHRRFHA YFPSGNSFPSILGDMLADAIGCIGFSWVRIFLEQSQEAASPACTELETIV LDWLGKAIGLPEEFLAFPKGSKGGGVIQTSASECVLVxxLAARAQAIKKL KQLHPSVEEGMLLSKLMAYCSKEAHSCVEKAAMICFVKLRILEPDEKCCL RGDxxxxxxxxxxxxxxxxxxxSTTLGTTSCCSFDNLPEVGPVCKSFPAV WLHVDGAxxxxxxxxPELKPMLGGIEYADSFNTNSNKWLLVNFDCSTMWV RDRFRLTSALVVDPLYLQHGYSDAAIDYRHWGVPLSRRFRWALYTFNTCS SQQEVQ--------LWFVLRSYGISGLQSYIRHHIRLAKRFEALVNRDRR FQVCNEVKLGLVCFRLKGSDELNQKLLSNINESGRLHMVPASVNEKYVIR FCAVAQNATEDDMLDRKKKEGLAYKRSFFVRMVSDPKIYNPKIAKSLASS RHRxRETExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx-------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx-----xxxxxVKLxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx------------------xxxxxxxxxxxxxxx xxxxxDIEEFRVKGKEMVDYICEYMDGLGSRRVQPTVEPGYLRDIIPTEA PNEPEDWDDIMADVDTKIMKGVCHWQHPRFHAYFPSGNSYPSIIGDMxxx xxxxxxxSWxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------KALALPEEFLASPPGS RGGGVI------------------QGSASECILVSMLAARNQAIQYLKKD VPDAEESSFLPRLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEANGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRTYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVIND--xGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDID- ----------------------------------HAWEVIQEFASDLLES MKIAEPPVKPLPDTTK----------------PLSRKLTRRLSFTRSVSR EVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGLSLGSLSISGLP IVDEKDC >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- ---------------------VCHWQHPRFHAYFPSGNSYPSIIGDMLSD AIGSIAFSWAA----------------------------------xxxxx xxxxxVLx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- ---------------------------------GKALALPEEFLASPPGS RGGGVI------------------QGSASECILVSMLAARNQAVQYLKKD VPDAEDSSFLPLLVAYCSTESHSCVEKAAMISLVKLRILEPDENCSLRGD TLLKAMEEDEAKGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRMYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKL---------TSALNVDPLYLQHKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDIGE AISSSSN-------------------xxxxTCGxHAWEVIQEFASDLLES MKIAEPPTKPLPDTTK----------------PLSRKLTRRLSFTRSVSR DVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGMSLGSLSISGLP IVDEKDC >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------MISLVKLRILEPDENCSLRGD TLLKAMEEDEANGLFPFFVSTTLGTTSSCAFDNLKEIGPVCRTYPSVWFH VDGAYAGNSFICPENRYLMNGIHYADSFNTNTNKWLLVAFDCSCLWIKDR NKLxxxxxxxxx------------HKRSEETIDYRHWGIPLSRRFRALKL WFVLRRYGIQGLQAYIRNHCRLAKRFEGLVRKDSRFEVINDVKMGLVCFR VNGTDRLNQELLANINASGKLHMIPSLVKCRYIIRFCVTAEHAKDEDIGE AISSSSNDGRGxxxxSPKTFPLSxxxx-------HAWEVIQEFASDLLES MKIAEPPVKPLPDTTKxxxxxxxxxxxFTRSVPLSRKLTRRLSFTRSVSR EVYRRSLSRSSLHDGATPINVLDDEENIVEDEDVFHSGLSLGSLSISGLP IVDEKDC