>Tge M----------------------------------------------------------- ---SC------------------------------------------------------- ---------VFDMQ---------------------------------------------- -------------------------QAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIEASLREKGWVAGILPIVE-RNLHA TTNIQAGFIKKENDVETVTEAAPAIDNWKEVTPDPAISYVDFVSLDEDVAVCGEVTDENI VAKVLNNNIQTEDGASGDEEDNSLAVQERPISSAAEAMDHIQELGYIQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEGSVDHSLVSCAHGTSTPQHSLVSCAHGTSKPQHSLVS CAHGTSKPQHSLVSCAHGTSKPQHSLVSCTHGTSKPQHSLVSCTHGASKPQHSLVSCSHG TSKPQHSLVSCTHDTSKPQHSLVSCTHDTSKPQHSLVSCTHDTSTPQHSLVSCTHGTSKP QHSLVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tpa M-GS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DDQFSSRGN--- -----------------------------------------------------------H YLFVYWQQCK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQ--PEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEGSVDHSLVSCAH------------------------- ------------------------------------------------------------ -------------DTSKPQHS----------------------------LVSCTHDTSKP QHSLVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tms MDGS---QDDS------------------------------------------------- ----------NMPEQPFHERIQKQQLMIEQQRQEELLRLQQ-----SAMAEKQQEEQERQ MRQRRQEEELFRLQQEALLEKQREL----------------------------------- -------------------------QAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDKRSKRK KKKKKRGRHQQKLELELQQQQKKDLETGEKESQVEIEY---------------------- ------------------------------------------------------------ ----------------------------------------------IQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VM----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ >Tte MDGS---QDDS------------------------------------------------- ----------NMPEQPFHERIQKQQLMIEQQRQEELLRLQQ-----SAMAEKQQEEQERQ LRQRRQEEELFRLQQEALLEKQREL----------------------------------- -------------------------QAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQQKLELELQQQQKKDLETGEKESQVEIEY---------------------- ------------------------------------------------------------ ----------------------------------------------IQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKDDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEGSVDHSLISCAHGISKPQHSLVSCAHGTSKPQHSLVS CTHDTSIPQHSLVSCTHDTSIPQHSLVSCAHGTSTPQHSLVSCAHGTSKPQHSLVSCAHA Y------------------------------------------------LLRSTPRGETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tbi M----------------------------------------------------------- ------------PEQPFHERIQKQQLMIEQQRQEELLRLQQVLDIDSAMAEKQQEEQERQ LRQRRQEEELFRLQQEALLEKQREL----------------------------------- -------------------------QAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQQKLELELQQQQKKDLETGEKESQVEIEY---------------------- ------------------------------------------------------------ ----------------------------------------------IQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKDDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEG------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tps MDGS---QDDS------------------------------------------------- ----------NMPEQPFHERIQKQQLMIEQQRQEELLRLQQ-----SAMAEKQQEEQERQ MRQRRQEEELFRLQQEALLEKQREL----------------------------------- --------------------------AMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIEY---------------------- ------------------------------------------------------------ ----------------------------------------------IQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRKVIVDVEAEEDLNSNFDFSKLRTPLFIFHYQLARPVIAIKVRQKGVQYLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEG------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tdi MDGS---QDDS------------------------------------------------- ----------NMPEQPFHERIQKQQLMIEQQRQEELLRLQQ-----SAMAEKQQEEQERQ MRQRRQEEELFRLQQEALLEKQREL----------------------------------- -------------------------QAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEMGENSFLTILDLLTDKPKIRQDSSC ATLSTDNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGVGGGGRAHQKDKRSKRK KKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIDLT-------AEDGEI-------- ---------EKENDEETVTEAAPAIDNWEEVTPDPANSYVDFVSVDEDVAESGDVTDTDI I---------------------------------------------VKETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEG------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tsi MEKGGLGQDFSVVAGGYCRIFDGCSPINVDGLGWACCWAAGAFPSRGSSGLALKEYLWTE RRSSCTSWWAPMPEQPFHERIQKQQLMIEQQRQEELLRLQQ-----SAMAEKQQEEQERQ MRQRRQEEELFRLQQEALLEKQRELGRGRLYLEEKLSHLSSGKKENYLGKTTFSIPNQDP NPSPPIIGSLDYRESSTQTMWSLKQQAMSIPPPISVTPVLPPPPPTISGMMPPGIDMTAP PPNTPIAPPPPQMRGPPPAVAMPPPPGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVD PPPSDMKEVKLPMALEQALAFKTERAKQIGVEAEEM------------------------ -----DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEEQRVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQHKLELELQQQQKKDLETGEKESQ--------------------------- ----------KENDEETVTEAAPVIDNWEEVTPDPANSYVDFVSVDEDVAESGGVTDTDI I---------------------------------------------AKETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKISGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEG------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tcm M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TLMTMK-- ------------------------------------------------------------ ---------------------------------EEEQ-RVVVGAGGGGRAHQKDKRSKRK KKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIDCS-------AVLLDFWEQRRGHW N--------TKENDEETVTEAAPVIDNWEEVTPDPANSYVDFVSVDEDVAESGDVTDTDI I---------------------------------------------AKETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEG------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKNKRKQRQQHQ-DNKQAKKY-- -----------------------------------------------KEF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KF----------------------------------------- ------------------------ >Tce M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RR------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------YIQETLGIHELEPMY RQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLEDEYDDDDIEEDENKKQ EEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEMHDVTARDPKLLVQLKAHRNTVPVPRH WCF----KRK----------------------------------------------YLQG KRGIEKPPFDLPEFIKKTGIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHD AFFKWQTKPRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPPWL IAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRPLYGDVFGIQVQD LQAEPEDEEVDTAIWGELESESEEESEEEEDEDEEGGGKEDDTGLVTPVEGLITPSGITS IPAGMETPEIIELRKRKIESEMEGSVDYSLVSCAHAY----------------------- ------------------------------------------------------------ -------------------------------------------------LLRSTPRGETP ALFQVLPEKRMDRVGGAMMASTHIYDMTGAGAPPPAPVIRRGGLEGSGTVELALDPSELD LVDTDAMAVRYEQQIREQQSQLQKEDLSDMLADHVARQKSTMTHELPNLFVSPQAVKYPI TSLSLLQNKEDDLSPIEIEPRVPPGTMSRFYFPPKPLKRKGLSHPTLREFPTFSRVFEIP STPRNRDSDVVTLHKVYGNTLPAKATRSTNSRTAWYLTCSLERMLYWLPMNVQLSVVGQV IVDDERHLLYINTSCPHVCGDENAATQHINTFNIRVQRNRLRNQLRSSLMVIHPLKDEEG KSSPSAIGSESSTSTHVTSRLCDQNWWLEKKQSNFVLTLSPSAIILYLRLRLTLPGLYPT SHGDSRCWDSVLPPTATHVAGTLSYLPRRLTLPGLYPTSHRDSHCRDSILPPTATPVLPV LLPSTSPPFPFACPCHRRFHEKVYTRSSSKSHTSLNTTLPSFKHQVDKRTWTSRRNIFST YQRMELGSKTALSWGRYVFNLRSQ